ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1715

Predictors of Gastrointestinal and Renal Involvement in Adult IgA Vasculitis

Alojzija Hocevar1, Ziga Rotar 2 and Matija Tomšič 3, 1Department of Rheumatology, University Medical Center Ljubljana, Slovenia, LJUBLJANA, Slovenia, 2UMC LJUBLJANA, DPT. OF RHEUMATOLOGY, LJUBLJANA, Slovenia, 3Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, LJUBLJANA, Slovenia

Meeting: 2019 ACR/ARP Annual Meeting

Keywords: , ,

Session Information

Date: Monday, November 11, 2019

Title: Vasculitis – Non-ANCA-Associated & Related Disorders Poster III: Behçet’s Disease & Other Vasculitides

Session Type: Poster Session (Monday)

Session Time: 9:00AM-11:00AM

Background/Purpose: IgA vasculitis (IgAV) is a common vasculitis of adult population, yet the disease in adults is still poorly defined. The aim of our study was to determine the predictors of gastrointestinal (GI) or renal involvement in adult IgAV

Methods: Medical records of histologically proven adult IgAV cases diagnosed between January 2013 and April 2019 at our secondary/tertiary rheumatology center were analyzed. The impact of 7 variables (age, gender, smoking, history of preceding infection, use of new medication prior IgAV, the extent of skin purpura (generalized above the waist vs. localized), and the presence of elevated serum immunoglobulin A (IgA) level) on the development of GI and renal involvement was evaluated using logistic regression models.

Results: During the 76-month observation period we identified 203 new adult IgAV cases (58.1% males, median (interquartile range) age 64 (47-76) years, 91 (44.8%) ever smokers). GI tract and renal involvement developed in 55 (27.1%) and 78 (38.4%) cases, respectively. Clinical characteristics of IgAV patients are presented in Table 1. In a multivariate logistic regression model generalized purpura increased (OR 5.45 (95%CI 2.56 – 11.59), p< 0.001) and elevated serum IgA level decreased (OR 0.45 (95%CI 0.21 – 0.95), p=0.037) GI tract involvement. Current smoking (OR 3.04 (1.34-6.89), p=0.008), generalized purpura (OR 1.97 (95%CI 1.06-3.65), p=0.032), elevated serum IgA (OR 1.96 (95%CI 1.02-3.74), p=0.041), and marginally also age (OR 1.02 (95%CI 1.01-1.04), p=0.012,) were associated with an increased risk of renal involvement in our cohort. Gender and potential triggers of IgAV (i.e. prior infections, and the use of new medication) did not significantly influence the clinical presentation of adult IgAV.

Conclusion: Generalized purpura predicted both renal and GI involvement in adult IgAV, active smoking renal involvement, while the serum IgA level had a divergent effect on renal and GI involvement.

Table 1. Clinical characteristics of IgAV cases

Disclosure: A. Hocevar, None; Z. Rotar, AbbVie, 9, Amgen, 5, 8, Eli-Lilly, 9, MSD, 5, Novartis, 9, Pfizer, 9, Sanofi, 5; M. Tomšič, None.

To cite this abstract in AMA style:

Hocevar A, Rotar Z, Tomšič M. Predictors of Gastrointestinal and Renal Involvement in Adult IgA Vasculitis [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/predictors-of-gastrointestinal-and-renal-involvement-in-adult-iga-vasculitis/. Accessed .

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