ACR Meeting Abstracts

ACR Meeting Abstracts

  • Meetings
    • ACR Convergence 2024
    • ACR Convergence 2023
    • 2023 ACR/ARP PRSYM
    • ACR Convergence 2022
    • ACR Convergence 2021
    • ACR Convergence 2020
    • 2020 ACR/ARP PRSYM
    • 2019 ACR/ARP Annual Meeting
    • 2018-2009 Meetings
    • Download Abstracts
  • Keyword Index
  • Advanced Search
  • Your Favorites
    • Favorites
    • Login
    • View and print all favorites
    • Clear all your favorites
  • ACR Meetings

Abstract Number: 1175

Periarticular Inflammation and Bone Marrow Oedema Are Important in the Evaluation of Enthesitis on MRI in Patients with Peripheral and Axial SpA

Xenofon Baraliakos1, Philipp Sewerin 2, Eugenio de Miguel 3, Christine Kleinmond 4, Ankita Shekhawat 5, Annette Wiedon 6 and Frank Behrens 7, 1Rheumazentrum Ruhrgebiet-Ruhr-University Bochum, Herne, Germany, Herne, Germany, 2Department of Rheumatology & Hiller Research Unit, University Hospital Düsseldorf,, Duesseldorf, Germany, 3Rheumatology Department, Hospital Universitario La Paz, Madrid, Spain, 4ClinProject GmbH, Eurasburg, Germany, 5Novartis Healthcare Pvt. Ltd., Hyderabad, India, 6Novartis Pharma GmbH, Nürnberg, Germany, 7CIRI/Rheumatology and Fraunhofer TMP, Goethe-University, Frankfurt, Germany

Meeting: 2019 ACR/ARP Annual Meeting

Keywords: axial spondyloarthritis, Enthesitis and clinical trials, Magnetic resonance imaging (MRI), Psoriatic arthritis

  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print
Session Information

Date: Monday, November 11, 2019

Title: Imaging Of Rheumatic Diseases Poster II

Session Type: Poster Session (Monday)

Session Time: 9:00AM-11:00AM

Background/Purpose: Enthesitis is a hallmark feature of Spondyloarthritis (SpA), and frequently localizes at the Achilles tendon1. Enthesitis is predominantly measured with clinical scores like Leeds Enthesitis Index (LEI), however, magnetic resonance imaging (MRI) might represent a more sensitive tool to recognize enthesitis in both, bone and soft tissues2, providing insight about the potential disconnect between pain at entheseal sites and objective inflammation. ACHILLES is the largest double blind, placebo-controlled, multicenter Phase 3 trial to date, designed to investigate enthesitis by clinical and imaging assessments in patients (pts) with active SpA. Here, we present the MRI parameters of the heel (evaluated by central readers) in pts who were not included in ACHILLES based on a negative MRI evaluation of the (local) investigator.

Methods: Pts (≥18 years) with active SpA (peripheral or axial) had to present in ACHILLES with clinical (LEI) and MRI-positive heel enthesitis (interpreted by either the local radiologist or rheumatologist), defined as enthesitis with/without bursitis and/or bone marrow edema with/without concomitant erosions in the area of the Achilles’ tendon insertion and/or the plantar aponeurosis. The present analysis included heel MRI characteristics of pts who failed to meet the MRI study inclusion criteria based on local MRI evaluation. The MRIs of screen-failed pts were evaluated by two independent central readers, blinded to any screen failure reason, in a consensus read fashion. Centralized reading of the heel MRIs was performed according to the Psoriatic arthritis magnetic resonance imaging scoring system (PsAMRIS)3. Since PsAMRIS was developed initially for the hands, additional parameters were introduced to allow for more accurate representation of the heel: a) bone oedema (with 1-33% of bone oedematous) were further specified by oedema length ≤/ >0.5 cm and b) bone erosions were further specified by assessing the localization.

Results: Overall, 204 (128 PsA and 76 axSpA) pts were randomized and 94 pts failed screening. Of the 94 screen-failed pts, 46 pts failed due to MRI negative heel enthesitis as assessed by investigators. Upon assessment by central readers, 12/46 (26.1%) were found to be MRI positive and 34/46 (73.9%) MRI negative for heel enthesitis; MRI parameters of both groups are shown in the Table. Overall, 8/12 (67%) MRIs evaluated for positive enthesitis presented with periarticular inflammation and 6/12 (50%) with bone oedema. PsAMRIS based quantification of bone oedema revealed 1-33% of bone edematous for 6 cases, with only 1/6 having an oedema length of >0.5 cm. Enthesitis was centrally read in 6/12 (50%) MRIs at the Achilles tendon insertion and in 5/12 (42%) at the Plantar aponeurosis calcaneal insertion.

Conclusion: In central reading, concomitant periarticular inflammation and bone marrow oedema at the tendon insertion were found to be critical for the confirmation of enthesitis on MRI in patients suffering from SpA.

References:

  1. Schett G, et al. Nat Rev Rheumatol. 2017;13:731─41.
  2. PoggenborgRP, et al. Ann Rheum Dis. 2015;74:823─9
  3. Ostergaard M, et al. J Rheumatol. 2009;36:1816─24

Table: MRI Parameters


Disclosure: X. Baraliakos, AbbVie, 2, 5, 8, Abbvie, 2, 5, 8, BMS, 2, 5, 8, 9, Bristol-Myers Squibb, 2, 5, 8, Celgene, 2, 5, 8, 9, Chugai, 2, 5, 8, 9, Janssen, 2, 5, 8, 9, Lilly, 2, 8, 9, Merck, 2, 5, 8, MSD, 2, 5, 8, 9, Novartis, 2, 5, 8, 9, Novatis, 2, 5, 8, Pfizer, 2, 5, 8, 9, UCB, 2, 5, 8, 9, UCB Pharma, 2, 5, 8, Werfen, 2, 5, 8; P. Sewerin, AbbVie, 2, 5, 8, Biogen, 5, 8, BMS, 5, 8, Celgene, 2, 5, 8, Chugai, 2, 5, 8, Hexal, 5, 8, Janssen-Cilag, 2, 5, 8, Lilly, 2, 5, 8, Novartis, 2, 5, 8, Pfizer, 2, 5, 8, Roche, 5, 8, Sanofi-Genzyme, 5, 8, Swedish Orphan Biovitrum, 5, 8, UCB, 2, 5, 8; E. de Miguel, AbbVie, 2, 5, 8, BMS, 8, BMS, MSD, UCB, Roche, 8, MSD, 8, Novartis, 2, 5, 8, Pfizer, 2, 5, 8, Roche, 8, UCB, 8; C. Kleinmond, Novartis, 5; A. Shekhawat, Novartis, 3; A. Wiedon, Novartis, 3; F. Behrens, Abbvie, 2, 5, 8, Biotest, 5, 8, BMS, 5, 8, Boehringer, 5, 8, Celgene, 5, 8, Chugai, 2, 5, 8, Galapagos, 5, 8, Genzyme, 5, 8, Janssen, 2, 4, 5, 8, Lilly, 5, 8, MSD, 5, 8, Novartis, 2, 5, 8, Pfizer, 2, 5, 8, Roche, 2, 5, 8, Sanofi, 5, 8, Sanofi-Genzyme, 5, 8, UCB, 5, 8.

To cite this abstract in AMA style:

Baraliakos X, Sewerin P, de Miguel E, Kleinmond C, Shekhawat A, Wiedon A, Behrens F. Periarticular Inflammation and Bone Marrow Oedema Are Important in the Evaluation of Enthesitis on MRI in Patients with Peripheral and Axial SpA [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/periarticular-inflammation-and-bone-marrow-oedema-are-important-in-the-evaluation-of-enthesitis-on-mri-in-patients-with-peripheral-and-axial-spa/. Accessed .
  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
  • Click to print (Opens in new window) Print

« Back to 2019 ACR/ARP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/periarticular-inflammation-and-bone-marrow-oedema-are-important-in-the-evaluation-of-enthesitis-on-mri-in-patients-with-peripheral-and-axial-spa/

Advanced Search

Your Favorites

You can save and print a list of your favorite abstracts during your browser session by clicking the “Favorite” button at the bottom of any abstract. View your favorites »

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

Wiley

  • Online Journal
  • Privacy Policy
  • Permissions Policies
  • Cookie Preferences

© Copyright 2025 American College of Rheumatology