ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 878

The Association of Serum Magnesium with Chondrocalcinosis and Osteoarthritis

Devyani Misra1, Xianbang Sun 2, Michael Nevitt 3, Beth Lewis 4, James Torner 5, Tuhina Neogi 2, Alice Lichtenstein 6, Nirupa Matthan 6 and David Felson 7, 1Beth Israel Deaconess Medical Center, Waban, MA, 2Boston University School of Medicine, Boston, MA, 3University of California at San Francisco, San Francisco, CA, 4University of Alabama at Birmingham, Birmingham, AL, 5University of Iowa at Iowa City, Iowa City, 6Tufts University, Boston, MA, 7Boston University School of Medicine, Department of Rheumatology, Boston

Meeting: 2019 ACR/ARP Annual Meeting

Keywords: Chondrocalcinosis and osteoarthritis

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print
Session Information

Date: Sunday, November 10, 2019

Title: 3S092: New Approaches to Old Diseases (875–879)

Session Type: ARP Abstract Session

Session Time: 2:30PM-4:00PM

Background/Purpose: High serum magnesium (Mg) may have anti-inflammatory effects and prevents the release of extracellular pyrophosphate, inhibiting CPP deposition. Cross-sectional data has linked low serum Mg levels with radiographic chondrocalcinosis (CC) but there is a paucity of longitudinal studies and an absence of studies of symptomatic CC. Since osteoarthritis (OA) and CC often co-exist and have other common risk factors, we evaluated the relation of serum Mg levels to prevalence and risk of 4 outcomes, radiographic CC, symptomatic CC, radiographic knee OA, and symptomatic knee OA in a large cohort of community dwelling older adults.

Methods: For each of the 4 outcomes we performed a nested case-control study within the Multicenter Osteoarthritis (MOST) study, a NIH-funded longitudinal cohort of persons with or at risk of knee OA. Serum Mg level (mEq/L) was measured (AU480, Beckman Coulter Inc., Brea CA 92821) at baseline. For each outcome, we excluded those who, at baseline had the outcome.  Our outcomes from baseline through 60 month follow-up were incident (new onset) radiographic OA (KL-grade ≥2 in either or both knees), symptomatic OA (radiographic OA with frequent knee pain in the same knee), radiographic CC (presence of CC in either or both knees) and symptomatic CC (radiographic CC with frequent knee pain in the same knee). To examine cross sectional baseline associations for each outcome, we took subjects selected for Mg assessment for the other outcomes and evaluated the association of serum Mg (per SD increase) to prevalent radiographic OA, radiographic and symptomatic CC using logistic regression. Using each case control sample, we then examined the longitudinal association of baseline serum Mg to incident radiographic OA, symptomatic OA, radiographic and symptomatic CC using Cox proportional hazards regression. All analyses were adjusted for age, sex, and BMI.

Results: Among 985 participants (mean age 62 yrs, 59% women and mean BMI 29.9 kg/, mean Mg levels 1.89 mEq/L) , the prevalence was 324 radiographic OA, 47 radiographic CC and 11 symptomatic CC. In cross-sectional analyses (see table), serum Mg was not associated with prevalence of radiographic OA (per standard deviation of Mg, OR=0.94, 95% CI 0.82, 1.08) but was modestly associated with radiographic CC (OR=0.70, 95% CI 0.52, 0.95) and symptomatic CC (OR= 0.63, 95% CI 0.35, 1.15).

Incidence of radiographic OA occurred in 250 of 606 persons; 336 of 893 had incident symptomatic OA; 46 of 772 had incident radiographic CC; 33 of 830 had incident symptomatic CC.  In longitudinal analyses, higher baseline serum Mg levels were not associated with risk of incident radiographic OA (HR=0.99, 95% CI 0.87, 1.16), symptomatic OA (HR 0.95, 95% CI 0.84, 1.07) or radiographic CC (HR=0.87, 95%CI 0.66, 1.17) but were associated with risk of symptomatic CC (HR= 0.60, 95% CI 0.43, 0.84).  

Conclusion: Higher serum magnesium levels were associated with a lower risk of symptomatic CC but not with radiographic CC, radiographic OA, or symptomatic OA. The association of Mg with incident symptomatic CC has important clinical implications and is consistent with cross sectional studies but is based on small numbers and needs replication.


Table


Disclosure: D. Misra, None; X. Sun, None; M. Nevitt, None; B. Lewis, None; J. Torner, None; T. Neogi, MerckSerono, 5, Novartis, 5; A. Lichtenstein, None; N. Matthan, None; D. Felson, None.

To cite this abstract in AMA style:

Misra D, Sun X, Nevitt M, Lewis B, Torner J, Neogi T, Lichtenstein A, Matthan N, Felson D. The Association of Serum Magnesium with Chondrocalcinosis and Osteoarthritis [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/the-association-of-serum-magnesium-with-chondrocalcinosis-and-osteoarthritis/. Accessed .
  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to 2019 ACR/ARP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/the-association-of-serum-magnesium-with-chondrocalcinosis-and-osteoarthritis/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology