ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2365

The Cross-Sectional and Longitudinal Associations Between Metabolic Syndrome and Hand Osteoarthritis – Data from the Framingham Study

Mette P. Strand1, Tuhina Neogi2, Jingbo Niu2, David T. Felson3,4 and Ida K. Haugen5, 1Medical Faculty, University of Oslo, Oslo, Norway, 2Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, 3Arthritis Research UK Centre for Epidemiology, Institute of Inflammation and Repair, University of Manchester, Manchester, United Kingdom, 4Clinical Epidemiology Unit, Boston University School of Medicine, Boston, MA, 5Rheumatology, Diakonhjemmet Hospital, Oslo, Norway

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: ,

Session Information

Date: Tuesday, November 15, 2016

Title: Osteoarthritis – Clinical Aspects - Poster II

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose:   The association between osteoarthritis (OA) and metabolic syndrome (MetS) is controversial. Hand OA, and especially erosive hand OA (1), may be more strongly related to systemic risk factors, such as MetS, than OA in lower limbs. Hence, our aim was to explore the associations between hand OA and MetS in the Framingham Offspring cohort.

Methods:   Hand x-rays and clinical data on MetS were available in 1090 persons between 50-75 years, of whom 785 had follow-up hand x-rays after 7 years. Baseline hand radiographs were read according to Kellgren-Lawrence (KL) scale. The longitudinal x-rays were similarly read in pairs according to KL scale and were also read for central erosions. We examined whether MetS and its components were associated with presence of radiographic hand OA (≥1 finger joint with KL grade ≥2) and erosive hand OA (≥1 finger joint with erosions) at baseline using logistic regression. Linear regression was performed with KL sum score as outcome. In longitudinal logistic regression analyses, we examined the associations between MetS and its components at baseline and incident radiographic hand OA in persons with no hand OA at baseline. Analyses were repeated using incident erosive hand OA in persons with no erosions at baseline. Age and sex were included in all models with/without additional adjustment for body mass index (BMI).

Results:   Mean (SD) age was 59.2 (6.3) years and 52% were women. At baseline, radiographic hand OA was present in n=492/1090 (45%), whereas erosive hand OA was found in n=52/785 (7%). N=492/1090 persons (45%) had MetS. In cross sectional analyses, MetS, central obesity and hypertension were associated with hand OA presence after adjusting for age and sex, but only the latter reached statistical significance (Table). No associations were found for KL sum score (data not shown) or erosive hand OA (Table). Incident hand OA and incident erosive hand OA occurred in 166/375 (44%) and 55/733 (8%), respectively. Whereas no associations were found for incident hand OA, there was a trend that MetS was associated with development of erosive OA, and a significant association was found for central obesity (Table). All associations remained similar after additional adjustment for BMI. Table: Associations between MetS and hand OA. 

  Cross-sectional analyses OR (95% CI)* Longitudinal analyses OR (95% CI)*
Hand OA presence Erosive hand OA presence Incident hand OA Incident erosive OA
MetS 1.23 (0.95,1.61) 0.71 (0.39,1.30) 0.78 (0.51,1.19) 1.66 (0.95,2.92)
Central obesity 1.23 (0.94,1.61) 0.69 (0.37,1.27) 1.40 (0.92,2.15) 1.78 (1.02,3.10) 
High BP or anti-hypertensive rx 1.41 (1.08,1.84) 1.01 (0.56,1.83) 1.10 (0.72,1.67) 1.19 (0.67,2.11) 
Diabetes or antidiabetic rx 1.14 (0.86,1.51) 0.74 (0.38,1.45) 0.89 (0.56,1.42) 1.32 (0.73,2.40)
Low HDL or lipid-lowering rx 1.09 (0.83,1.42) 0.77 (0.41,1.44) 1.23 (0.81,1.87) 1.23 (0.70,2.15)
High triglycerides 0.92 (0.69,1.23) 0.49 (0.25,0.96) 0.67 (0.43,1.05) 1.23 (0.65,2.31)
OR=odds ratio; CI=confidence interval; OA=osteoarthritis, MetS=metabolic syndrome; BP=blood pressure, HDL=high-density lipoprotein, rx=treatment. * Adjusted for age and sex.

Conclusion: No consistent results were found between MetS and the presence and development of hand OA. A significant association was found between central obesity and incident erosions, but the lack of associations in baseline analyses suggests that this may be a chance finding. References: 1) Marshall M. et al. Ann Rheum Dis. 2015;74:136-41.

Disclosure: M. P. Strand, None; T. Neogi, None; J. Niu, None; D. T. Felson, None; I. K. Haugen, None.

To cite this abstract in AMA style:

Strand MP, Neogi T, Niu J, Felson DT, Haugen IK. The Cross-Sectional and Longitudinal Associations Between Metabolic Syndrome and Hand Osteoarthritis – Data from the Framingham Study [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/the-cross-sectional-and-longitudinal-associations-between-metabolic-syndrome-and-hand-osteoarthritis-data-from-the-framingham-study/. Accessed .

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