Abstracts Archive - Page 588 of 2425 - ACR Meeting Abstracts

Abstract Number: 0538 • ACR Convergence 2021
Strengthening Nuclear Envelope Ameliorates UVB-triggered Skin Inflammation and Kidney Damage in Lupus Mice
Xing Lyu¹, Minghui Li², Ping L Zhang³, Victoria Werth⁴ and Ming-Lin Liu⁴, ¹Tianjin Medical University General Hospital, Philadelphia, PA, ²Tianjin Medical University General Hospital, Tianjin, China (People's Republic), ³Division of Anatomic Pathology,Beaumont Laboratories, Beaumont Health, Royal Oak, MI, ⁴University of Pennsylvania, Philadelphia, PA
Background/Purpose: Ultraviolet B (UVB) exposure triggers lupus flare by worsening skin lesions and systemic symptoms such as lupus nephritis. The effects of UVB-induced skin inflammation…
Abstract Number: 0537 • ACR Convergence 2021
The Clinical, Oral Small Molecule IRAK4 Inhibitor, GS-5718, Improves Survival and Reduces Disease Pathologies by Modulating Multiple Inflammatory Endpoints in the Murine NZB/W Model of Spontaneous Lupus
Adam Yadon¹, Vanessa Gorney², Angie Hammond³, Ethan Grant² and Astrid Clarke³, ¹Gilead Sciences, Inc., Seattle, WA, ²Gilead Sciences, Inc, Foster City, CA, ³Gilead Sciences, Inc, Seattle, WA
Background/Purpose: Lupus is a heterogenous autoimmune disease characterized by loss of immune tolerance, production of nucleic acid:autoantibody immune complexes, immune cell hyperactivation, and increased proinflammatory…
Abstract Number: 0532 • ACR Convergence 2021
Development of a Predictive Tool for the Rapid Progressive Knee Osteoarthritis Phenotype: Data from the Osteoarthritis Initiative
Alejandro Durán-Sotuela¹, Mercedes Fernández-Moreno¹, Maria Vázquez-Mosquera¹, Paula Ramos-Louro¹, Andrea Dalmao-Fernández¹, Sara Relaño¹, Victoria Suárez-Ulloa², Vanesa Balboa-Barreiro³, Natividad Oreiro¹, Jorge Vázquez-García¹, Francisco Blanco-García⁴ and Ignacio Rego-Pérez¹, ¹Servicio de Reumatología. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ²Plataforma de Bioinformática. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006, A Coruña, Spain, ³Unidad de apoyo a la Investigación. Instituto de Investigación Biomédica de A Coruña (INIBIC). Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). As Xubias, 15006. A Coruña, España, A Coruña, Spain, ⁴Unidad de Proteómica. Grupo de Investigación de Reumatología (GIR). Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas. Universidade da Coruña (UDC). C/ As Xubias de Arriba 84, 15006, A Coruña, España.Universidade da Coruña (UDC), Grupo de Investigación de Reumatología y Salud (GIR-S). Departamento de Fisioterapia, Medicina y Ciencias Biomédicas, Facultad de Fisioterapia, Campus de Oza, 15008, A Coruña, España., A Coruña, Spain
Background/Purpose: There is a pressing need of identifying patients suffering the rapid progressive phenotype of Osteoarthritis (RPOA) to implement prevention strategies and to include them…
Abstract Number: 0543 • ACR Convergence 2021
Novel Insights into Systemic Sclerosis Using a Sensitive Computational Method to Analyze Whole-genome Bisulfite Sequencing Data
Jeffrey Yu¹, Tianyuan Lu¹, Kaiqiong Zhao¹, Kathleen Oros Klein¹, Maximilien Lora², Ines Colmegna³, Celia MT Greenwood⁴ and Marie Hudson², ¹Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, Canada, ²McGill University, Montréal, QC, Canada, ³The Research Institute of the McGill University Health Centre, Montréal, QC, Canada, ⁴Epidemiology, Biostatistics and Occupational Health / Faculty of Medicine and Health Sciences / McGill University, Montréal, QC, Canada
Background/Purpose: While the etiology of systemic sclerosis (SSc) remains largely unknown, epigenetic dysregulation including abnormal DNA methylation is thought to contribute to its onset and…
Abstract Number: 0542 • ACR Convergence 2021
Functional Characterization of Glycoprotein Nonmetastatic Melanoma Protein B in Scleroderma Fibrosis
Pamela Palisoc¹, Leah Vaikutis¹, Ellen Model¹, Morgan Omara¹, Dinesh Khanna¹, Eliza Pei-Suen Tsou¹ and Amr Sawalha², ¹University of Michigan, Ann Arbor, MI, ²University of Pittsburgh, Pittsburgh, PA
Background/Purpose: Glycoprotein nonmetastatic melanoma protein B (GPNMB) is widely expressed on stromal cells and immune cells. It is involved in various cell functions such as…
Abstract Number: 0540 • ACR Convergence 2021
Behavioral Deficits May Precede Influx of Brain-Infiltrating Macrophages in Neuropsychiatric Symptoms of Systemic Lupus Erythematosus
Hadijat Makinde, Miranda Gurra, Yidan Wang, Sara Radecki and Carla Cuda, Northwestern University, Chicago, IL
Background/Purpose: Systemic lupus erythematosus (SLE) is a complex autoimmune disease that affects many end organs including the brain. Despite a prevalence of over 50% in…
Abstract Number: 0544 • ACR Convergence 2021
Targeting CD13/aminopeptidase N as a Novel Therapeutic Approach for Scleroderma Fibrosis
Eliza Pei-Suen Tsou, M.Asif Amin, Phillip Campbell, Mikel Gurrea-Rubio, Morgan Omara, Ellen Model, Pamela Palisoc, Mustafa Ali, Sirapa Vichaikul, Jonatan Hervoso, Jeffrey Ruth, Dinesh Khanna and David Fox, University of Michigan, Ann Arbor, MI
Background/Purpose: Aminopeptidase N, also known as CD13, is a Zn2+-dependent membrane bound ectopeptidase widely expressed in mammalian cells including rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS),…
Abstract Number: 0546 • ACR Convergence 2021
Integrated Analysis of Dermal Blister Fluid Proteomics and Genome-wide Skin Gene Expression Gives New Insight into Pathogenesis of Systemic Sclerosis
Kristina Clark¹, Eszter Csomor², Corrado Campochiaro³, Adam Taylor⁴, Yee Voan Teo², Katherine Nevin², Mary Morse², Voon Ong⁵, Emma Derrett-Smith⁶, Nicolas Wisniacki², Shaun Flint² and Christopher Denton⁷, ¹University College London, London, United Kingdom, ²GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom, ³Royal Free Hospital London, London, United Kingdom, ⁴GlaxoSmithKline, London, United Kingdom, ⁵University College London Medical School Royal Free Campus, London, United Kingdom, ⁶University College London Division of Medicine, London, United Kingdom, ⁷University College London Division of Medicine, Centre for Rheumatology and Connective Tissue Diseases, London, United Kingdom
Background/Purpose: Suction blister fluid provides a unique opportunity to analyse the dermal microenvironment of SSc. We report an integrated analysis of proteomic data from dermal…
Abstract Number: 0545 • ACR Convergence 2021
SIRT1 Modulates the Senescent Phenotype in Scleroderma Endothelial Cells
Ellen Model, Morgan Omara, Pamela Palisoc, Dinesh Khanna and Eliza Pei-Suen Tsou, University of Michigan, Ann Arbor, MI
Background/Purpose: Vascular abnormalities in systemic sclerosis (SSc) are characterized by injury to vascular wall and extensive damage of the microvessels. It has been shown that…
Abstract Number: 0541 • ACR Convergence 2021
N-formyl Methionine Peptide-mediated Neutrophil Activation in Systemic Sclerosis
Runa Kuley¹, Ryan Stultz², Bhargavi Duvvuri², Roger Hesselstrand³, J Lee Nelson⁴ and Christian Lood², ¹Division of Rheumatology, University of Washington, Seattle, WA, ²University of Washington, Seattle, WA, ³Lund University, Lund, Sweden, ⁴Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA
Background/Purpose: Systemic sclerosis (SSc) is a complex systemic autoimmune disease, and its etiology is unknown. Exaggerated neutrophil activation and formation of neutrophil extracellular traps (NETs)…
Abstract Number: 0535 • ACR Convergence 2021
Therapeutic Efficacy of a Biomimetic ALXR Agonist in Murine Systemic Lupus Erythematosus (SLE)
Priyal Dave¹, Tiange Dong¹, Andrew Mead¹, Isaac Asante¹, Brandon Ebright¹, Eugene Zhou¹, RIta Li¹, Nicos Petasis¹, William Stohl² and Stan Louie¹, ¹University of Southern California, Los Angeles, CA, ²University of Southern California Keck School of Medicine, Los Angeles, CA
Background/Purpose: Neutrophils are key initiators and promoters of autoimmunity, including SLE, via the elaboration of neutrophil extracellular traps (NETs). We tested the efficacy of the…
Abstract Number: 0516 • ACR Convergence 2021
Dual Fibroblast Transdifferentiation Mediated by Type I Interferon: Application to Anti-Ro Mediated Congenital Heart Block
Christina Firl¹, Miao Chang², Jill Buyon³ and Robert Clancy¹, ¹NYU Grossman School of Medicine, New York, NY, ²NYU Langone Health, New York, NY, ³NYU School of Medicine, New York, NY
Background/Purpose: Linking inflammation to fibrosis, a common end stage feature of many autoantibody mediated rheumatic diseases, remains a challenge. Indeed the signature hallmark of anti-Ro…
Abstract Number: 0487 • ACR Convergence 2021
A Needs Assessment for the Transition into a Rheumatology Program Director Role: Survey of Current and Former Rheumatology Program Directors
Rachel Wolfe¹, Fotios Koumpouras², Anisha Dua³, Philip Seo⁴, Simon Helfgott⁵ and Beth Jonas⁶, ¹Wake Forest Baptist Health, Winston-Salem, NC, ²Yale School of Medicine, New Haven, CT, ³Northwestern University, Chicago, IL, ⁴Johns Hopkins University, Baltimore, MD, ⁵Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ⁶University of North Carolina at Chapel Hill, Chapel Hill, NC
Background/Purpose: Clinical educators taking on the new role as program director (PD) must have the time and resources to learn about all the processes (e.g.,…
Abstract Number: 0424 • ACR Convergence 2021
Incremental Healthcare Costs of Eosinophilic Granulomatosis with Polyangiitis (EGPA) Compared to Asthma: Retrospective Analysis of Commercial Claims Data in the United States (US)
Christopher Bell¹, Juliana Meyers² and Mayank Ajmera², ¹GlaxoSmithKline, Research Triangle Park, NC, ²RTI-Health Solutions, Research Triangle Park, NC
Background/Purpose: Eosinophilic granulomatosis with polyangiitis (EGPA), formerly Churg-Strauss Syndrome, is a rare, complex multisystem disorder, characterized by vascular inflammation and multisystem organ damage. EGPA manifests…
Abstract Number: 0299 • ACR Convergence 2021
Sex Hormones and Risk of Sjögren’s Syndrome: Hypothesis Generating Findings Implicating Androgen and Estrogen Ratios
Sara McCoy¹, Christie Bartels², Scott Hetzel¹ and Jeffrey VanWormer³, ¹University of Wisconsin, Madison, WI, ²University of Wisconsin School of Medicine and Public Health, Madison, WI, ³Marshfield Research Institute, Marshfield, WI
Background/Purpose: Sjӧgren’s syndrome (SS) is the most female predominant systemic autoimmune disease, with peak onset around perimenopause. Estrogen appears to protect against SS, but prior…

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