Proposal for a Damage Index for Juvenile Idiopathic Arthritis Related Uveitis from the Multinational Interdisciplinary Working Group for Uveitis in Childhood Group (MIWGUC)

Ivan Foeldvari¹, Jordi Anton², Rosa Bou², Sheila Angeles-Han³, Regitze Bangsgaard⁴, Gabriele Brumm⁵, Tamás Constantin⁶, Clive Edelstein⁷, Jens Klotsche⁸, Kirsten Minden⁸, Elisabetta Miserocchi⁹, Susan Mary Nielsen⁴, Gabriele Simonini¹⁰ and Arnd Heiligenhaus¹¹, ¹Hamburg Center for Pediatric and Adolescent Rheumatology, Hamburg, Germany, ²Universitat de Barcelona, Hospital Sant Joan de Deu, Barcelona, Spain, ³Emory University School of Medicine, Atlanta, GA, ⁴Rigshospitalet, Copenhagen, Denmark, ⁵Klinik und Polyklinikum für Augenheilkunde, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany, ⁶Unit of Paediatric Rheumatology, 2nd Dpt of Pediatrics, Semmelweis University, Budapest, Hungary, ⁷GOS, London, United Kingdom, ⁸Epidemiology unit, German Rheumatism Research Center, Berlin, Germany, ⁹Department of Ophthalmology, Scientific Institute San Raffaele, University Vita-Salute, Milan, Italy, ¹⁰Pediatric Rheumatology, Anna Meyer Children's Hospital, Florence, Italy, ¹¹Department of Ophthalmology at St. Franziskus Hospital Muenster, University of Duisberg-Essen, Muenster, Germany

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: Uveitis

Session Information

Date: Sunday, November 13, 2016

Title: Pediatric Rheumatology – Clinical and Therapeutic Aspects - Poster I: Juvenile Idiopathic Arthritis, Uveitis

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: Juvenile idiopathic arthritis (JIA) associated Uveitis is the most common extraarticulare comorbidity of juvenile idiopathic arthritis. Nowdays it occurs about 10-15% of JIA patients. As innovative effective treatment options are emerging, it is extremely important for defining validated damage index in order to assess the effectivity of drugs to preventing damage, one of the main aims of the treatment.

Methods: Multinational Interdisciplinary Working Group for Uveitis in Childhood Group (MIWGUC) had prospectively evaluated the validity of the proposed outcome measures(1). Based on the data, we proposed a damage index using the nominal group technique in a consensus meeting in Barcelona, Spain, in November 2015.

Results: Following items were selected for assessing damage: Vision related permanent damage per eye /per patient - yes / no Right eye Left eye 1. flare 2. synechiae 3. cataract 4. maculopathy 5. Opticopathy 6. Decreased Visual acuity 7. Ocular hypertony – >21 mmHg 8. Ocular hypotony – <6 mmHg 9. Glaucomatous field loss and /or glaucomatous optic atrophy 10. Band-keratopathy 11. Epiretinal membrane formation 12. Visual deterioration – less then 0.3 in any eye 13. Uveitis related disability VAS 0-100 by ophthlamologist 14. Uveitis related disability VAS 0-100 by pediatric rheumatologist

Conclusion: We proposed items for assessing the damage index of JIA associated uveitis. The damage index should be a valid instrument for assessing the effectivity of a given drug in order to preventing damage. This proposal will be evaluated from the MIWGUC group in prospective study. References:

1. Heiligenhaus A, Foeldvari I, Edelsten C, Smith JR, Saurenmann RK, Bodaghi B, et al. Proposed outcome measures for prospective clinical trials in juvenile idiopathic arthritis-associated uveitis: a consensus effort from the multinational interdisciplinary working group for uveitis in childhood. Arthritis Care Res (Hoboken). 2012;64(9):1365-72.

Disclosure: I. Foeldvari, None; J. Anton, None; R. Bou, None; S. Angeles-Han, None; R. Bangsgaard, None; G. Brumm, None; T. Constantin, None; C. Edelstein, None; J. Klotsche, None; K. Minden, None; E. Miserocchi, None; S. M. Nielsen, None; G. Simonini, None; A. Heiligenhaus, None.

To cite this abstract in AMA style:

Foeldvari I, Anton J, Bou R, Angeles-Han S, Bangsgaard R, Brumm G, Constantin T, Edelstein C, Klotsche J, Minden K, Miserocchi E, Nielsen SM, Simonini G, Heiligenhaus A. Proposal for a Damage Index for Juvenile Idiopathic Arthritis Related Uveitis from the Multinational Interdisciplinary Working Group for Uveitis in Childhood Group (MIWGUC) [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/proposal-for-a-damage-index-for-juvenile-idiopathic-arthritis-related-uveitis-from-the-multinational-interdisciplinary-working-group-for-uveitis-in-childhood-group-miwguc/. Accessed .

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