ACR Meeting Abstracts

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  • Abstract Number: 0697 • ACR Convergence 2020

    Inferior Tendon Structure and Function Seen in Patients with Achilles Tendinopathy and Neovascularization of the Achilles Tendon

    Brian Honick1, Haraldur Sigurdsson1 and Karin Silbernagel1, 1University of Delaware, Newark, DE

    Background/Purpose: In prior research, the incidence rate of neovascularization with Achilles tendinopathy ranged between 47-88% of cases. The purpose of this study was to identify…
  • Abstract Number: 0696 • ACR Convergence 2020

    Femoral Cartilage Ultrasound Echo-Intensity Associates with Arthroscopic Cartilage Damage in People Following Anterior Cruciate Ligament Reconstruction

    Matthew Harkey1, Erin Little2, Mikaela Thompson3, Ming Zhang4, Jeffrey Driban4 and Matthew Salzler3, 1University of Massachusetts, Worcester, MA, 2Tufts Medical Center, Cambridge, MA, 3Tufts Medical Center, Boston, 4Tufts Medical Center, Boston, MA

    Background/Purpose: Over one-third of people will develop knee osteoarthritis within 10 years of an anterior cruciate ligament (ACL) injury. Ultrasound may be used to monitor…
  • Abstract Number: 0702 • ACR Convergence 2020

    Distinct Murine Cartilage Microbial DNA Signatures Are Seen in High Fat Diet-Induced Obesity and Aging

    Christopher Dunn1, Cassandra Garman2, Jake Martin2, Vladislav Izda2, Cassandra Velasco2 and Matlock Jeffries2, 1University of Oklahoma Health Sciences Center, Oklahoma Cityq, 2University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: The strongest nongenetic risk factors for primary knee OA are advanced age and obesity. We have previously shown a human cartilage microbial DNA signature…
  • Abstract Number: 0701 • ACR Convergence 2020

    miRNome Sequencing Identifies a Unique Profile of Circulating MicroRNAs in Early Knee Osteoarthritis

    S. Amanda Ali1, Rajiv Gandhi2, Pratibha Potla2, Sareh Keshavarzi2, Osvaldo Espin-Garcia2, Konstantin Shestopaloff2, Chiara Pastrello3, Dylan Bethune-Waddell2, Starlee Lively2, Anthony Perruccio4, Raj Rampersaud2, Christian Veillette2, Jason Rockel2, Igor Jurisica2, Tom Appleton5 and Mohit Kapoor6, 1Henry Ford Health System, Detroit, MI, 2Krembil RI, Toronto, Canada, 3University Health Network, Toronto, ON, Canada, 4Krembil Research Institute, UHN; University of Toronto, Toronto, ON, Canada, 5The University of Western Ontario, LONDON, ON, Canada, 6Krembil RI, Toronto, ON, Canada

    Background/Purpose: MicroRNAs have been shown to contribute to osteoarthritis (OA) pathophysiology, yet little is known about the circulating miRNome in OA. The circulating miRNome (e.g.…
  • Abstract Number: 0707 • ACR Convergence 2020

    Contribution of NOTUM and Glypicans to the Development of Osteoarthritis

    Arkaitz Mucientes1, Eva Herranz1, Pia Lois2, Gloria Candelas2, Lydia Abasolo1, Luis Rodriguez-Rodriguez1, Jose Ramon Lamas1 and Benjamin Fernandez-Gutierrez3, 1IdISSC, Madrid, Madrid, Spain, 2Hospital Clínico San Carlos, Madrid, Madrid, Spain, 3Hospital Clínico San Carlos / IdISSC, Madrid, Madrid, Spain

    Background/Purpose: Osteoarthritis (OA) is a degenerative disease characterized by altered homeostasis of joint cartilage and bone, the functionality of which relies on chondrocytes and osteoblasts,…
  • Abstract Number: 0709 • ACR Convergence 2020

    Anatomical Distribution of Mrgprd-expressing Nonpeptidergic C-fibers in the Mouse Knee

    Alia Obeidat1, Rachel Miller1 and Anne-Marie Malfait1, 1Rush University, CHICAGO, IL

    Background/Purpose: The voltage-gated sodium channel, NaV1.8, marks the majority of C-fiber nociceptors. We have used NaV1.8 tdTomato reporter mice to describe the nociceptive innervation of…
  • Abstract Number: 0704 • ACR Convergence 2020

    The Murine Ear Wound Cartilage Superhealer Trait, Mediated by the Gut Microbiome, Is Transgenerationally Heritable Following Cecal Transplantation

    Christopher Dunn1, Cassandra Garman2, Cassandra Velasco2, Vladislav Izda2, Jake Martin2 and Matlock Jeffries2, 1University of Oklahoma Health Sciences Center, Oklahoma City, 2University of Oklahoma Health Sciences Center, Oklahoma City, OK

    Background/Purpose: MRL/MpJ mice are substantially protected from developing post-traumatic osteoarthritis (OA), a trait with strong correlation to the ability to heal ear wounds. We have…
  • Abstract Number: 0699 • ACR Convergence 2020

    Lumbar Spine Stenosis Treatment : Is Surgery Better Than Medical Treatment in Afro-Descendant Populations ?

    Fabienne Louis-sidney1, Serge Arfi1, Moustapha Drame1, Christophe Deligny1, Philippe Cabre1 and Michel de Bandt1, 1University Hospital Martinique, Fort de France, Martinique

    Background/Purpose: Lumbar spinal stenosis (LSS) is a disabling condition, mostly prevalent in the aging population and associated with significant healthcare cost. Clinical presentation involving neurogenic…
  • Abstract Number: 0712 • ACR Convergence 2020

    Switching from Reference to Biosimilars Does Not Reduce Efficacy and Safety in Juvenile Idiopathic Arthritis

    Ilaria Maccora1, Gabriele Simonini2, Alessandra Bettiol3, Ilaria Pagnini4, Niccolò Lombardi5, Valerio Maniscalco6, Giada Crescioli5, Edoardo Marrani7, Roberto Bonaiuti5, Maria Vincenza Mastrolia8, Claudia Ravaldi9 and Alfredo Vannacci5, 1Paediatric Rheumatology Unit, Anna Meyer Children's University Hospital, School of Human Health Science, Florence, Italy, Florence, Italy, 2Rheumatology Unit, Meyer Children's University Hospital, Florence; NEUROFARBA Department, University of Florence, Italy, Florence, Italy, 32. Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology, University of Florence, Florence, Italy, Florence, 41. Rheumatology Unit, Anna Meyer Children’s Hospital and Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Paediatric, University of Florence, Florence, Italy, florence, Italy, 52. Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Pharmacology and Toxicology, University of Florence, Florence, Italy., Florence, Italy, 61. Rheumatology Unit, Anna Meyer Children’s Hospital and Department of Neurosciences, Psychology, Drug Research and Child Health, Section of Paediatric, University of Florence, Florence, Italy., florence, Italy, 7University of Florence, Firenze, Italy, 8Rheumatology Unit, Meyer Children's University Hospital, Firenze, Italy, Florence, Toscana, Italy, 93. Department of Health Sciences, University of Florence, Florence, Italy., Florence, Italy

    Background/Purpose: Limited data about the use of biosimilar are available in children with Juvenile Idiopathic Arthritis (JIA). To evaluate the long-term efficacy and safety of switching…
  • Abstract Number: 0715 • ACR Convergence 2020

    JIA-ACR50 Response as a Predictor of Minimal Disease Activity in Patients Aged 2–17 Years with Polyarticular-Course JIA Treated with SC Abatacept

    Nicolino Ruperto1, Hermine I Brunner2, Alberto Berman3, Francisco Ávila-Zapata4, Gerd Horneff5, Maria Alessio6, Mara Becker7, Alexandre Belot8, Ruben Burgos-Vargas9, Alina Boteanu10, Claudia Goldenstein-Schainberg11, Iloite Scheibel12, Maria Teresa Terreri13, Lawrence Zemel14, Robert Wong15, Margarita Askelson15, Marleen Nys16, Alberto Martini17 and Daniel J Lovell2, 1Istituto Giannina Gaslini, Genova, Italy, 2PRCSG, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 3Universidad Nacional de Tucumán and Centro Médico Privado de Reumatología, Tucumán, Argentina, 4Star Medica Hospital, Merida, Yucatan, Mexico, 5Asklepios Clinic Sankt Augustin, Sankt Augustin, Germany, 6Università di Napoli Federico II, Naples, Italy, 7Duke University School of Medicine, Durham, NC, 8Centre Hospitalier Universitaire de Lyon, Lyon, France, 9Department of Rheumatology, General Hospital of Mexico, Ciudad de Mexico, Mexico, 10Hospital Universitario Ramón y Cajal, Madrid, Spain, 11University of São Paulo, São Paulo, Brazil, 12Hospital Criança Conceição, Porto Alegre, Brazil, 13Federal University of São Paulo, São Paulo, Brazil, 14Connecticut Children’s Medical Center, Hartford, CT, 15Bristol-Myers Squibb Company, Princeton, NJ, 16Bristol-Myers Squibb Company, Braine-L’Alleud, Belgium, 17PRINTO, Istituto Giannina Gaslini, Genova, Italy

    Background/Purpose: Effectiveness of SC abatacept in patients with polyarticular-course JIA (pJIA) was shown in a 2-year, open-label Phase III international study (NCT01844518). Here we assess…
  • Abstract Number: 0716 • ACR Convergence 2020

    Variations in Adalimumab and Etanercept Dosing in Juvenile Idiopathic Arthritis and Their Effect on Treatment Outcome: A Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry Study

    Ruud Verstegen1, Peter Shrader2, Stephen Balevic3, Timothy Beukelman4, Colleen Correll5, Anne Dennos6, Thomas Phillips2 and Brian Feldman1, 1The Hospital for Sick Children, Toronto, ON, Canada, 2Duke University, Durham, 3Duke University Medical Center, Durham, 4University of Alabama at Birmingham, Birmingham, AL, 5University of Minnesota, Minneapolis, MN, 6Duke University, Durham, NC

    Background/Purpose: Different dosing strategies of adalimumab and etanercept have been used over the past decade in the treatment of juvenile idiopathic arthritis (JIA). With regards…
  • Abstract Number: 0711 • ACR Convergence 2020

    Alternative Dosing of Biologic Therapies Is Frequent Among Children with Juvenile Idiopathic Arthritis in the Childhood Arthritis and Rheumatology Research Alliance Registry

    Colleen Correll1, Peter Shrader2, Anne Dennos3, Thomas Phillips2, Natalie Shiff4, Ruud Verstegen5 and Timothy Beukelman6, 1University of Minnesota, Minneapolis, MN, 2Duke University, Durham, 3Duke University, Durham, NC, 4Florida, Gainesville, FL, 5The Hospital for Sick Children, Toronto, ON, Canada, 6University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: Biologic agents are integral to the treatment of juvenile idiopathic arthritis (JIA) and associated uveitis. Pediatric rheumatologists may increase the dosage of biologics beyond…
  • Abstract Number: 0719 • ACR Convergence 2020

    Anti-adalimumab Antibodies Detection Using a Novel Peptide-based Assay in a Cohort of Pediatric Patients with Chronic Rheumatic Disorders: A Pilot Study

    Edoardo Marrani1, Hendrik Rusche2, Francesco Terzani3, Elisa Peroni4, Feliciana Real-Fernandez5, Olivier Monasson4, Roberta Ponti6, Gabriele Simonini7, Anna Maria Papini3 and Paolo Rovero5, 1University of Florence, Firenze, Italy, 2Peptlab@CY and Laboratory of Chemical Biology, Cergy-Paris University, Cergy-Pontoise,, France, 3PeptLab, Dep. Chemistry, University of Florence, Sesto FIorentino, Italy, 4Peptlab@CY and Laboratory of Chemical Biology, Cergy-Paris University, cergy-pontoise, France, 5PeptLab, Dep. NEUROFARBA, University of Florence, Firenze, Italy, 6Pediatric Department, University of Udine, udine, Italy, 7Rheumatology Unit, Meyer Children's University Hospital, Florence; NEUROFARBA Department, University of Florence, Italy, Florence, Italy

    Background/Purpose: Immunogenicity and development of anti-drug antibodies have been associated with treatment failure and adverse events during biologic treatment. Anti-drug antibodies (ADAs) have been reported…
  • Abstract Number: 0714 • ACR Convergence 2020

    Response to Abatacept in JIA Categories: Results from the PRCSG/PRINTO JIA Abatacept Phase IV Registry

    Daniel J Lovell1, Nikolay Tzaribachev2, Esi Morgan3, Gabriele Simonini4, Thomas Griffin5, Ekaterina Alexeeva6, John Bohnsack7, Andrew Zeft8, Gerd Horneff9, Richard Vehe10, Valda Stanevicha11, Stacey Tarvin12, Maria Trachana13, Adam Huber14, Daniel Kietz15, Ilonka Orban16, Jason Dare17, Ivan Foeldvari18, Pierre Quartier19, Alyssa Dominique20, Tzuyung Douglas Kou20, Robert Wong20, Alberto Martini21, Hermine Brunner3 and Nicolino Ruperto22, 1PRCSG, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2Pediatric Rheumatology Research Institute, Bad Bramstedt, Germany, 3Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 4Anna Meyer Children's Hospital, Firenze, Italy, 5Levine Children's Hospital, Charlotte, NC, 6Scientific Center of Children’s Health of RAMS, Moscow, Russia, 7University of Utah and Primary Children's Hospital, Cincinnati, OH, 8Cleveland Clinic, Cleveland, OH, 9Asklepios Clinic Sankt Augustin, Sankt Augustin, Germany, 10University of Minnesota, Minneapolis, MN, 11Riga Stradins University, Riga, Latvia, 12Riley Children’s Health, Indianapolis, IN, 13Aristotle University of Thessaloniki, Thessaloníki, Greece, 14Dalhousie University, Halifax, NS, Canada, 15Children’s Hospital of Pittsburgh, Pittsburgh, PA, 16National Institute of Rheumatology and Physiotherapy, Budapest, Hungary, 17University of Arkansas for Medical Sciences, Little Rock, AR, 18Hamburg Centre for Pediatric and Adolescent Rheumatology, Hamburg, Germany, 19Necker-Enfants Malades University Hospital, Assistance Publique-Hopitaux de Paris, Paris, France, 20Bristol-Myers Squibb Company, Princeton, NJ, 21PRINTO, Istituto Giannina Gaslini, Genova, Italy, 22Istituto Giannina Gaslini, Genova, Italy

    Background/Purpose: Abatacept, a selective T-cell co-stimulation modulator, has been demonstrated to be well tolerated and effective in JIA in 2 Phase III studies.1,2 The ongoing…
  • Abstract Number: 0606 • ACR Convergence 2020

    A Systematic Review Exploring Pre-COVID-19 Telehealthcare Models Used in the Management of Patients with Rheumatological Disease

    Alexandra Nelson1 and Marina Anderson2, 1University of Liverpool, Liverpool, United Kingdom, 2Lancaster University, Lancaster, United Kingdom

    Background/Purpose: Recent advancements in the delivery and utilization of information and communication technologies (ICTs) have led to an increased application of telehealthcare services. Global coronavirus…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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