Background/Purpose:

The pregnancy outcomes in women with psoriasis have rarely been investigated. This nationwide population study aimed to estimate the risks of adverse maternal and neonatal outcomes in women with psoriasis compared with the general population.

Methods:

Among 2,350,339 singleton pregnancies identified using the Taiwan National Health Insurance and national birth registry between 2001 and 2012, 3,669 pregnancies were delivered by psoriasis patients. Odds ratios (ORs) and 95% confidence intervals (CIs) for maternal and Neonatal outcomes were estimated adjusted for age, sex, Charlson comorbidity score, birth year, maternal nationality and socioeconomic status using an adjusted generalized estimating equation model.

Results:

Pregnancies with psoriasis were associated with an adjusted OR (95% CIs) of 1.06 (1.01-1.12) for Cesarean delivery, 1.40 (1.09-1.81) for gestational hypertension, 1.53 (1.25-1.86) for preeclampsia, 1.47 (1.04-2.08) for antepartum hemorrhage, 1.59 (1.36-1.86) for severe postpartum hemorrhage, 1.13 (1.00-1.28) for gestational diabetes. Neonatal outcomes were also poorer, with an OR (95% CIs) of 1.51 (1.12-2.03) for stillbirth, 1.30 (1.16-1.45) for low birth weight, 1.11 (1.00-1.24) for prematurity, 1.12 (1.02-1.24) for small for gestational age, 1.49 (1.01-2.19) for an Apgar score <7 at 5 minutes.

Conclusion:

Both maternal and neonatal outcomes are worse in women with psoriasis than in the general population.

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ACR Meeting Abstracts - https://acrabstracts.org/abstract/pregnancy-outcomes-in-patients-with-psoriasis-a-nationwide-population-based-study/