ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 143

Rapid Infrared Microscopy (IRMS) For Differential Diagnosis Of Fibromyalgia and Other Central Sensitivity Syndromes

Kevin V. Hackshaw1, Luis Rodriguez-Saona2, Irving L. Rosenberg3, Marcal Plans2 and C.A. Tony Buffington4, 1Immunology/Rheumatology, The Ohio State University, Columbus, OH, 2Food Sciences, The Ohio State University, Columbus, OH, 3Immunology/ Rheumatology, The Ohio State University, Columbus, OH, 4Veterinary Biological Sciences, The Ohio State University, Columbus, OH

Meeting: 2013 ACR/ARHP Annual Meeting

Keywords:

Session Information

Title: Fibromyalgia, Soft Tissue Disorders and Pain I

Session Type: Abstract Submissions (ACR)

Background/Purpose:

Background/Purpose: The aim of this study was to investigate the ability of a rapid blood-spot-based method for diagnosis of Fibromyalgia (FM) using mid-infrared microspectroscopy (IRMS) to differentiate patients with FM from those with osteoarthritis (OA) and rheumatoid arthritis (RA) as well as another central sensitization disorder – Interstitial Cystitis (IC) – and to identify molecular species associated with the spectral patterns.

Methods:  Under IRB approval, blood samples were collected from patients diagnosed with FM (n = 14), RA (n = 15), or OA (n = 12) and IC – (n = 20).  Samples were prepared, placed onto a highly reflective slide, and spectra were collected using IRMS and compared using multivariate statistical modeling to differentiate groups.  Aliquots of samples also were subjected to metabolomic analysis.  

Results: IRMS separated subjects into classes based on spectral information with no misclassifications among FM, RA, OA and IC patients. Discriminating power was greatest based on spectral bands centered at 1560cm-1, which are associated with indole ring vibrations  of tryptophan or its derivatives. Metabolomic analysis revealed that RA and OA groups were metabolically similar, whereas biochemical differences were identified in the FM that were quite distinctive from those found in the other groups.

Conclusion: These results support the use of IRMS to differentiate patients with FM from those with other chronic pain or central sensitivity syndromes.  The accuracy and simplicity of the test may make it useful for earlier diagnosis of these syndromes.

Disclosure:

K. V. Hackshaw,
None;

L. Rodriguez-Saona,
None;

I. L. Rosenberg,
None;

M. Plans,
None;

C. A. T. Buffington,
None.

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