Session Information
Session Type: Abstract Submissions (ACR)
Background/Purpose: Periodontal disease (PD) is a chronic inflammatory disease, which has been reported to be associated with rheumatoid arthritis (RA). But, a few studies on an association between ankylosing spondylitis (AS) and PD showed inconsistent results. Thus, we performed a prospective and longitudinal study on the prevalence and course of PD and the effects of TNF-a blockers on PD in AS patients.
Methods: A total of 75 AS patients and 73 age- and gender-matched healthy controls (HC) were prospectively recruited. Full-mouth periodontal probing, 6 sites per tooth, was performed at the baseline and, if a subject had PD, 12 week after periodontal scaling. Periodontal status was assessed using the plaque index (PI), bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment loss (CAL). PD was defined using clinical case definitions proposed by the Centers for Disease Control and Prevention (CDC). AS disease activity, spinal mobility, and radiographic status were evaluated using the Bath ankylosing spondylitis disease activity score (BASDAI), Ankylosing Spondylitis Disease Activity Score (ASDAS), Bath Ankylosing Spondylitis Metrology Index (BASMI), and the modified Stoke AS Spinal Score (mSASSS).
Results: The prevalence of PD was comparable between subjects with HC and AS (58.9% versus 68.0%, p = 0.250). There was no significant difference in PI, BOP, PPD and CAL between the two groups. In AS patients, male gender (p = 0.009) was significantly associated with PD at the baseline examination, whereas the other variables including current use of TNF-a blockers (17/51 versus 4/24, p = 0.288) was not. Periodontal status 12 weeks after periodontal scaling was not different between AS (n = 29) and HC (n = 14, p = 0.317). In addition, among AS patients with PD, current use of TNF-a blockers did not affect periodontal treatment outcomes.
Conclusion: Contrast to RA patients, the prevalence and severity of PD was not increased in AS patients. Furthermore, TNF-a blocker usage in AS patients was associated with neither the prevalence of PD nor the outcome of treatment in our interim analyses.
Table 1. The prevalence and severity of periodontal disease in AS patients and healthy controls at the baseline.
|
Characteristics
|
AS
|
HC
|
P-value
|
|
Periodontal disease prevalence |
51 (68.0%) |
43 (58.9%) |
0.314 |
|
Periodontal disease severity |
0.607 |
||
|
Mild |
0 (0.0%) |
2 (2.7%) |
|
|
Moderate |
44 (58.7%) |
33 (44.6%) |
|
|
Severe |
7 (9.3%) |
10 (13.5%) |
|
|
Plaque index (%) |
25.0 [13.4-41.7]* |
23.2 [10.7-36.6] |
0.521 |
|
Probing pocket depth (mm) |
2.54 [2.30-2.77] |
2.54 [2.38-2.77] |
0.950 |
|
Bleeding on probing (%) |
11.8 [7.14-22.6] |
6.5 [6.35-17.6] |
0.231 |
|
Clinical attachment loss (mm) |
2.58 [2.38-2.86] |
2.58 [2.39-2.92] |
0.934 |
AS, ankylosing spondylitis; HC, healthy control; *, median [interquartile range]
Disclosure:
S. H. Chang,
None;
J. T. Lee,
None;
B. Y. Choi,
None;
H. J. Cho,
None;
J. J. Yoo,
None;
H. J. Oh,
None;
E. H. Kang,
None;
Y. W. Song,
None;
H. J. Lee,
None;
Y. J. Lee,
None.
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