Session Information
Session Type: Poster Session (Sunday)
Session Time: 9:00AM-11:00AM
Background/Purpose: Takayasu’s arteritis (TAK) is a large vessel vasculitis of the young women in their reproductive age. According to our previous report from single center TAK pregnancies may have a favorable outcome. On the other hand, pregnancy outcomes were worse in the French TAK cohort. Herein, we reported fetal and maternal complications of pregnancy in a larger group of Turkish TAK patients.
Methods: A total of 68 TAK patients, followed by Turkish Takayasu Study Group in 7 tertiary centers and diagnosed according to the 1990 ACR criteria were consecutively assessed for pregnancy and newborn outcome. Pregnancies were divided into 2 groups as pre-diagnosis (pre-d) and post-diagnosis (post-d) pregnancies and compared to fetomaternal complications (FMC) such as hypertension (HT), preeclampsia-eclampsia, abortion, prematurity, low birth weight. Post-d pregnancies were also divided into 2 groups according to FMC development status and baseline demographic data and TAK clinical characteristics were compared between groups.
Results: The mean age of the patients who received 167 pregnancy data retrospectively was 43±12.1 years. 42 (25.1%) of these pregnancies developed after the onset of the disease. FMC rate was higher in the post-d pregnancies than in the pre-d pregnancies [15 (35.7%), 20 (15.7%); p = 0.006]. FMC are shown in Table 1. Maternal heart failure, cardiovascular event or death was not observed in any pregnancy. Disease characteristics of patients with post-d pregnancies according to FMC development are seen in Table 2. None of the patients was smoker and had cardiovascular events.
Table 1: Fetomaternal complications in pre-d and post-d pregnancies (IUGR: Intrauterine growth retardation)
|
Pre-d pregnancies n: 127 (%) |
Post-d pregnancies n: 40 (%) |
p |
|
|
Maternal complications |
|||
|
Hypertension-new |
0 |
2 (5) |
0.061 |
|
Hypertension-worsening |
0 |
8 (20) |
0.000 |
|
Preeclampsia/eclampsia |
0 |
1 (2.5) |
0.249 |
|
Fetal complications |
|||
|
Abortion |
13 (10.2) |
4 (10) |
0.616 |
|
Prematurity |
2 (1.5) |
2 (5) |
0.258 |
|
Low birth weight |
2 (1.5) |
2 (5) |
0.153 |
|
IUGR |
1 (0.7) |
0 |
0.751 |
|
Fetal anomaly |
0 |
1 (2.5) |
0.249 |
|
Fetal death |
2 (1.5) |
0 |
0.564 |
Tablo 2: Disease characteristics of patients with post-d pregnancies according to FMC development (SS: Standard deviation)
|
FMC +, n:15 (%) |
FMC -, n:27 (%) |
p |
|
|
Age (Mean±SD) |
27.1±4.5 |
26.7±4.7 |
0.695 |
|
Hypertension |
4 (26.6) |
11 (40.7) |
0.285 |
|
Cardiac valvular disease |
3 (20) |
10 (37) |
0.215 |
|
Cerebrovascular event |
1 (6.6) |
2 (7.4) |
0.713 |
|
Renal artery involvement |
9 (60) |
8 (29.6) |
0.056 |
Conclusion: The most common maternal complications of TAK patients are associated with HT. It was observed that TAK negatively affected the fetal outcomes of pregnancies however the majority of the pregnancies were found as successful in our cohort.
To cite this abstract in AMA style:
Alpay-Kanitez N, Kaymaz-Tahra S, Yazici A, Cefle A, Kara M, Yarkan-Tugsal H, Gercik O, Akar S, Onen F, Aksu K, Keser G, Bes C, Kamalı S, Alibaz-Oner F, Direskeneli H. Pregnancy Outcome in Patients with Takayasu Arteritis: The Results of Turkish Takayasu Study Group [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/pregnancy-outcome-in-patients-with-takayasu-arteritis-the-results-of-turkish-takayasu-study-group/. Accessed .« Back to 2019 ACR/ARP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/pregnancy-outcome-in-patients-with-takayasu-arteritis-the-results-of-turkish-takayasu-study-group/