Potential Clinical Utility of Manu-Scan, the Novel Optical Molecular Imaging, in Patients with Hand Rheumatoid Arthritis

Dong Jin Go¹, Sang Jin Lee^1,2, Sang Hyun Joo³, Eun Hye Park⁴, Gi Jeong Cheon⁵, Sung Hwan Hong⁶ and Yeong Wook Song^1,4, ¹Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine, Seoul National University, Seoul, Korea, Republic of (South), ²Division of Rheumatology, Department of Internal Medicine, Kyungpook National University Hospital, Seoul, Korea, Republic of (South), ³Division of Rheumatology, Department of Internal Medicine, Jungang Medical Foundation, Jeju, Korea, Republic of (South), ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South), ⁵Department of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea, Republic of (South), ⁶Department of Radiology, Seoul National University Hospital, Seoul, Korea, Republic of (South)

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords: imaging techniques, inflammation and rheumatoid arthritis (RA)

Session Information

Date: Tuesday, November 7, 2017

Title: ARHP Imaging of Rheumatic Diseases Poster

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Recently, optical molecular imaging is expected to serve as the new technique for early diagnosis and treatment monitoring of rheumatoid arthritis (RA). “Manu-Scan” is the diffuse optical tomography detecting near infrared ray (wavelength 0.7-1.4um) beamed into patient’s joint. This pilot study was aimed to assess the clinical utility of Manu-Scan in patients with hand RA.

Methods: In 14 RA patients and 3 healthy controls, Manu-Scan was performed twice with a one-week interval to detect repetitive error, targeting metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints. Enrolled subjects also underwent joint physical exam, magnetic resonance imaging (MRI), bone scan (BS), and single photon emission computed tomography (SPECT) at the same time. Manu-Scan score was measured by contrast ratio between maximum and minimum scattering factors inside the joint.

Results: Among 215 hand joints assessed using Manu-Scan, 166 (77%) joints within repetitive error less than 20% (137 in RA patients and 29 in healthy controls) were valid for evaluation. Manu-Scan scores in RA joints were significantly lower than those in control joints (median 2.05 vs 2.80, p < 0.001). Manu-Scan scores were also lower in RA joints without tenderness or swelling (n = 44) compared with control joints (p = 0.002). In RA patients, Manu-Scan scores were negatively correlated with MRI grades (rho -0.502, p < 0.001), BS grades (rho – 0.516, p < 0.001), and SPECT scores (rho -0.178, p = 0.038). Moreover, even if RA joints were lesion-free on MRI (n = 69), Manu-Scan had moderate to good discriminatory ability between RA and control, based on ROC curve analysis (AUC 0.763 95% CI [0.661, 0.864]).

Conclusion: Manu scan could be utilized as a novel imaging modality reflecting synovial inflammation without exposure to radiation in RA patients. Further large-scale trial is needed to confirm this finding.

Disclosure: D. J. Go, None; S. J. Lee, None; S. H. Joo, None; E. H. Park, None; G. J. Cheon, None; S. H. Hong, None; Y. W. Song, None.

To cite this abstract in AMA style:

Go DJ, Lee SJ, Joo SH, Park EH, Cheon GJ, Hong SH, Song YW. Potential Clinical Utility of Manu-Scan, the Novel Optical Molecular Imaging, in Patients with Hand Rheumatoid Arthritis [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/potential-clinical-utility-of-manu-scan-the-novel-optical-molecular-imaging-in-patients-with-hand-rheumatoid-arthritis/. Accessed .

« Back to 2017 ACR/ARHP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/potential-clinical-utility-of-manu-scan-the-novel-optical-molecular-imaging-in-patients-with-hand-rheumatoid-arthritis/