ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 400

Performance of the European League Against Rheumatism/American College of Rheumatology Idiopathic Inflammatory Myopathies Classification Criteria in a Myositis Cohort from Argentina

Belén Virasoro1, Ramiro Gomez 2, Dafne Capelusnik 3, Andrea Braillard Poccard 4, Emilce Schneeberger 5, Silvia Papasidero 6, Malena Viola 7, Maria de la Vega 8, Carolina Costi 9, Mercedes Garcia 10, Cecilia Asnal 11, Ana Cappuccio 12, Demelza Yucra 13, Natalia Tamborenea 14, Mariano Rivero 15, Amelia Granel 16, Linda Vergel Orduz 13, Marina Dalpiaz 14, Juan Bande 6, Carolina Segura Escobar 15 and Cecilia Pisoni 17, 1CEMIC, buenos aires, Buenos Aires, Argentina, 2Hospital de Clínicas José de San Martín, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 3Instituto de Rehabilitacion Psicofisica, CABA, Ciudad Autonoma de Buenos Aires, Argentina, 4Hospital de Clínicas José de San Martin, Buenos Aires, Buenos Aires, Argentina, 5Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, 6Hospital General de Agudos Dr. E. Tornú, Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, 7Centro Reumatologia DOM, Buenos Aires, Buenos Aires, Argentina, 8CEIM Investigaciones Medicas, Buenos Aires, Argentina, 9Hospital General “San Martín” de la Plata, La Plata, Buenos Aires, Argentina, 10Hospital San Martín, La Plata, Argentina, 11Instituto Centenario, Buenos Aires, Buenos Aires, Argentina, 12Hospital Francés, Buenos Aires, Buenos Aires, Argentina, 13Sanatorio Güemes, Buenos Aires, Buenos Aires, Argentina, 14Hospital Rivadavia, Buenos Aires, Buenos Aires, Argentina, 15Hospital Británico, Buenos Aires, Buenos Aires, Argentina, 16Hospital San Roque,Gonnet,La Plata,Buenos Aires.Argentina, La Plata, Buenos Aires, Argentina, 17Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno (CEMIC), Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

Meeting: 2019 ACR/ARP Annual Meeting

Keywords: ,

Session Information

Date: Sunday, November 10, 2019

Title: Muscle Biology, Myositis & Myopathies Poster I

Session Type: Poster Session (Sunday)

Session Time: 9:00AM-11:00AM

Background/Purpose: Patients with Idiopathic Inflammatory Myopathies (IIM) have been classified mainly according to Bohan and Peter (B&P) criteria, proposed in 1975. In 2017 the new EULAR/ACR criteria were proposed. They are able to classify patients with IIM and they are applicable even without results of a muscle biopsy.

The objective of this study was to evaluate the performance of the new EULAR-ACR myositis classification criteria in a large retrospective cohort of IIM patients from Argentina.

We applied the EULAR-ACR criteria in an external real-world cohort of consecutive IM cases from the Argentinean Rheumatology Society Myositis study group. Consecutive patients with IM based on physician diagnosis were included in the database. Data were collected form a preexisting database.

Methods: B&P criteria and EULAR-ACR were applied to each patient. For the purpose of this study we applied the non-biopsy EULAR/ACR criteria to non-dermatomyositis (DM) patients without biopsy (in the original paper those criteria only applied to DM patients). And we also applied the non-biopsy criteria to patients with a biopsy to be able to evaluate whether IM diagnosis might have been done without a biopsy.

We compared the performance of EULAR-ACR criteria with physician diagnosis and with B&P criteria.

Results: A cohort of 132 patients with physician diagnosis of IM were included in the study.

Seventy-seven percent were females, mean age at IM diagnosis was 45 (SD 17) years.  Ninety- four (71%) without muscle biopsy and 37 (29%) with biopsy.

Table 1 shows the performance of all criteria in our cohort. EULAR-ACR criteria were considered positive if patient fulfilled probable or definitive criteria.

Figure 1 shows the performance of EULAR/ACR criteria (with and without biopsy) in patients who underwent muscle biopsy (37 patients)

Table 2 shows sensitivity of EULAR/ACR criteria according to the physician diagnosis as gold standard.

When we analyzed the sensitivity of EULAR-ACR (criteria without biopsy) according to B&P criteria as gold standard, the sensitivity was 86% (73.2-94.9). We were not able to evaluate the sensitivity of EULAR/ACR criteria with biopsy according to B&P criteria because all patients with biopsy fulfilled this criteria.

Conclusion: The sensitivity of EULAR-ACR criteria according to physician diagnosis in our cohort was lower than previous reports for both probable and definitive cut-off points. Sensitivity of EULAR-ACR criteria performed better using B&P criteria as gold standard. If criteria without biopsy are applied to patients with biopsy most of them fulfill criteria. Only in 6 patients of 37 the biopsy would change diagnosis.

Table 1. Performance of all criteria in our cohort. EULAR-ACR criteria were considered positive if patient fulfilled probable or definitive criteria.

Table 2. Sensitivity of EULAR/ACR criteria according to the physician diagnosis as gold standard

Figure 1. Performance of EULAR/ACR criteria in patients who underwent muscle biopsy.

Disclosure: B. Virasoro, None; R. Gomez, None; D. Capelusnik, None; A. Braillard Poccard, None; E. Schneeberger, None; S. Papasidero, None; M. Viola, None; M. de la Vega, AbbVie, 8, BMS, 8, Janssen, 8, Lilly, 8, Pfizer, 5, 8, Raffo, 5, 8, Roche, 9, Sanofi, 5, 8; C. Costi, None; M. Garcia, None; C. Asnal, None; A. Cappuccio, None; D. Yucra, None; N. Tamborenea, None; M. Rivero, None; A. Granel, None; L. Vergel Orduz, None; M. Dalpiaz, None; J. Bande, None; C. Segura Escobar, None; C. Pisoni, None.

To cite this abstract in AMA style:

Virasoro B, Gomez R, Capelusnik D, Braillard Poccard A, Schneeberger E, Papasidero S, Viola M, de la Vega M, Costi C, Garcia M, Asnal C, Cappuccio A, Yucra D, Tamborenea N, Rivero M, Granel A, Vergel Orduz L, Dalpiaz M, Bande J, Segura Escobar C, Pisoni C. Performance of the European League Against Rheumatism/American College of Rheumatology Idiopathic Inflammatory Myopathies Classification Criteria in a Myositis Cohort from Argentina [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10). https://acrabstracts.org/abstract/performance-of-the-european-league-against-rheumatism-american-college-of-rheumatology-idiopathic-inflammatory-myopathies-classification-criteria-in-a-myositis-cohort-from-argentina/. Accessed .

« Back to 2019 ACR/ARP Annual Meeting

ACR Meeting Abstracts - https://acrabstracts.org/abstract/performance-of-the-european-league-against-rheumatism-american-college-of-rheumatology-idiopathic-inflammatory-myopathies-classification-criteria-in-a-myositis-cohort-from-argentina/