Session Information
Date: Tuesday, November 10, 2015
Title: Vasculitis Poster III
Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose: The aim of this study is to analyze the activity parameters that affect the physicians global opinion (PGO) in TA.
Methods: The data of patients with TA who were followed in the Rheumatology outpatient clinic were retrospectively evaluated. Disease activity was assessed with, National İnstitutes of Healty (NIH) criteria, disease extent index-Takayasu (DEI.Tak), the Indian Takayasu Activity Score (ITAS2010), PGO, radiological activity parameters, and acute-phase reactants. According to the TA follow-up protocol of the Rheumatology and Radiology Board of our hospital, the patients were followed using B-mode/Doppler USG examinations and magnetic resonance angiography (MRA).
Results: 52 patients (48 females; mean age:46.8±13.2 years) who fulfilled the American College of Rheumatology(ACR) criteria for TA were enrolled in this study. 40 (76.9%) patients were categorized as having active disease in their first visits according to PGO. In the last visit, 31 (59.6%) patients had inactive disease, 19 (36.5%) had persistent disease and two (%3.9) had active disease. All the patients used the long-term glucocorticoid therapy and DMARDs. Six (%11.5) of them were on the treatment with biologics. Six (11.5%) patients underwent vascular surgery and 26 (50%) were performed endovascular repair for arterial stenosis. In total, 360 visits of patients were evaluated. PGO was that the disease was inactive in the 181 visits, persistan in the 99 visits and active in the 80 visits. The highest aggreement was found between PGO and the results of MRA and also B-mode/Doppler USG. NIH activation, DEI.Tak and ITAS2010 scores also well correlated with PGO. There was a poor agreement between PGO and hs-CRP.
Conclusion: The results of this study suggest that imaging had a significant impact on physician’s decision regarding disease activity in TA. Although disease activity scores including radiological activity parameters, NIH, DEI-Tak and ITAS2010 were well correlated with each other, there was a poor agreement between CRP and all the other activity parameters.
Table 1.Agreement rates and correlations of the disease activity parameters with each other and PGO in Takayasu arteritis
|
|
Hs-CRP |
ITAS2010 Score |
DEI.Tak Score |
NIH Score |
Positive B mode/ Doppler US |
Positive MRI |
PGO |
|
Hs-CRP |
|
0.2** |
0.19** |
0.29* |
0.19* |
0.32* |
0.32* |
|
ITAS2010 score |
0.2** |
|
0.93** |
0.68** |
0.47** |
0.43** |
0.55** |
|
DEI.Tak score |
0.19** |
0.93** |
|
0.70** |
0.47** |
0.44** |
0.54** |
|
NIH score |
0.29* |
0.68** |
0.70** |
|
0.55* |
0.51* |
0.64* |
|
Positive B mode/ Doppler US |
0.19* |
0.47** |
0.47** |
0.55* |
|
0.53* |
0.80* |
|
Positive MRA |
0.32* |
0.43** |
0.44** |
0.51* |
0.53* |
|
0.79* |
*kappa statistic, **Spearman ro. All p values were <0.05.
To cite this abstract in AMA style:
Yarkan H, Karaman S, Cetin P, Akar S, Gulcu A, Goktay AY, Can G, Birlik M, Akkoc N, Onen F. The Assessment of Disease Activity in Takayasu Arteritis; Six Years Experience from a Single Center [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/the-assessment-of-disease-activity-in-takayasu-arteritis-six-years-experience-from-a-single-center/. Accessed .« Back to 2015 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/the-assessment-of-disease-activity-in-takayasu-arteritis-six-years-experience-from-a-single-center/