Background/Purpose: Low levels of Insulin-dependent growth factor 1 (IGF-1) have been described in Fibromyalgia (FM) patients, suggesting that they have adult growth hormone (GH) deficiency. The prevalence of low IGF-1 and low GH has not yet been described. This study describes these prevalences.

Methods: Seventy-eight female FM patients were studied over a four year period in a solo private rheumatology practice. All fulfill 1990 and 2010 ACR FM criteria. Mean age was 45 years (range 20-68). Serum IGF-1 levels were measured and IV GH stimulation testing performed using either arginine or glucagon as the secretagogue.

Results: Mean IGF-1 was 133 ng/ml as compared to the expected level of 235 ng/ml. Of the 78 patients, 70 had low-for-age IGF-1. Of the 48 that took the IV GH stimulation test, 44 failed necessitating the use of subcutaneous GH preparations . The prevalence of GH deficiency in FM was at least 56%.

Conclusion:  GH deficiency is more common than believed in FM. More FM patients should be so tested.

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ACR Meeting Abstracts - https://acrabstracts.org/abstract/prevalence-of-growth-hormone-deficiency-in-fibromyalgia-patients/