Abstracts Archive - Page 888 of 2425 - ACR Meeting Abstracts

Abstract Number: 1944 • 2019 ACR/ARP Annual Meeting
Two Biomarkers with Predictive Capacity to Diagnosis Pre-Radiographic Knee Osteoarthritis: Data from the Osteoarthritis Initiative
María Camacho-Encina¹, Vanesa Balboa-Barreiro ², Rocío Paz-González ³, Valentina Calamia ³, Lucía Lourido ⁴, Patricia Fernández-Puente ³, Cristina Ruiz-Romero ⁵ and Francisco J. Blanco ⁶, ¹Proteomics Group-ProteoRed/ISCIII, Grupo de Investigación de Reumatología (GIR), INIBIC – Hospital Universitario de A Coruña, A Coruña, Spain., A Coruña, Spain, ²Grupo de Investigación de Reumatología (GIR), INIBIC-Hospital Universitario de A Coruña, A Coruña, Spain, A Coruña, Galicia, Spain, ³Proteomics Group, Rheumatology Division, ProteoRed, PRB2-ISCIII. INIBIC-Hospital Universitario A Coruña,15006 A Coruña-Spain, A Coruña, Galicia, Spain, ⁴Proteomics Group-ProteoRed/ISCIII, RIER, Grupo de Investigación de Reumatología (GIR), INIBIC – Hospital Universitario de A Coruña, A Coruña, Spain., A Coruña, Spain, ⁵Proteomics Group-ProteoRed/ISCIII, CIBER-BBN, Grupo de Investigación de Reumatología (GIR), INIBIC – Hospital Universitario de A Coruña, A Coruña, Spain., A Coruña, Spain, ⁶Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain
Background/Purpose: Osteoarthritis (OA) is the most prevalent rheumatic disorder of the middle-age population. The lack of sensitive diagnostics methods led to an identification of the…
Abstract Number: 1945 • 2019 ACR/ARP Annual Meeting
Polymorphisms in Genes Involved in Methotrexate Pathway: Predictor of Response to Methotrexate Therapy in Indian Rheumatoid Arthritis Patients
Ankita Singh¹, Harikrishnan Nair ², Vikas Gupta ², Pradeepta Sekhar ², Ramnath Misra ³ and Amita Aggarwal ⁴, ¹Sanjay Gandhi Post Graduate institute of medical science, Lucknow, India, Lucknow, Uttar Pradesh, India, ²Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India, ³Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Lucknow, Uttar Pradesh, India, ⁴Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India
Background/Purpose: Methotrexate (MTX) is first line therapy to treat rheumatoid arthritis (RA) patients. However, the response is variable with 50-60% showing response and this variability…
Abstract Number: 1946 • 2019 ACR/ARP Annual Meeting
Metabolic Regulation in Cybrids Obtained from Healthy and Osteoarthritic (OA) Patients: Impaired Metabolic Flexibility in OA Process
Andrea Dalmao-Fernández¹, Jenny Lund ², Tamara Hermida-Gómez ³, María E. Vázquez-Mosquera ¹, Ignacio Rego-Pérez ⁴, Francisco J. Blanco ⁴ and Mercedes Fernandez-Moreno ⁵, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Galicia, Spain, ²Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Oslo, Norway, ³Unidad de Bioingeniería Tisular y Terapia Celular (GBTTC-CHUAC). Grupo de Investigación en Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC). Sergas. Centro de Investigaciones Científicas Avanzadas (CICA), A Coruña, Spain, ⁴Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ⁵Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España. CIBER-BBM, A Coruña, Spain
Background/Purpose: Background: Osteoarthritis (OA) is the most frequent joint disease.The OA is a heterogeneous disorder. With acceptance of the joint as an organ, the pathogenesis…
Abstract Number: 1947 • 2019 ACR/ARP Annual Meeting
Integrating Genetic Risk Scores and Pre-Diagnostic Metabolomics to Infer Dysregulated Mechanisms in Rheumatoid Arthritis in Women
Su H. Chu¹, Jing Cui ², Jeffrey Sparks ², Bing Lu ², Clary Clish ³, Jessica Lasky-Su ¹, Elizabeth Karlson ² and Karen Costenbader ², ¹Brigham and Women's Hospital and Harvard Medical School, Boston, MA, ²Brigham and Women's Hospital, Boston, MA, ³Broad Institute of MIT and Harvard, Boston, MA
Background/Purpose: Rheumatoid arthritis genetic risk scores (RA-GRS) improve RA risk prediction, but the added predictive value over lifestyle risk factors is modest. Several human leukocyte…
Abstract Number: 1948 • 2019 ACR/ARP Annual Meeting
The Mechanism of DC-STAMP-Mediated Signaling in Cell-Cell Fusion and Osteoclast Maturation
Ananta Paine¹, Kerstin Tiedemann ², Maria de la luz Garcia-Hernandez ¹, Svetlana Komarova ² and Christopher Ritchlin ¹, ¹Division of Allergy, Immunology and Rheumatology, Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA, Rochester, NY, ²Faculty of Dentistry, McGill University, Montreal, Quebec, Canada; Shriners Hospital for Children-Canada, Montreal, Quebec, Canada, Montréal, QC, Canada
Background/Purpose: Osteoclasts (OC) are bone-resorbing, multinuclear cells that originate from myeloid progenitor cells through repetitive cycles of cell-cell fusion. Dendritic cell-specific transmembrane protein (DC-STAMP) is…
Abstract Number: 1949 • 2019 ACR/ARP Annual Meeting
The p.R321C Mutation in P62 Associated with Paget’s Disease of Bone Leads to a Change of Localization of the Protein in Human Osteoclasts
Nerea Gestoso-Uzal ¹, Ricardo Usategui-Martín ¹, Rogelio González-Sarmiento ¹ and Javier Del Pino-Montes¹, ¹Salamanca Institute of Biomedical Research (IBSAL), University Hospital of Salamanca- University of Salamanca, Salamanca-CSIC, Spain, Salamanca, Castilla y Leon, Spain
Background/Purpose: Paget´s disease of bone (PDB) is a chronic bone metabolic disorder. Currently, PDB is a focal disorder characterized by an increase in bone turnover…
Abstract Number: 1950 • 2019 ACR/ARP Annual Meeting
Apolipoprotein L1 Variant-Carrying Monocytes Exhibit Mitochondrial Respiration Defects
Ashira Blazer¹, Miao Chang ¹, Kimberly Robins ¹, Jill Buyon ² and Robert Clancy ², ¹NYU School of Medicine, New York, NY, ²NYU School of Medicine, New York
Background/Purpose: In SLE Apolipoprotein L1 (APOL1) risk variants associate with cardiovascular and kidney damage. APOL1 is both a secreted and tissue intrinsic protein; the latter…
Abstract Number: 1951 • 2019 ACR/ARP Annual Meeting
Transcriptomic Responses in CD4+ T Cells During Successful Therapy for Juvenile Idiopathic Arthritis
Tarbell Evan ¹, Kaiyu Jiang ¹, Tao Liu ² and James N. Jarvis³, ¹University at Buffalo Jacobs School of Medicine, Buffalo, NY, ²Roswell Park Cancer Instiyute, Buffalo, NY, ³University at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY
Background/Purpose: We have shown that therapeutic response in juvenile idiopathic arthritis (JIA) is a non-linear process invloving reorganization of gene expression networks. However, our earlier…
Abstract Number: 1952 • 2019 ACR/ARP Annual Meeting
Genes Associated with Nucleotide Oligomerization Domain-Like Receptor Signaling Pathway Are Upregulated in Discoid Lupus Erythematosus
Irene Calderon¹, Inhan Lee ² and Rina Mina ³, ¹SCDS, Cincinnati, OH, ²mcore, Ann Arbor, MI, ³University of Cincinnati, Cincinnati
Background/Purpose: Background: Discoid Lupus Erythematosus (DLE) is disfiguring autoimmune skin disorder, associated with defects in the adaptive immune system. The innate immune system is likely…
Abstract Number: 1953 • 2019 ACR/ARP Annual Meeting
Estimating the Infiltration of Immune Cells in Synovium of Rheumatoid Arthritis Compared to Osteoarthritis and Healthy Control Using Transcriptomic Profiling
Mahmood Hachim¹, Noha Elemam ¹, Ibrahim Hachim ², Suad Hannawi ³, Rifat Hamoudi ⁴ and Azzam Maghazachi ¹, ¹Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, Sharjah, United Arab Emirates, ²Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates, ³Ministry of Health and Prevention, Department of Rheumatology, Dubai, United Arab Emirates, ⁴1Sharjah Institute for Medical Research, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates
Background/Purpose: Rheumatoid arthritis (RA) is one of the most prevalent autoimmune and prototypic inflammatory diseases. It is a heterogeneous autoimmune disease with local and systemic…
Abstract Number: 1954 • 2019 ACR/ARP Annual Meeting
Association of Functional (GA)n Microsatellite Polymorphism in the FLI1 Gene with Susceptibility to Human Systemic Sclerosis
Aya Kawasaki¹, Keita Yamashita ², Takashi Matsushita ³, Hiroshi Furukawa ⁴, Yuya Kondo ⁵, Naoko Okiyama ⁶, Shouhei Nagaoka ⁷, Kota Shimada ⁸, Shoji Sugii ⁹, Masao Katayama ¹⁰, Shunsei Hirohata ¹¹, Akira Okamoto ¹², Noriyuki Chiba ¹³, Eiichi Suematsu ¹⁴, Keigo Setoguchi ¹⁵, Kiyoshi Migita ¹⁶, Takayuki Sumida ⁵, Shigeto Tohma ¹⁷, Minoru Hasegawa ¹⁸, Yasuhito Hamaguchi ³, Shinichi Sato ¹⁹, Yasushi Kawaguchi ²⁰, Kazuhiko Takehara ³ and Naoyuki Tsuchiya ¹, ¹Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan, ³Department of Dermatology, Kanazawa University, Kanazawa, Japan, ⁴Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan, ⁵Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ⁶Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ⁷Yokohama Minami Kyousai Hospital, Yokohama, Kanagawa, Japan, ⁸Department of Rheumatic Diseases, Tokyo Metropoitan Tama Medica Center, Fuchu, ⁹Department of Rheumatic Diseases, Tokyo Metropoitan Tama Medica Center, Fuchu, Japan, ¹⁰National Hospital Organization Nagoya Medical Center, Nagoya, Japan, ¹¹Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine, Tatsuno, Japan, ¹²National Hospital Organization HImeji Medical Center, Himeji, Hyogo, Japan, ¹³National Hospital Organization Morioka Medical Center, Morioka, Iwate, Japan, ¹⁴National Hospital Organization Kyushu Medical Center, Fukuoka, Japan, ¹⁵Tokyo Metropolitan Cancer and Infectious Dease Center Komagome Hospital, Tokyo, Tokyo, Japan, ¹⁶Department of Rheumatology, Fukushima Medical University School of Medicine, Fukushima, Japan, ¹⁷National Hospital Organization Tokyo National Hospital, Kiyose, Japan, ¹⁸Department of Dermatology, Fukui University, Fukui, ¹⁹University of Tokyo Graduate School of Medicine, Department of Dermatology, Tokyo, Japan, ²⁰Department of Rheumatology, Tokyo Women’s Medical University, Tokyo, Japan
Background/Purpose: Susceptibility genes which can account for the characteristic features of systemic sclerosis (SSc) such as fibrosis, vasculopathy and autoimmunity remain to be determined. A…
Abstract Number: 1955 • 2019 ACR/ARP Annual Meeting
Association of TERT and DSP Polymorphisms with Susceptibility to Myeloperoxidase-ANCA-Associated Vasculitis
Aya Kawasaki¹, Natsumi Namba ¹, Ken-ei Sada ², Fumio Hirano ³, Shigeto Kobayashi ⁴, Hidehiro Yamada ⁵, Hiroshi Furukawa ⁶, Kenji Nagasaka ⁷, Takahiko Sugihara ⁸, Aika Suzuki ⁹, Kunihiro Yamagata ¹⁰, Takayuki Sumida ¹¹, Shigeto Tohma ¹², Sakae Homma ¹³, Shoichi Ozaki ¹⁴, Hiroshi Hashimoto ¹⁵, Hirofumi Makino ¹⁶, Yoshihiro Arimura ¹⁷, Masayoshi Harigai ¹⁸ and Naoyuki Tsuchiya ¹, ¹Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ²Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Kitaku, Okayama, Japan, ³Department of Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan, ⁴Department of Internal Medicine, Juntendo University Koshigaya Hospital, Koshigaya, Japan, ⁵Center for Rheumatic diseases, Seirei Yokohama Hospital, Kawasaki, Japan, ⁶Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan, ⁷Department of Rheumatology, Ome Municipal General Hospital, Tokyo, ⁸Department of Lifetime Clinical Immunology, Tokyo Medical and Dental University, Tokyo, Japan, ⁹Department of Respiratory Medicine, Toho University Graduate School of Medicine, Tokyo, Japan, ¹⁰Department of Nephrology, University of Tsukuba, Tsukuba, Ibaraki, Japan, ¹¹Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan, ¹²National Hospital Organization Tokyo National Hospital, Kiyose, Japan, ¹³Department of Advanced and Integrated Interstitial Lung Diseases Research, School of Medicine, Toho University, Tokyo, Japan, ¹⁴St. Marianna University School of Medicine, Kawasaki, Japan, ¹⁵Juntendo University School of Medicine, Tokyo, Japan, ¹⁶Okayama University, Okayama, Japan, ¹⁷Nephrology and Rheumatology, Kyorin University School of Medicine, Tokyo, Japan, ¹⁸Department of Rheumatology, Tokyo Women's Medical University School of Medicine, Shinjuku-ku, Tokyo, Japan
Background/Purpose: Epidemiology of ANCA-associated vasculitis (AAV) is substantially different between East Asian and European populations. Microscopic polyangiitis (MPA) and MPO-ANCA positive AAV (MPO-AAV) are prevalent…
Abstract Number: 1956 • 2019 ACR/ARP Annual Meeting
Characterizing Arthritis Related to Immune Checkpoint Inhibitors Using Synovial Fluid and Matched Blood
Mazen Nasrallah¹, Molly Thomas ², Kasidet Manakongtreecheep ², Daniel Zlotoff ², Aleigha Lawless ², Hellen Giang ², Sara Schoenfeld ², Ryan Sullivan ², Genevieve Boland ², Kerry Reynolds ², Minna Kohler ², Andrew Luster ² and Alexandra-Chloé Villani ², ¹Massachusetts General Hospital, Boston, ²MGH, Boston
Background/Purpose: Monoclonal antibodies against CTLA-4 and PD-1 have revolutionized the field of immuno-oncology over the past decade. These therapies however are limited by immune related…
Abstract Number: 1957 • 2019 ACR/ARP Annual Meeting
Aggregation of Functional Variants in NOTCH4 Gene Increases SSc Risk
Pravitt Gourh¹, Sarah Safran ², Theresa Alexander ³, Steven Boyden ⁴, Ami Shah ⁵, Maureen Mayes ⁶, Ayo Doumatey ⁷, Amy Bentley ⁷, Daniel Shriner ⁷, Robyn Domsic ⁸, Thomas Medsger Jr ⁹, Paula Ramos ¹⁰, Richard Silver ¹¹, Virginia Steen ¹², John Varga ¹³, Vivien Hsu ¹⁴, Lesley Saketkoo ¹⁵, Elena Schiopu ¹⁶, Dinesh Khanna ¹⁷, Jessica Gordon ¹⁸, Brynn Kron ¹⁹, Lindsey Criswell ²⁰, Heather Gladue ²¹, Chris Derk ²², Elana Bernstein ²³, S Louis Bridges ²⁴, Victoria Shanmugam ²⁵, Kathleen Kolstad ²⁶, Lorinda Chung ²⁷, Suzanne Kafaja ²⁸, Reem Jan ²⁹, Marcin Trojanowski ³⁰, Avram Goldberg ³¹, Benjamin Korman ³², Peter Steinbach ³³, Settara Chandrasekharappa ⁷, James Mullikin ⁷, Adebowale Adeyemo ⁷, Charles Rotimi ⁷, Frederick Wigley ³⁴, Daniel Kastner ³⁵, Francesco Boin ³⁶ and Elaine Remmers ⁷, ¹National Institutes of Rheumatology, Bethesda, ²National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Bethesda, MD, ³University of Maryland, College Park, MD, ⁴University of Utah, SALT LAKE CITY, UT, ⁵Johns Hopkins Hospital, Baltimore, MD, ⁶Division of Rheumatology and Clinical Immunogenetics, University of Texas McGovern Medical School, Houston, Texas, USA, Houston, TX, ⁷National Human Genome Research Institute (NHGRI), Bethesda, MD, ⁸University of Pittsburgh, Pittsburgh, PA, ⁹University of Pittsburg School of Medicine, Pittsburg, PA, ¹⁰Medical University of South Carolina, Charleston, ¹¹Division of Rheumatology, Medical University of South Carolina, Charleston, SC, ¹²Georgetown University, Washington, D.C., USA, Georgetown, ¹³Northwestern University, Chicago,, IL, ¹⁴Rutgers- RWJ Medical School, SOUTH PLAINFIELD, NJ, ¹⁵New Orleans Scleroderma and Sarcoidosis Patient Care and Research Center, New Orleans; Tulane University School of Medicine, University Medical Center – Comprehensive Pulmonary Hypertension Center, USA, New Orleans, ¹⁶Department of Rheumatology, University of Michigan, Ann Arbor, ¹⁷Department of Medicine, University of Michigan, Ann Arbor, Michigan, USA, Ann Arbor, ¹⁸Hospital for Special Surgery, New York, NY, ¹⁹University of California San Francisco, San Francisco, CA, ²⁰University of California, San Francisco, San Francisco, ²¹Arthritis & Osteoporosis Consultants Of The Carolinas, Charlotte, NC, ²²University of Pennsylvania, Philadelphia, PA, ²³Division of Rheumatology, Columbia University, New York, NY, ²⁴University of Alabama at Birmingham, Birmingham, ²⁵George Washington University, Georgetown, DC, ²⁶Division of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, ²⁷Stanford University, Palo Alto, CA, ²⁸Department of Medicine. Rheumatology Division. UCLA, Los Angeles, CA, ²⁹University of Chicago Pritzker School of Medicine, Chicago, IL, ³⁰Boston University Medical Center, Boston, MA, ³¹New York University Langone Medical Center, New York, NY, ³²University of Rochester Medical Center, Rochester, NY, ³³Center for Molecular Modeling, Center for Information Technology, National Institutes of Health, Bethesda, MD, ³⁴Johns Hopkins University, Division of Rheumatology, Baltimore, ³⁵National Institutes of Health, Bethesda, MD, ³⁶UCSF, San Francisco, CA
Background/Purpose: Genetic studies of common variants in scleroderma (systemic sclerosis, SSc) have identified several susceptibility loci increasing SSc risk. Most of these common variants are…
Abstract Number: 1958 • 2019 ACR/ARP Annual Meeting
Contribution of MOCS on Xanthinuria Type III and Its Clinical Significance for Screening
Sung Kweon Cho¹ and Blanka Stiburkova ², ¹NCI, Frederick, MD, ²Institute of Rheumatology; Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Xanthinuria is a rare inherited disorder of purine metabolism (1 in 69,000). In the first step, determination of serum and urinary uric acid and…

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