ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 2900

Predictors Of Damage Accrual Over a 2 Year Period In a Large Multi-Racial/Ethnic Lupus Cohort

Megan E. B. Clowse1, Jennifer M. Grossman2, Joan T. Merrill3, Anca Askanase4, Olga Dvorkina5, Michael D. Lockshin6 and Cynthia Aranow7, 1Rheumatology, Duke University Medical Center, Durham, NC, 2Division of Rheumatology, Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, 3Clinical Pharmacology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Rheumatology, New York University School of Medicine, New York, NY, 5Medicine, SUNY Downstate Medical Center, Brooklyn, NY, 6Rheumatology, Hospital for Special Surgery, Weill Cornell Medical College, New York, NY, 7The Feinstein Institute, Manhasset, NY

Meeting: 2013 ACR/ARHP Annual Meeting

Keywords: Lupus and activity score

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print
Session Information

Title: Systemic Lupus Erythematosus - Clinical Aspects: Cardiovascular and Other Complications of Lupus

Session Type: Abstract Submissions (ACR)

Background/Purpose: Clinical experience and some previous research suggest that patients with lupus who live in more socio-economically vulnerable conditions fair worse than other patients. We sought to identify factors associated with damage accrual using the Lupus Clinical Trials Consortium, Inc. (LCTC) Lupus Data Registry, a patient registry of SLE in 16 lupus centers in North America.

Methods: The LCTC Lupus Data Registry began enrollment in 2010. We compared lupus patients who had accumulated ≥2 points in the SLICC Damage Index (SDI) over 2 years to those who had not with respect to demographics, features of disease, and factors that may enhance socio-economic vulnerability. A Cox proportional hazards model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between a ≥2 point change in SDI and factors that were statistically significant in a univariate analysis. A most parsimonious model was created using a backwards-selection process, keeping all variables in the multivariable model that had a p-value <0.10.

Results: 1,478 patients with documented SDI scores at both enrollment and follow-up contributed a total of 2,503 person-years of follow-up (mean 1.77 years). 91.4% were female, 37.4% were non-Hispanic Caucasian, 34.0% were non-Hispanic African-American, and 8.2% reported Hispanic ethnicity.

In univariate analysis, higher baseline damage, higher baseline lupus disease activity (SLEDAI), longer duration of SLE, and more ACR classification criteria were each associated with a ≥2point increase in SDI. Prior treatments with immunosuppressants or with high dose prednisone were also associated with damage accrual while hydroxychloroquine use at enrollment was protective against damage accrual.

Among socioeconomic characteristics, there was no association between rate of damage accrual and educational attainment, marriage status, and insurance status; however, a two-fold increase in the rate of damage accrual was observed for those not working compared to those who either were working or were students (RR 2.06, 95% CI 1.42-3.01). After adjusting for the other socioeconomic characteristics, this association remained (RR 2.34, 95% CI 1.53-3.56).

In the multivariable model, work was no longer significantly associated with the rate of damage accrual. Additional factors losing significance in the multivariable model included duration of SLE, number of ACR criteria, high dose prednisone, and prior immunosuppressant use. Baseline SDI (p<0.0001) and SLEDAI (p=0.0036) remained significantly associated with the rate of damage accrual.

Conclusion: Baseline SDI and SLE activity were associated with damage accrual. Socio-economic factors did not demonstrate independent associations, contrary to our perceived clinical experience. The cross-sectional relationship between work and damage may in fact be a result rather than a cause of severe illness and damage.

The authors would like to thank and acknowledge the Lupus Clinical Trials Consortium, Inc. (“LCTC”) for its financial support and for access to data in the LCTC Lupus Data Registry. The views expressed in this publication are those of the authors and LCTC is not responsible for its specific content.


Disclosure:

M. E. B. Clowse,
None;

J. M. Grossman,
None;

J. T. Merrill,
None;

A. Askanase,
None;

O. Dvorkina,
None;

M. D. Lockshin,
None;

C. Aranow,
None.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to 2013 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/predictors-of-damage-accrual-over-a-2-year-period-in-a-large-multi-racialethnic-lupus-cohort/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology