ACR Meeting Abstracts

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  • Abstract Number: 0448 • ACR Convergence 2020

    Disease-related factors associated to atherosclerotic disease in axial spondyloarthritis. A mutlicenter study with 806 patients.

    Inigo Gonzalez-Mazon1, Ivan Ferraz-Amaro2, Javier Rueda-Gotor3, Lara Sanchez-Bilbao4, David Martinez-Lopez5, Mario Agudo-Bilbao3, Fernanda Genre6, Sara Remuzgo-Martínez6, Veronica Pulito-Cueto6, Alfonso Corrales7, Leticia Lera-Gómez6, Virginia Portilla6, Vanesa Calvo-Río3, Cristina Mata8, Vanesa Hernández-Hernández9, Santos Castañeda10, Esther Francisca Vicente-Rabaneda11, C Fernandez-Carballido12, M Paz Martínez-Vidal13, David Castro-Corredor14, Joaquín Anino-Fernández14, Juan Carlos Quevedo-Abeledo15, Carlos Rodríguez-Lozano16, C. Fernandez-Diaz17, Esther Montes-Perez18, María Luz García Vivar,19, Eva Galínez-Agirregoikoa19, Javier Llorca20, Raquel López-Mejías6, Chamaida Plasencia21, Diana Peiteado22, Alejandro Balsa-Criado23, Nuria Barbarroja24, Lourdes Ladehesa-Pineda25, Rafaela Ortega-Castro26, Eduardo Collantes-Estévez25, Ricardo Blanco4 and Miguel Ángel González-Gay27, 1Hospital Universitario Marques de Valdecilla, Bezana, Spain, 2Division of Rheumatology. Hospital Universitario de Canarias. Spain., Santa Cruz de Tenerife, Spain, 3H.U. Marques de Valdecilla, Santander, Spain, 4Hospital Universitario Marques de Valdecilla, Santander, Spain, 5Hospital Universitario Marques de Valdecilla, Santander (SPAIN), Spain, 6Research group on Genetic Epidemiology and Atherosclerosis in Systemic Diseases and in Metabolic bone Diseases of the Musculoskeletal System, IDIVAL, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain, 7Research group on genetic epidemiology and atherosclerosis in systemic diseases and in metabolic bone diseases of the musculoskeletal system, IDIVAL; and Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander, Spain, 8Hospital de Laredo, Santander, Spain, 9Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain, 10Princesa University Hospital, Universidad Autónoma, Madrid, Madrid, Spain, 11Hospital Universitario de la Princesa, IIS-Princesa, UAM, Madrid, Madrid, Spain, 12H San Juan, Alicante, Spain, 13Hospital General Universitario de Alicante, Alicante, Spain, 14Hospital General Universitario de Ciudad Real, Ciudad Real, Spain, 15Hospital Dr. Negrín, Las Palmas de Gran Canaria, Spain, 16Hospital Universitario de Gran Canaria Dr. Negrín, Las Palmas de Gran Canaria, Spain, 17H. Marqués de Valdecilla, Madrid, Spain, 18Diagnóstico Médico Cantabria (DMC), Santander, Spain, 19Hospital Universitario Basurto, Bilbao, Spain, 20School of Medicine, University of Cantabria, and CIBER Epidemiología y Salud Pública (CIBERESP), Santander, Spain, 21Rheumatology, La Paz University Hospital-IdiPAZ, madrid, Spain, 22Hospital Universitario La Paz-IdiPaz, Madrid, Spain, 23HOSPITAL UNIVERSITARIO LA PAZ, madrid, Spain, 24Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, Cordoba, Spain, 25Rheumatology Department, Reina Sofia University Hospital/ Maimonides Institute for Research in Biomedicine of Cordoba (IMIBIC)/ University of Cordoba, Cordoba, Spain, Córdoba, Spain, 26Hospital Universitario Reina Sofía, Córdoba, Spain, 27Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain

    Background/Purpose: Cardiovascular (CV) mortality and morbidity is increased in ankylosing spondylitits (AS) due to a process of accelerated atherosclerosis. The disease-related factors involved in this…
  • Abstract Number: 0443 • ACR Convergence 2020

    Impact of the COVID-19 Pandemic on Racial and Ethnic Minority Groups Diagnosed with Rheumatic Diseases

    Emily Sirotich1, Teresa Semalulu1, Kevin Kennedy2, Salman Surangiwala3, Maggie Larche1, Jean Liew4, Mitchell Levine2, Graeme Reed5, Naira Ikram6, Carly Harrison7, Richard Howard8, Rashmi Sinha9, Monique Gore-Massy10 and Jonathan Hausmann11, 1McMaster University, Hamilton, ON, Canada, 2McMaster University, Hamilton, Canada, 3Queen’s School of Medicine, Kingston, Canada, 4University of Washington, Seattle, 5Canadian Spondylitis Association, Vancouver, Canada, 6Duke University, Durham, 7Lupus Chat, NA, 8Spondylitis Association of America, Van Nuys, CA, 9SJIA Foundation, Cincinnati, 10Lupus Foundation of America, Brooklyn, NY, 11Boston Children's Hospital / Beth Israel Deaconess Medical Center, Cambridge, MA

    Background/Purpose: The COVID-19 pandemic has exacerbated structural and systematic barriers in access to healthcare for racial and ethnic minorities. The impact of these increased barriers…
  • Abstract Number: 0457 • ACR Convergence 2020

    Improving Pneumococcal Vaccination Rates in Immunosuppressed Rheumatology Patients

    Julia Harris1, Michael Holland2, Emily Fox2, Amy Ivy3, Maria Ibarra2, Cara Hoffart2, Jordan Jones2, Leslie Favier4 and Ashley Cooper2, 1Children's Mercy Kansas City, Overland Park, KS, 2Children's Mercy Kansas City, Kansas City, MO, 3Children's Mercy Kansas City, Kansas City, 4Children's Mercy Kansas City, Leawood, KS

    Background/Purpose: The Centers for Disease Control and Prevention recommends pneumococcal vaccination of high-risk patients, including patients on iatrogenic immunosuppression. Many patients seen in the rheumatology…
  • Abstract Number: 0456 • ACR Convergence 2020

    Reduced Risk of Serious Pneumococcal Infection up to 10 Years After Immunization with 7-valent Conjugated Pneumococcal Vaccine in Patients with Inflammatory Arthritis

    Johanna Nagel1, Göran Jönsson2, Jan Åke Nilsson3, Chanchai Manuswin4, Martin Englund5, Tore Saxne1, Pierre Geborek1 and Meliha Kapetanovic1, 1Lund University, Skåne University Hospital, Department of Clinical Sciences Lund, Rheumatology, Lund, Sweden, Lund, Sweden, 2Lund University, Skåne University Hospital, Department of Clinical Sciences Lund, Infection Medicine, Lund, Sweden, Lund, Sweden, 3Rheumatology, Department of Clinical Sciences, Malmö, Lund University. Department of Rheumatology, Skåne University Hospital, Malmö and Lund, Sweden, Malmö, Sweden, 4Centre of Registers South, Skåne University Hospital, Lund, Sweden, Lund, Sweden, 5Lund University, Lund, Sweden

    Background/Purpose: The aim was to examine the rates of putative pneumococcal infections up to 10 years before and after administration of heptavalent conjugated pneumococcal vaccine…
  • Abstract Number: 0462 • ACR Convergence 2020

    Lupus-like Autoimmunity and Increased Interferon Response in Patients with STAT3-deficient Hyper-IgE Syndrome

    Brian Dizon1, Rishi Goel2, Shuichiro Nakabo2, Amanda Urban2, Meryl Waldman2, Lilian Howard2, Dirk Darnell2, Munir Buhaya2, Sarfaraz Hasni3, Mariana Kaplan4, Alexandra Freeman2 and Sarthak Gupta1, 1National Institutes of Health, BETHESDA, MD, 2National Institutes of Health, Bethesda, 3Lupus Clinical Trials Unit, NIAMS/NIH, Bethesda, MD, 4National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD

    Background/Purpose: Autosomal dominant hyper-IgE syndrome (AD-HIES), also known as Job’s syndrome, is a rare primary immunodeficiency caused by dominant-negative loss-of-function (LOF) mutations in signal transducer…
  • Abstract Number: 0461 • ACR Convergence 2020

    High-Throughput Single-Cell Analysis Reveals Unique Lung Cellular Subsets in a Murine Model of Rheumatoid Arthritis-Inflammatory Lung Disease

    Rohit Gaurav1, Ted Mikuls1, Geoffrey Thiele1, Amy Nelson1, Meng Niu1, Chittibabu Guda1, James Eudy1, Austin Barry1, Debra Romberger1, Michael Duryee1, Bryant England1 and Jill Poole1, 1University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Rheumatoid arthritis (RA)-associated inflammatory lung disease is an extra-articular manifestation of RA associated with increased morbidity and mortality, whose precise molecular mechanisms remain undetermined.…
  • Abstract Number: 0467 • ACR Convergence 2020

    Incidence of COVID-19 in Patients Treated with Infliximab Compared to Patients Treated with Rituximab

    Cathy Melong Pianta1, Kim Lauper1, Delphine Courvoisier1, Tim Cunningham2, Daniéle Allali3 and Axel Finckh4, 1Division of rheumatology, Geneva University Hospitals, Geneva, Switzerland, 2Private practice, Geneva, Geneva, Switzerland, 3Division of immunology, Geneva University Hospitals, Geneva, 4Division of Rheumatology, University Hospitals of Geneva, Geneva, Switzerland

    Background/Purpose: The prevalence of anti-SARS-CoV-2 IgG infection was estimated at 9.7% in the Geneva population end of April 2020. (1) Immunosuppressed patients may be at…
  • Abstract Number: 0469 • ACR Convergence 2020

    IFNγ Is Essential for Alveolar Macrophage Driven Lung Inflammation in Macrophage Activation Syndrome

    Denny Gao1, Maggie Henderlight1, Christopher Woods1, Alexei Grom1, Sherry Thornton1, Michael Jordan1, Katheryn Wikenheiser-Brokamp1 and Grant Schulert2, 1Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 2PRCSG, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH

    Background/Purpose: Macrophage activation syndrome (MAS) is a life-threatening cytokine storm syndrome frequently complicating systemic juvenile idiopathic arthritis (SJIA) and driven by IFNγ. MAS is also…
  • Abstract Number: 0464 • ACR Convergence 2020

    Assessment of the COVID-19 Pandemic from the Perspective of People with Rheumatic Musculoskeletal Diseases in Europe. Preliminary Results from the REUMAVID Study

    Marco Garrido-Cumbrera1, Helena Marzo-Ortega2, José Correa-Fernández3, Sergio Sanz-Gomez4, Laura Christen5 and Victoria Navarro-Compán6, 1Health & Territory Research (HTR), Universidad de Sevilla / Spanish Federation of Spondyloarthritis Associations, Sevilla, Spain, 2The University of Leeds, Leeds Institute for Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, Leeds Teaching Hospitals Trust, Leeds, UK, Leeds, United Kingdom, 3Health & Territory Research (HTR), Universidad de Sevilla, Sevilla, Spain, 4Health & Territory Research, Seville, Spain, 5Novartis Pharma AG, Basel, Switzerland, 6Hospital Universitario La Paz IdiPaz, Madrid, Pais Vasco, Spain

    Background/Purpose: The COVID-19 pandemic is an unprecedented public health crisis affecting people worldwide, including those with rheumatic and musculoskeletal diseases (RMDS).  REUMAVID aims to assess…
  • Abstract Number: 0459 • ACR Convergence 2020

    Autologous Hematopoietic Stem Cell Transplantation for Behçet’s Disease: A Retrospective Survey of Patients Treated in Europe, on the Behalf of the Autoimmune Diseases Working Party of the European Society for Blood and Bone Marrow Transplantation

    Mathieu Puyade1, Patel Amit2, Yeong Jer Lim3, Norbert Blank4, Manuela Badoglio5, Francesca Gualandi6, David D Ma7, Raffaella Greco8, Natalia Maximova9, Tobias Alexander10 and John A Snowden11, 1Service de Médecine Interne et Maladies Infectieuses ,CIC-1402 Centre Hospitalier Universitaire de Poitiers, Poitiers, France, 2The Christie NHS Foundation Trust, Manchester, United Kingdom, 3University of Liverpool, Liverpool, United Kingdom, 4Department of Hematology, Oncology and Rheumatology, Internal Medicine V, University Hospital of Heidelberg, Eppelheim, Germany, 5EBMT ADWP Office, Paris, France, 6U.O. EMATOLOGIA Centro Trapianti Midollo - OSPEDALE POLICLINICO SAN MARTINO, GENOVA, Italy, 7Department of Haematology and BM Transplantation, St Vincent’s Hospital Sydney and St Vincent’s Clinical School, Faculty of Medicine, Sidney, New South Wales, Australia, 8Ematologia Trapianto Midollo San Raffaele, Milano, Italy, 9Institute for Maternal and Child Health – IRCCS Burlo Garofolo, Trieste, Italy, 10Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Department of Rheumatology and Clinical Immunology, Berlin, Deutsches Rheuma-Forschungszentrum, Berlin, Germany, 11Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom

    Background/Purpose: Behçet’s Disease (BD) is a rare autoimmune disease mostly presenting with recurrent oral and genital aphtosis, ulcers, and uveitis. Rare patients are refractory to…
  • Abstract Number: 0472 • ACR Convergence 2020

    ApoB:ApoA1 Ratio Could Predict Atherosclerotic Risk in Juvenile-SLE Patients Associated with Altered Interferon Signalling in CD8+ T-cells

    George Robinson1, Kirsty Waddington2, Leda Coelewij2, Junjie Peng2, Meena Naja2, Chris Wincup2, Anna Radziszewska2, Hannah Peckham2, David Isenberg2, Yiannis Ioannou2, Ines Pineda Torra2, Coziana Ciurtin2 and Elizabeth Jury2, 1University College London, Hertford, United Kingdom, 2University College London, London, United Kingdom

    Background/Purpose: Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disease characterised by immune-dysregulation, chronic inflammation, type-I interferon (IFN) signatures and increased cardiovascular disease (CVD) risk…
  • Abstract Number: 0475 • ACR Convergence 2020

    To Attend or Note to Attend; The Medical Student’s Dilemma

    Benjamin Widener1, Amy Cannella1 and Sarah McBrien1, 1University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: We present a comparison of student’s outcomes with remote video-based learning versus lecture attendance in pre-clinical medical students during a musculoskeletal curriculum, thus allowing…
  • Abstract Number: 0476 • ACR Convergence 2020

    Using Consensus Building to Guide Rheumatology Curriculum Development for Internal Medicine Residents

    Sarah Goglin1 and Jennifer Babik2, 1University of California San Francisco, Burlingame, CA, 2University of California San Francisco, San Francisco, CA

    Background/Purpose: In spite of the increasing burden of rheumatic diseases in the United States, many patients have limited access to rheumatologists. As a result, internists…
  • Abstract Number: 0471 • ACR Convergence 2020

    Splice Site Variants in IKBKG, Encoding NEMO, Detected by a Customized Analysis of Next-Generation Sequencing Data Cause an Early-onset Autoinflammatory Syndrome of Panniculitis and Cytopenias in Male and Female Patients

    Adriana de Jesus1, Sofia Torreggiani2, Bin Lin2, Jacob Mitchell2, Eric Karlins3, Andrew Oler3, Sara Alehashemi4, Dana Kahle5, Katelin R. Honer2, Gema Souto Adeva2, Eric Hanson6, Gina Montealegre Sanchez7, Amer Khojah8, Timothy Moran9, Eveline Wu9, Chris Scott10, Timothy Ronan Leahy11, Emma Jane MacDermott11, Orla Killeen12, Thaschawee Arkachaisri13, Zoran Gucev14, Kathryn Phillippi15, Vafa Mammadova16, Gulnara Nasrullayeva16 and Raphaela Goldbach-Mansky17, 1Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Silver Spring, MD, 2Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Bethesda, MD, 3Bioinformatics and Computational Biosciences Branch/NIAID/NIH, Bethesda, MD, 4Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Clarksville, MD, 5Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Bethesda, 6Indiana University School of Medicine, Indianapolis, IN, 7NIAID/NIH, Rockville, MD, 8Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 9UNC Chapel Hill, Chapel Hill, NC, 10University of Cape Town, Cape Town, South Africa, 11Our Lady's Children's Hospital, Dublin, Ireland, 12National Centre for Paediatric Rheumatology, CHI at Crumlin, Dublin, Ireland, 13Duke-NUS Medical School, Singapore, Singapore, 14University Children's Hospital, Medical Faculty Skopje, Skopje, Macedonia, 15Akron Children’s Hospital, Akron, OH, 16Azerbaijan Medical University, Baku, Azerbaijan, 17Translational Autoinflammatory Disease Section (TADS)/NIAID/NIH, Potomac, MD

    Background/Purpose: The Inhibitor of Kappa-B Kinase Regulatory Subunit Gamma (IKBKG) is located on the X chromosome and encodes the NF-κB essential modulator (NEMO). Loss-of-function mutations…
  • Abstract Number: 0479 • ACR Convergence 2020

    Early DAS Response After DMARD-start Increases Probability of Achieving Sustained DMARD-free Remission in Rheumatoid Arthritis

    Marloes Verstappen1, Ellis Niemantsverdriet2, Xanthe Matthijssen2, Saskia le Cessie2 and Annette van der Helm - van Mil3, 1Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands, 2Leiden University Medical Center, Leiden, Netherlands, 3Leiden University Medical Center, Erasmus Medical Center, Leiden, Netherlands

    Background/Purpose: Sustained DMARD-free remission (SDFR) is increasingly achievable. The pathogenesis underlying SDFR-development is unknown and patient-characteristics at diagnosis poorly explain whether SDFR will be achieved.…
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