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  • Abstract Number: 1194 • ACR Convergence 2020

    MUC5B Promoter Variant rs35705950 and Risk Stratification for Rheumatoid Arthritis – Interstitial Lung Disease

    Pierre-Antoine Juge1, Fabienne Louis-Sidney2, Benjamin Granger3, Joanna Kedra4, Marie-Pierre Debray5, Esther Ebstein1, Raphaël Borie6, Arnaud Constantin7, Bernard Combe8, Rene-Marc Flipo9, Xavier Mariette10, Olivier Vittecoq11, Alain Saraux12, Guillermo Carvajal Alegria13, Jean Sibilia14, Francis Berenbaum15, Caroline Kannengiesser16, Bruno Crestani6, Catherine Boileau16, Bruno Fautrel17 and Philippe Dieude18, 1Université de Paris, Service de Rhumatologie Hôpital Bichat-Claude Bernard, AP-HP, Paris, France, 2Service de Rhumatologie, CHU de Fort de France, Martinique, France, Fort de France, France, 3Département de Biostatistiques, Santé Publique et Information Médicale, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalier Pitié-Salpêtrière, Paris, France., Paris, France, 4Sorbonne Université, Institut Pierre Louis d'Epidémiologie et de Santé Publique, UMR S1136, Paris, France, Paris, France, 5Université de Paris, Service de Radiologie Hôpital Bichat-Claude Bernard, AP-HP, Paris, France, 6Université de Paris, Service de Pneumologie Hôpital Bichat-Claude Bernard, AP-HP, Paris, France, 7Hospital Pierre Paul Riquet, Toulouse, France, 8University of Montpellier, Montpellier, France, 9Lille University Hospital, Lille, France, 10Paris-Sud University, Rueil-Malmaison, France, 11University Hospital of Rouen, Rouen, France, 12Department of Rheumatology, UBO, CHU, INSERM 1227 (LBAI), Brest, France, 13CHU de Brest, Service de Rhumatologie, Brest, France, 14CHU Strasbourg, Service de Rhumatologie, Strasbourg, France, 15AP-HP, Hôpital Saint-Antoine, Service de Rhumatologie, Centre de Recherche Saint-Antoine, INSERM UMR_S 938,Sorbonne Université, Paris, 75012, France, Paris, France, 16Université de Paris, Hôpital Bichat, Service de Génétique, AP-HP, Paris, Paris, France, 17Sorbonne University, INSERM, IPLES; Pitié-Salpêtrière Hospital, Paris, Ile-de-France, France, 18Université de Paris, Service de Rhumatologie Hôpital Bichat-Claude Bernard, AP-HP, Paris, Ile-de-France, France

    Background/Purpose: Interstitial lung disease (ILD) is an extra-articular manifestation of rheumatoid arthritis (RA) detected in 20 to 60% of patients with RA on high-resolution computed-tomography…
  • Abstract Number: 1195 • ACR Convergence 2020

    MUC5B rs35705950 and Rheumatoid Arthritis Associated Interstitial Lung Disease Progression

    Pierre-Antoine Juge1, Joshua Solomon2, Romain Garofoli3, Joyce S. Lee4, Fabienne Louis-Sidney5, Esther Ebstein1, Jorge Rojas-Serrano6, Montserrat I. Gonzalez-Perez6, Mayra Mejia6, Ivette Buendia-Roldan6, Ramces Falfan-Valencia7, Enrique Ambrocio-Ortiz7, Effrosyni Manali8, Spyros A. Papiris8, Theofanis Karageorgas9, Dimitrios Boumpas9, Katarina Antoniou10, Coline H.M. van Moorsel11, Joanne van Der Vis11, Yaël A. de Man11, Jan C. Grutters11, Caroline Kannengiesser12, Raphaël Borie13, Lidwine Wemeau-Stervinou14, Rene-Marc Flipo15, Hilario Nunes16, Yurdagul Uzunhan17, Dominique Valeyre18, Nathalie Saidenberg Kermanac'h19, Marie-Christophe Boissier20, Christophe Richez21, Thierry Schaeverbeke22, Tracy J. Doyle23, Paul Wolters24, Marie-Pierre Debray25, Catherine Boileau12, Raphaël Porcher26, Bruno Crestani13, David A. Schwartz4 and Philippe Dieude27, 1Université de Paris, Service de Rhumatologie Hôpital Bichat-Claude Bernard, AP-HP, Paris, France, 2National Jewish Health, Denver, CO, 3Hôpital Cochin, Service de Rééducation, Paris, Paris, France, 4Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA, Aurora, CO, 5Service de Rhumatologie, CHU de Fort de France, Martinique, France, Fort de France, France, 6Interstitial Lung Disease & Rheumatology Unit, Instituto Nacional de Enfermedades Respiratorias, Ismael Cosío Villegas, México City, México, Mexico, Mexico, 7HLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosio Villegas. Mexico City, Mexico, Mexico, Mexico, 82nd Pulmonary Medicine Department, University Hospital of Athens "Attikon", National and Kapodistrian University of Athens, Greece, Athens, Greece, 9Rheumatology and Clinical Immunology Unit, 4th Department of Internal Medicine, University Hospital of Athens "Attikon", National and Kapodistrian University of Athens, Greece, Athens, Greece, 10PS Department of Respiratory Medicine & Laboratory of Molecular & Cellular Pneumonology, Faculty of Medicine, University of Crete, Crete, Greece, Heraklion, Greece, 11St Antonius ILD center of excellence, St Antonius ziekenhuis, Nieuwegein, The Netherlands, Nieuwegein, Netherlands, 12Université de Paris, Hôpital Bichat, Service de Génétique, AP-HP, Paris, Paris, France, 13Université de Paris, Service de Pneumologie Hôpital Bichat-Claude Bernard, AP-HP, Paris, France, 14CHRU de Lille, Service de Pneumologie et Immuno-Allergologie, Centre de compétence des maladies pulmonaires rares, FHU IMMINENT, Lille, France, Lille, France, 15Lille University Hospital, Lille, France, 16Department of Pulmonology, Hôpital Avicenne, APHP, Bobigny, France, Bobigny, France, 17Hôpital Avicennes, Service de Pneumologie, AP-HP, Bobigny, Bobigny, France, 18Hôpital Avicenne, Service de pneumologie, AP-HP, Bobigny, Bobigny, France, 19Hôpital Avicennes, Service de Rhumatologie, AP-HP, Bobigny, Bobigny, France, 20Hôpital Avicenne, Service de Rhumatologie, AP-HP, Bobigny, Bobigny, France, 21Rheumatology Hospital, Pelligrin Hospital, Bordeaux University Hospital, Bordeaux, France, 22CHU de Bordeaux, Service de Rhumatologie, Bordeaux, France, 23Brigham and Women's Hospital, West Roxbury, MA, 24University of California, San Francisco, San Francisco, CA, 25Université de Paris, Service de Radiologie Hôpital Bichat-Claude Bernard, AP-HP, Paris, France, 26Centre d’Epidémiologie Clinique, AP-HP, Hôpital Hôtel-Dieu, F-75004 Paris, France, Paris, France, 27Université de Paris, Service de Rhumatologie Hôpital Bichat-Claude Bernard, AP-HP, Paris, Ile-de-France, France

    Background/Purpose: Rheumatoid arthritis (RA) associated interstitial lung disease (ILD) and idiopathic pulmonary fibrosis (IPF) sharephenotypic and genotypic similarities. Recently, in a large international genetic association…
  • Abstract Number: 1196 • ACR Convergence 2020

    Associations of Biological Sex with Interstitial Lung Disease in Patients with Rheumatoid Arthritis Are Independent of Other Known Risk Factors

    Austin Wheeler1, Gail Kerr2, Ilona Jileaeva3, Asha Krishna4, Bryant England1, Harlan Sayles1, Geoffrey Thiele1, Jill Poole1, Alison Petro1 and Ted Mikuls1, 1University of Nebraska Medical Center, Omaha, NE, 2Washington DC VA Medical Center, Washington, DC, 3Howard University Hospital, Washington, DC, 4Washington, D.C. VAMC, Washington, DC

    Background/Purpose: Extra-articular manifestations of rheumatoid arthritis (RA), such as nodules and interstitial lung disease (ILD), portend poor outcomes and are more common in men than…
  • Abstract Number: 1197 • ACR Convergence 2020

    Biomarkers for Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Systematic Review

    Dawson Shaver1, Daniel Van Kalsbeek1, Ariadne Ebel1, Daniel Hershberger1, Cynthia Schmidt1, Jill Poole1, Geoffrey Thiele1, Dana Ascherman2, Ted Mikuls1 and Bryant England1, 1University of Nebraska Medical Center, Omaha, NE, 2University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: RA-associated interstitial lung disease (RA-ILD) is among the most frequent and severe extra-articular manifestations of RA, contributing significantly to the excess mortality among RA…
  • Abstract Number: 1198 • ACR Convergence 2020

    Lifestyle and Clinical Risk Factors for Incident Rheumatoid Arthritis-Associated Interstitial Lung Disease Among Patients with Rheumatoid Arthritis

    Vanessa Kronzer1, Weixing Huang2, Paul Dellaripa3, Sicong Huang4, Vivi Feathers2, Bing Lu5, Christine Iannaccone6, Ritu Gill7, Hiroto Hatabu8, Mizuki Nishino8, Cynthia Crowson9, John Davis1, Michael Weinblatt4, Nancy Shadick10, Tracy J. Doyle11 and Jeffrey Sparks10, 1Mayo Clinic, Rochester, MN, 2Division of Rheumatology, Inflammation, and Immunity; Brigham and Women’s Hospital and Harvard Medical School, Boston, 3Division of Rheumatology, Brigham and Women's Hospital, Boston, Massachusetts, USA, Boston, MA, 4Brigham and Women's Hospital, Boston, MA, 5Brigham and Women's Hospital and Harvard Medical School, Newton, MA, 6Division of General Internal Medicine; Brigham and Women’s Hospital, Topsfield, MA, 7Department of Radiology; Harvard Medical School, Beth Israel Deaconess Medical Center, Topsfield, MA, 8Department of Radiology; Brigham and Women’s Hospital, Boston, 9Mayo Clinic, Rochester, Minnesota, USA, Rochester, MN, 10Division of Rheumatology, Inflammation, and Immunity; Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, 11Brigham and Women's Hospital, West Roxbury, MA

    Background/Purpose: Despite the known excess mortality of rheumatoid arthritis-associated interstitial lung disease (RA-ILD), its association with certain lifestyle factors such as obesity and future prediction…
  • Abstract Number: 1199 • ACR Convergence 2020

    Prevalence of Subclinical Interstitial Lung Disease After a Mean Rheumatoid Arthritis Duration of 13 Years: Results from the French ESPOIR Cohort

    Pierre-Antoine Juge1, Marie-Pierre Debray2, Esther Ebstein1, Raphaël Borie3, Arnaud Constantin4, Bernard Combe5, Bruno Fautrel6, Rene-Marc Flipo7, Xavier Mariette8, Olivier Vittecoq9, Alain Saraux10, Guillermo Carvajal Alegria11, Jean Sibilia12, Francis Berenbaum13, Bruno Crestani3 and Philippe Dieude14, 1Université de Paris, Service de Rhumatologie Hôpital Bichat-Claude Bernard, AP-HP, Paris, France, 2Université de Paris, Service de Radiologie Hôpital Bichat-Claude Bernard, AP-HP, Paris, France, 3Université de Paris, Service de Pneumologie Hôpital Bichat-Claude Bernard, AP-HP, Paris, France, 4Hospital Pierre Paul Riquet, Toulouse, France, 5University of Montpellier, Montpellier, France, 6Sorbonne University, INSERM, IPLES; Pitié-Salpêtrière Hospital, Paris, Ile-de-France, France, 7Lille University Hospital, Lille, France, 8Paris-Sud University, Rueil-Malmaison, France, 9University Hospital of Rouen, Rouen, France, 10Department of Rheumatology, UBO, CHU, INSERM 1227 (LBAI), Brest, France, 11CHU de Brest, Service de Rhumatologie, Brest, France, 12Department of rheumatology, University Hospitals of Strasbourg and French National Reference Center for Rare Auto-immune diseases, Strasbourg, France, 13AP-HP, Hôpital Saint-Antoine, Service de Rhumatologie, Centre de Recherche Saint-Antoine, INSERM UMR_S 938,Sorbonne Université, Paris, 75012, France, Paris, France, 14Université de Paris, Service de Rhumatologie Hôpital Bichat-Claude Bernard, AP-HP, Paris, Ile-de-France, France

    Background/Purpose: Interstitial lung disease (ILD) is a frequent extra-articular manifestation of rheumatoid arthritis (RA). It is associated with a high morbi-mortality. However, the exact prevalence…
  • Abstract Number: 1200 • ACR Convergence 2020

    Serum Anti-PAD4 and Anti-PAD3/4XR Antibodies in Rheumatoid Arthritis Associated-Interstitial Lung Disease Are Associated with Better Lung Function

    Tim Wilson1, Joshua Solomon2, Jeffrey Swigris2, Erika Darrah3 and M Kristen Demoruelle1, 1University of Colorado, Denver, CO, 2National Jewish Health, Denver, CO, 3Division of Rheumatology, Johns Hopkins University, Baltimore, MD

    Background/Purpose: Rheumatoid arthritis (RA) associated-interstitial lung disease (ILD) affects approximately 10% of RA patients. It is a leading cause of morbidity and mortality, which is…
  • Abstract Number: 1201 • ACR Convergence 2020

    Effect of Filgotinib on Pain in Patients with Rheumatoid Arthritis: Results from Phase 3 Clinical Trials

    Peter Taylor1, Arthur Kavanaugh2, Peter Nash3, Janet Pope4, Beatrix Bartok5, Ken Hasegawa5, Shangbang Rao5, Sander Strengholt6 and Rene Westhovens7, 1Botnar Research Centre, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom, 2Division of Rheumatology, Allergy, & Immunology, University of California San Diego Medical School, San Diego, CA, 3School of Medicine Griffith University, Brisbane, Queensland, Australia, 4Department of Medicine, University of Western Ontario, St. Joseph's Health Centre, London, ON, Canada, 5Gilead Sciences, Inc., Foster City, CA, 6Galapagos BV, Leiden, Netherlands, 7University Hospitals Leuven, Belgium, Leuven, Belgium

    Background/Purpose: RA patients (pts) often suffer substantial pain despite ongoing treatment (tx) and regard pain control as a top tx goal. Filgotinib (FIL)—a potent, oral…
  • Abstract Number: 1202 • ACR Convergence 2020

    Cannabis Use Assessment and Its Impact on Pain in Rheumatic Diseases: A Systematic Review and Meta-analysis

    Manon Guillouard1, Nicolas Authier1, Bruno Pereira1, Martin Soubrier1 and Sylvain Mathieu1, 1CHU Gabriel Montpied, Clermont-Ferrand, France

    Background/Purpose: Despite classic analgesic or effective treatments in rheumatic diseases, such as synthetic Disease Modifying Anti-Rheumatic Drugs in rheumatoid arthritis (RA), patients remain in pain…
  • Abstract Number: 1203 • ACR Convergence 2020

    Analysis of the Impact of Tofacitinib Treatment on Weight in Patients with Rheumatoid Arthritis

    Jürgen Wollenhaupt1, Jacques Morel2, Claire Daien3, Adeline Ruyssen-Witrand4, Cédric Lukas3, Christophe Richez5, Andrea Shapiro6, Douglass S Chapman7, Magali Cros8, Jose L Rivas9 and Gustavo Citera10, 1Struenseehaus Centre for Rheumatology and Clinical Immunology, Hamburg, Germany, 2Rheumatology department, CHU Montpellier and University of Montpellier, Montpellier, France, 3CHU Montpellier and University of Montpellier, Montpellier, France, 4Hôpital Purpan, CHU Toulouse, Toulouse, France, 5Groupe Hospitalier Pellegrin-CHU de Bordeaux, Bordeaux, France, 6Pfizer Inc, Peapack, NJ, 7Pfizer Inc, New York, NY, 8Pfizer Inc, Paris, France, 9Pfizer SLU, Madrid, Spain, 10Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina

    Background/Purpose: A prior post hoc analysis of tofacitinib clinical trial data reported improvements in RA outcomes with tofacitinib vs placebo (PBO) through Month (M)6, regardless…
  • Abstract Number: 1204 • ACR Convergence 2020

    Use of Multi-Biomarker Disease Activity Scores to Assess Biosimilarity in a Phase 3 Randomized Controlled Trial Comparing Biosimilar Infliximab-qbtx (PF‑06438179/GP1111) with EU-Sourced Reference Infliximab in Patients with Active RA

    Jonathan Kay1, Daniel Alvarez2, Muhammad Iftikharur Rehman3, Min Zhang4 and Noriko Iikuni5, 1University of Massachusetts Medical School, Worcester, MA, 2Pfizer, Collegeville, PA, 3Pfizer, Andover, MA, 4Pfizer, La Jolla, CA, 5Pfizer, New York, NY

    Background/Purpose: The multi-biomarker disease activity (MBDA; Vectra® DA, Myriad Genetics, Inc.) score is calculated from concentrations of 12 serum proteins to assess disease activity (DA)…
  • Abstract Number: 1205 • ACR Convergence 2020

    Soluble Vascular Biomarkers in Rheumatoid Arthritis and Ankylosing Spondylitis: Effects of One-year Anti-TNF-α Therapy

    Anita Pusztai1, Attila Hamar2, Ágnes Horváth2, Katalin Gulyás2, Edit Végh2, Nóra Bodnár2, György Kerekes2, Monika Czókolyová2, Szilvia Szamosi2, Levente Bodoki2, Katalin Hodosi2, Andrea Domján2, Gábor Nagy2, Luis Lopez3, Ejii Matsuura4, Zoltán Prohászka5, Sándor Szántó2, Zoltán Nagy2, Yehuda Shoenfeld6, Zoltán Szekanecz2 and Gabriella Szűcs2, 1University of Debrecen Faculty of Medicine, Department of Rheumatology, Debrecen, Hungary, 2University of Debrecen, Debrecen, Hungary, 3Corgenix Inc., Broomfield, CO, 4Okayama University, Okayama, Japan, 5Semmelweis University, Budapest, Hungary, 6Zabludowicz Center, Tel-Hashomer, Israel

    Background/Purpose: Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) have been associated with cardiovascular (CV) disease. The treatment of arthritis by tumour necrosis factor α (TNF-α)…
  • Abstract Number: 1206 • ACR Convergence 2020

    Associations of Vascular and Bone Status in Anti-TNF-treated Rheumatoid Arthritis and Ankylosing Spondylitis Patients

    Anita Pusztai1, Attila Hamar2, Monika Czókolyová2, Katalin Gulyás2, Ágnes Horváth2, Edit Végh2, Zsófia Pethő2, Szilvia Szamosi2, Emese Balogh2, Nóra Bodnár2, Ágnes Szentpétery3, Harjit Bhattoa2, György Kerekes2, Balázs Juhász2, Éva Szekanecz2, Katalin Hodosi2, Andrea Domján2, Sándor Szántó2, Hennie Raterman4, Willem Lems5, Zoltán Szekanecz2 and Gabriella Szűcs2, 1University of Debrecen Faculty of Medicine, Department of Rheumatology, Debrecen, Hungary, 2University of Debrecen, Debrecen, Hungary, 3Uppsala University Hospital, Uppsala, Sweden, 4Northwest Clinics, Alkmaar, Netherlands, 5Amsterdam Rheumatology and Immunology Centre, Amsterdam, Netherlands

    Background/Purpose: Cardiovascular (CV) disease and osteoporosis (OP) have become increasing challenges in the ageing population, even more in patients with inflammatory rheumatic diseases, such as…
  • Abstract Number: 1207 • ACR Convergence 2020

    Impact of Body Mass Index on Clinical Responses of Novel Subcutaneous Infliximab (CT-P13 SC) in Patients with Active Rheumatoid Arthritis: 1-Year Results from a Part 2 of Phase I/III Randomized Controlled Trial

    DaeHyun Yoo1, Rene Westhovens2, Piotr Wiland3, Marek Zawadzki4, Delina Ivanova5, Alfredo Berrocal Kasay6, Elias Chalouhi7, Eva Balázs8, SangJoon Lee9, SungHyun Kim9, NooRi Han9 and YooBin Jung9, 1Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, 2University Hospitals Leuven, Belgium, Leuven, Belgium, 3Medical Univeristy, Wroclaw, Poland, 4Medical Univeristy, Dpt of Rheumatology , Wroclaw, Wroclaw, Poland, 5Diagnostic-Consultative Center Aleksandrovska EOOD, Sofia, Bulgaria, 6ABK Reuma SRL, LIMA, Peru, 7Clinica Internacional Sede Lima, Lima, Peru, 8Dr. Bugyi István Hospital, Szentes, Hungary, 9Celltrion, Inc., Incheon, Republic of Korea

    Background/Purpose: In the analysis of PLANETRA, a Phase III randomized controlled trial (RCT), no significant association was found between body mass index (BMI) and clinical…
  • Abstract Number: 1208 • ACR Convergence 2020

    Utility of Measuring the Immunogenicity to CT-P13 for Subcutaneous Use in Patients with Active Rheumatoid Arthritis: 1-Year Results from a Multicenter, Randomized Controlled Pivotal Trial

    Rene Westhovens1, DaeHyun Yoo2, Piotr Wiland3, Marek Zawadzki4, Delina Ivanova5, Alfredo Berrocal Kasay6, Elias Chalouhi7, Eva Balázs8, SangJoon Lee9, SungHyun Kim9, JeeHye Suh9, ChanKyoung Hwang9 and DaeSeok Choi9, 1University Hospitals Leuven, Belgium, Leuven, Belgium, 2Hanyang University Hospital for Rheumatic Diseases, Seoul, Republic of Korea, 3Medical Univeristy, Wroclaw, Poland, 4Medical Univeristy, Dpt of Rheumatology , Wroclaw, Wroclaw, Poland, 5Diagnostic-Consultative Center Aleksandrovska EOOD, Sofia, Bulgaria, 6ABK Reuma SRL, LIMA, Peru, 7Clinica Internacional Sede Lima, Lima, Peru, 8Dr. Bugyi István Hospital, Szentes, Hungary, 9Celltrion, Inc., Incheon, Republic of Korea

    Background/Purpose: Novel subcutaneous infliximab (CT-P13 SC) was developed to augment the flexibility in the therapeutic use of infliximab and non-inferiority (NI) of CT-P13 SC versus…
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