ACR Meeting Abstracts

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  • Abstract Number: 0727 • ACR Convergence 2020

    Hip Involvement Leads to Poor Outcome in Adulthood in Children with Enthesitis Related Arthritis (ERA) Category of Juvenile Idiopathic Arthritis (JIA)

    Naveen R1, Namita Mohindra1, Neeraj Jain1 and Amita Aggarwal2, 1Sanjay Gandhi Post graduate institute of medical sciences, Lucknow, Uttar Pradesh, India, 2Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

    Background/Purpose: Enthesitis related arthritis (ERA) is the commonest category of JIA seen in India and constitutes 30-40% of all JIA patients. There are many studies…
  • Abstract Number: 0726 • ACR Convergence 2020

    Who Ordered the Stiff One? Characteristics of Polyarticular Juvenile Idiopathic Arthritis Patients Associated with the Presence and Increased Duration of Joint Stiffness

    Nayimisha Balmuri1, Victoria Cooley2, Linda Gerber2, Susan Goodman3, Bella Mehta3 and Karen Onel4, 1Hospital for Special Surgery, new york, NY, 2Weill Cornell Medicine, NY, NY, 3Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, 4Pediatric Rheumatology, Hospital for Special Surgery, New York, NY

    Background/Purpose: Joint stiffness as a sign of intra-articular inflammation may be an early presenting symptom of JIA. Studies following pain in chronic disease have shown…
  • Abstract Number: 0732 • ACR Convergence 2020

    Changing Evidence over Time: Updated Meta-analysis Regarding Anti-TNF Efficacy in Childhood Chronic Uveitis

    Ilaria Maccora1, Eleonora Fusco2, Edoardo Marrani3, AV Ramanan4 and Gabriele Simonini5, 1Paediatric Rheumatology Unit, Anna Meyer Children's University Hospital, School of Human Health Science, Florence, Italy, Florence, Italy, 2Rheumatology Unit, Anna Meyer Children's Hospital, School of Human Health Science, University of Florence, Florence, Italy, 3University of Florence, Firenze, Italy, 4Department of Paediatric Rheumatology, Bristol Royal Hospital for Children, Bristol, United Kingdom, 5Rheumatology Unit, Meyer Children's University Hospital, Florence; NEUROFARBA Department, University of Florence, Italy, Florence, Italy

    Background/Purpose: To summarize evidence regarding efficacy of anti-tumour necrosis factor-α (anti-TNFα) in childhood autoimmune chronic uveitis (cACU), refractory to common disease modifying antirheumatic drugs (DMARDs).Methods:…
  • Abstract Number: 0731 • ACR Convergence 2020

    Comparing S100 Proteins and Cytokine Levels in Tears Based on Uveitis Activity Laterality in Children with JIA-associated Uveitis and Non-JIA-U

    Jackeline Rodriguez-Smith1, Virginia Miraldi Utz2, Amy Cassedy1, Sherry Thornton1, Grant Schulert3, Alyssa Sproles4, Najima Mwase1, Theresa Hennard1, Mekibib Altaye2, Alexei Grom1 and Sheila Angeles-Han1, 1Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2Cincinnati Children's Hospital Medical Center, Cincinnati, 3PRCSG, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 4Cincinnati Children's Hospital, Cincinnati

    Background/Purpose: The pathogenesis of pediatric uveitis remains unclear. Studies of biomarkers using aqueous humor (AqH) identified S100 proteins, cytokines, and chemokines as potential biomarkers of…
  • Abstract Number: 0737 • ACR Convergence 2020

    “It’ll Go Away. There’s Nothing Wrong with you:” the Experience of Pain-Related Stigma Among Adolescents with Pain Amplification Syndrome

    Emily Wakefield1, William Zempsky1, Rebecca Puhl2 and Mark Litt3, 1Connecticut Children's/University of Connecticut School of Medicine, Hartford, CT, 2Rudd Center for Food Policy & Obesity/University of Connecticut, Hartford, CT, 3University of Connecticut School of Medicine, Farmington, CT

    Background/Purpose: Chronic pain in adolescence is a complex and significant medical condition, with a reported prevalence of 11-38%.1 Pain amplification syndrome (PAS), which includes fibromyalgia,…
  • Abstract Number: 0739 • ACR Convergence 2020

    Toll-like Receptor Inhibitor Peptide Improves the Clinical, Immunologic, and Pathologic Manifestations of Systemic Lupus Erythematosus

    Chang-Hee Suh1, Wook-Young Baek1, Ji-Won Kim1, Yang-Seon Choi2, Sung-Min Lee1, In-Ok Son1, Ki-Woong Jeon1 and Sangdun Choi2, 1Ajou University School of Medicine, Suwon, Republic of Korea, 2Ajou University, Suwon, Republic of Korea

    Background/Purpose: Toll-like receptors (TLRs) are a type of protein that plays a major role in the innate immune system. In recent years, several studies have…
  • Abstract Number: 0734 • ACR Convergence 2020

    Differences and Similarities Between down Syndrome-associated Arthritis and Juvenile Idiopathic Arthritis in the New Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry

    Jordan Jones1, Chelsey Smith2, Daniel J Lovell3 and Mara Becker4, 1Children's Mercy Kansas City, Kansas City, MO, 2Children's Mercy Kansas City, Holden, MO, 3PRCSG, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 4Duke University School of Medicine, Durham, NC

    Background/Purpose: Down syndrome-associated arthritis (DA) is under-recognized with delay in diagnosis (1). The majority of those with DA present with polyarticular, rheumatoid factor (RF) and…
  • Abstract Number: 0729 • ACR Convergence 2020

    Morbidity of JIA-associated Uveitis: Half of Patients Despite Systemic Treatment Still Show Ocular Damage During a Long-term Follow-up

    Francesca Minoia1, Luca Marelli2, Gisella Beatrice Beretta3, Micol Romano4, Elisabetta Miserocchi4, Chiara Mapelli3, Antonella Petaccia3, Stefano Lanni3, Irene Pontikaki4, Giovanni Filocamo3 and Rolando Cimaz5, 1Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, Milan, Italy, 2San Giuseppe Hospital, IRCCS Multimedica, Milan, Italy, Milan, Italy, 3Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy, Milan, Italy, 4ASST Gaetano Pini-CTO Institute, Milan, Italy, Milan, Italy, 5ASST Gaetano Pini-CTO Institute and Università degli Studi di Milano, Milan, Italy, Milan, Italy

    Background/Purpose: Uveitis is the most common extra-articular complication of juvenile Idiopathic arthritis (JIA). Due to its typical indolent and chronic course, children with this condition…
  • Abstract Number: 0742 • ACR Convergence 2020

    Effect of IA OnabotulinumtoxinA and Vanilloids on Substance P and Neurokinin 1 Receptor Expression in the Dorsal Root Ganglia of Mice with Monoarthritis

    Hollis Krug1, Nicole Blanshan2, Christopher Dorman2 and Sandra Frizelle2, 1Minneapolis VAHCS and University of Minnesota Medical School, Minneapolis, MN, 2Minneapolis VAHCS, Minneapolis

    Background/Purpose: Neurotoxins are increasingly being proposed as analgesics for arthritis pain. Phase II and III clinical trials have shown efficacy but with potential toxicities such…
  • Abstract Number: 0745 • ACR Convergence 2020

    Development of Functional Assays to Pre-qualify Human Mesenchymal Stem Cells for Rheumatoid Arthritis Treatment

    Maya Breitman1, Tracey Bonfield2, Arnold Caplan3, Hillard Lazarus4, Maricela Haghiac5, Jane Reese6 and Nora Singer1, 1The MetroHealth System, Case Western Reserve University School of Medicine, Cleveland, OH, 2National Center of Regenerative Medicine Case Western Reserve University School of Medicine, Cleveland, OH, 3Skeletal Research Center Case Western Reserve University School of Medicine, Cleveland, OH, 4Case Western Reserve University School of Medicine, Cleveland, OH, 5The MetroHealth System, Cleveland, OH, 6University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, OH

    Background/Purpose: Sero-positive rheumatoid arthritis (RA) is a chronic autoimmune disease that without effective treatment, leads to joint damage and disability. Not all patients respond to…
  • Abstract Number: 0746 • ACR Convergence 2020

    HDL-bound yRNA-derived Small RNAs Are Altered in Patients with Rheumatoid Arthritis

    Qiong Wu1, Quanhu Sheng1, Joseph Solus1, Danielle Michell1, Kasey Vickers1, Ryan Allen1, C. Michael Stein1 and Michelle Ormseth1, 1Vanderbilt University Medical Center, Nashville, TN

    Background/Purpose: Small RNAs (sRNAs), including microRNAs (miRNAs) and yRNA-derived sRNAs (yDRs), are important gene regulators and markers of disease. HDL, while known for its anti-atherogenic…
  • Abstract Number: 0741 • ACR Convergence 2020

    Constitutive Inhibitor Kappa B (IκB) Kinase 2 (IKK2) Activation Induces an Inflammatory State in Fibroblast-Like Synoviocytes

    Sergio Ramirez-Perez1, Umesh Gangishetti1, Kyle Jones1 and Pallavi Bhattaram2, 1Department of Orthopaedics, Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, 2EMORY UNIVERSITY, Atlanta, GA

    Background/Purpose: Fibroblast-like synoviocytes (FLS) are key players involved in the production of inflammatory mediators that trigger joint tissue damage in inflammatory arthritis (IA). The most…
  • Abstract Number: 0749 • ACR Convergence 2020

    Locating Cellular Subsets in Rheumatoid Arthritis Synovium Using CO-Detection by IndEXing (CODEX)

    Isabella Wulur1, David Boyle2, Lin Zhang1, Andrea Martin1, Robert Benschop3 and Gary Firestein4, 1Eli Lilly, Indianapolis, IN, 2UC San Diego, San Diego, CA, 3Eli Lilly and Company, Indianapolis, IN, 4University of California, San Diego, La Jolla, CA

    Background/Purpose: To better understand site-of-disease mechanisms in arthritis, the phenotypes and organization of synovial cells and infiltrates are critical. Conventional histology-based approaches are limited in…
  • Abstract Number: 0744 • ACR Convergence 2020

    Circulating Fibroblast Growth Factor-21 Levels in Rheumatoid Arthritis: Associations with Disease Characteristics, Body Composition, and Physical Functioning

    Patrick Gould1, Babette Zemel2, Elena Taratuta3 and Joshua Baker1, 1University of Pennsylvania, Philadelphia, PA, 2Children's Hospital of Philadelphia, Philadelphia, 3University of Pennsylvania, Philadelphia

    Background/Purpose: Rheumatoid arthritis (RA) can lead to changes in body composition, including muscle loss and excess adiposity, which are in turn associated with physical disability.…
  • Abstract Number: 0636 • ACR Convergence 2020

    Rheumatology Patient Experience and Trends During the SARS-COV-2 Pandemic

    Cuoghi Edens1, Kichul Ko1 and Kimberly Trotter1, 1University of Chicago, Chicago, IL

    Background/Purpose: Rheumatic disease patients are counseled on the immunosuppressive aspect of their rheumatic disease treatment and their increased risk of infection.  Little is known about…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM ET on November 14, 2024. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

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