Abstracts Archive - Page 823 of 2425 - ACR Meeting Abstracts

Abstract Number: 969 • 2019 ACR/ARP Annual Meeting
ß-adrenergic Receptor Activation: A Way to Enhance CD4 T Cell Suppression by Improving Regulatory B Cell Function
Nadine Honke¹, Birgit Opgenoorth ¹, Matthias Schneider ² and Georg Pongratz ³, ¹Department of Rheumatology, Hiller Research Center of Rheumatology, Heinrich-Heine-University Duesseldorf, Duesseldorf, Germany, ²Policlinic for Rheumatology & Hiller Research Centre for Rheumatology, Heinrich-Heine-University Duesseldorf, Düsseldorf, Germany, ³Policlinic and Hiller Research Unit of Rheumatology, UKD, Heinrich Heine University, Düsseldorf, Germany
Background/Purpose: Rheumatoid arthritis (RA) is an autoimmune disease in which next to other cell populations CD4 T cells play a crucial role. It has been…
Abstract Number: 970 • 2019 ACR/ARP Annual Meeting
New-onset ANCA-associated Vasculitis Is Associated with Significant Phenotypic B Cell Dysfunction
Emilie Chan¹, Susan Hartzell ², Lisa Anderson ², Chiara Cantarelli ², Chiara Guglielmo ², Ioannis Tassiulas ³, Sofia Andrighetto ², Andrea Angeletti ⁴, Joaquin Manrique Escola ⁵ and Paolo Cravedi ², ¹Mount Sinai Hospital, New York, NY, ²Mount Sinai Hospital, New York, ³Icahn School of Medicine, New York, ⁴Sant'Orsola-Malpighi Hospital, Bologna, Italy, ⁵Complejo Hospital de Navarra, Pamplona, Spain
Background/Purpose: ANCA-associated vasculitis (AAV) is characterized by the production of auto-antibodies and can be treated with rituximab, a B cell-depleting agent. Despite this, limited data…
Abstract Number: 971 • 2019 ACR/ARP Annual Meeting
B Cell ROCK1 Promotes Germinal Center Responses and Is Required for Optimal Humoral Immunity
Edd Ricker¹, Danny Flores-Castro ², Sanjay Gupta ³, Andrew Cheng ³, Yurii Chinenov ³, Tania Pannellini ², Young-Bum Kim ⁴ and Alessandra Pernis ⁵, ¹Hospital for Special Surgery, New York, NY, ²Autoimmunity and Inflammation Program, Hospital for Special Surgery, New York, ³Hospital for Special Surgery, New York, ⁴Beth Israel Deaconess Medical Center, Boston, MA, ⁵1.Autoimmunity and Inflammation Program, Hospital for Special Surgery. 2.David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery. 3.Department of Medicine, Weill Cornell Medical College, Cornell University, New York
Background/Purpose: Rho GTPases, such as RhoA, have emerged as important regulators of lymphocyte biology owing to their ability to be rapidly activated downstream of a…
Abstract Number: 972 • 2019 ACR/ARP Annual Meeting
Disease Severity Is Linked to an Increase in Autoantibody Diversity in IgG4-related Disease
Hang Liu¹, Cory Perugino ², Musie Ghebremichael ¹, Zachary Wallace ², Sydney Montesi ³, John Stone ⁴ and Shiv Pillai ⁵, ¹Ragon Institute of MGH, MTI and Harvard, Cambridge, ²Massachusetts General Hospital, Boston, ³Massachusetts General Hospital, Boston, MA, ⁴Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, ⁵Ragon Institude of MGH, MIT and Harvard, Charlestown, MA
Background/Purpose: The oligoclonal expansion in IgG4-related disease (IgG4-RD) of both plasmablasts and tissue-infiltrating CD4+ cytotoxic T lymphocytes, the identification of specific auto-antigens as B cell…
Abstract Number: 973 • 2019 ACR/ARP Annual Meeting
Serum IgG4 Concentrations Differ According to Race and Sex
Tyler Harkness¹, Xiaoqing Fu ¹, Yuqing Zhang ², Hyon K. Choi ², John Stone ³, Kimberly Blumenthal ¹ and Zachary Wallace ¹, ¹Massachusetts General Hospital, Boston, ²Massachusetts General Hospital, Boston, MA, ³Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA
Background/Purpose: Elevated IgG4 concentrations are used to support a diagnosis of IgG4-related disease (IgG4-RD). IgG4 concentrations are reported to be higher in male IgG4-RD patients…
Abstract Number: 974 • 2019 ACR/ARP Annual Meeting
Bruton’s Tyrosine Kinase (BTK) Inhibitors and Autoimmune Disease: Making Sense of BTK Inhibitor Specificity Profiles and Recent Clinical Trial Successes and Failures
Garth Ringheim¹, Matthew Wampole ¹ and Kinsi Oberoi ¹, ¹Clarivate Analytics, Philadelphia, PA
Background/Purpose: Clinical development of BTK/Tec family kinase inhibitors for treating autoimmune diseases has lagged that of their successful application in oncology. The lack of selective…
Abstract Number: 975 • 2019 ACR/ARP Annual Meeting
Functional Impairment of Mitf and the MiT Transcription Factor Family Dysregulates B Cell Activation and Function
Abhimanyu Amarnani¹, Ramile Dilshat ², Nikita Malakhov ³, Brian Ghezelaiagh ⁴, Chongmin Huan ¹, Erna Magnusdottir ², Eirikur Steingrimsson ² and Christopher Roman ¹, ¹SUNY Downstate Medical Center, Brooklyn, ²University of Iceland Biomedical Center, Reykjavik, Iceland, ³SUNY Downstate Medical Center, New York Presbyterian-Weill Cornell Medical Center, Brooklyn, ⁴SUNY Downstate Medical Center, Stony Brook University, Brooklyn
Background/Purpose: Autoreactive B cells are central in the development of many autoimmune diseases, such as systemic lupus erythematosus (SLE), and are normally eliminated or inactivated…
Abstract Number: 976 • 2019 ACR/ARP Annual Meeting
Identification of Novel Genes Associated with Dysregulation of B Cells in Patients with Primary Sjögren’s Syndrome
Jun Inamo¹, Katsuya Suzuki ², Masaru Takeshita ², Yoshiaki Kassai ³, Maiko Takigchi ⁴, Rina Kurisu ⁴, Yuumi Okuzono ⁴, Shinya Tasaki ⁵ and Tsutomu Takeuchi ⁶, ¹Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Tokyo, Japan, ²Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan, ³Immunology Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Shinjuku-ku, Tokyo, Japan, ⁴Immunology Unit, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Shinjuku-ku, Japan, ⁵Integrated Technology Research Laboratories, Pharmaceutical Research Division, Takeda Pharmaceutical Company Limited, Shinjuku-ku, Japan, ⁶Keio University School of Medicine, Tokyo, Japan
Background/Purpose: Dysregulation of B cells play a critical role in the pathogenesis of primary Sjögren’s syndrome (pSS). Long non-coding RNAs (lncRNAs), which have become the…
Abstract Number: 977 • 2019 ACR/ARP Annual Meeting
Conditional Deletion of MKL1 Inhibits Osteoclast Formation and Bone Erosions in Collagen Induced Arthritis Mice
Wenfeng Tan¹, Aishu Luo ¹, Yong Xu ², Shiyu Lin ³, Miaojia Zhang ⁴ and Fang Wang ³, ¹the First Affiliated Hospital of Nanjing Medical University, Nanjing, China (People's Republic), ²Nanjing Medical University, NANJING, China (People's Republic), ³the First Affiliated Hospital of Nanjing Medical University, Nanjing, ⁴the First Affiliated Hospital of Nanjing Medical University, Najing, China (People's Republic)
Background/Purpose: Excessively osteoclasts (OCs) activation play an essential role in bone erosions in rheumatoid arthritis (RA). Thus, controlling OCs would be an effective strategy to…
Abstract Number: 978 • 2019 ACR/ARP Annual Meeting
Light Mediated Therapeutics in Arthritis
Victoria Wickenheisser¹, Emily Rabjohns ², Emilia Zywot ³, Natalia Orlova ³, Christina Marvin ³, Song Ding ⁴, David Lawrence ⁴ and Teresa Tarrant ⁵, ¹Duke University School of Medicine, Durham, ²Department of Rheumatology, Duke University Hospital, Durham, NC, ³UNC Department of Chemistry, Chapel Hill, NC, ⁴Division of Medicinal Chemistry and Chemical Biology The UNC Eshelman School of Pharmacy at UNC, Chapel Hill, NC, ⁵Department of Medicine Division of Rheumatology and Immunology, Duke University Hospital, Durham, NC
Background/Purpose: Rheumatoid arthritis (RA) therapies are constrained by the failure to deliver sufficient quantities of drug to the inflamed site, systemic side effects, and the…
Abstract Number: 979 • 2019 ACR/ARP Annual Meeting
Platelet Derived Growth Factor Receptor Alpha (PDGFRα) Blockade Inhibits Arthritis in Mice
Bhanupriya Madarampalli¹, Paul Panipinto ¹, Erica Chow ¹, Kendahl Sugai ¹, Fanqi Shi ¹ and Erika Noss ¹, ¹University of Washington, Seattle, WA
Background/Purpose: The interplay between infiltrating immune cells and activated joint stromal cells drives inflammation, cartilage destruction, and bone erosion in rheumatoid arthritis (RA). Among joint…
Abstract Number: 980 • 2019 ACR/ARP Annual Meeting
Sema3B Expression Is Reduced in Rheumatoid Arthritis Patients and Has a Protective Role in a Murine Model of Arthritis
Ana Igea ¹, Tiago Carvalheiro ², Beatriz Malvar Fernandez ², Angela Rodriguez-Trillo ³, Trudy McGarry ⁴, Carmen Conde ⁵, Douglas Veale ⁶, Ursula Fearon ⁷, Africa Gonzalez ¹, Timothy R.D. Radstake ⁸, Kris A. Reedquist ² and Samuel Garcia⁹, ¹Department of Immunology, Centro de Investigaciones Biomédicas (CINBIO), Centro de Investigación Singular de Galicia, Instituto de Investigación Sanitaria Galicia Sur, Universidad de Vigo, Vigo, Spain, ²Department of Rheumatology and Clinical Immunology and Laboratory of Translational Immunology, University Medical Center Utrecht, University of Utrecht, Utrecht, Netherlands, ³laboratorio de Reumatología Experimental y Observacional, Instituto de Investigación Sanitaria de Santiago (IDIS)-Hospital Clinico (CHUS), Santiago de Compostela, Spain, ⁴Department of Molecular Rheumatology, Trinity Biomedical Science Institute, Trinity College Dublin, Dublin, Ireland, ⁵Laboratorio de Reumatología Experimental y Observacional, y Servicio de Reumatología, Instituto de Investigacion Sanitaria de Santiago (IDIS), Hospital Clínico Universitario de Santiago de Compostela (CHUS), SERGAS, Santiago de Compostela, Spain, ⁶EULAR Centre For Arthritis And Rheumatic Diseases and The Conway Institute, Dublin, Ireland, ⁷Molecular Rheumatology, Trinity Biomedical Sciences Institute, TCD, Dublin, Ireland, ⁸Department of Rheumatology/Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands., Utrecht, Netherlands, ⁹Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, University of Utrecht, Utrecht, Spain
Background/Purpose: The semaphorin family is a large group of proteins initially described in axon guidance. However, semaphorins also play a role in other processes involved…
Abstract Number: 981 • 2019 ACR/ARP Annual Meeting
Adipocytokines and Obesity in the Context of Rheumatoid and Osteoarthritis Mouse Models
Hani Manfred Sauermilch¹, Marie-Lisa Hülser ¹, Carina Schreiyäck ¹, Yubin Luo ², Aline Bozec ², Georg Schett ³, Ulf Müller-Ladner ⁴ and Elena Neumann ⁵, ¹Dept. of Rheumatology and Clinical Immunology, Campus Kerckhoff, Justus-Liebig-University Giessen, Germany, Giessen, Germany, ²Department Clinic of Medicine 3 - Immunology and Rheumatology, University of Erlangen-Nürnberg, Erlangen, Germany, Erlangen, Germany, ³Department of Internal Medicine 3, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany, ⁴Justus Liebig University Gießen, Department of Rheumatology and Clinical Immunology, Campus Kerckhoff, Bad Nauheim, Germany, Gießen, Hessen, Germany, ⁵Justus Liebig University Gießen, Department of Rheumatology and Clinical Immunology, Campus Kerckhoff, Bad Nauheim, Germany, Giessen, Hessen, Germany
Background/Purpose: Adipocytokines are bioactive factors mainly produced by adipose tissue and exert many important effects on energy homeostasis as well as immune responses. Osteoarthritis (OA)…
Abstract Number: 982 • 2019 ACR/ARP Annual Meeting
A Novel Role for Nod2 in Controlling Autoantibody Production and Arthritis in SKG Mice
Ruth Napier¹, Emily Vance ¹, James O'Dell ², Jill Poole ³, Bryant England ⁴, Michael Duryee ³, Ted Mikuls ², Holly Rosenzweig ⁵ and Geoffrey Thiele ², ¹Oregon Health & Science University and Portland VA Hospital, Portland, OR, ²VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, NE, ³University of Nebraska Medical Center, Omaha, NE, ⁴VA Nebraska-Western IA Health Care System & University of Nebraska Medical Center, Omaha, ⁵Oregon Health & Science University and Portland VA Hospital, Oregon
Background/Purpose: Rheumatoid arthritis (RA) is a systemic inflammatory disease that manifests in a chronic and debilitating polyarthritis. Although the etiology of RA is unknown pathogenic…
Abstract Number: 983 • 2019 ACR/ARP Annual Meeting
Fecal Transfer from Mice on High or Low Magnesium Diets Confers Arthritis Protection
Teresina Laragione¹, Carolyn Harris ¹ and Percio Gulko ¹, ¹Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: Magnesium (Mg) plays a key role in the immune response. We have previously demonstrated that alterations in the Mg balance by increasing or decreasing…

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