ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 907

Rituximab in Patients with Takayasu Arteritis: A Single Center Experience on Five Patients

Giulia Pazzola1, Francesco Muratore1, Luigi Boiardi2, Mariagazia Catanoso1, Alessandra Soriano3, Pierluigi Macchioni1, Lucia Spaggiari4, Massimiliano Casali5, Nicolò Pipitone1, Niccolò Possemato6 and Carlo Salvarani1, 1Rheumatology Unit, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, 2Rheumatology Unit, Arcispedale S.Maria Nuova, IRCCS, Reggio Emilia, Italy, 3Rheumatology Unti, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, 4Radiology, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, 5Nuclear Medicine, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy, 6Rheumatology Service, Arcispedale S Maria Nuova, IRCCS, Reggio Emilia, Italy

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: MRI, outcomes, positron emission tomography (PET), rituximab and takayasu arteritis

  • Tweet
  • Email
  • Print
Session Information

Date: Sunday, November 13, 2016

Title: Vasculitis - Poster I: Large Vessel Vasculitis and Polymyalgia Rheumatica

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: Takayasu arteritis (TAK) is a large vessel vasculitis involving the aorta and its major branches in patients younger than 40 years. Glucocorticoids (GCs) are the mainstay of treatment for TAK, but relapses and GC dependence are seen in more than two-thirds of patients. Increasing evidence supports a role for B cells in the pathogenesis of TAK. Circulating plasmablasts and memory B cells are increased, while naive B cells are decreased in patients with active TAK as compared with inactive and control patients [1]. These findings suggest a potential role for B cell depleting therapy in TAK. Our aim was to assess the efficacy of Rituximab (RTX) in a single center series of patients with TAK.

Methods: We conducted a prospective, single center, open-label study on 5 TAK patients treated with RTX. All patients satisfied the American college of Rheumatology classification criteria for TAK. Four of the 5 patients had a refractory disease and had received high dose GCs and synthetic and/or biological immunosuppressive (IS) agents before RTX. One new diagnosed, treatment naïve TAK patient refused GCs and received RTX in monotherapy. RTX was administered according to rheumatoid arthritis scheme (2 infusions of 1.000 mg, 15 days apart). Clinical evaluation, laboratory tests (full blood count, ESR, CRP) and imaging modalities (CTA or MRA, and PET/CT) were performed at first RTX administration and every 6 months thereafter. Disease activity was assessed using Kerr index. Radiographic disease progression was defined as new or worsening lesions at follow-up CTA or MRA. PET/CT was considered positive for active disease if two or more large vessels showed grade 2 FDG uptake or higher.

Results: Five patients (4 female) were included in the study. Mean (SD) age was 30.4 (17.4) years. At first RTX administration, all patientshad active disease according to Kerr index (≥2), and had evidence of active disease at PET/CT. Table 1 summarizes the main results of our study. Despite RTX treatment, 4 of the 5 patients had evidence of persistent disease activity and/or radiographic disease progression at follow-up CTA or MRA. Only one patient experienced long-term remission (30 months to date) after two courses of RTX.

Conclusion: Our data do not support a role for RTX in refractory TAK patients. References: [1] Hoyer BF et al. Takayasu arteritis is characterised by disturbances of B cell homeostasis and responds to B cell depletion therapy with rituximab. Ann Rheum Dis 2012;71:75–9. Table 1.

Case

Age/Sex

Disease duration (y)

Previous therapy

ESR/CRP

at first RTX (mm/h, mg/dl)

PDN dose at first RTX (mg/day)

Concomitant IS therapy

RTX courses

ESR/CRP 6 months after last RTX (mm/h, mg/dl)

Imaging (CTA/MRA) 6 months after last RTX

PET/CT 6 months after last RTX

Kerr index 6 months after last RTX

Outcome at last visit

1

20/F

2

MTX

38/6.2

25

MTX 20 mg/weekly

2

68/4.7

No disease progression

Positive

2

Active disease

2

32/F

0

None

49/4.6

0

None

1

61/3.4

Disease progression

Positive

3

Disease progression

3

21/F

1

MMF

12/2.7

50

MMF 2 gr/day

1

16/2.8

Disease progression

Positive

3

Disease progression

4

60/M

22

MTX, MMF, ADA, IFX

66/2.0

25

MMF 2 gr/day

2

18/0.5

No disease progression

Negative

0

Remission

5

19/F

5

MTX, AZA, TCZ, IFX, ADA

98/11.5

50

None

2

78/4.0

Disease progression

Positive

3

Disease progression

 


Disclosure: G. Pazzola, None; F. Muratore, None; L. Boiardi, None; M. Catanoso, None; A. Soriano, None; P. Macchioni, None; L. Spaggiari, None; M. Casali, None; N. Pipitone, None; N. Possemato, None; C. Salvarani, None.

To cite this abstract in AMA style:

Pazzola G, Muratore F, Boiardi L, Catanoso M, Soriano A, Macchioni P, Spaggiari L, Casali M, Pipitone N, Possemato N, Salvarani C. Rituximab in Patients with Takayasu Arteritis: A Single Center Experience on Five Patients [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/rituximab-in-patients-with-takayasu-arteritis-a-single-center-experience-on-five-patients/. Accessed .
  • Tweet
  • Email
  • Print

« Back to 2016 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/rituximab-in-patients-with-takayasu-arteritis-a-single-center-experience-on-five-patients/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology