Abstracts Archive - Page 848 of 2425 - ACR Meeting Abstracts

Abstract Number: 1344 • 2019 ACR/ARP Annual Meeting
Increased High Molecular Weight Adiponectin and Lean Mass During Tocilizumab Treatment in Patients with Rheumatoid Arthritis: A 12 Month Multicenter Study
Eric Toussirot¹, Hubert Marotte ², denis Mulleman ³, gregoire Cormier ⁴, fabienne Coury-Lucas ⁵, Philippe Gaudin ⁶, Emmanuelle Dernis ⁷, christine bonnet ⁸, richard damade ⁹, jean-luc Grauer ¹⁰, Tassadit Ait Abdesselam ¹¹, caroline Karras ¹², frederic Liote ¹³, Pascal Hilliquin ¹⁴, antoinette sacchi ¹⁵, Jean-Marie Berthelot ¹⁶, marc puyraveau ¹ and gilles dumoulin ¹, ¹University Hospital, Besancon, France, ²University Hospital, St Etienne, France, ³University hospital, Tours, France, ⁴CHD Vendée, La Roche sur Yon, France, ⁵University Hospital, Lyon, France, ⁶Rheumatology Department, CHU Grenoble Alpes Hôpital Sud and GREPI - Université Grenoble Alpes, EA7408, Grenoble - Echirolles, France, ⁷Rheumatology Department, Le Mans Central Hospital, Le Mans, France, ⁸University Hospital, Limoges, France, ⁹Centre Hospitalier, Chartres, France, ¹⁰Centre Hopsitalier, Montelimar, France, ¹¹Centre Hospitalier, Meaux, France, ¹²Hôpital Saint Joseph, Marseille, France, ¹³AP-HP, Paris, France, ¹⁴Centre Hospitalier, Corbeil Essones, France, ¹⁵Centre Hospitalier, Mantes la Jolie, France, ¹⁶University Hospital, Nantes, France
Background/Purpose: Patients with rheumatoid arthritis (RA) have an increased risk of cardiovascular (CV) diseases. Dyslipidemia is a known adverse reaction to tocilizumab (TCZ). TNFa blockade…
Abstract Number: 1345 • 2019 ACR/ARP Annual Meeting
Are There Differences in Efficacy and Safety of Biological Disease-modifying Antirheumatic Drugs Between Elderly-onset and Young-onset Rheumatoid Arthritis?
Sadao Jinno¹, Akira Onishi ², Kengo Akashi ², Motomu Hashimoto ³, Wataru Yamamoto ³, Koichi Murata ³, Tohru Takeuchi ⁴, Takuya Kotani ⁴, Yuichi Maeda ⁵, Kosuke Ebina ⁶, Yonsu Son ⁷, Hideki Amuro ⁷, Ryota Hara ⁸, Masanori Katayama ⁹, Jun Saegusa ² and Akio Morinobu ², ¹Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Osaka, Japan, ²Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan, ³Department of Advanced Medicine for Rheumatic Diseases, Kyoto University Graduate School of Medicine, Kyoto, Japan, ⁴Department of Internal Medicine IV, Osaka Medical College, Osaka, Japan, ⁵Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Osaka, Japan, ⁶Department of Musculoskeletal Regenerative Medicine, Osaka University, Graduate School of Medicine, Osaka, Japan, ⁷First Department of Internal Medicine, Kansai Medical University, Osaka, Japan, ⁸The Center for Rheumatic Disease, Department of Orthopedic Surgery, Nara Medical University, Nara, Japan, ⁹Department of Rheumatology, Osaka Red Cross Hospital, Osaka, Japan
Background/Purpose: To compare efficacy and safety of biological disease-modifying antirheumatic drugs (bDMARDs) between elderly-onset rheumatoid arthritis (EORA) and young-onset rheumatoid arthritis (YORA) patients. Methods: Patients with…
Abstract Number: 1346 • 2019 ACR/ARP Annual Meeting
Post-Traumatic Stress Disorder, Depression, Anxiety and Persistence of Methotrexate and TNF Inhibitors in Patients with Rheumatoid Arthritis
Luke Desilet¹, Joshua Baker ², Bryant England ³, Kaleb Michaud ¹, Jennifer Barton ⁴ and Ted Mikuls ⁵, ¹University of Nebraska Medical Center, Omaha, NE, ²University of Pennsylvania, Philadelphia, PA, ³VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, ⁴VA Portland Health Care System & Oregon Health & Science University, Portland, OR, ⁵VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, NE
Background/Purpose: Post-traumatic stress disorder (PTSD) is associated with worse outcomes among U.S. Veterans with rheumatoid arthritis (RA) in addition to reduced medication adherence in other…
Abstract Number: 1347 • 2019 ACR/ARP Annual Meeting
Achievement of Remission in Two Early Rheumatoid Arthritis Cohorts Implementing Different Treat-To-Target Strategies
Vibeke Norvang¹, Gina Hetland Brinkmann ², Kazuki Yoshida ³, Siri Lillegraven ⁴, Anna-Birgitte Aga ⁵, Joe Sexton ⁴, Sara K. Tedeschi ⁶, Till Uhlig ¹, Tore Kvien ¹, Maria Dahl Mjaavatten ⁴, Daniel Solomon ⁷, Espen Haavardsholm ¹ and Houchen Lyu ⁸, ¹Diakonhjemmet Hospital, Dept. of Rheumatology / University of Oslo, Faculty of Medicine, Oslo, Norway, ²Østfold Hospital Trust, Dept. of Rheumatology, Grålum, Norway, ³Brigham and Women's Hospital, Div. of Rheumatology, Immunology and Allergy, Boston, ⁴Diakonhjemmet Hospital, Dept. of Rheumatology, Oslo, Norway, ⁵Diakonhjemmet Hospital, Department of Rheumatology, Oslo, Oslo, Norway, ⁶Brigham and Women's Hospital, Div. of Rheumatology, Immunology and Allergy, Boston, MA, ⁷Brigham and Women´s Hospital, Div. of Rheumatology, Immunology and Allergy, Boston, MA, ⁸Brigham and Women´s Hospital, Div. of Rheumatology, Immunology and Allergy, Boston
Background/Purpose: A treat-to-target (TTT) approach results in superior outcomes compared to conventional care in patients with rheumatoid arthritis (RA). However, TTT strategies are still not…
Abstract Number: 1348 • 2019 ACR/ARP Annual Meeting
Impact of Tofacitinib on the Individual Components of the ACR Composite Score in Patients with Rheumatoid Arthritis: A Post Hoc Analysis of Phase 3 Trials
Louis Bessette¹, Maxime Dougados ², Eduardo Mysler ³, Mark Genovese ⁴, Cassandra Kinch ⁵, Kenneth Kwok ⁶, Tatjana Lukic ⁶, Tanya Girard ⁵, Pierre-Alexandre Landry ⁵ and Ronald van Vollenhoven ⁷, ¹Laval University, Quebec City, QC, Canada, ²Cochin Hospital, Paris, France, ³Organización Médica de Investigación, Buenos Aires, Argentina, ⁴Stanford University, Stanford, CA, ⁵Pfizer Canada ULC, Kirkland, QC, Canada, ⁶Pfizer Inc, New York, NY, ⁷Amsterdam Rheumatology and Immunology Center, Amsterdam, Netherlands
Background/Purpose: Tofacitinib is an oral JAK inhibitor for the treatment of RA. In clinical trials, standard criteria for measuring treatment efficacy in patients (pts) with…
Abstract Number: 1349 • 2019 ACR/ARP Annual Meeting
Earlier Biologic Initiation over Two Decades of Real World Observational Data from the RAPPORT Biologics Registry of Northern Alberta, Canada
Britney Jones¹, Bo Pan ¹, Joanne Homik ², Anthony Russell ², Walter P. Maksymowych ³, Jill Hall ¹ and Stephanie Keeling ¹, ¹University of Alberta, Edmonton, AB, Canada, ²University of Alberta, Edmonton, Canada, ³University of Alberta/CARE ARTHRITIS, Edmonton, AB, Canada
Background/Purpose: Rheumatoid (RA) and psoriatic arthritis (PsA) are inflammatory arthritides associated with significant potential functional disability if not well controlled. We reviewed the baseline demographic…
Abstract Number: 1350 • 2019 ACR/ARP Annual Meeting
Patient Disease Trajectories in Baricitinib-2 Mg-Treated Patients with Rheumatoid Arthritis and Inadequate Response to Biologic DMARDs
Mark Genovese¹, Michael Weinblatt ², Jianmin Wu ³, Bochao Jia ³, Amanda Quebe ³, Luna Sun ³, Yun-Fei Chen ³, Cameron Helt ³, A. Kirstin Bacani ³, Paulo Reis ³ and Janet Pope ⁴, ¹Stanford University, Stanford, CA, ²Brigham and Women's Hospital, Boston, MA, ³Eli Lilly and Company, Indianapolis, IN, ⁴Western University, London, ON, Canada
Background/Purpose: Baricitinib (BARI), a selective Janus kinase 1 and 2 inhibitor, is approved for the treatment of moderately-to-severely active RA in over 60 countries. In…
Abstract Number: 1351 • 2019 ACR/ARP Annual Meeting
Mortality of Rheumatoid Arthritis Patients, Treated to Target at Low Disease Activity: 17-years Follow-up of the BeSt Cohort
Johanna M Maassen¹, YPM Goekoop ², JHLM van Groenendael ³, WF Lems ⁴, PJSM Kerstens ⁵, Thomas Huizinga ⁶ and CF Allaart ¹, ¹Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands, Leiden, Netherlands, ²Haga Hospital, 's-Gravenhage, Netherlands, ³Reumazorg Zuid West Nederland, Rozendaal, Netherlands, ⁴Amsterdam UMC, Amsterdam, Netherlands, ⁵Westfriesgasthuis, Hoorn, Netherlands, ⁶Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: Rheumatoid arthritis is known to be associated with increased mortality over the years when compared to the general population. In the BeSt study, 508…
Abstract Number: 1352 • 2019 ACR/ARP Annual Meeting
Effects of Upadacitinib on Patient-Reported Outcomes After 24 Weeks in Patients with Active Rheumatoid Arthritis and an Inadequate Response to Conventional Synthetic or Biologic Disease-Modifying Anti-Rheumatic Drugs: Results from SELECT-NEXT and SELECT-BEYOND Phase 3 Studies
Martin Bergman¹, Namita Tundia ², Heidi Camp ², Sebastian Meerwein ³, Casey Schlacher ², Debbie Goldschmidt ⁴, Yan Song ⁵ and Vibeke Strand ⁶, ¹Drexel University College of Medicine, Stockholm, Sweden, ²AbbVie Inc., North Chicago, IL, ³AbbVie GmbH Co. KG, Ludwigshafen, Germany, Wiesbaden, Germany, ⁴Analysis Group, Inc., New York, NY, ⁵Analysis Group, Inc., Boston, MA, ⁶Division of Immunology/Rheumatology, Stanford University, Stanford, CA
Background/Purpose: Treatment with upadacitinib (UPA), a selective Janus kinase-1 (JAK-1) inhibitor, resulted in significant and clinically meaningful improvements in patient-reported outcomes (PROs) at Week 12…
Abstract Number: 1353 • 2019 ACR/ARP Annual Meeting
Impact of Smartphone Application Based Management in Rheumatoid Arthritis: SMART- RA Study
Ashit Syngle¹, Nidhi Garg ², Raveena Bhatia ³, Surbhi Rattan ⁴ and Kanchan Chauhan ⁴, ¹Healing Touch City Clinic/Fortis Multispeciality hospital, Chandigarh, Chandigarh, India, ²Chitkara College of Pharmacy, Chitkara University, Rajpura, India, ³Healing Touch City Clinic, Chandigarh, Chandigarh, India, ⁴Healing Touch City Clinic, Chandigarh, India
Background/Purpose: Rheumatoid arthritis (RA) treatment has improved considerably over the years. However, patient compliance remains critical to treatment outcomes. Patient compliance still poses challenges in…
Abstract Number: 1354 • 2019 ACR/ARP Annual Meeting
A Comparison of Convergent Validity and Sensitivity to Change of the Conventional Scoring Method to Alternative Scoring Methods of the Health Assessment Questionnaire in Rheumatoid Arthritis
Lai Ling Winchow ¹, Nimmisha Govind ¹, Eustasius Musenge ², Arvind Chopra ³, Thomas Huizinga ⁴ and Mohammed Tikly¹, ¹Chris hani baragwanath academic hospital, University of the Witwatersrand, Johannesburg, South Africa, ²School of Public Health, University of the Witwatersrand, Johannesburg, South Africa, ³Center for rheumatic diseases, Pune, India, ⁴Leiden University Medical Center, Leiden, Netherlands
Background/Purpose: The HAQ disability index (HAQ-DI) is the most widely used disease-specific measure of physical disability in RA. This study explores the sensitivity to change…
Abstract Number: 1355 • 2019 ACR/ARP Annual Meeting
A Comparison of Clinical Improvement Following a Major Therapeutic Change Utilizing Updated Treatment Thresholds Defined by Three Different Disease Activity Measures
Grant Cannon¹, Wei Chen ¹, JIncheng Shen ², Neil Accortt ³, David Collier ⁴ and Brian Sauer ¹, ¹Salt Lake City VA Medical Center and Univeristy of Utah, Salt Lake City, UT, ²Univeristy of Utah, Salt Lake City, UT, ³Amgen, Thousand Oaks, CA, ⁴Amgen Inc., Thousand Oaks, CA
Background/Purpose: Despite ACR recommendations to initiate a major therapeutic change (MTC) in rheumatoid arthritis (RA) patients with moderate/severe disease activity, our recent work has shown…
Abstract Number: 1356 • 2019 ACR/ARP Annual Meeting
DAS28-CRP Cut-offs for High Disease Activity Assessment Is Lower Than DAS28-ESR in Rheumatoid Arthritis
Jacob Greenmyer¹, John Stacy ¹, James Beal ² and Erdal Diri ¹, ¹University of North Dakota, School of Medicine Health Sciences, Minot, ND, ²University of North Dakota, School of Medicine Health Sciences, Grandforks, ND
Background/Purpose: Rheumatoid arthritis (RA) disease activity and treatment response are usually assessed by using Disease Activity Score 28-joint count (DAS28), which can be calculated using…
Abstract Number: 1357 • 2019 ACR/ARP Annual Meeting
Leptin-adjustment of the Multi-biomarker Disease Activity (MBDA) Score Reduces the Influence of Adiposity
Joshua Baker¹, Jeffrey Curtis ², David Chernoff ³ and Michael George ⁴, ¹University of Pennsylvania, Philadelphia, PA, ²University of Alabama at Birmingham, Birmingham, AL, ³Myriad Genetics, Inc, Salt Lake City, UT, ⁴University of Pennsylvania, Philadelphia
Background/Purpose: Obesity and excess adiposity influence inflammatory markers and bias assessments of disease activity, most notably among women. A leptin-adjusted multi-biomarker disease activity (MBDA-LA) score…
Abstract Number: 1358 • 2019 ACR/ARP Annual Meeting
Defining Minimal Clinically Important Changes for the Patient Activity Scale-II
Joshua Baker¹, Patricia Katz ² and Kaleb Michaud ³, ¹University of Pennsylvania, Philadelphia, PA, ²University of California, San Francisco, san francisco, CA, ³University of Nebraska Medical Center, Omaha, NE
Background/Purpose: The Patient Activity Scale (PAS)-II is an accepted disease activity measure used in the care of patients with rheumatoid arthritis (RA). A clinically important…

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