Serum Uric Acid As Short Term Mortality Predictor in the Acute Care Setting

Yuval Schwartz¹, Gideon Nesher^2,3 and Gabriel S Breuer^3,4, ¹Medicine, Shaare Zedek Medical Center, Jerusalem, Israel, ²Internal Medicine, Rheumatology, Shaare Zedek Medical Center, Jerusalem, Israel, ³Hebrew University School of Medicine, Jerusalem, Israel, ⁴Rheumatology, Shaare Zedek Medical Center, Jerusalem, Israel

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: Morbidity and mortality and uric acid

Session Information

Date: Sunday, November 8, 2015

Title: Metabolic and Crystal Arthropathies Poster I

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: Many studies have showed that the serum uric acid (SUA) is an independent predictor of adverse cardiovascular events and all-cause mortality, but some studies have yielded conflicting results. Even more contradicted issue is the relationship between SUA and mortality in acutely hospitalized patients. In this context there is scarce data about SUA as an independent predictor of short-come outcome in the hospitalized older patient. The aim of this study is to determine whether SUA obtained within 48 hours after admission can predict short-term outcome.

Methods: The analysis was conducted in an 850-bed medical center. 860 adult patients were admitted to internal medicine departments between March 1st 2014 and June 30th 2014. We evaluated SUA level drawn within 48 hours after admission as predictor of in-hospital mortality. In addition we collected clinical and epidemiological data.

Results: The mean age of patients was 78±14. The mortality rate was 15.1% (130 patients), and the mean SUA was 6.25 ± 2.70 mg/dl. The most common cause for hospitalization was pulmonary infection (16.8%) followed by congestive heart failure exacerbation (9.3%). The mortality rate was 11% (66 patients out of 562) in the group with SUA ≤ 7.5 in comparison to 27% (64 patients out of 171) in the group with SUA above this level [P < .001]. Moreover, SUA was an independent predictor of mortality in multivariate regression analysis, with odds ratio of 2.71 [confidence interval 1.82- 4.04 P < .001].

Table 1: Logistic regression analysis

Variables in the Equation	B	S.E.	Wald (df=1)	Exp(B)	95% C.I.for EXP(B)
Gender	0.01	0.2	0.00	1.01	0.69-1.49
Age	0.02	0.01	4.12*	1.02	1-1.03
creatinine	0.13	0.06	4.70*	1.14	1.01-1.29
Uric Acid	0.18	0.04	26.64***	1.2	1.12-1.29
Constant	-4.55	0.72	39.87	0.01

*p < .05, *** p< .001

Conclusion: SUA level is a strong independent predictor of short-term outcome in elderly patients admitted to internal medicine departments.

Disclosure: Y. Schwartz, None; G. Nesher, None; G. S. Breuer, None.

To cite this abstract in AMA style:

Schwartz Y, Nesher G, Breuer GS. Serum Uric Acid As Short Term Mortality Predictor in the Acute Care Setting [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/serum-uric-acid-as-short-term-mortality-predictor-in-the-acute-care-setting/. Accessed .

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