ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 705

Prevalence of Cervical Human Papillomavirus Infection in Women with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis

Claudia Mendoza Pinto1,2, Nicolás Molano-González3, Adriana Rojas-Villarraga4, Verónica Vallejo-Ruiz5, Socorro Méndez-Martínez6 and Mario García-Carrasco1,7, 1Systemic Autoimmune Diseases Research Unit,, UMAE, HE CMN Manuel Ávila Camacho-CIBIOR, Instituto Mexicano del Seguro Social, Puebla, Mexico, 2Departament of Research, Facultad de Medicina, Benemerita Universidad Autonoma de Puebla, Puebla, Mexico, 3Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia, 4Instituto de Investigaciones de la Fundación Universitaria de Ciencias de la Salud (FUCS), Bogotá, Colombia, 5Virology Laboratory, Centro de Investigación Biomédica de Oriente, Instituto Mexicano del Seguro Social, Metepec, Puebla, Mexico, 6Research in Health Coordination,, Delegation of Puebla, Instituto Mexicano del Seguro Social, Puebla, Mexico, 7Inmunología y Reumatología, Universidad Autónoma de Puebla, Puebla, Mexico

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: ,

Session Information

Date: Sunday, October 21, 2018

Title: Systemic Lupus Erythematosus – Clinical Poster I: Clinical Manifestations and Comorbidity

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: Human papillomavirus (HPV), a common sexually-transmitted infection, is considered a necessary cause of cervical cancer.

The objectives of this systematic review and meta-regression were: 1) to compare the prevalence of cervical HPV infection between SLE patients and healthy controls and 2) to evaluate the relationship between cervical HPV infection and traditional and SLE-related risk factors for cervical HPV infection in these patients.

Methods: We conducted a systematic literature review (PubMed, Cochrane library, Embase, Virtual Health Library and SciELO databases) following PRISMA guidelines and meta-regression to investigate the pooled prevalence of cervical HPV infection in adult women with SLE. The included articles were independently evaluated by two investigators who extracted information on study characteristics, defined outcomes, risk of bias and summarized strength of evidence [Quality of evidence using the Oxford Centre for evidence-based medicine (EBM) Levels of Evidence] Using meta-regression, we further analyzed whether factors such as multiple sexual partners and immunosuppressive therapy were associated with HPV prevalence. We evaluated the quality of evidence included using the Oxford Centre for evidence-based medicine (EBM) levels of evidence. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for studies providing data on HPV prevalence in women with SLE and in healthy controls.

Results: A total of 687 articles were identified; 9 full-text articles examining the prevalence of cervical HPV infection in SLE women were included , comprising 751 SLE women. Eight studies employed PCR using general primers. The HPV prevalence varied from 3.1% to 80.7%. From the random effects meta-analysis, the pooled prevalence of cervical HPV infection in SLE vs. controls was 34.15% (95% CI: 19.6%-52.5%) vs. 15.3% (95% CI 0.79-27.8%), OR = 2.87 (CI 95% 2.20-3.76) p< 0.0001 (Fig. 1), with large between-study heterogeneity (I2= 95.4%). When only SLE women were evaluated, meta-regression showed no significant differences between patients with and without a background of multiple sexual partners and any immunosuppressive therapy. In addition, the prevalence of cervical HPV infection did not significantly differ between SLE patients on azathioprine or cyclophosphamide.

Conclusion: This meta-analysis suggests that the prevalence of cervical HPV infection was higher in SLE women than in healthy controls. However, multiple sexual partners and any immunosuppressive therapy or specific immunosuppressive treatment (azathioprine and cyclophosphamide) were not associated with cervical HPV infection prevalence in these patients.

Disclosure: C. Mendoza Pinto, None; N. Molano-González, None; A. Rojas-Villarraga, None; V. Vallejo-Ruiz, None; S. Méndez-Martínez, None; M. García-Carrasco, None.

To cite this abstract in AMA style:

Mendoza Pinto C, Molano-González N, Rojas-Villarraga A, Vallejo-Ruiz V, Méndez-Martínez S, García-Carrasco M. Prevalence of Cervical Human Papillomavirus Infection in Women with Systemic Lupus Erythematosus: A Systematic Review and Meta-Analysis [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/prevalence-of-cervical-human-papillomavirus-infection-in-women-with-systemic-lupus-erythematosus-a-systematic-review-and-meta-analysis/. Accessed .

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