ACR Meeting Abstracts

ACR Meeting Abstracts

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  • Abstract Number: 0742 • ACR Convergence 2020

    Effect of IA OnabotulinumtoxinA and Vanilloids on Substance P and Neurokinin 1 Receptor Expression in the Dorsal Root Ganglia of Mice with Monoarthritis

    Hollis Krug1, Nicole Blanshan2, Christopher Dorman2 and Sandra Frizelle2, 1Minneapolis VAHCS and University of Minnesota Medical School, Minneapolis, MN, 2Minneapolis VAHCS, Minneapolis

    Background/Purpose: Neurotoxins are increasingly being proposed as analgesics for arthritis pain. Phase II and III clinical trials have shown efficacy but with potential toxicities such…
  • Abstract Number: 0741 • ACR Convergence 2020

    Constitutive Inhibitor Kappa B (IκB) Kinase 2 (IKK2) Activation Induces an Inflammatory State in Fibroblast-Like Synoviocytes

    Sergio Ramirez-Perez1, Umesh Gangishetti1, Kyle Jones1 and Pallavi Bhattaram2, 1Department of Orthopaedics, Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, 2EMORY UNIVERSITY, Atlanta, GA

    Background/Purpose: Fibroblast-like synoviocytes (FLS) are key players involved in the production of inflammatory mediators that trigger joint tissue damage in inflammatory arthritis (IA). The most…
  • Abstract Number: 0747 • ACR Convergence 2020

    Isotope-Labeling-LC-MS-based Metabolic Profiling of Multiple Serum Sample Sets for the Discovery of High-confidence Rheumatoid Arthritis Biomarkers

    Xiaohang Wang1, Wei Han1, Liang Li1, Stephanie Wichuk2, Edna Hutchings3, Rana Dadashova3, Joel Paschke3 and Walter Maksymowych2, 1Department of Chemistry, University of Alberta, Edmonton, AB, Canada, 2University of Alberta, Edmonton, AB, Canada, 3CARE Arthritis, Edmonton, AB, Canada

    Background/Purpose: Early diagnosis of rheumatoid arthritis (RA) is hampered by suboptimal accuracy of currently available serological biomarkers. In this work, we applied a high-performance chemical…
  • Abstract Number: 0746 • ACR Convergence 2020

    HDL-bound yRNA-derived Small RNAs Are Altered in Patients with Rheumatoid Arthritis

    Qiong Wu1, Quanhu Sheng1, Joseph Solus1, Danielle Michell1, Kasey Vickers1, Ryan Allen1, C. Michael Stein1 and Michelle Ormseth1, 1Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Small RNAs (sRNAs), including microRNAs (miRNAs) and yRNA-derived sRNAs (yDRs), are important gene regulators and markers of disease. HDL, while known for its anti-atherogenic…
  • Abstract Number: 0752 • ACR Convergence 2020

    Serum Proteomics Implicates Neutrophil Degranulation in Rheumatoid Arthritis Disease Activity

    Liam O'Neil1, Vidyanand Anaparti1, Dana Wiens1, Irene Smolik1, Xiaobo Meng1 and Hani El-Gabalawy1, 1University of Manitoba, Winnipeg, MB, Canada

    Background/Purpose: Though targeted therapeutics have improved outcomes in Rheumatoid Arthritis (RA) treatment, the understanding of the underlying biological mechanisms that mediate inflammatory arthritis in RA…
  • Abstract Number: 0754 • ACR Convergence 2020

    The Association Between Continuous Decreases in Serum RF Titers and Radiographic Remission of Joint Damage in RA Patients Treated with Biological or Targeted Synthetic DMARDs

    Takayoshi Owada1, Ayae Tanaka2, Hirokuni Hirata1, Masafumi Arima3, Yasutsugu Fukushima1 and Kazuhiro Kurasawa3, 1Dokkyo Medical University Saitama Medical Center, Koshigaya, Saitama, Japan, 2Dokkyo Medical University, Shimotsuga-Gun, Japan, 3Dokkyo Medical University, Mibu, Shimotsugagun, Tochigi, Japan

    Background/Purpose: Rheumatoid factors (RFs) are RA-related autoantibodies like anti-cyclic citrullinated peptide antibodies, and are used for classifying and diagnosing RA. In addition, positivity and high…
  • Abstract Number: 0749 • ACR Convergence 2020

    Locating Cellular Subsets in Rheumatoid Arthritis Synovium Using CO-Detection by IndEXing (CODEX)

    Isabella Wulur1, David Boyle2, Lin Zhang1, Andrea Martin1, Robert Benschop3 and Gary Firestein4, 1Eli Lilly, Indianapolis, IN, 2UC San Diego, San Diego, CA, 3Eli Lilly and Company, Indianapolis, IN, 4University of California, San Diego, La Jolla, CA

    Background/Purpose: To better understand site-of-disease mechanisms in arthritis, the phenotypes and organization of synovial cells and infiltrates are critical. Conventional histology-based approaches are limited in…
  • Abstract Number: 0744 • ACR Convergence 2020

    Circulating Fibroblast Growth Factor-21 Levels in Rheumatoid Arthritis: Associations with Disease Characteristics, Body Composition, and Physical Functioning

    Patrick Gould1, Babette Zemel2, Elena Taratuta3 and Joshua Baker1, 1University of Pennsylvania, Philadelphia, PA, 2Children's Hospital of Philadelphia, Philadelphia, 3University of Pennsylvania, Philadelphia

    Background/Purpose: Rheumatoid arthritis (RA) can lead to changes in body composition, including muscle loss and excess adiposity, which are in turn associated with physical disability.…
  • Abstract Number: 0757 • ACR Convergence 2020

    Sunlight Exposure, Sun-protective Behaviour, and Anti-citrullinated Protein Antibody Positivity: A General Population-based Study in Quebec, Canada

    Naizhuo Zhao1, Audrey Smargiassi2, Ines Colmegna3, Marie Hudson4, Marvin Fritzler5 and Sasha Bernatsky6, 1McGill University, Montreal, Canada, 2l’Université de Montréal, Montreal, Canada, 3The Research Institute of the McGill University Health Centre, Montreal, Canada, 4Division of Rheumatology, Jewish General Hospital, Montréal, QC, Canada, 5Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada, 6The Research Institute of the McGill University Health Centre, Montreal, ON, Canada

    Background/Purpose: Sunlight exposure has been associated with lower rheumatoid arthritis (RA) risk, but to our knowledge, no one has ever studied sunlight exposure and anti-citrullinated…
  • Abstract Number: 0760 • ACR Convergence 2020

    X-rays Bone Erosions Are Uncommon in Anti-CCP Positive Individuals At-risk of Rheumatoid Arthritis with Musculoskeletal Symptoms Without Clinical Synovitis, and Do Not Predict the Development of Inflammatory Arthritis

    Andrea Di Matteo1, Kulveer Mankia1, Jacqueline L Nam1, Edoardo Cipolletta2, Leticia Garcia-Montoya3, Laurence Duquenne1, Emma Rowbotham4 and Paul Emery5, 1University of Leeds and Leeds Musculoskeletal Biomedical Research Unit, Leeds, United Kingdom, 2Polytechnic University of Marche, Rheumatology Unit, Department of Clinical and Molecular Sciences, "Carlo Urbani" Hospital, Jesi (AN), Italy, 3The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Leeds, United Kingdom, 4Department of Radiology, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 5Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals NHS Trust, Leeds, UK, Leeds, United Kingdom

    Background/Purpose: In individuals at-risk of RA, the identification of reliable biomarkers for the future development of clinical arthritis is of critical importance for risk-stratification and…
  • Abstract Number: 0761 • ACR Convergence 2020

    Anti-Peptidylarginine Deaminase Antibodies in the Individuals with Arthralgia at Risk of Progression to Rheumatoid Arthritis

    Nora Petrovská1, Klára Prajzlerová1, Ivana Půtová2, Monika Gregová1, Petra Hánová2, Heřman Mann3, Karel Pavelka1, Jiří Vencovský1, Ladislav Šenolt1 and Mária Filková1, 1Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 2Institute of Rheumatology, Prague, Czech Republic, 3Institute of Rheumatology, Prague, Czech Republic. Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose: In order to identify the individuals at risk of imminent progression to rheumatoid arthritis (RA), EULAR has established a definition of clinically suspect arthralgia…
  • Abstract Number: 0756 • ACR Convergence 2020

    Increased Risk of Hospitalization in Patients with RA Who Are ACPA Positive and Shared Epitope Positive

    Joe Zhuo1, Manasi Suryavanshi1, Lawshia Priya2, Vadim Khaychuk1, John Vaile1, Jing Cui3, Nancy Shadick4 and Michael Weinblatt3, 1Bristol-Myers Squibb Company, Princeton, NJ, 2Mu-Sigma, Bangalore, India, 3Brigham and Women's Hospital, Boston, MA, 4Division of Rheumatology, Inflammation, and Immunity; Brigham and Women’s Hospital and Harvard Medical School, Boston, MA

    Background/Purpose: A strong genetic association between HLA-DRB1 alleles containing the shared epitope (SE) and RA has been described.1 The SE has been associated with ACPA…
  • Abstract Number: 0764 • ACR Convergence 2020

    Uncovering Novel Biomarkers for Rheumatoid Arthritis from Feature Selection and Machine Learning Approaches on Synovium and Blood Gene Expression Data

    Dmitry Rychkov1, Jessica Neely1 and Marina Sirota1, 1UCSF, San Francisco, CA

    Background/Purpose: There is an urgent need to develop objective biomarkers for early diagnosis and monitoring of disease activity in Rheumatoid arthritis (RA). Here we define…
  • Abstract Number: 0759 • ACR Convergence 2020

    Presence of Ultrasound Imaging Biomarkers Are Good Predictors of Arthritis Development in a Population at Risk for Rheumatoid Arthritis

    Yogan Kisten1, Alexandra Circiumaru1, Malena Loberg-Haarhaus2, Nancy Vivar2, Aleksandra Antovic3, Hamed Rezaei2, Erik Af Klint1, Aase Hensvold1 and Anca Catrina1, 1Rheumatology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Stockholm, Stockholms Lan, Sweden, 2Rheumatology clinic, Karolinska University Hospital, Stockholm, Sweden, Stockholm, Stockholms Lan, Sweden, 3Center for Rheumatology, Academic Specialist Center, Stockholm Health Region, Stockholm, Sweden, Stockholm, Stockholms Lan, Sweden

    Background/Purpose: Ultrasound (US) imaging biomarkers in the context of Anti-Citrullinated Protein Antibody (ACPA) autoimmunity might play an important role in the very early detection of…
  • Abstract Number: 0651 • ACR Convergence 2020

    Readmission Risk and Quality of Care in Patients Presenting to the Emergency Department with Gout Flares

    Luigi Brunetti1, Janaki Vekaria1, Peter Lipsky2 and Naomi Schlesinger3, 1Rutgers Ernest Mario School of Pharmacy, piscataway, NJ, 2AMPEL BioSolutions LLC., Charlottesville, VA, 3Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ

    Background/Purpose: Gout is the most common inflammatory arthritis and its economic burden is substantial, with estimates for the overall cost exceeding $20 billion (US) annually.…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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