Synovitis of Sternoclavicular and Peripheral Joints Can be Detected By Ultrasound in Patients with SAPHO Syndrome

Masataka Umeda¹, Shinya Kawashiri^1,2, Ayako Nishino³, Hideki Nakamura¹ and Atsushi Kawakami⁴, ¹Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, ²Department of Community Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan, ³Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki Universit, Nagasaki, Japan, ⁴Department of Immunology and Rheumatology, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki City, Japan

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: Imaging and ultrasound

Session Information

Date: Sunday, November 13, 2016

Title: Imaging of Rheumatic Diseases - Poster I: Ultrasound and Emerging Technologies

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: Synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome is characterized by multiple osteoarticular inflammation and dermatologic disorders such as palmoplantar pustulosis. Although the single available study evaluated enthesitis by ultrasound (US), we have been unable to find any study that evaluated abnormalities detected by US of the sternoclavicular joint (SCJ) and peripheral joint (PJ) in patients with SAPHO syndrome. The objective of the present study was to determine the prevalence of US abnormalities of the SCJ and PJ in patients with SAPHO syndrome.

Methods: Thirteen patients with SAPHO syndrome who fulfilled diagnostic criteria proposed by Kahn for SAPHO syndrome 2003 and 13 healthy individuals age- and sex-matched were enrolled. Synovitis, defined by synovial hypertrophy with power Doppler (PD) signals, of the SCJ and the PJ including wrist, MCP, PIP and the other symptomatic joints were evaluated by US.

Results: All of the patients had anterior chest wall symptoms, and spinal and peripheral symptoms were seen in 69.2% and 46.2% of the patients, respectively. Synovitis with PD signals was detected in 16 (61.5%) of the 26 SCJ and 11 (84.6%) of the SAPHO syndrome patients, and none of the controls. Synovitis with PD signals in any PJ was detected in 4 (30.7%) of the SAPHO syndrome patients. Tenosynovitis or tendinitis of the hands was seen in two (15.4%) patients.

Conclusion: Our study has demonstrated that US can detect the abnormalities of the SCJ and PJ in SAPHO syndrome with high sensitivity. US may be a useful method for the early diagnosis of SAPHO syndrome. ADDIN EN.REFLIST

Disclosure: M. Umeda, None; S. Kawashiri, None; A. Nishino, None; H. Nakamura, None; A. Kawakami, None.

To cite this abstract in AMA style:

Umeda M, Kawashiri S, Nishino A, Nakamura H, Kawakami A. Synovitis of Sternoclavicular and Peripheral Joints Can be Detected By Ultrasound in Patients with SAPHO Syndrome [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/synovitis-of-sternoclavicular-and-peripheral-joints-can-be-detected-by-ultrasound-in-patients-with-sapho-syndrome/. Accessed .

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