ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 542

Predictors for Cardiovascular Events in Patients with Psoriatic Arthritis – a Cohort Study

Lihi Eder1, Arane Thavaneswaran1, Vinod Chandran1, Hua Shen2, Richard J. Cook2 and Dafna D. Gladman1, 1University of Toronto, Toronto Western Hospital, Toronto, ON, Canada, 2Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, ON, Canada

Meeting: 2014 ACR/ARHP Annual Meeting

Keywords: Atherosclerosis, Cardiovascular disease, psoriatic arthritis and risk assessment

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print
Session Information

Title: Spondyloarthropathies and Psoriatic Arthritis - Clinical Aspects and Treatment I

Session Type: Abstract Submissions (ACR)

Background/Purpose

The prevalence of cardiovascular (CV) morbidity is increased in patients with psoriatic arthritis (PsA). CV risk is only partially explained by traditional CV risk factors. We aimed to identify predictors for CV events in a cohort of patients with PsA.

Methods

A retrospective cohort analysis was conducted in patients attending a large PsA clinic from 1978 to 2013. Patients were assessed at 6-12 month intervals according to a standard protocol. The collected information included demographics, lifestyle habits, medical history and disease-related outcomes. The following factors were assessed as candidate predictors of CV events: traditional CV risk factors, measures of PsA disease activity and laboratory biomarkers of inflammation. The primary outcome was the time to the first major CV event that comprised myocardial infarction (MI), ischemic stroke, re-vascularization or CV death. The secondary outcome was the time to any first CV event that included major CV events, angina, transient ischemic accident (TIA) and congestive heart failure (CHF). Each event was confirmed by reviewing hospital records and death certificates. Cox proportional hazard model, with time-dependent explanatory variables and date of birth as the time of origin, was used to compute the multivariate relative risk (RR) for incident CV events adjusting for sex and duration of PsA.

Results

The analysis included 1103 patients with PsA for a combined follow-up time of 10,751 person-years, during which 104 cardiovascular events occurred (57 MI, 9 stroke, 19 revascularization, 2 CV death, 10 angina, 1 TIA and 6 CHF). The mean follow-up period was 9.8±8.5 years. The mean age at the first visit was 44±12.9 years and 56.3% of the patients were males. The incidence rate of CV events did not change significantly across the three decades from 1978 to 2013 (p=0.65). The following variables were associated with a higher incidence rate of major CV events: diabetes (RR 2.7, p=0.002), hypertension (RR 1.93 p=0.003), high triglycerides (RR 1.95 p=0.005), high cholesterol (RR 1.58 p=0.05), erythrocyte sedimentation rate (ESR) (RR 1.36 p=0.009), leukocyte count (RR 2.19 p=0.007) and tender joint count (RR 1.34, p=0.01). The variables that were associated with a higher incidence rate of any CV event were: diabetes (RR 2.68 p=0.0007), hypertension (RR 1.99, p=0.0008), high triglycerides (RR 1.71 p=0.02), ESR (RR 1.3 p=0.02) and tender joint count (RR 1.34 p=0.007). Achieving a minimal disease activity state was associated with a lower incidence rate of major CV events (RR 0.56, p=0.009) and any CV event (RR 0.62, p=0.02). No association was found between the use of non-steroidal anti-inflammatory drugs, disease modifying anti rheumatic agents or TNFα blockers and CV events.

Conclusion

Cardiovascular morbidity in patients with PsA is explained by the combined effect of elevated inflammatory burden and traditional CV risk factors. The achievement of a minimal disease activity state may decrease CV risk in patients with PsA.


Disclosure:

L. Eder,
None;

A. Thavaneswaran,
None;

V. Chandran,
None;

H. Shen,
None;

R. J. Cook,
None;

D. D. Gladman,
None.

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to 2014 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/predictors-for-cardiovascular-events-in-patients-with-psoriatic-arthritis-a-cohort-study/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology