ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 2566

Spinal Mobility in the Cervical and the Lumbar Spine Correlates with Magnetic Resonance Imaging Findings in Patients with Ankylosing Spondylitis

Xenofon Baraliakos1, Kay-Geert A. Hermann2, Stephen Xu3, Benjamin Hsu3 and Jürgen Braun1, 1Rheumazentrum Ruhrgebiet, Herne, Germany, 2Radiology, Charité Universitätsmedizin Berlin, Campus Mitte, Berlin, Germany, 3Janssen Research & Development, LLC., Spring House, PA

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: MRI and ankylosing spondylitis (AS)

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print
Session Information

Title: Spondyloarthropathies and Psoriatic Arthritis - Clinical Aspects and Treatment III

Session Type: Abstract Submissions (ACR)

Background/Purpose Spinal mobility, as assessed by the Bath Ankylosing Spondylitis Metrology Index, BASMI, and imaging findings have been reported to correlate on the group level. Treatment with anti-TNF leads to improvement of both spinal inflammation as assessed by magnetic resonance imaging (MRI) and total BASMI scores. Using data from the golimumab (GLM) in ankylosing spondylitis (AS) study (GO-RAISE), we analyzed the relationship between single components of BASMI and MRI scores of the corresponding spinal segments in anti-TNF-treated AS patients.

Methods Complete MR imaging sets and spinal mobility data were available for 91 pts who participated in GO-RAISE. The MRI scores for active (ASspiMRI-a) and chronic changes (ASspiMRI-c) of the cervical and lumbar spine were compared to BASMI values for the cervical (cervical rotation [CR] and tragus-to-wall [TTW]) and the lumbar (lumbar flexion [LF] and lateral lumbar flexion [LLF]) spine using the linear definition. Spearman correlation coefficients were calculated for baseline scores and for changes in both BASMI and ASspiMRI-a and -c measurements of patients treated with GLM or placebo (PBO) after 14 weeks and after 2 years of GLM therapy. Subanalyses were performed with regard to age.

Results At baseline, ASspiMRI-a scores of the cervical spine correlated with TTW (r=0.31, p=0.003) and CR (r=0.32, p=0.002) measurements, while ASspiMRI-a scores of the lumbar spine correlated with LF and LLF scores (both r=0.41, p<0.0001). In addition, ASspiMRI-c scores of the cervical spine correlated with TTW (r=0.46) and CR (r=0.45), both p<0.0001, while ASspiMRI-c scores of the lumbar spine correlated with LF (r=0.34, p=0.001) and LLF scores (r=0.41, p<0.0001). ASspiMRI-a scores correlated better in patients <40 years (TTW: r=0.31, p=0.04, LLF: r=0.42, p=0.005), while ASspiMRI-c scores correlated better in patients > 40 years (TTW: r=0.35, p=0.015, LLF: r=0.48, p<0.001). In contrast, no significant correlations were found in change scores (data not shown). There was a negative correlation between MRI chronicity scores and lateral lumbar flexion at 2y: r=-0.26, p=0.037.

Conclusion Our data confirm earlier reports on patients with active AS which showed that both inflammation and structural changes contribute to impairments of spinal mobility. In addition, we demonstrate significant correlations of MRI findings with detailed spinal mobility measures before anti-TNF treatment was started. Inflammatory changes had greater impact on spinal mobility in younger patients, while structural changes had more influence on spinal mobility in older patients. The correlation of the observed changes in MRI scores and spinal mobility was significant but not high. This may be due to the different mixture of active and chronic changes in individual patients.


Disclosure:

X. Baraliakos,

Janssen R and D, LLC,

2;

K. G. A. Hermann,

Janssen R and D, LLC,

2;

S. Xu,

Janssen R and D, LLC,

3;

B. Hsu,

Janssen Research & Development, LLC.,

3;

J. Braun,

Abbott, Bristol Myers Squibb, Celgene, Celltrion, Chugai, Johnson & Johnson, MSD, Novartis, Pfizer, Roche, UCB Pharma,

5,

Abbott, Bristol Myers Squibb, Celgene, Celltrion, Chugai, Johnson & Johnson, MSD, Novartis, Pfizer, Roche, UCB Pharma,

2.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to 2014 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/spinal-mobility-in-the-cervical-and-the-lumbar-spine-correlates-with-magnetic-resonance-imaging-findings-in-patients-with-ankylosing-spondylitis/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology