Background/Purpose:
Interleukin-33 (IL-33) is a new member of the IL-1 family of cytokines which signals via receptor, ST2(IL-33R), and has an important role in Neutrophil migrations, Th2 responses and mast cell responses. This study aims to measure the serum levels of IL-33 and soluble ST2 (sST2) in patients with Behcet’s disease (BD) and to examine their association with disease activity.
Methods: Fifty three BD patients were evaluated for disease activity, determined by BDCAF, IBDDAM, ESR/CRP levels. IL-33 and sST2 were measured by sandwich ELISA in the 53 BD serum samples and compared with 31 age- and sex-matched healthy controls. The cutaneous expressions of IL-33 and sST2 in BD patients with erythema nodosum(EN) or EN-like lesion was compared with normal control skin tissues by immunohistochemical stains
Results:
Serum IL-33 level was significantly higher in active BD patients [ 594.48 pg/ml] compared with normal controls [ 224.23 pg/ml] (P<0.05), and soluble ST2(sST2) level was also significantly higher in active BD patients [99.01 pg/ml] compared with normal controls [23.56 pg/ml]. The tissue expressions of IL-33 and sST2, shown by immunohistochemistry, were higher in BD compared with the controls. Serum sST2 level correlated significantly with BDCAF, IBDDAM, ESR and CRP. Multiple linear regression showed that both serum CRP and serum sST2 were independent predictive factor for IBDDAM (regression coefficient: 0.519 ; P = 0.000, regression coefficient: 0.300 ; P = 0.016, respectively)
Conclusion:
These results suggest that IL-33 and sST2 area increased in Behcet’s disease and The level of sST2 are correlated with Behcet’s disease activity index (IBDDAM) and acute phase reactant (ESR, CRP) and also a independent predictive factor of IBDDAM, suggesting a potential role of sST2 as a surrogate marker of disease activity of BD.
Disclosure:
D. J. Kim,
None;
J. H. Lee,
None;
J. H. Ju,
None;
S. H. Park,
None;
H. Y. Kim,
None;
S. K. Kwok,
None.
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ACR Meeting Abstracts - https://acrabstracts.org/abstract/serum-level-of-il-33-and-soluble-st2-and-their-association-with-disease-activity-in-patients-with-behcets-disease/