Abstracts Archive - Page 947 of 2607 - ACR Meeting Abstracts

Abstract Number: 1659 • ACR Convergence 2020
Synergistic Effect of Quadriceps Weakness and Obesity in Women at Risk of Knee Osteoarthritis
Jose Rubio¹, David Felson², Xiaoyang Chen³, Kathy Bacon⁴, Neil Segal⁵, Michael Nevitt⁶, Cora Lewis⁷, Tuhina Neogi² and Devyani Misra⁸, ¹Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, ²Boston University School of Medicine, Boston, MA, ³Boston University, Boston, MA, ⁴Boston University School of Medicine, Boston, ⁵University of Kansas Medical Center, Kansas City, ⁶University of California San Fransisco, Orinda, CA, ⁷University of Alabama Birmingham, Birmingham, AL, ⁸Beth Israel Deaconess Medical Center, Boston, MA
Background/Purpose: Quadriceps weakness is associated with an increased risk of incident symptomatic and radiographic knee osteoarthritis (OA), particularly in women. Stronger quadriceps muscles may confer…
Abstract Number: 1660 • ACR Convergence 2020
Sleep Disturbance and Pain Severity and Multi-site Pain: A Prospective 10.7-year Follow-up Study
Feng Pan¹, Jing Tian¹, Flavia Cicuttini² and Graeme Jones¹, ¹University of Tasmania Menzies Institute for Medical Research, Hobart, Tasmania, Australia, ²Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia
Background/Purpose: Sleep disturbance is often comorbid with chronic pain disorders, with emerging evidence suggesting a stronger effect of sleep disturbance on pain than vice versa;…
Abstract Number: 1661 • ACR Convergence 2020
Systematic Review and Meta-Analysis of the Prevalence of Neuropathic-Like Pain and Pain Sensitisation in People with Knee and Hip Osteoarthritis
Luigi Zolio¹, Kai Ying Lim², Mabel Yan¹, Mahnuma Estee³, Sultana Monira Hussain⁴, Flavia Cicuttini⁴ and Anita Wluka⁵, ¹Alfred Health, Melbourne, Australia, ²Monash University, Kuala Lumpur, Malaysia, ³Monash University, Melbourne, Australia, ⁴Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia, ⁵Monash University, Melbourne, Victoria, Australia
Background/Purpose: Pain in osteoarthritis (OA) may be nociceptive or neuropathic-like in nature. In knee OA, pain severity is known to be poorly correlated with joint…
Abstract Number: 1662 • ACR Convergence 2020
Do Weight-bearing versus Non-weight-bearing Pain Reflect Different Pain Mechanisms in Knee Osteoarthritis?: The Multicenter Osteoarthritis Study
Jean Liew¹, John Farrar², Na Wang³, Lisa Carlesso⁴, Kosaku Aoyagi³, Laura Frey Law⁵, Cora Lewis⁶, Michael Nevitt⁷ and Tuhina Neogi³, ¹University of Washington, Seattle, WA, ²University of Pennsylvania, Philadelphia, PA, ³Boston University School of Medicine, Boston, MA, ⁴McMaster University, Hamilton, ON, Canada, ⁵University of Iowa, Iowa City, IA, ⁶University of Alabama Birmingham, Birmingham, AL, ⁷University of California, San Francisco, San Francisco, CA
Background/Purpose: Pain with weightbearing in knee OA is thought to be related to the activation of nociceptors; however, this is not considered the sole mechanism…
Abstract Number: 1663 • ACR Convergence 2020
Walking for Exercise May Be Symptom and Structure Modifying for Those with Established OA and with Varus Alignment – Data from the Osteoarthritis Initiative
Grace Lo¹, Surabhi Vinod², Matthew Harkey³, Timothy McAlindon⁴, Andrea Kriska⁵, Bonny Rockette-Wagner⁵, Charles Eaton⁶, Marc Hochberg⁷, Rebecca Jackson⁸, C. Kent Kwoh⁹, Michael Nevitt¹⁰ and Jeffrey Driban⁴, ¹Michael E. Debakey VA Medical Center, Baylor College of Medicine, Houston, TX, ²Baylor College of Medicine, Houston, ³University of Massachusetts, Worcester, MA, ⁴Tufts Medical Center, Boston, MA, ⁵University of Pittsburgh, Pittsburgh, PA, ⁶Department of Family Medicine and Epidemiology, Warren Alpert Medical School of Brown University,Department of Epidemiology, School of Public Health of Brown University, Providence, RI, ⁷University of Maryland School of Medicine, Baltimore, MD, ⁸Ohio State University, Columbus, OH, ⁹The University of Arizona, Tucson, AZ, ¹⁰University of California, San Francisco, San Francisco, CA
Background/Purpose: Walking for exercise is recommended for knee osteoarthritis (OA) management though benefits have not been demonstrated in epidemiologic studies. We aimed to assess the…
Abstract Number: 1664 • ACR Convergence 2020
Walking Energetics, Fatigue, and Physical Activity in People with Knee Osteoarthritis
Kharma Foucher¹, Burcu Aydemir¹ and Chun-Hao Huang¹, ¹University of Illinois at Chicago, Chicago, IL
Background/Purpose: Osteoarthritis (OA) is associated with limitations in physical activity (PA) for many reasons which are not fully understood. While pain can be associated with…
Abstract Number: 1665 • ACR Convergence 2020
Sociodemographic and Clinical Predictors of Childhood-Onset SLE Disease Activity in the Childhood Arthritis and Rheumatology Research Alliance Registry
Emily Smitherman¹, Rouba Chahine¹, Timothy Beukelman¹, Andrea Knight², AKM Rahman¹, Mary Beth Son³, Jeffrey R Curtis⁴ and Aimee Hersh⁵, ¹University of Alabama at Birmingham, Birmingham, AL, ²Division of Rheumatology, The Hospital for Sick Children and Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ³Boston Children's Hospital, Boston, MA, ⁴Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, ⁵University of Utah and Primary Children's Hospital, Salt Lake City
Background/Purpose: Patients with childhood-onset systemic lupus erythematosus (cSLE) are at high risk for early morbidity and mortality, but predictors of moderate/high cSLE disease activity have…
Abstract Number: 1666 • ACR Convergence 2020
Elucidating Research Priorities in Childhood-Onset Systemic Lupus Erythematosus: A Qualitative Study
Laura Cannon¹, Anne Skelley-Caliendo², Aimee Hersh³ and Andrea Knight⁴, ¹Duke University, Durham, NC, ²Northwestern University, Chicago, IL, ³University of Utah and Primary Children's Hospital, Salt Lake City, ⁴Division of Rheumatology, The Hospital for Sick Children and Department of Paediatrics, University of Toronto, Toronto, ON, Canada
Background/Purpose: An estimated 15 to 20% of patients with systemic lupus erythematosus (SLE) have childhood-onset SLE (cSLE). Given the early onset of cSLE, patients often…
Abstract Number: 1667 • ACR Convergence 2020
Development of Autoimmune Diseases and HLA Associations in Children with Neonatal Lupus and Their Unaffected Siblings
Amit Saxena¹, Aaron Garza Romero², Daniel Gratch³, Peter Izmirly⁴, Hannah Ainsworth⁵, Miranda Marion⁵, Carl Langefeld⁶, Robert Clancy⁷ and Jill Buyon⁸, ¹NYU School of Medicine, New York, ²Gonzaba Medical Group, San Antonio, ³NYU Langone Health, New York, ⁴Department of Medicine, New York University School of Medicine, New York, NY, ⁵Wake Forest School of Medicine, Winston-Salem, ⁶Wake Forest School of Medicine, Winston Salem, NC, ⁷New York University School of Medicine, New York, NY, ⁸Department of Medicine, NYU School of Medicine, New York, NY
Background/Purpose: Neonatal Lupus (NL) is a model of passively acquired autoimmunity conferred by exposure to maternal anti-Ro antibodies with major manifestations being congenital heart block…
Abstract Number: 1668 • ACR Convergence 2020
Long-Term Outcomes in Children Born to Anti-Ro and/or Anti-La Positive Mothers
Talia Diaz¹, Daniela Dominguez², Edgar Jaeggi³, Andrea Knight⁴, Carl A. Laskin⁵, Lawrence Ng⁶, Franklin Silverio¹, Earl D. Silverman⁷ and Linda Hiraki⁸, ¹Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ²Division of Rheumatology, The Hospital for Sick Children, Toronto, Canada, ³Fetal Cardiac Program, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Division of Rheumatology, The Hospital for Sick Children and Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ⁵Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada, ⁶Division of Rheumatology, Hospital for Sick Children, Toronto, Canada, ⁷Division of Rheumatology, The Hospital for Sick Children, Translational Medicine, Research Institute, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto., Toronto, ON, Canada, ⁸Division of Rheumatology, The Hospital for Sick Children, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto., Toronto, ON, Canada
Background/Purpose: Neonatal Lupus Erythematosus (NLE) is an acquired autoimmune disorder associated with the transplacental passage of maternal anti-Ro and/or anti-La antibodies. Previous studies have suggested…
Abstract Number: 1669 • ACR Convergence 2020
Genetics of Age at Diagnosis in Systemic Lupus Erythematosus
Raffaella Carlomagno¹, Fangming Liao², JingJing Cao², Dafna Gladman³, Marisa Klein-Gitelman⁴, Andrea Knight⁵, Deborah Levy¹, Karen Onel⁶, Andrew Paterson², Christine Peschken⁷, Janet Pope⁸, Zahi Touma⁹, Murray Urowitz¹⁰, Declan Webber¹, Joan Wither¹¹, Earl D. Silverman¹² and Linda Hiraki¹³, ¹Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ²Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada, ³Krembil Research Institute, Toronto Western Hospital, Toronto, ON, Canada, ⁴Division of Rheumatology, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, ⁵Division of Rheumatology, The Hospital for Sick Children and Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ⁶Pediatric Rheumatology, Hospital for Special Surgery, New York, NY, ⁷Departments of Medicine and Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada, ⁸Department of Medicine, University of Western Ontario, St. Joseph's Health Centre, London, ON, Canada, ⁹University of Toronto, Toronto, ON, Canada, ¹⁰University Health Network, University of Toronto, Toronto, ON, Canada, ¹¹University of Toronto Lupus Clinic, Centre for Prognosis Studies in Rheumatic Diseases, Toronto Western Hospital, University Health Network, Toronto, ON, Canada, ¹²Division of Rheumatology, The Hospital for Sick Children, Translational Medicine, Research Institute, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto., Toronto, ON, Canada, ¹³Division of Rheumatology, The Hospital for Sick Children, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto., Toronto, ON, Canada
Background/Purpose: Genome wide association studies (GWAS) have identified >90 SNPs associated with systemic lupus erythematosus (SLE) risk. However, there may be additional loci impacting the…
Abstract Number: 1670 • ACR Convergence 2020
Low Copy Number of Long C4 Genes Is a Genetic Risk Factor for Childhood Onset SLE (cSLE) but Is Associated with Higher Age of Disease Onset
Fatima Barbar-Smiley¹, Danlei Zhou², Joanne Drew², Bi Zhou², Cagri Yildirim-Toruner², Vidya Sivaraman³, Wael Jarjour⁴, Stacy Ardoin² and Chack-Yung Yu⁵, ¹Nationwide Children's Hospital/The Ohio State University, Columbus, OH, ²Nationwide Children's Hospital, Columbus, OH, ³Nationwide Children's Hospital, Bexley, OH, ⁴The Ohio State University, Columbus, OH, ⁵Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH
Background/Purpose: Hypocomplementemia is a marked feature of systemic lupus erythematosus (SLE), which may be a result of consumption initiated by immune complexes between self-nuclear antigens…
Abstract Number: 1671 • ACR Convergence 2020
Identifying Rare Genetic Variants in Childhood-onset Monogenic Systemic Lupus Erythematosus
Melissa Misztal¹, Fangming Liao², Sergey Naumenko³, Andrea Knight⁴, Daniela Dominguez⁵, JingJing Cao², Declan Webber⁶, Bhooma Thiruvahindrapuram⁷, Deborah Levy⁶, Andrew Paterson², Earl D. Silverman⁸ and Linda Hiraki⁹, ¹Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Oakville, ON, Canada, ²Genetics & Genome Biology, Research Institute, The Hospital for Sick Children, Toronto, Canada, ³The Centre for Computational Medicine, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada, ⁴Division of Rheumatology, The Hospital for Sick Children and Department of Paediatrics, University of Toronto, Toronto, ON, Canada, ⁵Division of Rheumatology, The Hospital for Sick Children, Toronto, Canada, ⁶Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada, ⁷The Centre for Applied Genomics, The Hospital for Sick Children, Toronto, ⁸Division of Rheumatology, The Hospital for Sick Children, Translational Medicine, Research Institute, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto., Toronto, ON, Canada, ⁹Division of Rheumatology, The Hospital for Sick Children, Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto., Toronto, ON, Canada
Background/Purpose: Among children diagnosed with systemic lupus erythematosus (SLE), there exists monogenic forms of SLE, where rare variants in a single gene lead to disease.…
Abstract Number: 1672 • ACR Convergence 2020
Renal Activity Index for Lupus Nephritis Distinguishes Active Renal Disease Among Childhood Systemic Lupus Erythematosus Patients
Najla Aljaberi¹, Arjun Mathur², Steffy Jose³, Theresa Hennard⁴, Angela Merritt¹, Qing Ma⁵, James Rose⁵, Rashmi Sahay⁶, Chunyan Liu⁶, Scott Wenderfer⁷ and Hermine I Brunner⁸, ¹Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Division of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, ³Renal Section, Baylor College of Medicine and Texas Children's Hospital, Houston, ⁴Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ⁵Divison of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, ⁶Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, ⁷Renal Section, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, ⁸PRCSG, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH
Background/Purpose: Renal involvement in childhood-onset systemic lupus erythematosus (cSLE) is a major cause of morbidity and mortality. Current tools to identify lupus nephritis (LN) fall…
Abstract Number: 1673 • ACR Convergence 2020
Principles of Pediatric Lupus Nephritis in a Contemporary Multi-Center Cohort
Kathleen Vazzana¹, Ankana Daga², Beatrice Goilav³, Ekemini Ogbu⁴, Daryl Okamura⁵, Catherine Park⁶, Rebecca Sadun⁷, Emily Smitherman⁸, Brian Stotter⁹, Scott Wenderfer¹⁰ and Laura Lewandowski¹¹, ¹National Institute of Health/Children's National Hospital, Washington, DC, ²Harvard, Boston, MA, ³The Children’s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, ⁴Johns Hopkins University, Baltimore, MD, ⁵Seattle's Children's, Seattle, WA, ⁶Emory University, Atlanta, GA, ⁷Duke University, Durham, NC, ⁸University of Alabama at Birmingham, Birmingham, AL, ⁹Washington University School of Medicine, St. Louis, MO, ¹⁰Renal Section, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, ¹¹NIAMS, NIH, Rockville, MD
Background/Purpose: Lupus nephritis (LN) is a well-established and life-threatening manifestation of systemic lupus erythematosus (SLE) that is more common in children than adults. The demographics…

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