Abstracts Archive - Page 994 of 2607 - ACR Meeting Abstracts

Abstract Number: 808 • 2019 ACR/ARP Annual Meeting
Long-Term Outcome of Tocilizumab for Patients with Giant Cell Arteritis: Results from Part 2 of a Randomized Controlled Phase 3 Trial
John Stone¹, Min Bao ², Jian Han ², Martin Aringer ³, Daniel Blockmans ⁴, Elisabeth Brouwer ⁵, Maria C. Cid ⁶, Bhaskar Dasgupta ⁷, Jürgen Rech ⁸, Carlo Salvarani ⁹, Robert Spiera ¹⁰ and Sebastian Unizony ¹, ¹Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, ²Genentech, South San Francisco, CA, ³Division of Rheumatology, Department of Medicine III, University Medical Center & Faculty of Medicine Carl Gustav Carus, TU Dresden, Dresden, Germany, Dresden, Germany, ⁴Department of General Internal Medicine, University Hospitals Gasthuisberg, Leuven, Belgium, ⁵Department of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands, ⁶Department of Autoimmune Diseases, Hospital Clínic, University of Barcelona, Institut d’Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain, ⁷Southend University Hospital, NHS Foundation Trust, Westcliff-on-Sea, United Kingdom, ⁸Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany, ⁹Division of Rheumatology, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy, ¹⁰Hospital for Special Surgery, New York, NY
Background/Purpose: Tocilizumab (TCZ) 162 mg administered subcutaneously weekly (QW) or every-other-week (Q2W) plus 26-wk prednisone tapering resulted in higher rates of sustained glucocorticoid (GC)–free remission…
Abstract Number: 809 • 2019 ACR/ARP Annual Meeting
TNF-α Drives Progressive Obliterative Pulmonary Vascular Disease and Represents a Novel Model of Connective-Tissue Disease Associated Pulmonary Arterial Hypertension (CTD-PAH)
Benjamin Korman¹, Richard Bell ¹, R James White ², Maria de la luz Garcia-Hernandez ³, Emily Wu ², Pamela Slattery ², Nelson Huertas ², Stacey Duemmel ², Marc Nuzzo ², Homaira Rahimi ⁴, Craig Morrell ², Christopher Ritchlin ³ and Edward Schwarz ², ¹University of Rochester Medical Center, Rochester, NY, ²University of Rochester, Rochester, NY, ³Division of Allergy, Immunology and Rheumatology, Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA, Rochester, NY, ⁴University of Rochester Medical Center, Rochester
Background/Purpose: Pulmonary arterial hypertension (PAH) is a severe cardiopulmonary disease characterized by an obliterative vasculopathy and vascular remodeling, right heart hypertrophy, and premature death. Connective…
Abstract Number: 810 • 2019 ACR/ARP Annual Meeting
Small Vessel Vasculitis Syndrome with Autoinflammation Caused by De Novo Mutations in LYN Kinase
Adriana de Jesus¹, Gina Montealegre Sanchez ², Helen Freeman ³, Neil Martin ⁴, Ebun Omoyinmi ⁵, Katherine Calvo ⁶, Richard Chyi-chia Lee ⁷, Murray Passo ⁸, Natasha Ruth ⁸, David Kleiner ⁷, Yan Huang ⁹, Nirali Shah ¹⁰, Paul Brogan ¹¹, SuJin Hwang ¹², HyeSun Kuehn ¹², Sergio Rosenzweig ¹², Zuoming Deng ¹³, Anna Huttenlocher ¹⁴, Susan Moir ¹⁵, Douglas Kuhns ¹⁶ and Raphaela Goldbach-Mansky ¹⁷, ¹Translation Autoinflammatory Diseases Section/NIAID/NIH, Silver Spring, MD, ²Translational Autoinflammatory Disease Section/NIAID/NIH, Bethesda, ³Raigmore Hospital, Inverness, United Kingdom, ⁴Royal Hospital for Children, Glasgow, United Kingdom, ⁵University College London Institute of Child Health, London, United Kingdom, ⁶Hematology Service/Department of Laboratory Medicine/NIH, Bethesda, MD, ⁷Laboratory of Pathology/NCI/NIH, Bethesda, MD, ⁸Medical University of South Carolina, Charleston, SC, ⁹Translational Autoinflammatory Disease Section/NIAID/NIH, Bethesda, MD, ¹⁰Pediatric Oncology Branch/NCI/NIH, Bethesda, MD, ¹¹Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, ¹²Immunology Service/Department of Laboratory Medicine/NIH, Bethesda, MD, ¹³Biomining and Discovery Section/NIAMS/NIH, Bethesda, MD, ¹⁴Department of Pediatrics/University of Wisconsin, Madison, WI, ¹⁵Immunopathogenesis Section/NIAID/NIH, Bethesda, MD, ¹⁶Collaborative Clinical Research Branch/NIAID/NIH, Bethesda, MD, ¹⁷Translational Autoinflammatory Diseases Section/NIAID/NIH, Bethesda, MD
Background/Purpose: Lyn kinase is a member of the Src family of non-receptor tyrosine-protein kinases that modifies signals from various cell surface receptors and regulates innate…
Abstract Number: 811 • 2019 ACR/ARP Annual Meeting
Monomethyl Fumarate as a Novel Therapy for Macrophage Activation Syndrome: Mechanism of Action in an Animal Model
Chhanda Biswas ¹, Thomas Burn ¹, Niansheng Chu ¹ and Edward Behrens¹, ¹The Children's Hospital of Philadelphia, Philadelphia
Background/Purpose: Macrophage activation syndrome (MAS) is a deadly systemic inflammatory condition marked by an increase in enzymes of iron metabolism including ferritin and heme-oxygenase 1…
Abstract Number: 812 • 2019 ACR/ARP Annual Meeting
Sex Differences in Autoimmunity and Cardiovascular Risk Could Be Associated with Altered Treg Phenotype and Lipoprotein Metabolism
George Robinson¹, Kirsty Waddington ¹, Anna Radziszewska ¹, Hannah Peckham ¹, David A Isenberg ², Yiannis Ioannou ¹, Coziana Ciurtin ³, Ines Pineda-Torra ¹ and Elizabeth Jury ¹, ¹University College London, London, United Kingdom, ²Centre for Rheumatology, London, United Kingdom, ³Centre for Adolescent Rheumatology, University College London London, UK, Londond, United Kingdom
Background/Purpose: Males and females have altered immune responses resulting in variation in autoimmune risk. Sex differences exist in the frequency and activity of immune-cell subsets…
Abstract Number: 813 • 2019 ACR/ARP Annual Meeting
Monocyte and Macrophage Transcriptional Phenotypes in Systemic Juvenile Idiopathic Arthritis Reveal TRIM8 as a Mediator of IFNγ Hyperresponsiveness and Risk for Macrophage Activation Syndrome
Grant Schulert¹, Thuy Do ¹, Sanjeev Dhakal ¹, Ndate Fall ², Mario Medvedovich ³, Sherry Thornton ¹, Nathan salomonis ² and Alexei A. Grom ¹, ¹Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³University of Cincinnati College of Medicine, Cincinnati, OH
Background/Purpose: Systemic juvenile idiopathic arthritis (SJIA) is a severe and distinct subtype of childhood arthritis. Children with SJIA are at risk for macrophage activation syndrome…
Abstract Number: 814 • 2019 ACR/ARP Annual Meeting
Interferon Signature and Cytokine Patterns Define Novel Autoinflammatory Diseases
Adriana de Jesus¹, Yangfeng Hou ², Stephen Brooks ³, Louise Malle ⁴, Angelique Biancotto ⁵, Yan Huang ⁶, Katherine Calvo ⁷, Bernadette Marrero ⁸, Susan Moir ⁹, Andrew Oler ¹⁰, Zuoming Deng ³, Gina Montealegre Sanchez ¹, Scott Canna ¹¹ and Raphaela Goldbach-Mansky ¹², ¹Translational Autoinflammatory Disease Section/NIAID/NIH, Bethesda, ²Department of Rheumatology, Shandong Provincial Qianfoshan Hospital, Shandong University, Shandong, China (People's Republic), ³Biomining and Discovery Section/NIAMS/NIH, Bethesda, MD, ⁴Translational Autoinflammatory Diseases Section (TADS), NIAID/NIH, Bethesda, ⁵NIH/CHI, Bethesda, ⁶Translational Autoinflammatory Disease Section/NIAID/NIH, Bethesda, MD, ⁷Hematology Service/Department of Laboratory Medicine/NIH, Bethesda, MD, ⁸Computational Systems Biology Section/NIAID/NIH, Bethesda, ⁹Immunopathogenesis Section/NIAID/NIH, Bethesda, MD, ¹⁰NIH/NIAID, Bethesda, ¹¹UPMC Children's Hospital of Pittsburgh, Pittsburgh, ¹²Translational Autoinflammatory Diseases Section/NIAID/NIH, Bethesda, MD
Background/Purpose: Undifferentiated systemic autoinflammatory diseases (USAID) present diagnostic and therapeutic challenges. Cytokine dysregulation may identify disease groups that respond to targeted treatments. IFN-signaling blocking treatments…
Abstract Number: 815 • 2019 ACR/ARP Annual Meeting
Expression Profiling of Genes in Rheumatoid Fibroblast‑like Synoviocytes Regulated by Fas Ligand Using cDNA Microarray Analysis
Koji Fukuda¹, Yasushi Miura ², Shinya Hayashi ¹, Toshihisa Maeda ³ and Ryosuke Kuroda ¹, ¹Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Japan, ²Division of Orthopedic Science, Department Of Rehabilitation Science, Kobe University Graduate School of Health Sciences, Kobe, Japan, ³Matsubara Mayflower Hospital, Kobe, Japan
Background/Purpose: Fas ligand (FasL) is a member of tumor necrosis factor superfamily (TNFSF6) and reported to contribute to synovial hyperplasia of rheumatoid arthritis (RA). Apoptosis…
Abstract Number: 816 • 2019 ACR/ARP Annual Meeting
The Long Non-coding RNA HOTAIR Regulates BMP2 and Wnt Pathways in Synovial Fibroblasts
Muriel Elhai¹, Raphael Micheroli ¹, Mojca Frank-Bertoncelj ², Kerstin Klein ¹, Oliver Distler ³ and Caroline Ospelt ², ¹Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Switzerland., Zürich, Switzerland, ²University Hospital Zürich, Zürich, Switzerland, ³Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland
Background/Purpose: Mechanisms involved in joint patterning of rheumatic diseases remain unknown. The long non-coding RNA HOTAIR is exclusively expressed in synovial fibroblasts (SF) from lower…
Abstract Number: 817 • 2019 ACR/ARP Annual Meeting
Enhanced Expression of mRNA for TAK1 in CD34+ Cells of the Bone Marrow in Rheumatoid Arthritis
Shunsei Hirohata¹, Tatsuo Nagai ², Tetsuya Tomita ³ and Hideki Yoshikawa ³, ¹Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Tatsuno, Japan, ²Kitasato University School of Medicine, Sagamihara, Japan, ³Osaka University Graduate School of Medicine, Osaka, Japan
Background/Purpose: Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial hyperplasia, consisting of type A macrophage-like synoviocytes and type B fibroblast-like synoviocytes (FLS).…
Abstract Number: 818 • 2019 ACR/ARP Annual Meeting
Semaphorins: From Angiogenesis to Inflammation in Rheumatoid Arthritis
Jerome Avouac¹, Sonia Pezet ², Eloïse Vandebeuque ¹ and Yannick Allanore ¹, ¹Paris Descartes University, Cochin Hospital, Rheumatology department, Paris, France, ²INSERM U1016, Paris, France
Background/Purpose: Synovial neoangiogenesis is an early and crucial event to promote the development of the hyperplasic proliferative pathologic synovium in rheumatoid arthritis (RA). A recent…
Abstract Number: 819 • 2019 ACR/ARP Annual Meeting
The Long Noncoding RNA HOTTIP Regulates Cell Cycle and Inflammatory Response in Hand Synovial Fibroblasts
Mojca Frank-Bertoncelj ¹, Tadeja Kuret², Ana Županič ³, Snezna Sodin-Semrl ⁴, Oliver Distler ⁵ and Caroline Ospelt ¹, ¹University Hospital Zürich, Zürich, Switzerland, ²University Hospital Zürich, Zurich, Tajikistan, ³University Hospital Zürich, Zurich, Switzerland, ⁴University Medical Center Ljubljana, Ljubljana, Slovenia, ⁵Dept. of Rheumatology, University Hospital Zürich, Zürich, Switzerland, Zürich, Switzerland
Background/Purpose: Previously we showed that the long noncoding RNA (lncRNA) HOTTIP is exclusively expressed in synovial fibroblasts (SF) from distal joints, such as small joints…
Abstract Number: 820 • 2019 ACR/ARP Annual Meeting
Diurnal Stability of Transcriptional Profiles in Rheumatoid Arthritis
Louise Bennett¹, Fraser Morton ¹, George Fragoulis ¹, Caron Paterson ¹, Dominic Rimmer ², Gary Semple ³, Alison Young ³, Jagtar S Nijjar ⁴, Michael Barrett ⁵, Stefan Siebert ¹, Duncan Porter ⁵, Carl Goodyear ⁶ and Iain McInnes ¹, ¹Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, United Kingdom, ²Clinical Research Facility, NHS Greater Glasgow and Clyde, Glasgow, United Kingdom, ³Clinical Research Facility, NHS Greater Glasgow and Clyde, Glasgow, ⁴Department of Medicine, University of Cambridge, Cambridge, United Kingdom, ⁵Institute of Infection, Immunity & Inflammation, University of Glasgow, Glasgow, ⁶University of Glasgow, Glasgow, United Kingdom
Background/Purpose: Our understanding of disease pathogenesis in Rheumatoid Arthritis (RA) is rapidly expanding with the advent of ‘Omics’ techniques. Importantly, current analysis takes into account…
Abstract Number: 821 • 2019 ACR/ARP Annual Meeting
Trends in Incidence and Prevalence of Osteoarthritis in the United Kingdom: Findings from the Clinical Practice Research Datalink (CPRD)
Subhashisa Swain¹, Aliya Sarmanova ², Christian Mallen ³, Chang Fu Kuo ⁴, Carol Coupland ⁵ and Weiya Zhang ⁶, ¹University of Nottingham, Nottingham, England, United Kingdom, ²2. Bristol Medical School, Population Health Sciences, University of Bristol, UK, Bristol, England, United Kingdom, ³Research Institute for Primary Care and Health Sciences, Keele University, UK, Keele, United Kingdom, ⁴4. Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan (Republic of China), ⁵5. Division of Primary Care, School of Medicine, University of Nottingham, Nottingham, England, United Kingdom, ⁶1. Academic Rheumatology, Division of Rheumatology, Orthopaedics and Dermatology, University of Nottingham, Nottingham, England, United Kingdom
Background/Purpose: Osteoarthritis (OA) is by far the most common arthritis.(1) However, its chronological trend in the United Kingdom (UK) is not known. We aimed to…
Abstract Number: 822 • 2019 ACR/ARP Annual Meeting
Cigarette Smoking Is a Risk Factor for ANCA-Associated Vasculitis
Greg McDermott¹, Xiaoqing Fu ¹, John Stone ², Yuqing Zhang ³, Hyon K. Choi ³ and Zachary Wallace ¹, ¹Massachusetts General Hospital, Boston, ²Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, ³Massachusetts General Hospital, Boston, MA
Background/Purpose: ANCA-associated vasculitis (AAV) is a systemic small vessel vasculitis of unclear etiology associated with excess morbidity and mortality compared to the general population. Environmental…

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