Abstracts Archive - Page 700 of 2425 - ACR Meeting Abstracts

Abstract Number: 1086 • ACR Convergence 2020
The Diagnostic Value and Clinical Significance of Myositis-Specific Antibodies in Patients Suspected to Have Autoimmune Myopathies and/or Autoimmune Rheumatic Diseases
Sarah El Chami¹, Christopher Williams¹, Ghaith Noaiseh¹, Amrita Bath¹ and Duaa Jabari¹, ¹The University of Kansas Health System, Kansas city, KS
Background/Purpose: Myositis-specific antibodies (MSA) are thought to be highly specific in patients with idiopathic inflammatory myopathies.[1] However, in clinical practice these antibodies are frequently found…
Abstract Number: 1092 • ACR Convergence 2020
NMR-Based Serum Metabolomics, Is It Different in Clinico-Serological Clusters of Idiopathic Inflammatory Myositis?
Naveen R¹, Anupam Guleria², Dinesh Kumar², Umesh Kumar², Anamika Anuja¹, Vikas Agarwal³ and Latika Gupta⁴, ¹Sanjay Gandhi Post graduate institute of medical sciences, Lucknow, Uttar Pradesh, India, ²Centre of Biomedical Research, Sanjay Gandhi post graduate institute of medical sciences, Lucknow, Uttar Pradesh, India, ³Sanjay Gandhi Post Graduate Institute of Medical Sciences, LUCKNOW, India, ⁴Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
Background/Purpose: Idiopathic inflammatory myositis (IIM) are rare and heterogenous. Myositis specific antibodies (MSA) show mutual exclusivity and identify specific clinical phenotypes1. Most biomarker studies are…
Abstract Number: 1091 • ACR Convergence 2020
A Computer-Aided Diagnostic System for Quantitative Scoring of Extent of Interstitial Lung Disease (ILD) in Dermatomyositis/Polymyositis Associated ILD
Sangmee Bae¹, Andrea Oh², Grace Kim³, Jonathan Goldin³ and Christina Charles-Schoeman⁴, ¹University of California Los Angeles, Los Angeles, CA, ²National Jewish Health, Denver, CO, ³University of California, Los Angeles, Los Angeles, ⁴University of California, Los Angeles, Los Angeles, CA
Background/Purpose: Interstitial lung disease (ILD) occurs in up to 80% of patients with dermatomyositis (DM) and polymyositis (PM), and is a leading cause of morbidity…
Abstract Number: 1097 • ACR Convergence 2020
Immunophenotypic Characterization of Myeloid Derived Supressor Cells (MDSCs) and Their Relationship to the Clinical Characteristics of Patients with Inflammatory Myopathies
Hector Culebro¹, Jose Torres-Ruiz², Fabiola Cassiano Quezada¹ and Alfredo Perez Fragoso¹, ¹INCMNSZ, MEXICO, Mexico, ²NIAMS, National Institute of Health, Bethesda
Background/Purpose: Myeloid derived suppressor cells (MDSCs) including their granulocyte (Gr-MDSCs) and monocyte (Mo-MDSCs) subtypes constitute a cellular subset with potent immune regulatory capacity. An augmented…
Abstract Number: 1099 • ACR Convergence 2020
High Burden of Infections in Indian Patients with Idiopathic Inflammatory Myopathy: Validation of Observations from the MyoCite Dataset
Rudrarpan Chatterjee¹, Pankti Mehta², Vikas Agarwal¹ and Latika Gupta², ¹Sanjay Gandhi Post Graduate Institute of Medical Sciences, lucknow, Lucknow, Uttar Pradesh, India, ²Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
Background/Purpose: Infections are a major cause of morbidity and mortality in idiopathic inflammatory myopathy (IIM), more so in India.[1-3] The objective of this study was…
Abstract Number: 1094 • ACR Convergence 2020
Long Term Open Label Extension of Study of Tofacitinib in Refractory Dermatomyositis
Julie Paik¹, Jemima Albayda¹, Eleni Tiniakou¹, Grazyna Purwin¹, Andrew Koenig² and Lisa Christopher-Stine¹, ¹Johns Hopkins University, Baltimore, MD, ²Pfizer Inc, New York City, NY
Background/Purpose: Tofacitinib is a pan-JAK inhibitor that demonstrated safety and efficacy in a 12 week open label trial of 10 subjects with refractory dermatomyositis (NCT03002649).…
Abstract Number: 1089 • ACR Convergence 2020
Intermuscular Adipose Tissue in Patients with Systemic Lupus Erythematosus
Jorge Gamboa¹, Daniel Carranza Leon¹, Rachelle Crescenzi¹, Adriana Marton², Annette Oeser¹, Cecilia Chung¹, Jens Titze², Michelle Ormseth¹ and C. Michael Stein¹, ¹Vanderbilt University Medical Center, Nashville, TN, ²Duke NUS Medical School, Singapore, Singapore
Background/Purpose: Patients with systemic lupus erythematosus (SLE) have reduced physical activity and frequently complain of fatigue. Exercise reduces fatigue in patients with SLE; however, the…
Abstract Number: 1102 • ACR Convergence 2020
Neuropathic Pain in Inflammatory Hand Osteoarthritis(OA) Lowers Quality of Life and May Require Another Approach Than Anti-inflammatory Treatment
Coen van der Meulen¹, Lotte van de Stadt¹, Féline Kroon², Marion Kortekaas¹, Annelies Boonen³, Stefan Böhringer⁴, Monique Reijnierse², Frits Rosendaal², Naghmeh Riyazi⁵, Mirian Starmans⁶, Franktien Turkstra⁷, Jende Van Zeben⁸, CF Allaart² and Margreet Kloppenburg², ¹LUMC, Leiden, Netherlands, ²Leiden University Medical Center, Leiden, Netherlands, ³Maastricht University Medical Center, Maastricht, Netherlands, ⁴LUMC, Leiden, ⁵HAGA ziekenhuis, the hague, Netherlands, ⁶Zuyderland MC, Heerlen, Netherlands, ⁷Reade, Amsterdam, Netherlands, ⁸Franciscus Gasthuis & Vlietland, Rotterdam, Netherlands
Background/Purpose: To investigate whether neuropathic pain is present in patients with inflammatory hand OA, to investigate characteristics of those patients and the impact of neuropathic…
Abstract Number: 1105 • ACR Convergence 2020
RANK-L Activity: Understanding the Pathogenesis of Erosive Osteoarthritis
Kalyna Jakibchuk¹, Javier Rangel-Moreno¹, Bethany Marston², Jennifer Anolik¹ and Allen Anandarajah¹, ¹University of Rochester Medical Center, Rochester, NY, ²University of Rochester Medical Center, Rochester
Background/Purpose: Erosive osteoarthritis (EOA) is characterized by osteoarthritic findings with central erosions and collapse of the interphalangeal joint subchondral bone plate. A number of studies…
Abstract Number: 1106 • ACR Convergence 2020
MMP Mediated Type I Collagen Degradation Is Associated with Erosive Hand Osteoarthritis in a Hospital-based Observational Cohort – the NOR-HAND Study
Christian Thudium¹, Neha Sharma², Marthe Gløersen³, Peder Frederiksen², Anne C. Bay-Jensen¹ and Ida Haugen³, ¹Nordic Bioscience, Herlev, Denmark, ²Nordic Bioscience, Herlev, ³Diakonhjemmet Hospital, Oslo, Norway
Background/Purpose: Hand osteoarthritis (OA) is a common degenerative joint disease affecting mainly the interphalangeal and first carpometacarpal joints. The disease manifests as inflammation and deterioration…
Abstract Number: 1101 • ACR Convergence 2020
Effect of Transcutaneous Vagal Nerve Stimulation in Erosive Hand Osteoarthritis: Results from an Open-label Non-randomized Pilot Trial
Alice Courties¹, Camille Deprouw², Emmanuel Maheu³, Eric Gibert⁴, Jacques-Eric Gottenberg⁵, Julien Champey⁶, Béatrice Banneville⁷, Camille Chesnel⁸, Gerard Amarenco⁸, Alexandra Rousseau⁹, Francis Berenbaum¹ and Jeremie Sellam¹, ¹AP-HP, Hôpital Saint-Antoine, Service de Rhumatologie, Centre de Recherche Saint-Antoine, INSERM UMR_S 938,Sorbonne Université, Paris, 75012, France, Paris, France, ²1. AP-HP, Hôpital Saint-Antoine, Service de Rhumatologie, Paris, 75012, France, Paris, France, ³AP-HP, Hôpital Saint-Antoine, Service de Rhumatologie, Paris, 75012, Paris, France, ⁴Cabinet de Rhumatologie, 94200 Ivry sur Seine, Paris, France, ⁵Service de Rhumatologie, Centre national de référence pour les maladies auto-immunes systémiques, Hôpital universitaire de Strasbourg, Université de Strasbourg, Strasbourg,, Strasbourg, France, ⁶AP-HP, Hôpital Saint-Antoine, Service de Rhumatologie, Paris, 75012,, paris, France, ⁷AP-HP, Hôpital Pitié-Salpêtrière, Service de Rhumatologie, Paris, 75013, Paris, France, ⁸Sorbonne Université, GRC 001, GREEN Groupe de Recherche Clinique en Neuro-Urologie, AP-HP, Hôpital Tenon, F-75020 Paris,, Paris, France, ⁹AP-HP, Hôpital Saint-Antoine, Unité de Recherche Clinique de l'Est Parisien (URC-Est), Paris, 75012,, Paris, France
Background/Purpose: Beyond classical effect on vegetative functions, the activation of the vagus nerve inhibits inflammation and reduces the pain signal. Vagus nerve stimulation (VNS) can…
Abstract Number: 1112 • ACR Convergence 2020
Relationship of Depth-Specific Subchondral Bone Mineral Density and Pain in Knee Osteoarthritis: The Multicenter Osteoarthritis Study
Jean Liew¹, JD Johnston², Na Wang³, John Lynch⁴, Cora Lewis⁵, James Torner⁶ and Tuhina Neogi³, ¹University of Washington, Seattle, WA, ²University of Saskatchewan, Saskatoon, SK, Canada, ³Boston University School of Medicine, Boston, MA, ⁴UCSF, San Francisco, CA, ⁵University of Alabama Birmingham, Birmingham, AL, ⁶University of Iowa, Iowa City, IA
Background/Purpose: OA has traditionally been considered a disease of cartilage but early OA changes in subchondral bone may precede cartilage abnormalities. Altered subchondral bone mineral…
Abstract Number: 1109 • ACR Convergence 2020
Pain in Women with Knee and/or Hip Osteoarthritis Is Related to Systemic Inflammation and to Adipose Tissue Dysfunction and Distribution: A Cross-sectional Metabolic Biomarkers Cohort Study
Jeremie Sellam¹, Anne-Christine Rat², Soraya Fellahi³, Jean-Philippe Bastard⁴, Willy NGUEYON SIME⁵, Hang Korng EA⁶, Pascal Richette⁷, Jacqueline Capeau⁸, Francis Guillemin⁹ and Francis Berenbaum¹, ¹AP-HP, Hôpital Saint-Antoine, Service de Rhumatologie, Centre de Recherche Saint-Antoine, INSERM UMR_S 938,Sorbonne Université, Paris, 75012, France, Paris, France, ²Universite de Caen Normandie and Université de Lorraine, EA 4360, Caen, France, ³AP-HP INSERM, Paris, France, ⁴INSERM AP-HP UPEC, Paris, France, ⁵Universite de Lorraine, INSERM, CIC, Nancy, France, ⁶Universite de Paris, AP-HP, INSERM, paris, France, ⁷Department of Rheumatology, Lariboisière Hospital, Paris, France, ⁸INSERM Sorbonne Universite, Paris, France, ⁹Universite de Lorraine CIC INSERM, Nancy, France
Background/Purpose: Beyond the link between metabolic diseases and osteoarthritis (OA) risk, some studies have suggested an association between metabolic syndrome or visceral obesity and OA-related…
Abstract Number: 1104 • ACR Convergence 2020
The Disability Associated with Hand Osteoarthritis Is Substantial in a Cohort of Post-menopausal Women : The QUALYOR Study
Maxime Auroux¹, Blandine Merle², Eric Lespessailles³ and Roland Chapurlat¹, ¹Hospices Civils de Lyon, Lyon Cedex 03, Rhone-Alpes, France, ²INSERM UMR 1033, Université de Lyon, Lyon Cedex 03, Rhone-Alpes, France, ³Regional Hospital and University of Orleans, Orléans, France
Background/Purpose: Osteoarthritis (OA) is a highly prevalent disease, affecting more than 400 millions individuals around the world. Hand osteoarthritis (HOA) is the most frequent form…
Abstract Number: 0996 • ACR Convergence 2020
Bacteria-Derived Indole Drives Autoimmune Arthritis by Altering B Cell Glycosylation of Autoantibodies
Brandon Trent¹, Meagan Chriswell², Widian Jubair³ and Kristine Kuhn¹, ¹University of Colorado Anschutz Medical Campus, Aurora, CO, ²UC Denver SOM, Denver, CO, ³University of Colorado Denver, Denver, CO
Background/Purpose: Background: Dysbiosis of gut bacterial communities in rheumatoid arthritis (RA) is a noted phenomenon in both murine models and human patients; however, the mechanisms…

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