ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 394

Sexual Health in 39 Female Patients with Idiopathic Inflammatory Myopathies

Barbora Hermankova 1, Maja Spiritovic 2, Sabina Oreska 3, Hana Storkanova 4, Petr Cesak 1, Katerina Kubinova 5, Martin Klein 4, Karel Pavelka 3, Ladislav Senolt 3, Herman Mann 3, Jiří Vencovský 3 and Michal Tomcik3, 1Faculty of Physical Education and Sport, Department of Physiotherapy, Charles University, Prague, Czech Republic, Prague, Czech Republic, 2Faculty of Physical Education and Sport, Department of Physiotherapy, Charles University, Prague, Czech Republic, Prague 2, Hlavni mesto Praha, Czech Republic, 3Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague 2, Czech Republic, 4Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague, Czech Republic, 5Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Prague, Czech Republic, Prague 2

Meeting: 2019 ACR/ARP Annual Meeting

Keywords:

Session Information

Date: Sunday, November 10, 2019

Title: Muscle Biology, Myositis & Myopathies Poster I

Session Type: Poster Session (Sunday)

Session Time: 9:00AM-11:00AM

Background/Purpose: Idiopathic inflammatory myopathies (IIM) are characterized by inflammation and weakness of skeletal muscles, pulmonary and articular involvement, which can have a negative impact on all aspects of quality of life including sexual life. The aim of this study was to assess sexual functioning in female IIM patients compared to age-/sex-matched healthy controls (HC) and to determine the association between sexual health impairment and disease activity, treatment, physical and psychological aspects of the disease.

Methods: In total, 39 women (29 currently have a partner) with IIM [mean age: 54.7, disease duration: 11.8 years, dermatomyositis (DM, 19)/ polymyositis (PM, 16)/ necrotizing myopathy (IMNM, 3)/ inclusion body myositis (IBM, 1)], who fulfilled the Bohan/Peter 1975 criteria for DM/PM, and 39 healthy controls (30 currently have a partner, mean age: 54.7 years) without rheumatic diseases filled in 11 well-established and validated questionnaires assessing sexual function (FSFI, SFQ28, BISFW, PISQ-12), quality of sexual life (SQoL-F), pelvic floor function (PFIQ-7), fatigue (FIS, MAF), physical activity (HAP), and depression (BDI-II). A standard laboratory testing was performed. Data are presented as mean ± SEM.

Results: Patients with IIM had significantly higher prevalence and greater severity of sexual dysfunction (FSFI, BISF-W, SFQ28, PISQ-12) and worse sexual quality of life (SQoL-F) compared to HC (table). Worse scores in IIM patients were associated with increased inflammation [CRP: FSFI (r=-0.378, p=0.0190), SFQ-28 Satisfaction domain (r=-0.346, p=0.0356), SQoL-F (r=-0.331, p=0,0479], greater muscle weakness of m. gluteus maximus/ m. gluteus medius/ m. iliopsoas [FSFI: (r=0.426, p=0.0368), (r=0.370, p=0.0368), (r=0.394, p=0.0252), SQoL-F (r=0.504, p=0.0044), (r=0.421, p=0.0204), (r=0.462, p=0.0100)], greater fatigue [FIS: FSFI (r=-0.358 , p=0.0154), BISF-W (r=-0.415, p=0.0084), SQoL-F (r=-0.327, p=0.0481)], more severe depression [BDI-II: FSFI Arousal domain (r=-0.357, p=0.0299)], deteriorated quality of life [HAQ: BISF-W (r=-0.464, p=0.0033)], and worse ability to perform physical activities [HAP: FSFI (r=0.405, p=0.0105), BISF-W (r=0.480, p=0.0019)]. No associations were found with disease duration, prednisone dose or serum levels of muscle enzymes.

Conclusion: Women with IIM reported significantly impaired sexual function and sexual quality of life compared to age-matched healthy controls. Worse scores in IIM were associated with disease activity, physical activity, fatigue, depression and quality of life.

Acknowledgements: Supported by MHCR 023728 and GA UK 1578119


Table1_Results_IIM_ACR2019

Disclosure: B. Hermankova, None; M. Spiritovic, None; S. Oreska, None; H. Storkanova, None; P. Cesak, None; K. Kubinova, Ministry of Health, Czech Republic, project 00023728, 2; M. Klein, None; K. Pavelka, AbbVie, 8, Abbvie, 5, 8, Amgen, 5, 8, BMS, 8, Egis, 5, 8, Lilly, 5, 8, MSD, 8, Novartis, 5, 8, Pfizer, 5, 8, Roche, 5, 8, UCB, 8; L. Senolt, None; H. Mann, None; J. Vencovský, projeMinistry of Health, Czech Republic, project 00023728, 2; M. Tomcik, None.

To cite this abstract in AMA style:

Hermankova B, Spiritovic M, Oreska S, Storkanova H, Cesak P, Kubinova K, Klein M, Pavelka K, Senolt L, Mann H, Vencovský J, Tomcik M. Sexual Health in 39 Female Patients with Idiopathic Inflammatory Myopathies [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/sexual-health-in-39-female-patients-with-idiopathic-inflammatory-myopathies/. Accessed .

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