Performance of Clinical Disease Activity Index (CDAI) and Simplified Disease Activity Index (SDAI) Appears to be Better Than Gold Standard Disease Assessment Score (DAS-28 CRP)

Pooja Dhaon¹, Siddharth K. Das², Ragini Srivastava³ and Urmila Dhakad⁴, ¹Medicine, Hind Institute of Medical Sciences, Uttar Pradesh, India., Barabanki, India, ²Rheumatology, Prof. and Head, Rheumatology, K.G. Medical University, Lucknow, Lucknow, India, ³Rheumatology, Senior Research Officer, Rheumatology, K.G. Medical University, Lucknow, India, Lucknow, India, ⁴Rheumatology, Asst Professor, K.G. Medical University, Lucknow, India, Lucknow, India

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: Evaluation, remission and rheumatoid arthritis (RA)

Session Information

Date: Tuesday, November 15, 2016

Title: Rheumatoid Arthritis – Clinical Aspects - Poster III: Treatment – Monitoring, Outcomes, Adverse Events

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose : To compare the performance of DAS-28 CRP, CDAI and SDAI composite measures to assess status of patients with Rheumatoid Arthritis on Methotrexate, versus DAS-28 CRP as the gold standard.

Methods : 135 patients with RA as per the 2010 ACR/EULAR criteria were included in the prospective study. The disease activity was assessed at baseline and at every 6 weeks for 24 weeks, by DAS-28 CRP, CDAI and SDAI. Patients were divided into groups of remission, low, moderate and high activity on the basis of predefined cut-offs for DAS-28 CRP, CDAI, and SDAI. A Spearman correlation between composite measures and inter-group comparison of the measures were performed.

Results : There was an excellent positive correlation between DAS-28 CRP and CDAI (linear weighted k baseline – 0.545), DAS-28 CRP and SDAI (linear weighted k – 0.689) at baseline. There was moderate agreement between DAS-28 CRP and CDAI (linear weighted k final visit – 0.458) at final visit. There was moderate correlation between SDAI and DAS 28 CRP at final visit (linear weighted k– 0.470). (Fig shows excellent correlation between CDAI vs DAS 28 CRP and SDAI vs DAS28 CRP at base line but not at final visit. However, correlation between CDAI vs SDAI remained excellent). Patients in remission as per DAS-28 CRP had significantly more residual disease activity compared to SDAI and CDAI remission criteria.

Conclusion: The study shows an excellent strong positive correlation between DAS-28 CRP, CDAI and SDAI at initial evaluation but not at final visit. SDAI and CDAI based remission criteria seems to be better than DAS28-CRP based remission criteria.

Disclosure: P. Dhaon, None; S. K. Das, None; R. Srivastava, None; U. Dhakad, None.

To cite this abstract in AMA style:

Dhaon P, Das SK, Srivastava R, Dhakad U. Performance of Clinical Disease Activity Index (CDAI) and Simplified Disease Activity Index (SDAI) Appears to be Better Than Gold Standard Disease Assessment Score (DAS-28 CRP) [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/performance-of-clinical-disease-activity-index-cdai-and-simplified-disease-activity-index-sdai-appears-to-be-better-than-gold-standard-disease-assessment-score-das-28-crp/. Accessed .

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