Abstracts Archive - Page 845 of 2425 - ACR Meeting Abstracts

Abstract Number: 1299 • 2019 ACR/ARP Annual Meeting
Clinical Significance of Magnetic Resonance Imaging Derived Femur Bone Shape in Young Adults
Minh-Tu Vo ¹, Michael Bowes ², Alison Venn ³, Flavia Cicuttini ⁴, Lyn March ⁵, Terence Dwyer ⁶, Tao Meng ³, Marita Cross ⁵, Graeme Jones ⁷, Saliu Balogun ¹, Changhai Ding ⁷ and Benny Antony⁷, ¹University of Tasmania, Hobart, Tasmania, Australia, ²Imorphics, Manchester, England, United Kingdom, ³University of Tasmania, Hobart, Australia, ⁴Monash University, Melbourne, Australia, ⁵University of Sydney, Sydney, Australia, ⁶University of Oxford, Oxford, United Kingdom, ⁷Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia
Background/Purpose: The femur bone shape derived from magnetic resonance imaging (MRI) of the knee is associated with the incidence and progression of knee osteoarthritis (OA),…
Abstract Number: 1300 • 2019 ACR/ARP Annual Meeting
Predictor of Placebo Response in Hand Osteoarthritis: A Post Hoc Analysis of Two Randomized Controlled Trials
Se Han Ahn¹, Jin Kyun Park ², Kichul Shin ³, Yun Jong Lee ⁴, Yeong-Wook Song ⁵, Yunhee Choi ⁶ and Eun Bong Lee ⁷, ¹Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Gwacheon-si, Kyonggi-do, Republic of Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, seoul, Republic of Korea, ³Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea., seoul, Republic of Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea, ⁵Seoul National University Hospital, Seoul, Republic of Korea, ⁶Division of Medical Statistics, Medical Research Collaborating Center, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea., seoul, Republic of Korea, ⁷Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, seoul
Background/Purpose: Osteoarthritis (OA) in hands is common in middle-aged and elderly population. The mainstay treatment of hand OA is to control the symptoms with a combination of non-pharmacological and…
Abstract Number: 1301 • 2019 ACR/ARP Annual Meeting
Rates of Incident Radiographic Knee Osteoarthritis and Knee Replacement by Sex and Race, Across Three Large, Diverse Cohorts
C. Kent Kwoh¹, Amanda Nelson ², Yvonne Golightly ³, Erin Ashbeck ⁴, Liubov Arbeeva ⁵, Na Wang ⁶, Jeffrey Duryea ⁷ and Tuhina Neogi ⁶, ¹University of Arizona, Tucson, AZ, ²University of North Carolina at Chapel Hill, Chapel Hill, NC, ³University of North Carolina at Chapel Hill Department of Epidemiology and Thurston Arthritis Research Center, Chapel Hill, NC, ⁴The University of Arizona Arthritis Center, University of Arizona, Tuccson, AZ, Tucson, AL, ⁵University of North Carolina at Chapel Hill Thurston Arthritis Research Center, Chapel Hill, NC, ⁶Boston University School of Medicine, Boston, MA, ⁷Harvard Medical School Department of Radiology Brigham and Women's Hospital, Boston, MA
Background/Purpose: Previous studies have suggested differences in the development of incident radiographic knee osteoarthritis (RKOA) and the receipt of knee replacement (KR) by sex and…
Abstract Number: 1302 • 2019 ACR/ARP Annual Meeting
Subcutaneous Tanezumab vs NSAID for the Treatment of Osteoarthritis: Efficacy and General Safety Results from a Randomized, Double-Blind, Active-Controlled, 80-Week, Phase-3 Study
Marc C. Hochberg¹, John Carrino ², Thomas Schnitzer ³, Ali Guermazi ⁴, Eric Vignon ⁵, David Walsh ⁶, Alexander White ⁷, Satoru Nakajo ⁸, Robert Fountaine ⁹, Anne Hickman ⁹, Glenn Pixton ¹⁰, Lars Viktrup ¹¹, Mark T. Brown ⁹, Christine R. West ⁹ and Kenneth M. Verburg ⁹, ¹University of Maryland School of Medicine, Baltimore, MD, ²Hospital for Special Surgery, New York, NY, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Boston Medical Center, Boston, ⁵Université Claude Bernard Lyon 1, Lyon, France, ⁶Sherwood Forest Hospitals NHS Foundation Trust, Nottingham, United Kingdom, ⁷Progressive Medical Research, Port Orange, FL, ⁸Nakajo Orthopaedic Clinic, Miyagi, Japan, ⁹Pfizer Inc, Groton, CT, ¹⁰Pfizer Inc, Morrisville, NC, ¹¹Eli Lilly and Company, Indianapolis, IN
Background/Purpose: Tanezumab is a monoclonal antibody that inhibits nerve growth factor and is under investigation for chronic pain treatment. Tanezumab administered intravenously was effective and…
Abstract Number: 1303 • 2019 ACR/ARP Annual Meeting
Intra-Articular TPX-100 Significantly Delays Pathological Bone Shape Change at 6 and 12 Months in Moderate to Severe Tibiofemoral OA
Dawn McGuire¹, Michael Bowes ², Alan Brett ², Neil Segal ³, Meghan Miller ⁴, David Rosen ⁴ and Yoshinari Kumagai ⁴, ¹OrthoTrophix, Orinda, CA, ²Imorphics, Manchester, England, United Kingdom, ³University of Kansas Medical Center, Kansas City, KS, ⁴OrthoTrophix, Oakland, CA
Background/Purpose: Pathological bone shape changes in the femur precede cartilage changes in knee OA and predict disease onset and progression to joint failure (Neogi 2013;…
Abstract Number: 1304 • 2019 ACR/ARP Annual Meeting
Efficacy and Safety of Hylan G-F 20 versus Intra-Articular Corticosteroids in Patients with Knee Osteoarthritis: A Systematic Literature Review, Meta-Analysis, and Network Meta-analysis
Xavier Chevalier ¹, Brendan Sheehan ², Craig Whittington ³, Chunyi Ho ⁴, Wilson Ngai⁵ and Gustavo Campos ⁶, ¹Department of Rheumatology, Hospital henri Mondor, Paris University XII, Creteil, France, ²Department of Medicine, Dalhousie University, Saint John, NB, Canada, ³Doctor Evidence, Santa Monica, CA, ⁴Doctor Evidence, Santa Monica, ⁵Sanofi, U.S. Medical Affairs, Bridgewater, ⁶Universidade Estadual de Campinas, Campinas, Brazil
Background/Purpose: Knee OA is a progressive joint disease which affects more than 250 million people worldwide. Meta-analysis (MA) has demonstrated that IA CS were more…
Abstract Number: 1305 • 2019 ACR/ARP Annual Meeting
Quality Improvement in Diagnostic and Therapeutic Arthrocentesis in the Flexed Knee Using Pneumatic Compression of the Suprapatellar Bursa
Fatemeh Jafari Farshami¹, Jaren Trost ², Wilmer Sibbitt ², Maheswari Muruganandam ², Philip Band ³, Monthida Fangtham ¹, Nicole Emil ¹, William Hayward ⁴, Luke Haseler ⁵ and Arthur Bankhurst ¹, ¹Department of Internal Medicine, Division of Rheumatology and School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, ²Department of Internal Medicine, Division of Rheumatology and School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, ³Department of Orthopaedic Surgery, Biochemistry & Molecular Pharmacology NYU School of Medicine, New York City, New York City, NY, ⁴The Department of Exercise and Sport Sciences, New Mexico Highlands University, Las Vegas, NM, ⁵Faculty of Health Sciences, School of Physiotherapy and Exercise Science, Curtin University, Perth, Australia
Background/Purpose: Arthrocentesis is an essential procedure in diagnosing inflammatory and septic arthritis and is a basic procedure for intra-articular therapy, including therapeutic arthrocentesis and intra-articular…
Abstract Number: 1306 • 2019 ACR/ARP Annual Meeting
Risk Factors for Pain After Total Joint Replacement in Osteoarthritis: Different Pain Measures, Distinct Predictors?
Joana Barroso¹, Kenta Wakaizumi ², Thomas Schnitzer ¹, Vasco Galhardo ³ and Apkar Apkarian ¹, ¹Northwestern University Feinberg School of Medicine, Chicago, IL, ²Northwestern University, Chicago, IL, ³Porto University, Porto, Portugal
Background/Purpose: Prognostic factors for pain persistence after total joint replacement (TJR) in osteoarthritis (OA) have been repeatedly proposed. These factors are commonly considered to act…
Abstract Number: 1307 • 2019 ACR/ARP Annual Meeting
A Prospective, Multi-center, Randomized, Clinical Trial Comparing the Effectiveness and Safety of Cooled Radiofrequency Ablation versus a Single Injection of Hyaluronic Acid in the Management of OA Knee Pain
Antonia Chen¹, Fred Khalouf ², Michael DePalma ³, Keith Zora ⁴, Lynn Kohan ⁵, Maged Guirguis ⁶, Douglas Beall ⁷, Eric Loudermilk ⁸, Matthew Pingree ⁹, Ignacio Badiola ¹⁰ and Jeffrey Lyman ¹¹, ¹Brigham and Women’s Hospital, Boston, MA, ²University Orthopedics Center, Altoona, PA, ³Virginia iSpine Physicians, Richmond, VA, ⁴University Orthopedics Center, State College, PA, ⁵University of Virginia School of Medicine, Charlottesville, VA, ⁶Ochsner Clinic Foundation, New Orleans, LA, ⁷Clinical Investigations, Edmond, OK, ⁸PCPMG Clinical Research Unit LLC, Anderson, SC, ⁹Mayo Clinic, Rochester, MN, ¹⁰University of Pennsylvania, Philadelphia, PA, ¹¹Institute for Orthopedic Research and Innovation, Coeur d'Alene, IN
Background/Purpose: This prospective, randomized, multi-center study was conducted to compare pain relief, functional improvement, and the safety of cooled radiofrequency ablation (CRFA) to hyaluronic acid…
Abstract Number: 1308 • 2019 ACR/ARP Annual Meeting
Subject Enrichment Criteria for Phase 3 Studies of Lorecivivint (SM04690), a Potential Disease-Modifying Knee Osteoarthritis Drug: A Post Hoc Study on the Effects of Baseline Comorbid Pain and Joint Space Width on Patient-Reported Outcomes
Sarah Kennedy ¹, Chris Swearingen ¹, Jeyanesh Tambiah¹, Daniel Clauw ² and Philip G Conaghan ³, ¹Samumed, LLC, San Diego, ²Division of Rheumatology, Department of Internal Medicine and Division of Anesthesia, Michigan Medicine, Ann Arbor, MI, ³Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom
Background/Purpose: Patient-reported outcomes (PROs) in knee osteoarthritis (OA) trials have been difficult to accurately measure due to heterogenous sources of pain (e.g., from comorbid conditions…
Abstract Number: 1309 • 2019 ACR/ARP Annual Meeting
Concordance of Baseline Pain Measures (Across Two Reporting Instruments) Influences Treatment Effect: Post Hoc Analysis of a Phase 3 Randomized Controlled Trial of Triamcinolone Acetonide Extended-Release in Patients with Knee Osteoarthritis
Philip G Conaghan¹, Edgar Ross ², Alan Kivitz ³, Dennis Turk ⁴, Andrew Spitzer ⁵, Deryk Jones ⁶, Ryan Lanier ⁷, Amy Cinar ⁸, Joelle Lufkin ⁸ and Scott Kelley ⁸, ¹Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds & NIHR Leeds Biomedical Research Centre, Leeds, United Kingdom, ²Brigham and Women's Hospital, Boston, MA, ³Altoona Center for Clinical Research, Duncansville, PA, ⁴University of Washington, Seattle, ⁵Cedars-Sinai Medical Center, Los Angeles, ⁶Ochsner Sports Medicine Institute, Harahan, GA, ⁷Analgesic Solutions, Natick, ⁸Flexion Therapeutics, Burlington
Background/Purpose: In a Phase 3 randomized controlled study, differing efficacy results were observed when triamcinolone acetonide extended-release (TA-ER) was compared to conventional TA crystalline suspension…
Abstract Number: 1310 • 2019 ACR/ARP Annual Meeting
Osteoarthritis: What’s in a Name?
Warren A Katz¹, ¹Penn Medicine; University of Pennsylvania School of Medicine, Upper Gwynedd, PA
Background/Purpose: The nomenclature of "osteoarthritis" (OA) has been a source of confusion and likely misdiagnosis for centuries. Prior to 1759, most patients with joint diseases…
Abstract Number: 1311 • 2019 ACR/ARP Annual Meeting
Prevalence of Symptomatic Axial Osteoarthritis and Poliarticular Phenotypes in Spain: EPISER 2016 Study
Maite Silva-Díaz¹, Francisco J. Blanco ², Victor Quevedo Vila ³, Daniel Seoane-Mato ⁴, Sagrario Bustabad-Reyes ⁵ and on behalf of the Working Group Proyecto EPISER2016 ⁶, ¹Servicio de Reumatología. Complexo Hospitalario Universitario A Coruña (CHUAC)-INIBIC, A Coruña, Spain, ²Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ³Unidad de Reumatología. Hospital Comarcal Monforte de Lemos., Lugo, Spain, ⁴Unidad de Investigación. Sociedad Española de Reumatología., Madrid, Spain, ⁵eumatología. Hospital Universitario de Canarias., La Laguna, Santa Cruz de Tenerife, Spain, ⁶Grupo de trabajo del proyecto EPISER2016, Madrid, Spain
Background/Purpose: Osteoarthritis (OA) is a heterogeneous group of diseases with common clinical and radiographic manifestations involving the peripheral and axial skeletal. OA is the most…
Abstract Number: 1312 • 2019 ACR/ARP Annual Meeting
Knee Morphology Associates with Tibio-Femoral and Patello-Femoral Osteoarthritis: A Case-Control Study
Anand Ramachandran Nair¹, Weiya Zhang ², Michael Doherty ² and Abhishek Abhishek ³, ¹Academic Rheumatology, School of Medicine, University of Nottingham, Nottingham, UK, Nottingham, England, United Kingdom, ²Academic Rheumatology, Division of Rheumatology,School of Medicine, University of Nottingham, Nottingham, UKArthritis Research UK Pain Centre, Nottingham, UKNational Institute for Health Research, Nottingham Biomedical Research Centre, Nottingham, UK, Nottingham, England, United Kingdom, ³Academic Rheumatology, School of Medicine, University of Nottingham,Nottingham,UK National Institute for Health Research, Nottingham Biomedical Research Centre, Nottingham,UK, Nottingham, England, United Kingdom
Background/Purpose: Although several morphological features of the hip joint predispose to hip osteoarthritis (OA), only a few are known to associate with knee OA. The…
Abstract Number: 1313 • 2019 ACR/ARP Annual Meeting
Readmissions After Staged vs Simultaneous Bilateral Total Knee Replacements (TKR)
Linda Russell¹, Bella Mehta ², Emily Lai ³, Jackie Finik ⁴, Haley Tornberg ⁵, Huong Do ¹, Anne Bass ⁶, Peter Sculco ¹, Thomas Sculco ⁵, Lazaros Poultsides ⁷, Stavros Memtsoudis ⁵ and Susan Goodman ⁶, ¹Hospital for Special Surgery, New York, ²Hospital for Special Surgery/Weill Cornell Medicine, New York, ³Hospital for Special Surgery Healthcare Research Institute, New York, NY, ⁴Hospital for Special Surgery, New York, NY, New York, NY, ⁵Hospital for Special Surgery, New York, NY, ⁶Hospital for Special Surgery/Weill Cornell Medicine, New York, NY, ⁷NYU Langone Health, New York, NY
Background/Purpose: The safety of bilateral total knee replacements (BTKR) under the same anesthesia as compared to staging within 12 months is debated. The advantage is…

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