ACR Meeting Abstracts

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  • Abstract Number: 1633 • ACR Convergence 2022

    Genetic Risk, Adherence to a Healthy Lifestyle, and Incident Gout in US Women and Men

    Kehuan Lin1, Natalie McCormick1, Leo Lu2, amit johi3, Chio Yokose4 and Hyon Choi5, 1Massachusetts General Hospital, Boston, MA, 2Arthritis Research Canada, Vancouver, BC, Canada, 3Regeneron, Boston, MA, 4Massachusetts General Hospital, Waltham, MA, 5MASSACHUSETTS GENERAL HOSPITAL, Lexington, MA

    Background/Purpose: Lifestyle and genetic factors have been independently related to incident gout risk. However, it remains unknown whether the genetic risk of gout is affected…
  • Abstract Number: 1638 • ACR Convergence 2022

    Epidemiology of Rheumatoid Arthritis and Rheumatoid Arthritis-Interstitial Lung Disease in the Veterans Health Administration from 2004 to 2018

    Benjamin Fletcher1, Punyasha Roul2, Yangyuna Yang3, Brian Sauer4, Jorge Rojas5, Grant Cannon6, Joshua Baker7, Ted Mikuls8 and Bryant England3, 1University of Nebraska Medical Center, Omaha, 2UNMC, Omaha, NE, 3University of Nebraska Medical Center, Omaha, NE, 4Salt Lake City VA/University of Utah, Salt Lake City, UT, 5George E. Wahlen Department of Veterans Affairs Salt Lake City Health Care System, Salt Lake City, UT, 6Salt Lake City VA, Salt Lake city, 7University of Pennsylvania and Corporal Michael J. Crescenz VA Medical Center, Philadelphia, 8Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Epidemiologic studies estimating RA prevalence and incidence have primarily been conducted in populations where the majority of RA patients are women. Because of phenotypic…
  • Abstract Number: 1637 • ACR Convergence 2022

    Association of Dermatomyositis with Cardiovascular Disease: A Case-Control Study in the All of Us Research Program

    Jill Shah1, Keya Shah2, Daniel Mazori1, Avrom Caplan1, Emily Hejazi1 and Alisa Femia1, 1Ronald O. Perelman Department of Dermatology, New York University Langone Health, New York, NY, 2Department of Medicine, NYU Langone Hospital - Long Island, Mineola, NY

    Background/Purpose: Previous studies on the association of dermatomyositis (DM) with cardiovascular (CV) disease have used combined idiopathic inflammatory myositis cohorts, included only non-United States (US)…
  • Abstract Number: 1639 • ACR Convergence 2022

    A Phase 3, 56-Week, Multicenter, Randomized, Double-Blind, Placebo Controlled Trial (OA-11) to Evaluate the Efficacy and Safety of a Single Injection of Lorecivivint Injected in the Target Knee Joint of Moderate to Severe Osteoarthritis Participants

    Yusuf Yazici1, Christopher Swearingen2, Heli Ghandehari3, Jon Britt4, ismail simsek5, Mark Fineman6, Sarah Kennedy2, Jeyanesh Tambiah7 and Timothy McAlindon8, 1New York University School of Medicine, La Jolla, CA, 2Biosplice Therapeutics, Inc, San Diego, CA, 3Biosplice Therapeutics, Inc., San Diego, CA, 4Biosplice Therapeutics, Inc., Los Angeles, CA, 5Alpine Immunesciences, San Diego, CA, 6Biosplice Therapeutics, San Diego, CA, 7Biosplice Ther Inc., San Diego, CA, 8Tufts Medical Center, Arlington, MA

    Background/Purpose: Knee osteoarthritis (OA) is a common joint disorder associated with pain, disability, and joint damage. There remains a large unmet need for treatments that…
  • Abstract Number: 1636 • ACR Convergence 2022

    Long-term Renal Survival of Patients with LN by Renal Response Status in the Toronto Lupus Cohort

    Murray Urowitz1, Mary E. Georgiou2, Jiandong Su3, Anne MacKinnon3, Yulia Green4, Kerry Gairy2, Roger A Levy5 and Patricia C. Juliao6, 1University of Toronto, University Health Network, Schroeder Arthritis Institute, Toronto, ON, Canada, 2GlaxoSmithKline, Value Evidence and Outcomes, Brentford, United Kingdom, 3University of Toronto Lupus Program, Schroeder Arthritis Institute, University Health Network, Division of Rheumatology, Toronto, ON, Canada, 4GlaxoSmithKline, Clinical Development, Brentford, United Kingdom, 5GlaxoSmithKline, Global Medical Affairs, Collegeville, PA, 6GlaxoSmithKline, Value Evidence and Outcomes, Collegeville, PA

    Background/Purpose: Approximately 40% of adult patients with SLE develop LN, which can lead to end-stage kidney disease (ESKD).1 Renal response is used in clinical trials…
  • Abstract Number: 1618 • ACR Convergence 2022

    Combined Orbital and Cranial Vessel Wall MRI for Diagnosis and Longitudinal Monitoring of Giant Cell Arteritis

    Rennie Rhee, Shubhasree Banerjee, Vatsal Bhatt, Madhura Tamhankar, Quy Cao, Naomi Amudala, Sherry Chou, Morgan Burke, Laurie Loevner, Peter Merkel and Jae Song, University of Pennsylvania, Philadelphia, PA

    Background/Purpose: In giant cell arteritis (GCA), there is a critical need to identify patients at risk for vision loss ("ocular GCA"). MRI evaluates neurovascular anatomy…
  • Abstract Number: 1643 • ACR Convergence 2022

    Use of Oral Analgesics and Risk of Comorbidities in Osteoarthritis: Findings from Primary Care Settings in the UK

    Subhashisa Swain1, Carol Coupland2, Anne Kamps3, Jos Runhaar4, Andrea Dell ‘Isola5, Aleksandra Turkiewicz5, Danielle E Robinson1, Victoria Y Strauss1, Christian Mallen6, Chang-Fu Kuo7, Aliya Sarmanova8, Daniel Prieto Alhambra1, Martin Englund5, Sita Bierma-Zeinstra3, Michael Doherty2 and Weiya Zhang2, 1University of Oxford, Oxford, United Kingdom, 2University of Nottingham, Nottingham, United Kingdom, 3Erasmus University Medical Centre, Rotterdam, Netherlands, 4Erasmus Medical Center, Rotterdam, Netherlands, 5Lund University, Lund, Sweden, 6Keele University, Keele, United Kingdom, 7Chang Gung Memorial Hospital, Taoyuan, Taiwan, 8University of Bristol, Bristol, United Kingdom

    Background/Purpose: People with osteoarthritis (OA) often have multiple other conditions (comorbidities).Role of different oral analgesics on the development of comorbidities in people with OA have…
  • Abstract Number: 1644 • ACR Convergence 2022

    Effect of a Lifestyle Program Based on a Whole Food Plant-based Diet, Physical Activity, and Stress Management in Patients with Metabolic Syndrome-Associated Osteoarthritis: A Randomized Controlled Trial

    Wendy Walrabenstein1, Carlijn Wagenaar1, Marike van der Leeden2, Martijn Gerritsen1, Martin van der Esch1 and Dirkjan van Schaardenburg2, 1Reade Rheumatology Center, Amsterdam, Netherlands, 2Amsterdam UMC, Amsterdam, Netherlands

    Background/Purpose: Metabolic syndrome with low grade inflammation is associated with chronic diseases including osteoarthritis (OA) (1). A combination of an intensive diet with exercise produced…
  • Abstract Number: 1646 • ACR Convergence 2022

    Major Adverse Cardiovascular Events and Mortality with Opioids versus NSAIDs Initiation in Patients with Rheumatoid Arthritis

    Gulsen Ozen1, Sofia Pedro2 and Kaleb Michaud3, 1University of Nebraska Medical Center, Bellevue, NE, 2Forward, The National Databank for Rheumatic Diseases, Wichita, KS, 3University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: Pain management is challenging in RA where ~60% of patients with well-controlled disease activity still experience bothersome pain. The opioid epidemic in the US…
  • Abstract Number: 1647 • ACR Convergence 2022

    Increased Risk of Lung Cancer in Rheumatoid Arthritis and Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Matched Cohort Study with Cancer Registry Linkage

    Rebecca Brooks1, Yangyuna Yang1, Punyasha Roul2, Brent Luedders1, Namrata Singh3, Brian Sauer4, Grant Cannon5, Joshua Baker6, Ted Mikuls7 and Bryant England1, 1University of Nebraska Medical Center, Omaha, NE, 2UNMC, Omaha, NE, 3University of Washington, Bellevue, WA, 4Salt Lake City VA/University of Utah, Salt Lake City, UT, 5Retired, Salt Lake City, UT, 6University of Pennsylvania, Philadelphia, PA, 7Division of Rheumatology, University of Nebraska Medical Center, Omaha, NE

    Background/Purpose: While patients with RA are predisposed to developing lung cancer, prior epidemiologic studies have been limited in their ability to account for potential confounders…
  • Abstract Number: 1649 • ACR Convergence 2022

    Five-Year Cardiovascular Event Risk in Early Rheumatoid Arthritis Patients Who Received Treat-to-Target Management

    Lai-shan Tam1, Tsz On Lam2 and Man Choi Wan3, 1The Chinese University of Hong Kong, Hong Kong, China, 2Prince of Wales Hospital, Hong Kong, Hong Kong, 3Ruttonjee Hospital, Hong Kong, Hong Kong, Hong Kong

    Background/Purpose: Rheumatoid arthritis (RA) is known to cause increased risk of cardiovascular (CV) disease (CVD) due to the underlying inflammation. The year of 2010 revolutionised…
  • Abstract Number: 1648 • ACR Convergence 2022

    Risk of Vascular Events Under the Treatments with Janus Kinase Inhibitors in Patients with Rheumatoid Arthritis: An Analysis Using Japanese Health Insurance Database

    Eiichi Tanaka1, Ryoko Sakai2, Eisuke Inoue3 and Masayoshi Harigai1, 1Division of Rheumatology, Department of Internal Medicine, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan, 2Meiji Pharmaceutical University, Tokyo, Japan, 3Research Administration Center, Showa University, Shinagawa-ku, Japan

    Background/Purpose: Janus kinase inhibitors (JAKIs) have shown positive therapeutic impacts on treatments for rheumatoid arthritis (RA), whereas, concerns have been raised about the risk of…
  • Abstract Number: 1641 • ACR Convergence 2022

    Determination and Characterization of Patient Subgroups with Different Pain Progression in Hand Osteoarthritis

    Coen van der Meulen1, Lotte van de Stadt1, Frits Rosendaal1, Jos Runhaar2 and Margreet Kloppenburg1, 1Leiden university medical center, Leiden, Netherlands, 2Erasmus Medical Center, Rotterdam, Netherlands

    Background/Purpose: Pain is central to hand osteoarthritis (OA). Previous studies reported stable mean pain levels on the short to midterm. Subgroups with different pain trajectories…
  • Abstract Number: 1476 • ACR Convergence 2022

    Anti-Neutrophil Extracellular Traps (NET) Antibodies and Their Association with Disease Activity and Clinical Phenotypes in Systemic Lupus Erythematosus

    Rosa Arvizu-Rivera1, jiram torres-Ruiz2, Alfredo Pérez-Fragoso2, Beatriz Alcalá-Carmona3, Miroslava Nuñez-Aguirre4, Ana Sofía Vargas-Castro4, Abdiel Absalón-Aguilar3, Jaquelin Lira-Luna4 and Diana Gómez-Martín2, 1Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de México, Mexico, 2INCMNSZ, Ciudad de México, Mexico, 3Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, Mexico, 4Instituto Nacional de Ciencias Medicas y Nutricion "Salvador Zubiran", Ciudad de México, Mexico

    Background/Purpose: Enhanced netosis has been acknowledged as pathogenic in Systemic Lupus Erythematosus (SLE). The presence of antibodies against neutrophil extracellular traps (anti-NETs) in patients with…
  • Abstract Number: 1656 • ACR Convergence 2022

    Efficacy and Safety of Cenerimod in Patients with Moderate to Severe Systemic Lupus Erythematosus (SLE): A Multicenter, Randomized, Parallel-Group, Double-Blind, Placebo-Controlled, Dose-Finding Phase 2b Trial

    Anca Askanase1, Ouali Berkani2, clélia Cahuzac3, peter Cornelisse3, David D'Cruz4, Kenneth Kalunian5, Joan Merrill6, Marilia Pozzobon3 and Sandra Navarra7, 1Columbia University Medical Center, New York, NY, 2IDORSIA, Allschwil, Switzerland, 3Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland, 4Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom, 5University of California San Diego, La Jolla, CA, 6Oklahoma Medical Research Foundation, Oklahoma City, OK, 7University of Santo Tomas, Manila, Philippines

    Background/Purpose: Sphingosine-1-phosphate (S1P) regulates lymphocyte egress from lymphoid organs. In an SLE proof-of-concept study, cenerimod—a potent, selective S1P receptor modulator—reduced lymphocyte count and disease activity…
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Embargo Policy

All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

Accepted abstracts are made available to the public online in advance of the meeting and are published in a special online supplement of our scientific journal, Arthritis & Rheumatology. Information contained in those abstracts may not be released until the abstracts appear online. In an exception to the media embargo, academic institutions, private organizations, and companies with products whose value may be influenced by information contained in an abstract may issue a press release to coincide with the availability of an ACR abstract on the ACR website. However, the ACR continues to require that information that goes beyond that contained in the abstract (e.g., discussion of the abstract done as part of editorial news coverage) is under media embargo until 10:00 AM CT on October 25. Journalists with access to embargoed information cannot release articles or editorial news coverage before this time. Editorial news coverage is considered original articles/videos developed by employed journalists to report facts, commentary, and subject matter expert quotes in a narrative form using a variety of sources (e.g., research, announcements, press releases, events, etc.).

Violation of this policy may result in the abstract being withdrawn from the meeting and other measures deemed appropriate. Authors are responsible for notifying colleagues, institutions, communications firms, and all other stakeholders related to the development or promotion of the abstract about this policy. If you have questions about the ACR abstract embargo policy, please contact ACR abstracts staff at [email protected].

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