ACR Meeting Abstracts

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  • Abstract Number: 0359 • ACR Convergence 2021

    Patient Journey with Axial Spondyloarthritis: Critical Issues from the Patient Perspective. Results from the European Map of Axial Spondyloarthritis (EMAS)

    Marco Garrido-Cumbrera1, Denis Poddubnyy2, Christine Bundy3, Laura Christen4, Raj Mahapatra5, Souzi Makri6, Carlos Jesús Delgado-Domínguez7, Sergio Sanz-Gomez7, Pedro Plazuelo-Ramos8 and Victoria Navarro-Compán9, 1Health & Territory Research (HTR), University of Seville, Sevilla, Spain, 2Department of Rheumatology, Charité – Universitätsmedizin, Berlin, Germany, 3Cardiff University, Cardiff, Wales, United Kingdom, 4Novartis Pharma AG, Basel, Switzerland, 5Axial Spondyloarthritis International Federation (ASIF), London, United Kingdom, 6Cyprus League Against Rheumatism (CYPLAR), Limassol, Cyprus, 7Health & Territory Research (HTR), Universidad de Sevilla, Seville, Spain, 8Spanish Federation of Spondyloarthritis Associations (CEADE), Madrid, Spain, 9Rheumatology service, Hospital Universitario La Paz-IdiPaz, Madrid, Spain

    Background/Purpose: The journey of axial spondyloarthritis (axSpA) for most patients is slow and arduous. The goal of this analysis is to assess the journey to…
  • Abstract Number: 0358 • ACR Convergence 2021

    Work Participation in Patients with Axial Spondyloarthritis in Germany: Results from a Multicenter, Observational Survey

    Uta Kiltz1, Kirsten Hoeper2, Ludwig Hammel3, Sebastian Lieb4, Andreas Haehle4 and Dirk Meyer-Olson5, 1Rheumazentrum Ruhrgebiet Herne, Ruhr-Universität Bochum, Herne, Germany, 2Regionales Kooperatives Rheumazentrum Niedersachsen e. V.; Medizinische Hochschule Hannover, Department of Rheumatology and Immunology, Hannover, Germany,, Hannover, Germany, 3Deutsche Vereinigung Morbus Bechterew e.V.,, Schweinfurt, Germany, 4Novartis Pharma GmbH, Immunology, Hepatology and Dermatology, Nürnberg, Germany, 5m&i Fachklinik Bad Pyrmont, Hannover, Germany

    Background/Purpose: Axial spondyloarthritis (axSpA) is a chronic inflammatory condition often associated with impaired working participation1 not only translating to devastating outcomes for patients (pts) but…
  • Abstract Number: 0357 • ACR Convergence 2021

    Identifying Predictors of Unemployment in Axial Spondyloarthropathy: Data from the Ankylosing Spondylitis Registry of Ireland

    Sinead Maguire1, Wilson Fiona2, Phil Gallagher3 and Finbar (Barry) O'Shea1, 1St James's Hospital, Dublin, Ireland, 2Discipline of Physiotherapy, Trinity College Dublin, Dublin, Ireland, 3St Vincent's Hospital, Dublin, Ireland

    Background/Purpose: Axial spondyloarthropathy (axSpA) is an inflammatory arthritis of the axial skeleton. Persistent disease activity can result in significant disability and affect ability to maintain…
  • Abstract Number: 0352 • ACR Convergence 2021

    Native American and African American Rheumatic Disease Patients Exhibit Accelerated Biological Aging Compared to European Americans

    Joseph Kheir, Carla Guthridge, Nicolas Dominguez, Wade DeJager, Sarah Cooper, Joel Guthridge and Judith James, Oklahoma Medical Research Foundation, Oklahoma City, OK

    Background/Purpose: The universal process of aging is associated with increased risk of disease and death as a result of changing physiologic and molecular processes. In…
  • Abstract Number: 0363 • ACR Convergence 2021

    Disease Course and Disease Burden in Patients with Axial Spondyloarthritis: Results from 5-year Multicountry Prospective Observational Study

    Denis Poddubnyy1, Joachim Sieper2, Servet Akar3, Santiago Muñoz-Fernández4, Hildrun Haibel2, Fabiana Ganz5 and Robert Inman6, 1Department of Rheumatology, Charité – Universitätsmedizin, Berlin, Germany, 2Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany, 3Izmir Katip Celebi University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Izmir, Turkey, 4Servicio de Reumatología, Hospital Universitario Infanta Sofía, Madrid, Spain, 5Abbvie Inc., North Chicago, IL, 6University Health Network, Toronto, ON, Canada

    Background/Purpose: Patients (pts) with axial SpA (axSpA) can be classified into radiographic axSpA (r-axSpA) and non-radiographic axSpA (nr-axSpA) based on the presence or absence of…
  • Abstract Number: 0362 • ACR Convergence 2021

    Achievement of Stringent Thresholds of Disease Control Is Associated with Reduced Burden on Work and Household Productivity in Patients with Axial Spondyloarthritis

    Martin Rudwaleit1, Pedro Machado2, Lianne Gensler3, Vanessa Taieb4, Natasha de Peyrecave5, Bengt Hoepken6 and Désirée van der Heijde7, 1University of Bielefeld, Klinikum Bielefeld, Bielefeld, Germany, 2Centre for Rheumatology & Department of Neuromuscular Diseases, University College London, London, United Kingdom, 3Department of Rheumatology, University of California San Francisco, San Francisco, CA, 4UCB Pharma, Slough, United Kingdom, 5UCB Pharma, Brussels, Belgium, 6UCB Pharma, Monheim am Rhein, Germany, 7Department of Rheumatology, Leiden University Medical Center, Meerssen, Netherlands

    Background/Purpose: Axial spondyloarthritis (axSpA) is associated with increased absence from work and reduced work productivity, which can impact employment status.1 TNF inhibitors such as certolizumab…
  • Abstract Number: 0360 • ACR Convergence 2021

    Factors Associated with Pain Intensity in Axial Spondyloarthritis. Results from the EuropeanMap of Axial Spondyloarthritis (EMAS)

    Marco Garrido-Cumbrera1, Victoria Navarro-Compán2, Christine Bundy3, Laura Christen4, Raj Mahapatra5, Souzi Makri6, Carlos Jesús Delgado-Domínguez7, José Correa-Fernández7, Pedro Plazuelo-Ramos8 and Denis Poddubnyy9, 1Health & Territory Research (HTR), University of Seville, Sevilla, Spain, 2Rheumatology service, Hospital Universitario La Paz-IdiPaz, Madrid, Spain, 3Cardiff University, Cardiff, Wales, United Kingdom, 4Novartis Pharma AG, Basel, Switzerland, 5Axial Spondyloarthritis International Federation (ASIF), London, United Kingdom, 6Cyprus League Against Rheumatism (CYPLAR), Limassol, Cyprus, 7Health & Territory Research (HTR), Universidad de Sevilla, Seville, Spain, 8Spanish Federation of Spondyloarthritis Associations (CEADE), Madrid, Spain, 9Department of Rheumatology, Charité – Universitätsmedizin, Berlin, Germany

    Background/Purpose: Pain is a hallmark of axial spondyloarthritis (axSpA) and can significantly deteriorate patients’ health status. This analysis aims to investigate factors associated with pain…
  • Abstract Number: 0364 • ACR Convergence 2021

    Dose Tapering of TNF Inhibitors in Patients with Axial Spondyloarthritis in Routine Care – 2-year Clinical and MRI Outcomes and Predictors of Successful Tapering

    Marie Wetterslev1, Stylianos Georgiadis2, Inge Juul Sørensen3, Susanne Juhl Pedersen2, Sara Nysom Christiansen4, Merete Lund Hetland1, Cecilie Heegaard Brahe2, Mads Bakkegaard5, Anne Duer6, Mikael Boesen7, Kasper Kjærulf Gosvig8, Jakob Møllenbach Møller8, Niels Steen Krogh9, Bente Jensen5, Ole Rintek Madsen5, Jan Christensen5, Annette Hansen5, Jesper Nørregaard5, Henrik Røgind5 and Mikkel Ostergaard10, 1Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark, 2Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, 3Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, 4Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, Denmark, 5Center for Rheumatology and Spine Diseases, Rigshospitalet, Copenhagen, Denmark, 6Department of Radiology, Rigshospitalet, Glostrup, Copenhagen, Denmark, 7Department of Radiology, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark, 8Department of Radiology, Herlev and Gentofte Hospital, Copenhagen, Denmark, 9ZiteLab ApS, Copenhagen, Denmark, Frederiksberg, Denmark, 10Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup, and Department of Clinical Medicine, University of Copenhagen, Glostrup, Denmark

    Background/Purpose: In a 2-year follow-up study of patients with axial spondyloarthritis (axSpA) in clinical remission who tapered Tumor Necrosis Factor inhibitor (TNFi) treatment according to…
  • Abstract Number: 0366 • ACR Convergence 2021

    Why Is It so Difficult for AxSpA Patients to Find a Job? Results from the European Map of Axial Spondyloarthritis (EMAS)

    Marco Garrido-Cumbrera1, Victoria Navarro-Compán2, Christine Bundy3, Souzi Makri4, Laura Christen5, José Correa-Fernández6, Sergio Sanz-Gomez6, Raj Mahapatra7, Carlos Jesús Delgado-Domínguez6 and Denis Poddubnyy8, 1Health & Territory Research (HTR), University of Seville, Sevilla, Spain, 2Rheumatology service, Hospital Universitario La Paz-IdiPaz, Madrid, Spain, 3Cardiff University, Cardiff, Wales, United Kingdom, 4Cyprus League Against Rheumatism (CYPLAR), Limassol, Cyprus, 5Novartis Pharma AG, Basel, Switzerland, 6Health & Territory Research (HTR), Universidad de Sevilla, Seville, Spain, 7Axial Spondyloarthritis International Federation (ASIF), London, United Kingdom, 8Department of Rheumatology, Charité – Universitätsmedizin, Berlin, Germany

    Background/Purpose: AxSpA is associated with substantial negative consequences regarding work status and career prospects. The aim is to identify factors associated with barriers to job…
  • Abstract Number: 0365 • ACR Convergence 2021

    A Cluster Analysis in Patients with Axial Spondyloarthritis Using TNFi Based on Clinical Characteristics

    Seulkee Lee, Seonyoung Kang, Yeonghee Eun, Hyungjin Kim, Hoon-Suk Cha, Eun-Mi Koh and Jaejoon Lee, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

    Background/Purpose: Previous studies using cluster analysis technique in axial spondyloarthritis (axSpA) patients have consistently identified distinct groups of patients in terms of their clinical characteristics:…
  • Abstract Number: 0361 • ACR Convergence 2021

    Factors Associated with Engaging in Physical Activity in Axial Spondyloarthritis. Results from the European Map of Axial Spondyloarthritis (EMAS)

    Marco Garrido-Cumbrera1, Victoria Navarro-Compán2, Christine Bundy3, Laura Christen4, Raj Mahapatra5, Souzi Makri6, Carlos Jesús Delgado-Domínguez7, David Gálvez-Ruiz7, Pedro Plazuelo-Ramos8 and Denis Poddubnyy9, 1Health & Territory Research (HTR), University of Seville, Sevilla, Spain, 2Rheumatology service, Hospital Universitario La Paz-IdiPaz, Madrid, Spain, 3Cardiff University, Cardiff, Wales, United Kingdom, 4Novartis Pharma AG, Basel, Switzerland, 5Axial Spondyloarthritis International Federation (ASIF), London, United Kingdom, 6Cyprus League Against Rheumatism (CYPLAR), Limassol, Cyprus, 7Health & Territory Research (HTR), Universidad de Sevilla, Seville, Spain, 8Spanish Federation of Spondyloarthritis Associations (CEADE), Madrid, Spain, 9Department of Rheumatology, Charité – Universitätsmedizin, Berlin, Germany

    Background/Purpose: Physical activity is an essential component in axial spondyloarthritis (axSpA) care, improving physical and mental wellbeing. This analysis aims to identify factors associated with…
  • Abstract Number: 0355 • ACR Convergence 2021

    Utilization of a Clinical Data Research Network to Assess Systemic Lupus International Collaborating Clinics Classification Criteria Attributes in Patients with Systemic Lupus Erythematosus

    Noah Forrest1, Kathryn Jackson2, Al'ona Furmanchuk2, Anika Ghosh2, Jennifer Pacheco2, Vesna Mitrovic2, Abel Kho2, Rosalind Ramsey-Goldman2 and Theresa Walunas2, 1Feinberg School of Medicine, Chicago, 2Northwestern University, Chicago, IL

    Background/Purpose: Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by a heterogenous clinical phenotype that may present differently over time and between patients, which…
  • Abstract Number: 0336 • ACR Convergence 2021

    The Incremental Clinical Utility of a Multianalyte Assay Panel with Cell-Bound Complement Activation Products versus a Traditional ANA Testing Strategy for the Diagnosis and Treatment of SLE

    Tyler O'Malley1, Fenglong Xie2, yujie Su2, cassie Clinton2, Debra J. Zack1, Jeffrey Curtis3 and John Wegener1, 1Exagen Inc., Vista, CA, 2University of Alabama at Birmingham, Birmingham, AL, 3Division of Clinical Immunology and Rheumatology, Department of Medicine, Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL

    Background/Purpose: The comparative clinical utility of various diagnostic tests to aid the differential diagnosis of SLE is unclear. We compare the outcomes of testing with…
  • Abstract Number: 0307 • ACR Convergence 2021

    Cerebellar Ataxia in Primary Sjogren’s Syndrome, Is Gluten Sensitivity the Answer?

    Fu Chuen Kon1, Mohammed Akil2, Rachael Kilding2, Kar-Ping Kuet2, Priya Shanmugarajah3, Nigel Hoggard4 and Marios Hadjivassiliou3, 1Department of Rheumatology, Sheffield Teaching Hospitals NHS Trust, Sheffield, 2Department of Rheumatology, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom, 3Academic Department of Neurosciences, Sheffield Teaching Hospitals NHS Trust and University of Sheffield, Royal Hallamshire Hospital, Sheffield United Kingdom, Sheffield, United Kingdom, 4Academic Unit of Radiology, Royal Hallamshire Hospital, Sheffield, United Kingdom

    Background/Purpose: Cerebellar ataxia is an uncommon neurological complication of Primary Sjogren’s Syndrome (PSS), with case reports being the highest level of evidence available. The underlying…
  • Abstract Number: 0244 • ACR Convergence 2021

    Development of Candidate Criteria for Axial Disease in Juvenile Spondyloarthritis: An International Collaboration

    Pamela Weiss1, Timothy Brandon1, Amita Aggarwal2, Ruben Burgos-Vargas3, Robert Colbert4, Gerd Horneff5, Rik Joos6, Ronald Laxer7, Kirsten Minden8, Angelo Ravelli9, Nicolino Ruperto10, Judith Smith11, Matthew Stoll12, Shirley Tse7, Filip Van den Bosch13, Walter Maksymowych14, Robert Lambert15, David Biko16, Nancy Chauvin17, Michael Francavilla16, Jacob Jaremko15, Nele Herregods18, Ozgur Kasapcopur19, Mehmet YILDIZ20 and Alison Hendry21, 1Children's Hospital of Philadelphia, Philadelphia, PA, 2Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, 3Department of Rheumatology, General Hospital of Mexico, Ciudad de Mxico, Mexico, 4NIH/NIAMS, Bethesda, MD, 5Paediatric Rheumatology International Trials Organisation (PRINTO), Sankt Augustin, Germany, 6Ghent University, Ghent, Belgium, 7SickKids, Toronto, ON, Canada, 8German Rheumatism Research Center, Berlin, Germany, 9Istituto Giannina Gaslini, Genoa, Italy, 10IRCCS Istituto Giannina Gaslini; PRINTO, Clinica Pediatrica e Reumatologia, Genova, Italy, 11University of Wisconsin, Madison, WI, 12University of Alabama at Birmingham, Birmingham, AL, 13Dept. of Rheumatology - Ghent University Hospital, Ghent, Belgium, Ghent, Belgium, 14Department of Medicine, University of Alberta, Alberta, Canada, Edmonton, AB, Canada, 15University of Alberta, Edmonton, AB, Canada, 16University of Pennsylvania, Philadelphia, PA, 17Penn State Health, Hershey, PA, 18Universitair Ziekenhuis Ghent, Ghent, Belgium, 19Istanbul University-Cerrahpasa, Cerrahpasa Medical School, İstanbul, Turkey, 20Istanbul University-Cerrahpasa, Faculty of Medicine, Pediatric Rheumatology, İstanbul, Turkey, 21NZ Familial GI Cancer Service, Auckland, New Zealand

    Background/Purpose: As part of a larger study developing classification criteria for axial disease in children with spondyloarthritis (SpA), the objective of this project phase was…
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