Proposal for the Definition of Inactivity of Juvenile Idiopathic Arthritis Related Uveitis from the Multinational Interdisciplinary Working Group for Uveitis in Childhood Group (MIWGUC)

Ivan Foeldvari¹, Jordi Anton², Rosa Bou², Sheila Angeles-Han³, Regitze Bangsgaard⁴, Gabriele Brumm⁵, Tamás Constantin⁶, Clive Edelstein⁷, Jens Klotsche⁸, Kirsten Minden⁸, Elisabetta Miserocchi⁹, Susan Mary Nielsen⁴, Gabriele Simonini¹⁰ and Arnd Heiligenhaus¹¹, ¹Hamburg Center for Pediatric and Adolescent Rheumatology, Hamburg, Germany, ²Universitat de Barcelona, Hospital Sant Joan de Deu, Barcelona, Spain, ³Emory University School of Medicine, Atlanta, GA, ⁴Rigshospitalet, Copenhagen, Denmark, ⁵Klinik und Polyklinikum für Augenheilkunde, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany, ⁶Unit of Paediatric Rheumatology, 2nd Dpt of Pediatrics, Semmelweis University, Budapest, Hungary, ⁷GOS, London, United Kingdom, ⁸Epidemiology unit, German Rheumatism Research Center, Berlin, Germany, ⁹Department of Ophthalmology, Scientific Institute San Raffaele, University Vita-Salute, Milan, Italy, ¹⁰Pediatric Rheumatology, Anna Meyer Children's Hospital, Florence, Italy, ¹¹Department of Ophthalmology at St. Franziskus Hospital Muenster, University of Duisberg-Essen, Muenster, Germany

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: Uveitis

Session Information

Date: Sunday, November 13, 2016

Title: Pediatric Rheumatology – Clinical and Therapeutic Aspects - Poster I: Juvenile Idiopathic Arthritis, Uveitis

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: Juvenile idiopathic arthritis (JIA) associated uveitis is the most common extraarticulare comorbidity of juvenile idiopathic arthritis. Nowdays it occurs in about 10-15% of JIA patients. As effective treatment options are emerging, is it extremely important to propose validated definition of inactivity, which is main aim of the treatment.

Methods: Multinational Interdisciplinary Working Group for Uveitis in Childhood Group (MIWGUC) had prospectively evaluated the validity of the proposed outcome measures(1). Based on these data, we proposed a definition of inacitivity using the nominal group technique in a consensus meeting in Barcelona, Spain, in November 2015.

Results: The following items were selected to define inacitivity. It is required, that in both eyes the following condition is reached: 1. Slit lamp total number of AC cells: 0 inflammatory cells *In aphakic patients ,some cells may be present, in the anterior vitreous 2. Absence of Optic disc edema *The presence of isolated optic disc edema may not be a sign of activity 3. Absence Macular edema *The presence of isolated macular edema may not be a sign of activity 4. Absence of Vitreous haze *The presence of isolated vitreous haze may not be a sign of activity 5. VAS score of activity physician 0-100: must be 0

Conclusion: We proposed items to define inactivity of JIA associated uveitis, which is a major goal of treatment. This proposal will be validated from the MIWGUC group in prospective study. References:

1. Heiligenhaus A, Foeldvari I, Edelsten C, Smith JR, Saurenmann RK, Bodaghi B, et al. Proposed outcome measures for prospective clinical trials in juvenile idiopathic arthritis-associated uveitis: a consensus effort from the multinational interdisciplinary working group for uveitis in childhood. Arthritis Care Res (Hoboken). 2012;64(9):1365-72.

Disclosure: I. Foeldvari, None; J. Anton, None; R. Bou, None; S. Angeles-Han, None; R. Bangsgaard, None; G. Brumm, None; T. Constantin, None; C. Edelstein, None; J. Klotsche, None; K. Minden, None; E. Miserocchi, None; S. M. Nielsen, None; G. Simonini, None; A. Heiligenhaus, None.

To cite this abstract in AMA style:

Foeldvari I, Anton J, Bou R, Angeles-Han S, Bangsgaard R, Brumm G, Constantin T, Edelstein C, Klotsche J, Minden K, Miserocchi E, Nielsen SM, Simonini G, Heiligenhaus A. Proposal for the Definition of Inactivity of Juvenile Idiopathic Arthritis Related Uveitis from the Multinational Interdisciplinary Working Group for Uveitis in Childhood Group (MIWGUC) [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/proposal-for-the-definition-of-inactivity-of-juvenile-idiopathic-arthritis-related-uveitis-from-the-multinational-interdisciplinary-working-group-for-uveitis-in-childhood-group-miwguc/. Accessed .

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