ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1382

The 11q23.3 Genomic Region – rs964184- Is Associated With Cardiovascular Disease In Patients With Rheumatoid Arthritis

Raquel lopez Mejias1, Fernanda Genre2, Mercedes García-Bermúdez3, Santos Castañeda4, Carlos González-Juanatey5, J. Llorca6, Encarnación Amigo7, Alfonso Corrales8, Jose A. Miranda-Filloy9, Javier Rueda-Gotor1, Carmen Gomez vaquero10, Luis Rodriguez Rodriguez11, Benjamin Fernandez Gutierrez11, Alejandro Balsa12, Dora Pascual-Salcedo13, Francisco Javier López-Longo14, Patricia Carreira15, Ricardo Blanco1, Isidoro González-Alvaro16, Javier Martin17 and Miguel A. Gonzalez-Gay18, 1Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain., Santander, Spain, 2Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IDIVAL, Santander, Spain, 3Immunology and Cellular Biology, Instituto de Parasitologia y Biomedicina López-Neyra, IPBLN-CSIC, Granada, Spain, 4Rheumatology, Hospital Universitario de La Princesa, IIS Princesa, Madrid, Spain, 5Cardiology Division, Hospital Lucus Augusti, Lugo, Spain, 6Department of Epidemiology and Computational Biology, School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), IDIVAL, Santander, Spain, 7Hospital Universitario Lucus Augusti, Rheumatology Division, Lugo, Spain, 8Hospital Universitario Marqués de Valdecilla. IDIVAL. Santander. Spain, Santander, Spain, 9Rheumatology, Division of Rheumatology, Hospital Lucus Augusti, Lugo, Spain, 10Department of Rheumatology, Hospital Universitario Bellvitge, Barcelona, Spain, 11Department of Rheumatology, Hospital Clínico San Carlos, Madrid, Spain, 12Rheumatology unit, La Paz University Hospital, Rheumatology, Madrid, Spain, 13La Paz University Hospital, Rheumatology, Madrid, Spain, 14Hospital General Universitario Gregorio Marañón, Department of Rheumatology, Madrid, Spain, 15Rheumatology, Hospital Universitario 12 de Octubre, Madrid, Spain, 16Rheumatology, Hospital Universitario de La Princesa. IIS La Princesa, Madrid, Spain, 17Instituto de Parasitologia y Biomedicina Lopez-Neyra (IPBLN-CSIC), Granada, Spain, 18Epidemiology, Genetics and Atherosclerosis Research Group on Systemic Inflammatory Diseases, Rheumatology Division, IFIMAV, Santander, Spain

Meeting: 2013 ACR/ARHP Annual Meeting

Keywords: ,

Session Information

Title: Rheumatoid Arthritis - Human Etiology and Pathogenesis

Session Type: Abstract Submissions (ACR)

Background/Purpose:

Rheumatoid arthritis (RA) is a complex polygenic inflammatory disease associated with accelerated atherosclerosis and high risk of cardiovascular (CV) disease. A recent meta-analysis has described the rs964184 polymorphism as one of the most important signals associated with coronary artery disease, increased LDL-cholesterol and decreased HDL-cholesterol levels in non-rheumatic Caucasian individuals. In the present study we assessed the potential association of this gene polymorphism with CV disease in RA.

Methods:

2160 Spanish patients with RA were genotyped for the rs964184 polymorphism. Three hundred and eighty-four (17.7%) of them had experienced CV events. The rs964184 polymorphism was genotyped with TaqMan single-nucleotide polymorphism (SNP) genotyping assays (C___8907629_10) in a 7900 HT real-time polymerase chain reaction (PCR) system

Results:

Sex (men), age at RA diagnosis and most traditional CV risk factors (diabetes mellitus, dyslipidemia and smoking habit) were associated with increased risk of CV events (p<0.05 in all the cases). Interestingly, when RA patients were stratified according to the presence or absence of CV disease after adjusting for sex, age at RA diagnosis, and traditional CV risk factors, we observed that RA patients carrying the rs964184 GG genotype had significantly higher risk of CV events than those with CC genotype (HR = 2.91, 95% CI: 1.36 – 6.26, p = 0.006).

Conclusion:

Our results indicate that rs964184 polymorphism is associated with CV disease in RA.

Disclosure:

R. lopez Mejias,
None;

F. Genre,
None;

M. García-Bermúdez,
None;

S. Castañeda,
None;

C. González-Juanatey,
None;

J. Llorca,
None;

E. Amigo,
None;

A. Corrales,
None;

J. A. Miranda-Filloy,
None;

J. Rueda-Gotor,
None;

C. Gomez vaquero,
None;

L. Rodriguez Rodriguez,
None;

B. Fernandez Gutierrez,
None;

A. Balsa,
None;

D. Pascual-Salcedo,
None;

F. J. López-Longo,
None;

P. Carreira,
None;

R. Blanco,
None;

I. González-Alvaro,
None;

J. Martin,
None;

M. A. Gonzalez-Gay,
None.

« Back to 2013 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/the-11q23-3-genomic-region-rs964184-is-associated-with-cardiovascular-disease-in-patients-with-rheumatoid-arthritis/