Temporal Relationship Between Enteropathic Spondylitis Symptoms/diagnosis and Inflammatory Bowel Diseases Diagnosis: HUR-BIO Real Life Results

Bayram Farisoğulları¹, Gozde Kubra Yardımcı ¹, Alper Sarı ¹, Berkan Armagan ², Emre Bilgin ¹, Ertugrul Cagri Bolek ¹, Levent Kilic ³, Omer Karadag ⁴, Ali Akdoğan ¹, Şule Apras Bilgen ³, Ali İhsan Ertenli ¹, Sedat Kiraz ³ and Umut Kalyoncu ⁵, ¹Hacettepe University Vasculitis Centre, Ankara, Turkey, Ankara, Turkey, ²Department of Internal Medicine, Hacettepe University, Faculty of Medicine, Ankara, Turkey., Ankara, Turkey, ³Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey, ⁴Hacettepe University Vasculitis Centre, Ankara, Turkey / Vasculitis and Lupus Clinic, Addenbrooke’s Hospital, University of Cambridge, UK, Ankara, Turkey, ⁵Hacettepe University Department of Rheumatology, Ankara, Turkey

Meeting: 2019 ACR/ARP Annual Meeting

Keywords: inflammatory arthritis and spondylarthritis, inflammatory bowel disease (IBD)

Session Information

Date: Sunday, November 10, 2019

Title: Spondyloarthritis Including Psoriatic Arthritis – Clinical Poster I: Axial Spondyloarthritis, Clinical Features

Session Type: Poster Session (Sunday)

Session Time: 9:00AM-11:00AM

Background/Purpose: The correlation between the time frame of the symptoms/diagnosis of spondylitis and the diagnosis of inflammatory bowel disease (IBD) on patients of enteropathic spondylitis (eSpA) is not precisely known. Aim of this study was to determine the timing of symptoms/diagnosis of SpA and the diagnosis of IBD on the patients with eSpA.

Methods: HUR-BIO (Hacettepe University Rheumatology Biologic Registry) is a prospective, single center database of biological treatments since 2005. HUR-BIO SpA registry included 2576 SpA patients, and 90 (3.5%) patients had enteropathic arthritis (EA). Sacroiliitis was defined at 59 (65.5%) patients as modified New York criteria or based on ASAS magnetic resonance imaging. Enteropathic spondylitis defined as inflammatory bowel disease and radiological sacroilitis with inflammatory back pain/spine symptoms. Demographic, clinical, laboratory, therapeutic data and imaging features were collected from this database. Patients with available data about the timing of IBD diagnosis, SpA symptoms and SpA diagnosis were included in the analysis. The temporal relationship between the diagnosis of IBD and the symptom and / or diagnosis of SpA was assessed.

Results: Fifty nine (44.1% female) eSpA patients enrolled in this study. Mean age was 45.0 ± 13.0 years, mean disease duration was 9.9 ± 7.8 years. IBD type was UC in 31 (52.5%) patients, CD in 28 (47.5%) patients. The symptoms of spondylitis were present in 49 (83%) patients before the diagnosis of IBD [CD 96.4% vs UC 71.0%, p=0.009] (Table 1). In 23 patients, SpA diagnosis was made after IBD diagnosis [CD 25% vs UC 51%, p=0.036]. The median time lag between the diagnosis of IBD and SpA was 2 (1-9) years for CD, 7.5 (2-23) years for UC, p=0.027. The mean delay time for the diagnosis of SpA in patients with eSpA was 4 (0-31) years [4 (0-31) years in CD vs 3 (0-22) years UC patients, p:0.57].

Conclusion: In most of eSpA patients, spondylitis symptoms were present before diagnosis of IBD and this finding was more prominent in CD. On the other hand, the diagnosis of spondylitis was made after the diagnosis of IBD in almost 40% of patients. In UC, this condition was more distinct.

enteropatik artrit süre tablosu-dönüştürüldü

Disclosure: B. Farisoğulları, None; G. Yardımcı, None; A. Sarı, None; B. Armagan, None; E. Bilgin, None; E. Bolek, None; L. Kilic, None; O. Karadag, None; A. Akdoğan, None; �. Apras Bilgen, None; A. Ertenli, None; S. Kiraz, None; U. Kalyoncu, UCB, 5.

To cite this abstract in AMA style:

Farisoğulları B, Yardımcı G, Sarı A, Armagan B, Bilgin E, Bolek E, Kilic L, Karadag O, Akdoğan A, Apras Bilgen �, Ertenli A, Kiraz S, Kalyoncu U. Temporal Relationship Between Enteropathic Spondylitis Symptoms/diagnosis and Inflammatory Bowel Diseases Diagnosis: HUR-BIO Real Life Results [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/temporal-relationship-between-enteropathic-spondylitis-symptoms-diagnosis-and-inflammatory-bowel-diseases-diagnosis-hur-bio-real-life-results/. Accessed .

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