Session Information
Session Type: Abstract Submissions (ACR)
Background/Purpose Reliable and validated classification criteria are needed to conduct high quality clinical research in systemic sclerosis (SSc). The most widely used classification criteria for SSc are ACR criteria published in 1980. Recently, ACR and EULAR Collabarative Initiative has prpposed a new set of criteria for the classification of SSc. In our study, we aimed to compare the sensitivity and specificity of the new ACR/EULAR criteria to the ACR criteria in our SSc population.
Methods
Two rheumatology centers from Turkey participated in this study. The features present at disease onset in patients with SSc seen between 2008-2013 were retrospectively reviewed. For the evaluation of specificity, patients admitted to each center between the same time period for conditions other than SSc, in whom ANA was deemed necessary within the diagnostic work-up, were included as controls.
Results
Onehundredandtwo SSc patients (93 females, 9 males, mean age: 47.9±13.9) and 80 controls (70 females, 10 males, mean age: 48.4±11.6) were included into the study. ANA was positive in 89.2%, anti-Scl-70 in 31.7%, and anti-centromere in 21.6% of the patients. Digital ulcers were present in 34.7% of SSc patients, pulmonary hypertension in 42.2%, interstitial lung disease in 38.3%, and renal crisis in 2%.
The sensitivity of ACR&EULAR and ACR1980 criteria were, respectively, 92.2 % and 78.4%. The specificity of ACR/EULAR and ACR1980 criteria were, respectively, 89.3% and 76.7%. According to the new critera göre 10 patients were misclassified, and according to ACR1980 criteria 18 patients were misclassified. The sensitivity of ACR 1980 criteria was significantly better in SSc patients with interstitial lung disease when compared to others (91.7% vs. 74.%1, p=0.036). According to the New criteria set, however, the sensitivity tended to be higher in the group with anti-Scl-70 positivity (91.7% vs. 74.1%, p=0.09). The sensitivity and the specificity of the criteria were not different in patients with certain other clinical features or other antibody positivities.
Conclusion
We observed that the new ACR/EULAR SSc classification criterianın had better sensitivity and specifity in our SSc patients; and it led to misclassification in a less number of patients.
Disclosure:
N. Cakir,
None;
O. N. Pamuk,
None;
M. A. Balci,
None.
« Back to 2014 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/performance-of-the-new-acr-criteria-in-systemic-sclerosis-a-multicenter-study/