Abstracts Archive - Page 999 of 2607 - ACR Meeting Abstracts

Abstract Number: 883 • 2019 ACR/ARP Annual Meeting
B Cell-specific MyD88 Regulates Pathology After Disease Onset in Murine Lupus
Jeremy Tilstra¹, Minjung Kim ¹, Claire Leibler ¹ and Mark Shlomchik ¹, ¹University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease defined by immune dysregulation, antibody formation, followed by end-organ damage. MyD88 is a central immune…
Abstract Number: 884 • 2019 ACR/ARP Annual Meeting
Interferon-Alpha Disrupts Multiple B Cell Tolerance Mechanisms in 3H9 Mice
Dario Ferri ¹, Yuriy Baglaenko ², Kieran Manion ³, Carolina Munoz-Grajales ⁴ and Joan Wither⁵, ¹University Health Network, Toronto, ON, Canada, ²Brigham Woman's Hospital, Boston, ³Krembil Research Institute, Toronto, ON, Canada, ⁴University Health Network, Toronto, Canada, ⁵University Health Network, Krembil Research Institute, Toronto, ON, Canada
Background/Purpose: Interferon-alpha (IFNα) is elevated in Systemic Lupus Erythematosus (SLE) and is thought to play a central role in its pathogenesis. Amongst IFNα’s many effects…
Abstract Number: 885 • 2019 ACR/ARP Annual Meeting
TLR9 Signaling in HCV-Associated Atypical Memory B Cells Triggers Th1 and Rheumatoid Factor Autoantibody Responses
Chloé COMARMOND¹, Valerie Lorin ², Cindy Marques ¹, Anna Maciejewski-Duval ¹, Nizar Joher ², Cyril Planchais ², Maxime Touzot ³, Thierry Hieu ², Valentin Quiniou ¹, Anne Desbois ⁴, Michelle Rosenzwajg ¹, David Klatzmann ¹, Patrice Cacoub ⁵, Hugo Mouquet ² and David Saadoun ⁵, ¹Assistance Publique des Hopitaux de Paris, PARIS, France, ²Institut Pasteur, PARIS, France, ³Institut Curie, Paris, France, ⁴GHPS, Paris, France, ⁵AP-HP, Groupe Hospitalier Pitié-Salpêtrière, Department of Internal Medicine and Clinical Immunology, F-75013, Paris, France, Paris, France
Background/Purpose: Hepatitis C virus (HCV) infection contributes to the development of autoimmune disorders such as cryoglobulinemia vasculitis (CV). However, it remains unclear why only some…
Abstract Number: 886 • 2019 ACR/ARP Annual Meeting
Mesenchymal Stem Cell Senescence Alleviates Their Chondrogenic and Seno-Suppressive Properties, Contributing to Osteoarthritis Development
Olivier Malaise¹, Yassin Tachikart ², Michael Constantinides ², Marcus Mumme ³, Daniele Noel ², Jing Wang ⁴, Christian Jorgensen ² and Jean-Marc brondello ², ¹GIGA Research, CHU and University of Liège, Liège, Belgium, ²IRMB, INSERM U1183, University of Montpellier, Montpellier, France, ³University Hospital of Basel, Basel, Switzerland, ⁴INM, INSERM U1050, University of Montpellier, Montpeller, France
Background/Purpose: Tissue accumulation of p16INK4A-positive senescent cells is associated with age-related disorders such as osteoarthritis (OA). These senescent cells induce a tissue loss of function through…
Abstract Number: 887 • 2019 ACR/ARP Annual Meeting
Critical Role of the Cholinergic System Involvement in Osteoarthritis
Alice Courties¹, Ariane Do ¹, Sarah Leite ², Audrey Pigenet ², Morgane Belle ³, Geoffroy Nourissat ⁴, Alain Sautet ⁵, Alain Chedotal ³, Uwe Maskos ⁶, Francis Berenbaum ⁷ and Jérémie Sellam ¹, ¹Service de Rhumatologie, AP-HP Hôpital Saint-Antoine, Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, Paris, France, Paris, France, ²Sorbonne Université, INSERM, Centre de Recherche Saint-Antoine, Paris, France, Paris, France, ³Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France, Paris, France, ⁴Chirurgie orthopédique, Clinique Maussins, Groupe Ramsay générale de santé, 67 rue de Romainville, 75019, Paris, Paris, France, ⁵Chirurgie orthopédique, AP-HP Hôpital Saint-Antoine, Paris, Paris, France, ⁶Unité de neurobiologie intégrative des systèmes cholinergiques, CNRS UMR 3571, Institut Pasteur, Paris, Paris, France, ⁷Sorbonne Université-Inserm CDR Saint-Antoine, AP-HP, Paris, France
Background/Purpose: The efferent vagus nerve can regulate inflammation via its principal neurotransmitter acetylcholine (ACh), a concept referred as the 'cholinergic anti-inflammatory pathway'. ACh interacts with members of…
Abstract Number: 888 • 2019 ACR/ARP Annual Meeting
Mitochondrial DNA Impact on Joint Degeneration Process Using DMM OA and Spontaneous Aging Conplastic Mice Models
Morena Scotece¹, Ignacio Rego-Pérez ², Ana Victoria Lechuga-Vieco ³, María Concepción Jiménez Gómez ³, Purificación Filgueira-Fernández ⁴, José Antonio Enriquez ³ and Francisco J. Blanco ², ¹Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Spain, ²Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ³Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Madrid, Spain, ⁴Instituto de Investigación Biomédica de A Coruña (INIBIC), A Coruña, Galicia, Spain
Background/Purpose: Accumulated data indicated that osteoarthritis has a strong genetic component with a prevalent role of mitochondria and mtDNA variations. In the present work, we…
Abstract Number: 889 • 2019 ACR/ARP Annual Meeting
Identification of Genetic Variants Associated with Erosive Hand Osteoarthritis Using Pedigrees from a State-Wide Population-Based Cohort
Nikolas Kazmers¹, Kendra Novak ¹, Zhe Yu ², Tyler Barker ³, Tyler Abraham ⁴, Robin Romero ⁴ and Michael Jurynec ¹, ¹University of Utah, Department of Orthopaedics, Salt Lake City, UT, ²Huntsman Cancer Institute - Utah Population Database Resource, Salt Lake City, UT, ³Intermountain Healthcare, Precision Genomics, Murray, UT, ⁴Intermountain Healthcare, Precision Genomics, St. George, UT
Background/Purpose: Erosive osteoarthritis (EOA) of the hand is a characterized radiographically with centrally-located interphalangeal joint erosions, and clinically by its rapid onset, rapid rate of…
Abstract Number: 890 • 2019 ACR/ARP Annual Meeting
Adenosine A2A Receptor Signaling Activates FoxO1 and FoxO3 and Promotes Cartilage Autophagy
Benjamin Friedman¹, Carmen Corciulo ², Cristina Castro-Rivera ² and Bruce Cronstein ², ¹Department of Medicine, Division of Rheumatology NYUSoM, NYC, ²NYU Langone, New York
Background/Purpose: Osteoarthritis (OA) is a debilitating and costly condition caused by loss of articular cartilage secondary to chondrocyte dysfunction. Autophagy is a homeostatic pathway that…
Abstract Number: 891 • 2019 ACR/ARP Annual Meeting
Lorecivivint (SM04690), a Potential Disease-Modifying Osteoarthritis Drug, Inhibits CLK2 and DYRK1A, Novel Molecular Regulators of Wnt Signaling, Chondrogenesis, and Inflammation
Vishal Deshmukh¹, Alyssa O'Green ¹, Carine Bossard ¹, Tim Seo ¹, Lisa Lamangan ¹, Maureen Ibanez ¹, Abdullah Ghias ¹, Carolyn Lai ¹, Long Do ¹, Shawn Cho ¹, Joseph Cahiwat ¹, Kevin Chiu ¹, Melinda Pedraza ¹ and Yusuf Yazici ¹, ¹Samumed, LLC, San Diego, CA
Background/Purpose: In the synovial joint, Wnt pathway upregulation contributes to osteoarthritis (OA) by increasing osteocyte differentiation, cartilage thinning, and inflammation. Lorecivivint (LOR; SM04690), a novel…
Abstract Number: 892 • 2019 ACR/ARP Annual Meeting
Adverse Childhood Experiences Are Associated with Systemic Lupus Erythematosus in a Clinical Population from Bronx, New York
Roberto Valdovinos¹, Nicole Brown ², Miguelina Germán ², Qi Gao ³, Kaye Brathwaite ², Kimberly Reidy ², Dawn Wahezi ⁴, Chaim Putterman ⁵, Ruth E. Stein ² and Tamar Rubinstein ⁶, ¹Albert Einstein College of Medicine, Philadelphia, PA, ²Children's Hospital at Montefiore/Albert Einstein College of Medicine, Bronx, ³Albert Einstein College of Medicine, Bronx, ⁴Children’s Hospital at Montefiore, New York, ⁵Albert Einstein College of Medicine, New York, NY, ⁶Children's Hospital at Montefiore/Albert Einstein College of Medicine, Bronx, NY
Background/Purpose: Adverse Childhood Experiences (ACEs), which can result in chronic stress, are associated with autoimmune diseases in adulthood and arthritis in childhood. Recently ACEs were…
Abstract Number: 893 • 2019 ACR/ARP Annual Meeting
The Presence of Extractable Nuclear Antigens (ENA) Antibodies in a Large Population-based Cohort from the Netherlands and Their Association with Known Risk Factors for Systemic Lupus Erythematosus and Primary Sjögren Syndrome
Petra Yntema-Eckenhaussen ¹, Suzanne Arends ¹, Elisabeth Brouwer ², Caroline Roozendaal ³, Hendrika Bootsma ⁴, Johanna Westra ¹ and Karina de Leeuw¹, ¹Dept. of Rheumatology and Clinical Immunology - University Medical Center Groningen (UMCG), University of Groningen, Groningen, Netherlands, ²Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ³Dept. of Laboratory Medicine - University Medical Center Groningen (UMCG), University of Groningen, Groningen, Netherlands, ⁴University of Groningen, Groningen, Netherlands
Background/Purpose: Previous studies have demonstrated that years before clinical onset of auto-immune diseases, auto-antibodies can already be present. However, it is also known that some…
Abstract Number: 894 • 2019 ACR/ARP Annual Meeting
Frequency, Severity and Costs of Flares Increase with Disease Severity in Newly Diagnosed Systematic Lupus Erythematous: A Real-World Cohort Study, United States, 2004–2015
Miao Jiang ¹, Barnabas Desta ¹, Aimee Near ², Xia Wang ¹ and Edward Hammond¹, ¹AstraZeneca, Gaithersburg, MD, ²IQVIA, Durham, NC
Background/Purpose: We evaluated the real-world frequency and severity of flares and associated costs 1 year post diagnosis in a US cohort with newly diagnosed SLE.Methods:…
Abstract Number: 895 • 2019 ACR/ARP Annual Meeting
A Spatial-temporal Analysis of Organ-specific Lupus Flares in Relation to Fine Particulate Matter Pollution and Temperature
George Stojan¹, Anton Kvit ², Frank Curriero ² and Michelle Petri ³, ¹Johns Hopkins University, Baltimore, MD, ²Johns Hopkins Bloomberg School of Public Health, Baltimore, ³Johns Hopkins University School of Medicine, Baltimore, MD
Background/Purpose: We performed a spatial-time cluster analysis of the Hopkins Lupus Cohort with the goal of identifying potential clusters of SLE organ specific flares and…
Abstract Number: 896 • 2019 ACR/ARP Annual Meeting
Hydroxychloroquine Use and Cardiovascular Events Among Patients with Systemic Lupus Erythematosus and Rheumatoid Arthritis
April Jorge¹, Na Lu ², Hyon K. Choi ¹, John Esdaile ³, Diane Lacaille ⁴ and J. Antonio Avina-Zubieta ⁵, ¹Massachusetts General Hospital, Boston, MA, ²Massachusetts General Hosptial, Boston, MA, ³Arthritis Research Canada and the University of British Columbia, Richmond, BC, Canada, ⁴Arthritis Research Canada and University of British Columbia, Vancouver, BC, Canada, ⁵Arthritis Research Canada and the University of British Columbia, Vancouver, BC, Canada
Background/Purpose: Hydroxychloroquine (HCQ) is near-universally recommended for patients with SLE and is often used in the treatment of RA. Use of HCQ has been associated…
Abstract Number: 897 • 2019 ACR/ARP Annual Meeting
Mortality Rates After Coronary Revascularization Procedures Among Systemic Lupus Erythematosus Compared to Diabetes Mellitus and General Population Medicaid Patients
Medha Barbhaiya¹, Sarah Chen ², Candace Feldman ³, Hongshu Guan ³, Brendan Everett ⁴ and Karen Costenbader ⁴, ¹Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, ²Brigham and Women's Hospital and Harvard Medical School, Boston, ³Brigham and Women's Hospital, Boston, ⁴Brigham and Women's Hospital, Boston, MA
Background/Purpose: Despite similar myocardial infarction risks in SLE and diabetes mellitus (DM) patients, individuals with SLE enrolled in Medicaid had substantially higher rates of coronary…

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