ACR Meeting Abstracts

ACR Meeting Abstracts

  • Home
  • Meetings Archive
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP Annual Meeting
    • 2017 ACR/ARHP PRSYM
    • 2016-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • Register
    • View and print all favorites
    • Clear all your favorites
  • Meeting Resource Center

Abstract Number: 1821

The Co-Occurrence Patterns of MRI Lesions and Incident Knee Osteoarthritis: The MOST Study

Jingbo Niu1, David T. Felson2, Tuhina Neogi3, Michael C. Nevitt4, Cora E. Lewis5, James Torner6, Ali Guermazi7, Frank Roemer8 and Yuqing Zhang3, 1Clinical Epidemiology Research and Training Unit, Boston University, Boston, MA, 2Clinical Epidemiology Research & Training Unit, Boston University School of Medicine, Boston, MA, 3Boston University School of Medicine, Boston, MA, 4Epidemiology & Biostatistics, UCSF (University of California, San Francisco), San Francisco, CA, 5Preventive Medicine, University of Alabama, Birmingham, Birmingham, AL, 6Epidemiology, University of Iowa, Iowa City, IA, 7Radiology, Boston University School of Medicine, Boston, MA, 8Klinikum Augsburg, Augsburg, Germany

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: MRI and osteoarthritis

  • Tweet
  • Email
  • Print
Save to PDF
Session Information

Session Title: Osteoarthritis - Clinical Aspects I: Imaging in Osteoarthritis

Session Type: Abstract Submissions (ACR)

Background/Purpose: MRI imaging provides insights of tissue-specific lesions of osteoarthritis (OA) and has the advantage of identifying earlier pathological changes that are not evident on radiographs. While MRI lesions often co-occur, the co-occurrence patterns and their relation to the risk of incident OA have not been well evaluated. We identified distinct subgroups of knees using a latent class model according to patterns of pathological changes on MRI and examined their relation to incident radiographic knee OA (incROA).

Methods: The MOST Study recruited 3,026 subjects with or at risk for knee OA. We obtained baseline knee MRI and knee radiographs at each visit. MRIs were scored using the Whole Organ Magnetic Resonance Score (WORMS). Tibiofemoral (TF) incROA was defined by a new occurrence of KL≥2 on PA view radiograph by Month 84, and patellofemoral (PF) incROA was defined by a new occurrence of PF OA on lateral view. For specific lesions on MRI in the TF joint, i.e., cartilage morphology, meniscal tear, meniscal extrusion, bone marrow lesion, synovitis, and effusion, we used the worst WORMS score among all sub-regions to represent the severity of that lesion in the knee. We performed latent class modeling (SAS: Proc LCA) to identify subgroups of knees by patterns of MRI lesions. Each knee was assigned to a specific subgroup according to its highest membership probability. We then examined the relation of subgroups of MRI lesions to the risk of TF incROA after adjusting for age, sex, race, clinic site, history of knee injury and surgery using logistic regression model. We took the same approach to identify subgroups of MRI lesions in the PF joint and assess their relation to PF incROA.

Results: Among 579 knees without TF OA (mean age: 60.1 years, BMI 29.2 kg/m2, 59% women), we identified 4 subgroups based on baseline MRI lesions with average posterior probability 0.82: mostly normal (Group 1, 48.0%); predominantly cartilage lesion (Group 2, 24.9%); predominantly meniscal lesions (Group 3, 13.8%); and combined cartilage and meniscal lesions (Group 4, 13.3%) (Table). In Group 3, meniscal tear was more prevalent than meniscal extrusion. Bone marrow lesion, synovitis, and effusion were common in Groups 2 and 4. The risk of TF incROA was 12.2%, 22.9%, 31.3% and 44.2%, for Group 1, 2, 3 and 4, respectively. The corresponding odds ratios (ORs) of TF incROA and 95% CI were 1.0, 2.5 (1.4, 4.4), 5.4 (2.8, 10.5), and 8.2 (4.3, 15.7). Similarly, 4 subgroups of MRI lesions were identified in PF joints among 660 knees without PF OA. The ORs of PF incROA for each subgroup were 1.0, 4.3, 8.9, and 17.0, respectively.

Conclusion: The latent class analysis allowed insights of the patterns of MRI lesions. Among the four subgroups of MRI lesions we identified, the co-occurrence of cartilage and meniscal lesion markedly increased the risk of incident ROA, and the meniscal lesion subgroup posed a higher risk than the cartilage lesion subgroup.

Table. Baseline MRI lesions in the subgroups identified by latent class analysis

Group1

Group 2

Group 3

Group 4

TF joint

Mostly normal

Predominantly cartilage lesion

Predominantly meniscal lesions

Combined cartilage and meniscal lesions

N of knees

278

144

80

77

%TF cartilage morphology,

0 (no lesion)

62.2

0.0

37.5

0.0

 2 (mild lesion)

13.7

24.3

30.0

7.8

 3-4 (moderate lesion)

14.4

47.2

32.5

46.8

2.5/5-6 (lesion extending to bone)

9.7

28.5

0.0

45.5

%Meniscal tear, 

1+(any lesion)

0.0

20.8

100.0

58.4

%Meniscal extrusion,

1+(any lesion)

19.8

0.0

45.0

96.1

%TF bone marrow lesion

1+(any lesion)

18.0

65.3

31.3

68.8

%Synovitis,  

1+(any lesion)

36.3

86.8

47.5

76.6

%Effusion,   

1+(any lesion)

29.1

83.3

43.8

83.1

PF joint     

Mostly normal

Combined mild/ moderate cartilage and meniscal lesions

Predominantly meniscal lesions

Combined moderate/ severe cartilage and meniscal lesions

N of knees

203

121

94

242

%PF cartilage morphology,

0 (no lesion)

75.9

0.8

38.3

0.4

 2 (mild lesion)

4.4

55.4

13.8

0.0

 3-4 (moderate lesion)

19.7

43.8

39.4

41.3

2.5/5-6 (lesion extending to bone)

0.0

0.0

8.5

58.3

%Meniscal tear, 

1+(any lesion)

14.8

48.8

94.7

17.4

%Meniscal extrusion,

1+(any lesion)

19.7

22.3

89.4

30.2

%PF bone marrow lesion

1+(any lesion)

6.9

61.2

19.1

91.7

%Synovitis,  

1+(any lesion)

36.9

62.8

66.0

68.2

%Effusion,   

1+(any lesion)

24.1

55.4

77.7

69.4


Disclosure:

J. Niu,
None;

D. T. Felson,
None;

T. Neogi,
None;

M. C. Nevitt,
None;

C. E. Lewis,
None;

J. Torner,
None;

A. Guermazi,
None;

F. Roemer,
None;

Y. Zhang,
None.

  • Tweet
  • Email
  • Print
Save to PDF

« Back to 2014 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/the-co-occurrence-patterns-of-mri-lesions-and-incident-knee-osteoarthritis-the-most-study/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

ACR Convergence: Where Rheumatology Meets. All Virtual. November 5-9.

ACR Pediatric Rheumatology Symposium 2020

© COPYRIGHT 2021 AMERICAN COLLEGE OF RHEUMATOLOGY

Wiley

  • Home
  • Meetings Archive
  • Advanced Search
  • Meeting Resource Center
  • Online Journal
  • Privacy Policy
  • Permissions Policies
loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.