ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1391

Patient-Acceptable Symptom State in Psoriatic Arthritis: Prevalence and Associated Factors in Real Clinical Practice

Rubén Queiro1, Juan Cañete2, Carlos Alberto Montilla-Morales3 and Miguel A. Abad4, 1Rheumatology Division, HUCA, Oviedo, Spain, 2Rheumatology Service, Hospital Clínic de Barcelona, Barcelona, Spain, 3Hospital Clínico Universitario de Salamanca. Spain, Salamanca, Spain, 4FEA Reumatología, Hospital Virgen del Puerto, Cáceres, Spain

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: ,

Session Information

Date: Monday, October 22, 2018

Title: Patient Outcomes, Preferences, and Attitudes Poster I: Patient-Reported Outcomes

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose:

Treatment goals in psoriatic arthritis (PsA) are remission or low disease activity. We know little about whether these objectives correlate well with a patient-acceptable symptom state (PASS).To analyze the frequency of PASS in routine clinical practice, we used the Psoriatic Arthritis Impact of Diseases (PsAID) questionnaire proposed by EULAR.

Methods:

Cross-sectional multicenter study including patients with PsA according to CASPAR criteria. Patients with at least one year of disease evolution and under treatment with synthetic (s) and / or biological DMARDs were included. The MDA, VLDA, DAPSA remission and clinical (c) DAPSA remission (without CRP) were measured as treatment targets. A PsAID value <4 was defined as PASS. Factors associated with PASS were analyzed by uni and multivariate models.

Results:

This study included 227 patients, 123 men and 104 women, with a mean age of 53.2 ± 12.4 years. The average duration of PsA was 9.6 ± 7.7 years. One hundred and thirty three (58.6%), 26 (11.5%), 52 (30.6%), 65 (36.9%) and 125 (55%) patients were in MDA, VLDA, DAPSA remission, cDAPSA remission, and PASS, respectively . Mean PsAID was significantly lower in patients reaching any of the treatment targets (p <0.0001). Unajusted associations with PASS (p< 0.25) were: age, BMI, level of education, work situation, smoking, debut pattern, DIP disease, family history of PsA, ischemic heart disease, obesity, CRP, NSAID use, corticoids use, structural damage in hands, and sindesmophytes. Involvement of DIP joints (OR 0.40, 95%CI: 0.20-0.79, p = 0.009), PsA family history (OR 0.25, 95%CI: 0.09-0.72, p = 0.010) and higher CRP values (0.92, 95% CI: 0.85-0.99), p = 0.036, decreased the odds of PASS in the multivariate model.

Conclusion: More than half of patients treated with systemic therapies under routine clinical practice reach a PASS status according to the PsAID. The involvement of DIP joints, higher CRP levels and PsA family history are associated with lower odds of achieving that status.

Acknowledgement

MAAPs study group: A. Cabez; S. Gómez; JC. Torre Alonso; JA. Román Ivorra; J. Sanz; J. Salvatierra; J. Calvo Alén; A. Sellas; FJ. Rodriguez; A. Bermúdez; M. Romero; M. Riesco; JC. Cobeta; F. Medina; A. Aragón; ML. García; A. Urruticoechea; CM. González; E. Judez; B. González; P. Fernández; L. Pantoja; R. Morlá.

Disclosure: R. Queiro, None; J. Cañete, None; C. A. Montilla-Morales, None; M. A. Abad, None.

To cite this abstract in AMA style:

Queiro R, Cañete J, Montilla-Morales CA, Abad MA. Patient-Acceptable Symptom State in Psoriatic Arthritis: Prevalence and Associated Factors in Real Clinical Practice [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/patient-acceptable-symptom-state-in-psoriatic-arthritis-prevalence-and-associated-factors-in-real-clinical-practice/. Accessed .

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