ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 3026

The Effects of Lrg on the Differentiation of Naïve T Cells

Hayato Urushima1, Minoru Fujimoto2, Chiharu Iwahashi1, Tomoharu Ohkawara2, Hiromi Honda2, Satoshi Serada1 and Tetsuji Naka2, 1Laboratory for Immune Signal, National Institute of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan, 2Laboratry of immune signal, National Institute of Biomedical Innovation, Health and Nutrition, Ibaraki, Japan

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: T cells and rheumatoid arthritis (RA)

  • Tweet
  • Email
  • Print
Session Information

Date: Tuesday, November 10, 2015

Title: T cell Biology and Targets in Autoimmune Disease Poster II

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose:  Previously, we have identified leucine-rich alpha 2 glycoprotein (LRG) as a disease marker of Rheumatoid arthritis(RA). Although LRG is produced in site of inflammation such as synovial tissues, its function is still unclear. Recently, LRG has been reported to modulate TGF-β signaling. TGF-β is essential for differentiation of Th17 and Treg, and these cells play important roles in the pathogenesis of RA, for example, by regulating osteoclast differentiation. So, LRG is may be involved in the pathogenesis of RA through the regulation of T lymphocyte differentiation. In this study, we aimed to elucidate the function of LRG on T lymphocyte differentiation and to examine the involvement of LRG in the pathogenesis of RA.

Methods: Naïve T lymphocyte were isolated from WT mice to examine the effects of LRG on the differentiation into Th17 and Treg. Male C57BL/6 mice and LRG KO mice were subjected to collagen-induced arthritis (CIA).

Results: In the presence of TGF-β alone, the differentiation of Treg was promoted by LRG. However, in the presence both TGF-β and IL6, LRG enhanced the differentiation into Th17 by increasing STAT3 phosphorylation. In CIA model, the numbers of Th17 in regional lymph nodes and serum levels of IL17 were significantly lower in LRG KO mice than in WT mice.

Conclusion: We propose that LRG promote differentiation of Th17 by enhancing phosphorylation of STAT3 and Smad in naïve T cells in the presence both TGF-b and IL6, and might involve in the arthritis pathology.


Disclosure: H. Urushima, None; M. Fujimoto, None; C. Iwahashi, None; T. Ohkawara, None; H. Honda, None; S. Serada, None; T. Naka, None.

To cite this abstract in AMA style:

Urushima H, Fujimoto M, Iwahashi C, Ohkawara T, Honda H, Serada S, Naka T. The Effects of Lrg on the Differentiation of Naïve T Cells [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/the-effects-of-lrg-on-the-differentiation-of-naive-t-cells/. Accessed .
  • Tweet
  • Email
  • Print

« Back to 2015 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/the-effects-of-lrg-on-the-differentiation-of-naive-t-cells/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology