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  • Abstract Number: 1356 • ACR Convergence 2022

    Patient-perceived Disease Burden and Self-reported Medication Adherence in Systemic Autoimmune Diseases: A Monocentric Observational Study

    Camille Mettler1, Veronique Le Guern2, Paul Legendre1, Caroline Morbieu1, Tali-Anne Swebel1, Xavier Puéchal3, Pascal Cohen3, Hicham Kardaoui1, Alexandre Moores1, Luc Mouthon3, Nathalie Costedoat-Chalumeau4 and Benjamin Terrier3, 1Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Cochin Hospital, Paris, France, 2Hôpital Cochin, Paris, France, 3National Referral Center for Rare Systemic Autoimmune Diseases, Cochin Hospital, Paris, France, 4Inserm DR Paris 5, Paris, France

    Background/Purpose: Systemic autoimmune diseases (AID) are chronic conditions with significant burden related to the disease itself, its management, and treatments. Burden refers to the workload…
  • Abstract Number: 1360 • ACR Convergence 2022

    Clinical Characteristics and Outcomes of North American Youth with Lupus Nephritis Requiring Dialysis Treated with Cyclophosphamide

    Christine Wang1, Rebecca Sadun2, Wenru Zhou3, Kristen Miller3, Claire Palmer3, Stacy P Ardoin4, Christine Bacha5, Emily Hause6, Joyce Hui-Yuen7, Nicole Ling8, Maria Pereira9, Meredith Riebschleger10, Kelly Rouster-Stevens11, Aliese Sarkissian12, Julia Shalen13, William Soulsby14, Marinka Twilt15, Eveline Wu16, Laura Lewandowski17, Scott Wenderfer18 and Jennifer Cooper19, 1Children's Hospital of Colorado/University of Colorado, Denver, CO, 2Duke University, Durham, NC, 3University of Colorado School of Medicine, Aurora, CO, 4Division of Rheumatology, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University, Columbus, OH, 5Nationwide Children's Hospital, Columbus, OH, 6University of Minnesota, Minneapolis, MN, 7Cohen Children’s Medical Center, Hofstra-Northwell School of Medicine, Feinstein Institutes for Medical Research, Queens, NY, 8UCSF, San Francisco, CA, 9Baylor College of Medicine, Houston, TX, 10University of Michigan, Ann Arbor, MI, 11Emory University/Children's Healthcare of Atlanta, Atlanta, GA, 12University of North Carolina at Chapel Hill, Chapel Hill, NC, 13Johns Hopkins University, Baltimore, MD, 14University of California, San Francisco, San Francisco, CA, 15Alberta Children's Hospital, Calgary, AB, Canada, 16University of North Carolina, Chapel Hill, NC, 17NIAMS, NIH, Bethesda, MD, 18British Columbia Children's Hospital, Vancouver, BC, Canada, 19University of Colorado/Children's Hospital Colorado, Denver, CO

    Background/Purpose: Few studies have evaluated the clinical characteristics and outcomes of youth with lupus nephritis (LN) treated with cyclophosphamide (CYC) who initially required kidney replacement…
  • Abstract Number: 1358 • ACR Convergence 2022

    Adherence to Early DMARD Strategies in Newly Diagnosed RA Patients Seen in Routine Care: Results from the Canadian Early Arthritis Cohort Study

    Yuxuan Jiang1, orit schieir2, Marie-France Valois2, Susan Bartlett3, Louis Bessette4, Gilles Boire5, Glen Hazlewood6, Carol Hitchon7, Edward Keystone8, Diane Tin9, Carter Thorne10, Vivian Bykerk11, Janet Pope12 and Canadian Early Arthritis Cohort (CATCH) Investigators13, 1Michael G DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada, 2McGill University, Montréal, QC, Canada, 3McGill University, Montreal, QC, Canada, 4Centre de l'Ostoporose et de Rhumatologie de Québec, Québec, QC, Canada, 5Universite de Sherbrooke, Sherbrooke, QC, Canada, 6University of Calgary, Calgary, AB, Canada, 7University of Manitoba, Winnipeg, MB, Canada, 8Keystone Consulting Enterprises Inc., Toronto, ON, Canada, 9The Arthritis Program Research Group, Newmarket, ON, Canada, 10Southlake Regional Health Centre, Newmarket, ON, Canada, 11Hospital for Special Surgery, New York, NY, 12University of Western Ontario, London, ON, Canada, 13The Canadian Early Arthritis Cohort (CATCH), Bowmanville, ON, Canada

    Background/Purpose: Early diagnosis coupled with early intensive treatment strategies have led to marked improvements in rheumatoid arthritis (RA) patient outcomes. Despite improved access to numerous…
  • Abstract Number: 1363 • ACR Convergence 2022

    Impact of SARS-CoV-2 on the Clinical Presentation of Juvenile Idiopathic Inflammatory Myopathies

    Jessica Perfetto1, Donna Yoo2, Carolina Tamashiro3, Megan Perron4, Natalia Vasquez Canizares5 and Dawn Wahezi6, 1The Children's Hospital at Montefiore, Division of Rheumatology, Bronx, NY, 2Albert Einstein College of Medicine, Bronx, NY, 3The Children's Hospital at Montefiore, Department of Pediatrics, Bronx, NY, 4Children's Hospital Colorado, Division of Rheumatology, Aurora, CO, 5Children's Hospital at Montefiore/ Albert Einstein College of Medicine, New York, NY, 6Children's Hospital at Montefiore, Bronx, NY

    Background/Purpose: Viruses can trigger juvenile idiopathic inflammatory myopathies (JIIM), including juvenile dermatomyositis (JDM), juvenile polymyositis (JPM), and overlap myositis. There is growing evidence that infection…
  • Abstract Number: 1362 • ACR Convergence 2022

    Validation of the 2016 ACR/EULAR Myositis Response Criteria in Juvenile Dermatomyositis (JDM) Clinical Trials and Consensus Profiles

    Hanna Kim1, Didem Saygin2, Christian Douglas3, john mcgrath3, Jesse Wilkerson3, angela Pistorio4, Ann Reed5, Chester Oddis6, Frederick Miller7, Jiří Vencovský8, Nicola Ruperto9, Rohit Aggarwal10 and Lisa G Rider7, 1Division of Rheumatology, Department of Medicine, George Washington University School of Medicine and Health Sciences; Juvenile Myositis Therapeutic and Translation Studies Unit, PTRB, NIAMS, NIH, Bethesda, MD, 2University of Chicago, Chicago, IL, 3Social and Scientific Systems, Inc., Durham, NC, 4IRCCS Istituto Giannina Gaslini, Genoa, Italy, 5Duke University School of Medicine, Durham, NC, 6University of Pittsburgh, Pittsburgh, PA, 7Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Bethesda, MD, 8Institute of Rheumatology and Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, 9IRCCS Istituto Giannina Gaslini; PRINTO, Clinica Pediatrica e Reumatologia, Genova, Italy, 10Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA

    Background/Purpose: Juvenile dermatomyositis (JDM) ACR-EULAR myositis response criteria (MRC) were developed based on absolute % changes in 6 core set measures (CSM) differentially weighted to…
  • Abstract Number: 1365 • ACR Convergence 2022

    Adverse Events Associated with Belimumab Use in Pediatric Patients: Review and Analyses of the FDA Adverse Event Reporting System Database

    Ivone Kim, Debra Ryan, Carmen Cheng and Cindy Kortepeter, Food and Drug Administration, Silver Spring, MD

    Background/Purpose: FDA approved belimumab, the first targeted biological treatment for SLE, in March 2011 for adults with active, seropositive SLE receiving standard therapy. The indicated…
  • Abstract Number: 1364 • ACR Convergence 2022

    Diffuse Juvenile Systemic Sclerosis Patients Show Distinct Organ Involvement and Have More Severe Disease in the Largest jSSc Cohort of the World. Results from the the Juvenile Scleroderma Inception Cohort

    Ivan Foeldvari1, Jens Klotsche2, Ozgur Kasapcopur3, Amra Adrovic4, Kathryn Torok5, Maria Teresa Terreri6, Ana Paula Sakamoto7, Brian Feldman8, FLAVIO SZTAJNBOK9, Valda Stanevica10, Jordi Anton11, Sindu Johnson12, Raju Khubchandani13, Ekaterina Alexeeva14, Maria Katsicas15, Sujata Sawhney16, Vanessa Smith17, Simone Appenzeller18, Tadey Avcin19, Mikhail Kostik20, Thomas Lehman21, Hana Malcova22, Edoardo Marrani23, Clare Pain24, Dieneke Schonenberg-Meinema25, Walter Alberto Sifuentes-Giraldo26, Natalia Vasquez-Canizares27, Patricia Costa Reis28, Mahesh Janarthanan29, Dana Nemcova30, Anjali Patwardhan31, Maria José Santos32, Sima Abu Alsaoud33, Cristina Battagliotti34, Lillemor Berntson35, Blanca Bica36, Jürgen Brunner36, Rolando Cimaz37, Despina Eleftheriou38, Liora Harel39, Gerd Horneff40, Daniela Kaiser41, Tilmann Kallinich42, Dragana Lazarevic43, Farzana Nuruzzaman44 and Nicola Helmus45, 1Hamburger Zentrum für Kinder- und Jugendrheumatologie, Hamburg, Germany, 2German Rheumatism Research Center, Berlin, Germany, 3Istanbul University-Cerrahpaşa, Cerrahpaşa Medical School, Istanbul, Turkey, 4Cerrahpaşa Medical School, Istanbul University, Istanbul, Turkey, 5Pediatric Rheumatology, Children's Hospital of UPMC, Pittsburgh, PA, 6Universidad Federal São Paulo, São Paulo, Brazil, 7Federal University of Sao Paulo (UNIFESP), São Paulo, Brazil, 8Division of Rheumatology, The Hospital for Sick Children; Child Health Evaluative Services, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 9UFRJ/UERJ, São Paulo, Brazil, 10Children's Clinical University Hospital, Zemgales priekšpilseta, Riga, Latvia, 11Pediatric Rheumatology, Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain, 12University of Toronto, Toronto, ON, Canada, 13SRCC Children's Hospital, Mumbai, India, 14National Medical Research Center of Children's Health, Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation,, Moscow, Russia, 15Hospital Garrahan, Buenos Aires, Argentina, 16Sir Ganga Ram Hospital, Sector 37 noida, Uttar Pradesh, India, 17Department of Rheumatology, Ghent University Hospital – Department of Internal Medicine, Ghent University, Belgium – Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC), Gent, Belgium, 18Unicamp, Campinas, São Paulo, Brazil, 19University Children's Hospital University Medical Center Ljubljana, Ljubljana, Slovenia, 20Saint-Petersburg State Pediatric Medical University, Saint Petersburg, Russia, 21Hospital for Special Surgery, New York, NY, 22Motol University Hospital, Prague, Czech Republic, 23University of Florence, Firenze, Italy, 24Alder Hey Children’s NHS Foundation Trust, Liverpool, United Kingdom, 25Emma Children’s Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands, 26Hospital Universitario Ramon y Cajal, Madrid, Spain, 27Children’s Hospital at Montefiore, Bronx, NY, 28Hospital de Santa Maria, Lisbon, Portugal, 29SRI RAMACHANDRA INSTITUTE OF HIGHER EDUCATION AND RESEARCH, Chennai, India, 30Charles University, Prague, Czech Republic, 31University of Missouri, Columbia, MO, 32Hospital Garcia de Orta, Almada, Charneca da Caparica, Portugal, 33Makassed, Jerusalem, Israel, 34Hospital de Niños Dr Orlando Alassia, Santa Fe, Argentina, 35Dept. of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden, 36UNIVERSIDADE FEDERAL DO RIO DE JANEIRO, Rio de Janeiro, Brazil, 37University of Milano, Milano, Italy, 38Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, 39Schneider Children's Medical center, Tel Aviv University, Nettnja, Israel, 40Pediatrics, Asklepios Klinik Sankt Augustin GmbH, Sankt Augustin, Germany, 41Children's Hospital Lucerne, Lucerne, Switzerland, 42Charité - Universitätsmedizin Berlin, Nuremberg, Germany, 43Faculty of Medicine, University of Niš, Nis, Serbia, 44Stony Brook Children's Hospital, East Setauket, NY, 45Hamburg Centre for Pediatric and Adolescence Rheumatology, Hamburg, Germany

    Background/Purpose: Juvenile systemic sclerosis (jSSc) is an orphan disease with a prevalence of 3 in 1 000 000 children. In adult patients there are significant…
  • Abstract Number: 1367 • ACR Convergence 2022

    Patient and Physician Reported Outcomes of Juvenile Systemic Sclerosis Patients Significantly Improve over 12 Months Observation Period in the Juvenile Systemic Scleroderma Inception Cohort

    Ivan Foeldvari1, Jens Klotsche2, Ozgur Kasapcopur3, Amra Adrovic4, Kathryn Torok5, Maria Teresa Terreri6, Brian Feldman7, Jordi Anton8, Maria Katsicas9, Valda Stanevica10, FLAVIO SZTAJNBOK11, Simone Appenzeller12, Tadey Avcin13, Mikhail Kostik14, Edoardo Marrani15, Walter Alberto Sifuentes-Giraldo16, Sindu Johnson17, Raju Khubchandani18, Dana Nemcova19, Maria José Santos20, Cristina Battagliotti21, Lillemor Berntson22, Blanca Bica23, Jürgen Brunner23, Rolando Cimaz24, Despina Eleftheriou25, Liora Harel26, Gerd Horneff27, Mahesh Janarthanan28, Tilmann Kallinich29, Kirsten Minden30, Anjali Patwardhan31, Dieneke Schonenberg-Meinema32, Vanessa Smith33 and Nicola Helmus34, 1Hamburger Zentrum für Kinder- und Jugendrheumatologie, Hamburg, Germany, 2German Rheumatism Research Center, Berlin, Germany, 3Istanbul University-Cerrahpaşa, Cerrahpaşa Medical School, Istanbul, Turkey, 4Cerrahpaşa Medical School, Istanbul University, Istanbul, Turkey, 5Pediatric Rheumatology, Children's Hospital of UPMC, Pittsburgh, PA, 6Universidad Federal São Paulo, São Paulo, Brazil, 7Division of Rheumatology, The Hospital for Sick Children; Child Health Evaluative Services, SickKids Research Institute; Department of Paediatrics, University of Toronto, Toronto, ON, Canada, 8Pediatric Rheumatology, Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain, 9Hospital Garrahan, Buenos Aires, Argentina, 10Children's Clinical University Hospital, Zemgales priekšpilseta, Riga, Latvia, 11UFRJ/UERJ, São Paulo, Brazil, 12Unicamp, Campinas, São Paulo, Brazil, 13University Children's Hospital University Medical Center Ljubljana, Ljubljana, Slovenia, 14Saint-Petersburg State Pediatric Medical University, Saint Petersburg, Russia, 15University of Florence, Firenze, Italy, 16Hospital Universitario Ramon y Cajal, Madrid, Spain, 17University of Toronto, Toronto, ON, Canada, 18SRCC Children's Hospital, Mumbai, India, 19Charles University, Prague, Czech Republic, 20Hospital Garcia de Orta, Almada, Charneca da Caparica, Portugal, 21Hospital de Niños Dr Orlando Alassia, Santa Fe, Argentina, 22Dept. of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden, 23UNIVERSIDADE FEDERAL DO RIO DE JANEIRO, Rio de Janeiro, Brazil, 24University of Milano, Milano, Italy, 25Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom, 26Schneider Children's Medical center, Tel Aviv University, Nettnja, Israel, 27Pediatrics, Asklepios Klinik Sankt Augustin GmbH, Sankt Augustin, Germany, 28SRI RAMACHANDRA INSTITUTE OF HIGHER EDUCATION AND RESEARCH, Chennai, India, 29Charité - Universitätsmedizin Berlin, Nuremberg, Germany, 30Charité Universitätsmedizin Berlin, Berlin, Germany, 31University of Missouri, Columbia, MO, 32Emma Children’s Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands, 33Department of Rheumatology, Ghent University Hospital – Department of Internal Medicine, Ghent University, Belgium – Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC), Gent, Belgium, 34Hamburg Centre for Pediatric and Adolescence Rheumatology, Hamburg, Germany

    Background/Purpose: Juvenile systemic sclerosis (jSSc) is an orphan disease with a prevalence of 3 in 1 000 000 children. The Juvenile Systemic Scleroderma Inception cohort…
  • Abstract Number: 1369 • ACR Convergence 2022

    Sun Protection Use in Patients Followed in a Pediatric Rheumatology Clinic in an Urban Setting

    Tom Elena Dubov1, Dawn Wahezi2, Evin Rothschild2, Tamar Rubinstein3 and Tamara Tanner4, 1NYCH+H/Jacobi, Bronx, NY, 2Children's Hospital at Montefiore, Bronx, NY, 3Albert Einstein College of Medicine, White Plains, NY, 4Montefiore Medical Center, Bronx, NY

    Background/Purpose: Exposure to sunlight has been implicated as a major contributing factor in the pathogenesis of systemic lupus erythematosus (SLE) and juvenile dermatomyositis (JDM). Despite…
  • Abstract Number: 1370 • ACR Convergence 2022

    Abatacept in the Treatment of Refractory Juvenile Dermatomyositis

    Gulnara Mamyrova1, William Nguyen2, Hassan Awal1, Derek Jones1, Alison Ehrlich3, Kathleen Brindle4, Shahriar Haji-Momenian4, Robert Sheets5, Adeline Y. Chin6, Shajia Lu7, Massimo Gadina7, Hanna Kim8, Olcay Y. Jones9, Lisa G Rider10 and Rodolfo V Curiel1, 1Division of Rheumatology, Department of Medicine, George Washington University School of Medicine and Health Sciences, Washington, DC, 2Division of Rheumatology, Department of Medicine, George Washington University, School of Medicine and Health Sciences, Washington, DC, 3Department of Dermatology, George Washington University School of Medicine and Health Sciences, Washington, DC, 4Department of Radiology, George Washington University School of Medicine and Health Sciences, Washington, DC, 5Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of California San Diego, Rady Children's Hospital, San Diego, CA, 6Juvenile Myositis Therapeutic and Translation Studies Unit, PTRB, NIAMS, NIH, Bethesda, MD, 7Translational Immunology Section, NIAMS, NIH, Bethesda, MD, 8Division of Rheumatology, Department of Medicine, George Washington University School of Medicine and Health Sciences; Juvenile Myositis Therapeutic and Translation Studies Unit, PTRB, NIAMS, NIH, Bethesda, MD, 9Division of Rheumatology, Department of Medicine, George Washington University School of Medicine and Health Sciences; Pediatric Rheumatology, Walter Reed National Military Medical Center, Bethesda, MD, 10Environmental Autoimmunity Group, Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health, Bethesda, MD

    Background/Purpose: This open-label 24-week study was conducted to evaluate the safety and efficacy of abatacept in patients with refractory juvenile dermatomyositis (JDM).Methods: Ten patients of…
  • Abstract Number: 1330 • ACR Convergence 2022

    Impact of COVID-19 Severity on Physical Function, Mobility, Falls and Fractures Among Older Patients After Hospitalization: A Longitudinal Study

    Clara Wong1, Diego Cabrera2, Mary Geda3, Andrew Cohen3, Lauren Ferrante3, Alexandra Hajduk3 and Evelyn Hsieh2, 1Yale School of Public Health, New Haven, CT, 2Section of Rheumatology, Allergy and Immunology, Yale School of Medicine, New Haven, CT, 3Yale School of Medicine, New Haven, CT

    Background/Purpose: No longitudinal studies have examined the impact of COVID-19 or COVID-19 severity on physical function and disability outcomes among older adults. Multiple factors, including…
  • Abstract Number: 1281 • ACR Convergence 2022

    Less Than Half of Cryoglobulin Tests Ordered at a Tertiary Hospital Network Are Successfully Completed: An Opportunity for Improvement

    Joo Young (Esther) Lee1, Alexis Baass2, Sasha Bernatsky3, Evelyne Vinet2 and Arielle Mendel2, 1McGill University, Montréal, QC, Canada, 2McGill University Health Centre, Montréal, QC, Canada, 3Research Institute of the McGill University Health Centre, Montréal, QC, Canada

    Background/Purpose: Cryoglobulin detection is essential for the diagnosis of cryoglobulinemic vasculitis, a condition leading to high healthcare use, organ damage, and even death. Successful cryoglobulin…
  • Abstract Number: 1184 • ACR Convergence 2022

    Intracellular Calcium Signals Regulate the Pro-fibrotic Phenotype of Scleroderma Fibroblasts via Calcium/calmodulin-dependent Kinase II

    Sirapa Vichaikul1, William Brodie2, Megan Mattichak2, Qi Wu2, Dinesh Khanna2 and Eliza Pei-Suen Tsou2, 1Michigan Medicine, Howell, MI, 2University of Michigan, Ann Arbor, MI

    Background/Purpose: We performed an in-depth analysis of the involvement of histone reader bromodomain extra-terminal proteins (BETs) in scleroderma (SSc) fibrosis and showed that JQ1, a…
  • Abstract Number: 0991 • ACR Convergence 2022

    Prior Use of Autoimmune Disease Treatments Among Patients with Systemic Lupus Erythematosus, Rheumatoid Arthritis, or Myositis Hospitalized with COVID-19

    Cassandra Calabrese1, Gelareh Atefi2, Kristin Evans3, Meghan Moynihan3, Liisa Palmer3 and Sandra Sze-jung Wu4, 1Cleveland Clinic Foundation, Cleveland Heights, OH, 2AstraZeneca, Wilmington, DE, 3Merative, Cambridge, MA, 4AstraZeneca, Hockessin, DE

    Background/Purpose: To compare use of autoimmune disease treatments between patients with and without severe COVID-19 (COVID) in cohorts of patients with systemic lupus erythematosus (SLE),…
  • Abstract Number: 1373 • ACR Convergence 2022

    Increased Patient Contact May Mitigate Flares Among jSLE Patients

    Jessica Fennell, Deanna Jannat-Khah, DrPH, MSPH and karen onel, Hospital for Special Surgery, New York, NY

    Background/Purpose: Optimizing jSLE management is crucial to prevent flares as the damage sustained during flares contributes to lifelong morbidity and mortality. The onset of the…
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All abstracts accepted to ACR Convergence are under media embargo once the ACR has notified presenters of their abstract’s acceptance. They may be presented at other meetings or published as manuscripts after this time but should not be discussed in non-scholarly venues or outlets. The following embargo policies are strictly enforced by the ACR.

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