ACR Meeting Abstracts

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  • Abstract Number: 1925 • ACR Convergence 2020

    Ultrasound Follow-up Examination of Intima-Media-Thickness of the Temporal and Axillary Artery over Six Months in Patients with Newly Diagnosed Giant Cell Arteritis

    Lara Burg1, Peter Brossart2, Charlotte Behning3 and Valentin Schaefer4, 1Clinic for Internal Medicine III, Department of Oncology, Haematology, Rheumatology and Clinical Immunology, University Hospital Bonn, Germany, Bonn, Nordrhein-Westfalen, Germany, 2Clinic for Internal Medicine III, Department of Oncology, Hematology and Rheumatology, University Hospital Bonn, Germany, Bonn, Nordrhein-Westfalen, Germany, 3Institute for Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Germany, Bonn, Nordrhein-Westfalen, Germany, 4Clinic of Internal Medicine III, Department of Oncology, Hematology and Rheumatology, University Hospital Bonn, Germany, Bonn, Nordrhein-Westfalen, Germany

    Background/Purpose: Ultrasound (US) plays an important role in diagnosis of giant cell arteritis (GCA). To date it is unknown how intima-media-thickness (IMT) of affected arteries…
  • Abstract Number: 1926 • ACR Convergence 2020

    Efficacy of Adjunctive Methotrexate in Patients with Giant Cell Arteritis Treated with Tocilizumab Plus Prednisone Tapering: Subanalysis of a Phase 3 Trial

    John H. Stone1, Jian Han2 and Shalini V. Mohan2, 1Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA, 2Genentech, South San Francisco, CA

    Background/Purpose: There is conflicting evidence for methotrexate (MTX) efficacy in giant cell arteritis (GCA).1,2 Subanalysis of data from the 52-week, double-blind, randomized controlled GiACTA trial…
  • Abstract Number: 1927 • ACR Convergence 2020

    Ultrasonographic Halo Score as a Marker for Diagnosis and Monitoring of Disease Activity in GCA

    Alwin Sebastian1, Abdul Kayani1, Sue Innes2, Jo Jackson2, Kornelis S. M. van der Geest3 and Bhaskar Dasgupta1, 1Rheumatology, Mid and South Essex University Hospital NHS Foundation Trust, Southend University Hospital, United Kingdom, Westcliff on sea, England, United Kingdom, 2School of Sport, Rehabilitation and Exercise science, Colchester Campus, University of Essex, United Kingdom, Colchester, England, United Kingdom, 3Rheumatology and Clinical Immunology, University Medical Center Groningen, Netherlands, Groningen, Netherlands

    Background/Purpose: EULAR recommendations highlights ultrasound (US) as the first line imaging investigation for giant cell arteritis (GCA). Traditionally, the halo sign and compression sign have…
  • Abstract Number: 1928 • ACR Convergence 2020

    Quantitative Ultrasound of Temporal, Axillary and Subclavian Arteries to Monitor Tocilizumab Treatment in Patients with Newly Diagnosed Giant Cell Arteritis: A 24 Week Analysis

    Luca Seitz1, Lisa Christ1, Godehard Scholz1, Fabian Lötscher1, Jennifer Amsler1, Florian Kollert1, Stephan Reichenbach1 and Peter Villiger1, 1Department of Rheumatology, Immunology and Allergology, University of Bern, Inselspital, Switzerland, Bern, Switzerland

    Background/Purpose: Tocilizumab (TCZ) suppresses CRP. Thus, CRP cannot be used as a marker for disease activity in GCA patients treated with TCZ and monitoring of…
  • Abstract Number: 1929 • ACR Convergence 2020

    Visual Ischemia During Relapse and Follow-up of Giant Cell Arteritis: A Systematic Review

    Kubra Bugdayli1, Patompong Ungprasert2, Kenneth Warrington3 and Matthew J. Koster3, 1Case Western Reserve University MetroHealth Medical Center, Cleveland, 2Cleveland Clinic Foundation, Cleveland, 3Mayo Clinic, Rochester, MN

    Background/Purpose: The purpose of this study was to characterize the frequency of visual ischemia (VI) as a manifestation of relapse or during follow-up in patients…
  • Abstract Number: 1930 • ACR Convergence 2020

    Thirty-Day Readmission Rate in Patients Who Were Initially Admitted for Active Giant Cell Arteritis

    Shu Cao1, Caroline Bresnan2, Si Li3, Yichen Wang3 and Yih Chang Lin1, 1University of South Florida, Morsani College of Medicine, Tampa, FL, 2University of South Florida, Morsani College of Medicine, Tampa, 3The Wright Center for Graduate Medical Education, Scranton

    Background/Purpose: Giant cell arteritis (GCA) is a large vessel vasculitis with high potential for morbidity leading to frequent hospitalizations and significant economic burden to the…
  • Abstract Number: 1931 • ACR Convergence 2020

    Effect of Cumulative Glucocorticoid Dose and Inflammation on Weight Change During Treatment of Giant Cell Arteritis

    Naomi Serling-Boyd1, Xiaoqing Fu2, Yuqing Zhang3, Sebastian Unizony1, Zachary Wallace4, Hyon Choi5 and John H. Stone6, 1Massachusetts General Hospital, Boston, MA, 2Massachusetts General Hospital, Boston, 3Massachusetts General Hospital, Quincy, MA, 4Massachusetts General Hospital, Newton, MA, 5Massachusetts General Hospital, Department of Medicine, Division of Rheumatology, Lexington, MA, 6Massachusetts General Hospital Rheumatology Unit, Harvard Medical School, Boston, MA

    Background/Purpose: Giant cell arteritis (GCA) is a form of large vessel vasculitis that requires treatment with high-dose, long-term glucocorticoids (GC). Weight gain, among other side-effects…
  • Abstract Number: 1932 • ACR Convergence 2020

    Giant Cell Arteritis – the Relationship Between the Extensiveness of Vasculitis and the Clinical Presentation

    Alojzija Hocevar1, Rok Jese1, Matija Tomsic1 and Ziga Rotar1, 1University Medical Center Ljubljana, LJUBLJANA, Slovenia

    Background/Purpose: Recent data show that the extensiveness of inflammation observed on colour Doppler ultrasonography (CDS) may indicate the risk for ocular ischaemia giant cell arteritis…
  • Abstract Number: 1933 • ACR Convergence 2020

    Small Vessel Vasculitis Surrounding a Preserved Temporal Artery: Search for Tissue Biomarkers with Potential Diagnostic Value

    Georgina Espígol-Frigolé1, Roser Alba-Rovira2, Salvador Naranjo-Suárez3, Magda Terenas4, Sergio Prieto-González1, Marc Corbera-Bellalta3, Javier Marco-Hernández4, Marco A. Alba1, Farah Kamberovic3, Roberto Ríos-Garcés1, Jose Hernández-Rodríguez1 and Maria C. Cid1, 1Vasculitis Research Unit, Department of Systemic Autoimmune Diseases, Hospital Clínic de Barcelona, IDIBAPS, University of Barcelona, Barcelona, Spain., Barcelona, Catalonia, Spain, 2Vasculitis Research Unit, Department of Autoimmune Diseases, Hospital Clínic, University of Barcelona, IRB-CELLEX. Institut d’Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain, Barcelona, 3IDIBAPS, Barcelona, Spain, 4Hospital Clinic Barcelona, Barcelona, Spain

    Background/Purpose: Systemic vasculitides are complex and heterogeneous diseases with overlapping features that frequently pose a diagnostic challenge to clinicians. The temporal artery biopsy (TAB) is…
  • Abstract Number: 1934 • ACR Convergence 2020

    What Is the Significance of Periarterial Temporal Small Vessel Inflammation (SVI) on Temporal Artery Biopsy (TAB) in the Diagnosis of Vasculitis? A Systematic Review and Meta-analysis

    Elise Belilos1, Steven Carsons2 and Sonya Mehta1, 1NYU Winthrop Hospital, Mineola, NY, 2NYU Long Island School of Medicine, Mineola, NY

    Background/Purpose: Isolated inflammation of small vessels including capillaries, venules and arterioles surrounding a normal temporal artery (SVI) in patients suspected of having giant cell arteritis…
  • Abstract Number: 1935 • ACR Convergence 2020

    Predictors of Early Mortality for Giant Cell Arteritis at the Time of Diagnosis

    Eduardo Dourado1, Sofia Barreira2, Ana Rita Cruz-Machado3, Joana Martinho3, Diana Raimundo4, Luísa Brites5, Helena Assunção5, Vítor Teixeira6, Nikita Khmelinskii3, Carla Macieira3, José A. P. da Silva7, João Eurico Fonseca8 and Cristina Ponte3, 1Rheumatology Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Lisboa, Portugal, 2Rheumatology Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisbon, Portugal, 3Rheumatology Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal, 4Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal, 5Rheumatology Department, Centro Hospitalar Universitário Coimbra, Coimbra, Portugal, 6Rheumatology Department, Centro Hospitalar Universitário do Algarve, Faro, Portugal, 79.Centro Hospitalar e Universitário Coimbra (Rheumatology Department), Coimbra, Portugal, Coimbra, Portugal, 8Instituto de Medicina Molecular, Faculdade Medicina Universidade de Lisboa and Centro Hospitalar Universitário Lisboa Norte., Lisboa, Portugal

    Background/Purpose: Giant cell arteritis (GCA) is the most common form of primary systemic vasculitis, typically affecting patients aged > 50 years. If left untreated, GCA…
  • Abstract Number: 1936 • ACR Convergence 2020

    Prospective Analysis of Flow Velocity of the Central Retinal Artery in Newly Diagnosed Patients with Giant Cell Arteritis with Visual Symptoms and Controls

    Lara Burg1, Katharina Reinking2, Peter Brossart3, Robert Finger2, Charlotte Behning4 and Valentin Schaefer5, 1Clinic for Internal Medicine III, Department of Oncology, Haematology, Rheumatology and Clinical Immunology, University Hospital Bonn, Germany, Bonn, Nordrhein-Westfalen, Germany, 2Department of Ophthalmology, University Hospital Bonn, Germany, Bonn, Nordrhein-Westfalen, Germany, 3Clinic for Internal Medicine III, Department of Oncology, Hematology and Rheumatology, University Hospital Bonn, Germany, Bonn, Nordrhein-Westfalen, Germany, 4Institute for Medical Biometry, Informatics and Epidemiology, University Hospital Bonn, Germany, Bonn, Nordrhein-Westfalen, Germany, 5Clinic of Internal Medicine III, Department of Oncology, Hematology and Rheumatology, University Hospital Bonn, Germany, Bonn, Nordrhein-Westfalen, Germany

    Background/Purpose: Giant cell arteritis (GCA) is the most common form of systemic vasculitis in patients aged 50 years and older.1 Visual symptoms as amaurosis and…
  • Abstract Number: 1937 • ACR Convergence 2020

    Aortic Aneurysm in Giant Cell Arteritis: A Nationwide Analysis

    Jiayi Zheng1, Ruoning Ni2, Yan Tang3 and Liangjing Lu4, 1Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China (People's Republic), 2St. Agnes Hospital, Baltimore, MD, 3Department of Stomatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China (People's Republic), 4Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (People's Republic)

    Background/Purpose: Giant cell arteritis (GCA) is an inflammatory vasculopathy affecting primarily medium and large sized arteries. Previous studies have demonstrated a higher prevalence of aortic…
  • Abstract Number: 1938 • ACR Convergence 2020

    Risk for Vision Loss and Relapse in Patients with Giant Cell Arteritis

    Anne Bull Haaversen1 and Andreas Diamantopoulos2, 1Martina Hansens Hospital, Hosle, Norway, 2Martina Hansens Hospital, Baerum, Norway

    Background/Purpose: Giant cell arteritis (GCA) involves both the cranial and large vessels. Studies have shown that while the vision loss rates are higher, the relapse…
  • Abstract Number: 1939 • ACR Convergence 2020

    Definitions and Reliability Assessment of Chronic Ultrasound Lesions of the Axillary Artery in Giant Cell Arteritis: A Study from the OMERACT Large Vessel Vasculitis Ultrasound Working Group

    Valentin Schaefer1, Stavros Chrysidis2, Greta Carrara3, Wolfgang Schmidt4, George A. Bruyn5, Bhaskar Dasgupta6, Eugenio De Miguel7, Andreas Diamantopoulos8, Christina Duftner9, Ulrich Fredberg10, Berit Nielsen11, Wolfgang Hartung12, Alojzija Hocevar13, Annamaria Iagnocco14, Aaron Juche4, Tanaz Kermani15, Tove Lorenzen16, Pierluigi Macchioni17, Marcin Milchert18, Uffe Døhn19, Sara Monti20, Chetan Mukhtyar21, Cristina Ponte22, Carlo Scire23, Lene Terslev24, Luca Seitz25 and Christian Dejaco26, 1Clinic of Internal Medicine III, Department of Oncology, Hematology and Rheumatology, University Hospital Bonn, Germany, Bonn, Nordrhein-Westfalen, Germany, 2Sydvestjysk Sygehus Esbjerg, Esbjerg, Denmark, 3Epidemiology Unit, Italian Society for Rheumatology, Milan, Italy, 4Immanuel Krankenhaus Berlin Buch, Berlin, Germany, 5Rheumatology, Reumakliniek Lelystad, Lelystad, Netherlands, 6Rheumatology, Mid and South Essex University Hospital NHS Foundation Trust, Southend University Hospital, United Kingdom, Westcliff on sea, England, United Kingdom, 7Rheumatology Department, Hospital Universitario La Paz, Madrid, Spain, 8Martina Hansens Hospital, Baerum, Norway, 9Medical University Innsbruck, Innsbruck, Austria, 10Silkeborg Regional Hospital, Silkeborg, Denmark, 11Aarhus University Hospital, Aarhus, Denmark, 12Asklepios Klinik Bad Abbach, Bad Abbacg, Germany, 13University Medical Center, Rheumatology, Ljubljana, LJUBLJANA, Slovenia, 14Università degli Studi di Torino, Academic Rheumatology Centre, Turin, Italy, 15David Geffen School of Medicine / University of California, Los Angeles, CA, 16Copenhagen Center for Arthritis Research, Copenhagen, Denmark, 17Unità Operativa di Reumatologia/Arcispedale S. Maria Nuova, Reggio Emilia, Italy, 18Pomeranian Medical University, Szczecin, Poland, 19Center for Rheumatology and Spine Diseasesand COPECARE, Copenhagen, Denmark, 20Fondazione IRCCS Policlinico S Matteo, University of Pavia, Pavia, Italy, 21Norfolk and Norwich University Hospitals NHS Foundation Trust, Norwich, United Kingdom, 22Rheumatology Department, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal, 23University of Ferrara, Ferrara, Italy, 24Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup., Copenhagen, Denmark, 25Department of Rheumatology, Immunology and Allergology, University of Bern, Inselspital, Switzerland, Bern, Switzerland, 26South Tyrol Health Trust, Hospital of Bruneck, Bruneck, Italy

    Background/Purpose: The OMERACT Ultrasound (US) large vessel vasculitis task force has recently defined the US appearance of normal axillary arteries (AA) and the key elementary…
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