ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 2177

The Forced Oscillation Technique Is a Sensitive Method for Detection of Obstructive Airway Disease in Patients with Primary Sjögren’s Syndrome

Anna M. Nilsson1, Elke Theander2, Roger Hesselstrand3, Per Wollmer4 and Thomas Mandl5, 1Dept of Rheumatology, Skane University Hospital Malmo, Lund University, Malmo, Sweden, 2Dept of Rheumatology, Skane University Hospital Malmo, Lund University, Malmö, Sweden, 3Rheumatology, Lund University, Lund, Sweden, 4Dept of Clinical Physiology, Skane University Hospital Malmo, Lund University, Malmö, Sweden, 5Dept of Rheumatology, Skåne University Hospital Malmo, Lund University, Sweden, Malmö, Sweden

Meeting: 2012 ACR/ARHP Annual Meeting

Keywords: diagnosis and pulmonary complications, Sjogren's syndrome

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print
Session Information

Title: Sjögren's Syndrome - Clinical

Session Type: Abstract Submissions (ACR)

Background/Purpose: To study signs of obstructive airway disease in patients with primary Sjögren’s syndrome (pSS) by the forced oscillation technique (FOT), a method that may aid in distinguishing between peripheral and central airway obstruction. 

Methods:

37 female pSS patients (median age 64, range 38-77 years) without known chronic obstructive pulmonary disease (COPD), participating in a longitudinal follow-up study of pulmonary function, and 74 female population-based controls (median age 64, range 47-77 years), also without known COPD, and matched with regard to gender, age, height, weight and tobacco consumption were included in the study. The pSS patients and controls were after inhalation of beta agonist studied by the FOT, evaluating airway resistance and reactance, at different oscillation frequencies, as well as the resonance frequency. pSS patients were also assessed by spirometry according to which 14 were diagnosed with obstructive airway disease (OAD) (12 with COPD and 2 with abnormal reversibility test). 

Results:

pSS patients had significantly increased resistances at 5-25Hz (p<0.001), decreased reactances at 10-35Hz (p<0.001) and an increased resonance frequency (p=0.002) whilst the resistance slope between 5 and 20Hz was not significantly different (p=NS) in comparison with controls. Airway resistance was negatively correlated and airway reactance positively correlated to the vital capacity, the forced expiratory volume in 1 second and the diffusion capacity for carbon monoxide. Both pSS patients with and without OAD had significantly increased resistances at 5-25Hz (p<0.001) and decreased reactances at 10-35Hz (p<0.001) in comparison with controls respectively, whilst only the former had a significantly increased resonance frequency (p<0.001). 

Conclusion:

pSS patients showed FOT signs of airway obstruction, possibly due to airway sicca, impaired mucus clearance and bronchial inflammation. OAD also affect central airways in pSS. Also pSS patients without spirometric signs of OAD show clear FOT signs of airway obstruction. FOT thus seems to be a sensitive method in detecting airway obstruction in pSS patients.


Disclosure:

A. M. Nilsson,
None;

E. Theander,
None;

R. Hesselstrand,
None;

P. Wollmer,
None;

T. Mandl,
None.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to 2012 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/the-forced-oscillation-technique-is-a-sensitive-method-for-detection-of-obstructive-airway-disease-in-patients-with-primary-sjogrens-syndrome/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology