Abstracts Archive - Page 572 of 2425 - ACR Meeting Abstracts

Abstract Number: 0299 • ACR Convergence 2021
Sex Hormones and Risk of Sjögren’s Syndrome: Hypothesis Generating Findings Implicating Androgen and Estrogen Ratios
Sara McCoy¹, Christie Bartels², Scott Hetzel¹ and Jeffrey VanWormer³, ¹University of Wisconsin, Madison, WI, ²University of Wisconsin School of Medicine and Public Health, Madison, WI, ³Marshfield Research Institute, Marshfield, WI
Background/Purpose: Sjӧgren’s syndrome (SS) is the most female predominant systemic autoimmune disease, with peak onset around perimenopause. Estrogen appears to protect against SS, but prior…
Abstract Number: 0298 • ACR Convergence 2021
The Clinical Phenotype of Isolated Ocular and Oral Dryness in Sjogren Syndrome, Fulfilling the 2016 ACR-EULAR Classification Criteria
Loukas Chatzis¹, Andreas Goules², Chiara Baldini³, Vasilis Pezoulas⁴, Ourania Argyropoulou¹, Paraskevi Voulgari⁵, Sofia Kouvelioti⁶, Dimitrios Fotiadis⁷, Fotini Skopouli⁸, Haralampos Moutsopoulos⁹ and Athanasios Tzioufas¹, ¹Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, ²Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, ³University of Pisa, Pisa, Italy, ⁴Unit of Medical Technology and Intelligent Information Systems, University of Ioannina, Ioannina, Greece, Ioannina, Greece, ⁵Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece, ⁶Leophoros Kifisias 81, Ampelokipoi, Athens, Greece, ⁷Department of Biomedical Research, Institute of Molecular Biology and Biotechnology, FORTH, Ioannina, Greece, Ioannina, Greece, ⁸Department of Nutrition and Clinical Dietetics, Harokopio University of Athens, Athens, Greece, ⁹Athens Academy of Athens, Chair Medical Sciences/Immunology, Athens, Greece
Background/Purpose: Dry mouth and eyes are the main clinical features of Sjögren’s syndrome (SS), although a minority of patients present without sicca manifestations and isolated…
Abstract Number: 0297 • ACR Convergence 2021
Describing the Disease Burden of Primary Sjögren’s Syndrome Patients: Results from a Real-World Survey in the US
Briana Ndife¹, Ben Hoskin², Megan Hughes² and Nicola Booth², ¹Novartis, East Hanover, NJ, ²Adelphi Real World, Bollington, United Kingdom
Background/Purpose: Primary Sjogren’s syndrome is a highly heterogeneous condition, with limited understanding of the burden of disease. The objective of this study was to describe…
Abstract Number: 0292 • ACR Convergence 2021
Suppressed Paraoxonase-1 Activity and Elevated Oxylipins Associate with the Presence of Small Airways Disease in Patients with Rheumatoid Arthritis
Amir Razmjou¹, Jennifer Wang², Ani Shahbazian², Srinivasa Reddy³ and Christina Charles-Schoeman², ¹University of California Los Angeles Medical Center, Los Angeles, CA, ²Department of Medicine, University of California, Los Angeles, Los Angeles, CA, ³David Geffen School of Meicine, UCLA, Los Angeles, CA
Background/Purpose: Lung disease in patients with rheumatoid arthritis (RA) is common and associates with significantly increased morbidity and mortality. Oxidative stress plays an important role…
Abstract Number: 0303 • ACR Convergence 2021
Extraglandular Manifestations as Initial Presentation in a Cohort of Patients with Primary Sjögren’s Syndrome
Lucia Alascio¹, Silvia Papasidero¹, María Alejandra Medina¹, Juan Manuel Bande¹, Silvana Perez¹, Eliana Serrano¹, Diana Klajn¹, Jose Caracciolo¹, Rosella Tralice², Erick Rodríguez², Felix Romanini², Anastasia Secco², Sinda Zalles³, Carolina Segura Escobar³, Julia Demarchi³, Geofredo Guillermo Earsman⁴, Laura Raiti⁵, Sofia Velez⁶ and Alejandro Martinez⁷, ¹Hospital General de Agudos Dr. Enrique Tornú, Buenos Aires, Argentina, ²Hospital Rivadavia, Buenos Aires, Buenos Aires, Argentina, ³Hospital Británico, Buenos Aires, Buenos Aires, Argentina, ⁴Hospital Británico, Buenos Aires, La Lucila, Argentina, ⁵Clínica Bessone, Buenos Aires, Buenos Aires, Argentina, ⁶Consultorio privado de reumatología, Buenos Aires, Argentina, ⁷Fundación respirar, Buenos Aires, Mexico City, Mexico
Background/Purpose: Primary Sjögren's Syndrome (pSS) is a systemic autoimmune disease which is mostly characterized by the presence of xerophthalmia and xerostomia, caused by the lymphoplasmacytic…
Abstract Number: 0302 • ACR Convergence 2021
Loss of TAM Receptor Mer Contributes to Sjögren’s Syndrome–like Disease in Mice
Richard Witas and Cuong Nguyen, University of Florida, Gainesville, FL
Background/Purpose: Sjögren’s syndrome (SjS) is a chronic autoimmune disease primarily involving the exocrine glands where the involvement of the innate immune system is largely uncharacterized.…
Abstract Number: 0300 • ACR Convergence 2021
Salivary Gland Epithelial Cells Transcriptomic Analysis Highlight Their Potential Involvement in Extracellular Matrix Modification in Sjögren’s Syndrome
Elodie Rivière¹, Juliette Pascaud¹, Franck Letourneur², Gaetane Nocturne¹ and Xavier Mariette³, ¹Immunology of viral Infections and Autoimmune Diseases, IDMIT, CEA - Université Paris Sud - INSERM U1184 ; Rheumatology, APHP, Université Paris Saclay, Le Kremlin Bicêtre, France, ²Plateforme Génomique : GENOM'IC — Institut Cochin, Paris, France, ³Université Paris- Saclay, Rheumatology, Paris, France
Background/Purpose: Salivary gland epithelial cells (SGECs) participate to the hyper activation of the immune system in primary Sjögren’s syndrome (pSS). This study aimed to analyze…
Abstract Number: 0304 • ACR Convergence 2021
Renal Involvement in Sjőgren’s Syndrome: Predictors and Impact on Patient Outcome
Rudrarpan Chatterjee¹, Anu Balakrishnan², Rajat Kharbanda¹, Upendra Rathore¹, Latika Gupta¹, Durga P Misra¹, Vikas Agarwal², Amita Aggarwal¹ and Able Lawrence², ¹Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, ²Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India
Background/Purpose: Renal disease in primary Sjogren's syndrome (pSS) can occur in form of tubulointerstitial nephritis (TIN) or glomerulonephritis (GN). Data from India on pSS is…
Abstract Number: 0306 • ACR Convergence 2021
Allergic Disorders in Primary Sjögren’s Syndrome Compared with Rheumatoid Arthritis
Misako Higashida-Konishi¹, Keisuke Izumi², Tatsuya Shimada³, Satoshi Hama⁴, Mitsuhiro Akiyama⁵, Hisaji Oshima⁴ and Yutaka Okano⁶, ¹Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center, Meguroku, Japan, ²Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center/Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan, ³Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center/ Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, ⁴Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center, tokyo, Japan, ⁵Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center/ Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Palo Alto, CA, ⁶Department of Connective Tissue Diseases, National Hospital Organization Tokyo Medical Center, Kawasaki, Japan
Background/Purpose: Allergic disorders are occasionally seen in patients with primary Sjögren's syndrome (pSS) [1]. Risk factors are unclear for allergic disorders.We aimed to compare the…
Abstract Number: 0305 • ACR Convergence 2021
Artificial Neural Networks Approaches to Predict Myocardial Fibrosis in Primary Sjögren Syndrome Patients Without Cardiac Symptoms
Hitomi Kobayashi¹, Yasuyuki Kobayashi², Atsuma Nishiwaki¹, Isamu Yokoe¹, Haraoka Masaki³, Eichi Takaya³, Yousuke Nagasawa¹, Noboru Kitamura¹, Masami Takei¹ and Hideki Nakamura¹, ¹Nihon University School of Medicine, Itabashi, Japan, ²St. Marianna University School of Medicine, kowasaki, Japan, ³St. Marianna University School of Medicine, Kawaski, Japan
Background/Purpose: A recent meta-analysis of cardiovascular diseases demonstrated that the odds of heart failure (HF) was more than 2.54-fold higher in primary Sjögren syndrome (pSS)…
Abstract Number: 0301 • ACR Convergence 2021
Activation of Akt Signaling Pathway in the Minor Salivary Glands of Patients with Primary Sjögren’s Syndrome Does Not Relate with Clinical Phenotype
Ioanna Stergiou¹, Loukas Chatzis², Asimina Papanikolaou³, Stavroula Giannouli⁴, Athanasios Tzioufas², Michael Voulgarelis² and Efstathia Kapsogeorgou², ¹Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, ²Department of Pathophysiology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece, ³Department of Haemopathology, "Evangelismos" Hospital, Athens, Greece, Athens, Greece, ⁴2nd Department of Internal Medicine, Hippokrateion Hospital, National and Kapodistrian University of Athens, Athens, Greece, Athens, Greece
Background/Purpose: Akt is a phosphoinositide-dependent serine/threonine kinase with diverse regulatory functions that has been implicated in numerous pathological processes, including oncogenesis and autoimmune diseases. Indirect…
Abstract Number: 0295 • ACR Convergence 2021
Weight History and Associations with Cardiovascular Risk in Patients with Rheumatoid Arthritis
Lydia Federico¹, Kaleb Michaud², Kristin Wipfler³, Gulsen Ozen⁴ and Joshua Baker¹, ¹University of Pennsylvania, Philadelphia, PA, ²University of Nebraska Medical Center, Omaha, NE, ³FORWARD, The National Databank for Rheumatic Diseases, Omaha, NE, ⁴University of Nebraska Medical Center, Bellevue, NE
Background/Purpose: Cardiovascular disease (CVD) is the leading cause of mortality in rheumatoid arthritis (RA), but traditional CVD risk factors may not accurately characterize risk. For…
Abstract Number: 0276 • ACR Convergence 2021
Pulse Pressure as a Predictor of Carotid Plaque in Rheumatoid Arthritis Patients
Natalia Guajardo-Jauregui, Iris Colunga-Pedraza, Jose Azpiri-Lopez, Dionicio Galarza-Delgado, Alejandra Rodriguez-Romero, Julieta Loya-Acosta, Alejandro Meza-Garza, Jesus Cardenas-de La Garza, Salvador Lugo-Perez and Jessica Castillo-Treviño, Hospital Universitario "Dr Jose E. Gonzalez", Monterrey, Mexico
Background/Purpose: Pulse pressure (PP) is defined as the difference between systolic and diastolic blood pressure and represents arterial compliance and reflective properties of blood flow.…
Abstract Number: 0247 • ACR Convergence 2021
Three-year Effectiveness in Patients with JIA Initiating Abatacept: Results from the PRCSG/PRINTO JIA Real-World Registry
Nicolino Ruperto¹, Hermine Brunner², Nikolay Tzaribachev³, Ilonka Orbán⁴, Valda Staņēviča⁵, Ana Quintero del Rio⁶, Pierre Quartier⁷, Adam Huber⁸, Dan Kietz⁹, Jason Dare¹⁰, Daniel Kingsbury¹¹, T. Brent Graham¹², Ivan Foeldvari¹³, Julisa Patel¹⁴, Alyssa Dominique¹⁵, Lixian Dong¹⁵, Tzuyung Douglas Kou¹⁵, Robert Wong¹⁶, Alberto Martini¹⁷ and Daniel Lovell¹⁸, ¹IRCCS Istituto Giannina Gaslini; PRINTO, Clinica Pediatrica e Reumatologia, Genova, Italy, ²Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ³PRI Research, Bad Bramstedt, Germany, ⁴National Institute of Rheumatology and Physiotherapy, Budapest, Hungary, ⁵Riga Stradins University, Riga, Latvia, ⁶Dr. Ramon Ruiz Arnau University Hospital, Bayamόn, PR, ⁷Necker-Enfants Malades University Hospital, Assistance Publique-Hopitaux de Paris, Paris, France, ⁸Dalhousie University, Halifax, NS, Canada, ⁹Children’s Hospital of Pittsburgh, Pittsburg, PA, ¹⁰University of Arkansas for Medical Sciences, Little Rock, AR, ¹¹Randall Children's Hospital at Legacy Emanuel, Portland, OR, ¹²Vanderbilt University Medical Center, Nashville, TN, ¹³Hamburg Centre for Pediatric and Adolescent Rheumatology, Hamburg, Germany, ¹⁴Children’s Hospital of Georgia, Augusta University Medical Center, Augusta, GA, ¹⁵Bristol Myers Squibb, Princeton, NJ, ¹⁶Bristol Myers Squibb, Basking Ridge, NJ, ¹⁷Paediatric Rheumatology International Trials Organisation (PRINTO), Genoa, Italy, ¹⁸Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, OH
Background/Purpose: The ongoing phase 4 Pediatric Rheumatology Collaborative Study Group (PRCSG)/Paediatric Rheumatology INternational Trials Organisation (PRINTO) registry was designed to assess the long-term (up to…
Abstract Number: 0184 • ACR Convergence 2021
Phase III, Randomized Trial Comparing Clinical Outcomes Between Patients with Moderate-to-severe Chronic Plaque Psoriasis Receiving Adalimumab Reference Product (RP) Continuously versus Those Who Switched Between BI 695501 and Adalimumab RP
Alan Menter¹, Dorothy McCabe², Benjamin Lang³, Jennifer Schaible⁴ and Sravan Kumar Eduru⁵, ¹Baylor Scott & White, Dallas, TX, ²Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT, ³Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany, ⁴Boehringer Ingelheim Pharma GmbH & Co. KG, Boberach, Germany, ⁵(Formerly at) Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim am Rhein, Germany
Background/Purpose: BI 695501 is a FDA-approved biosimilar to adalimumab RP (AbbVie), and is approved in seven indications, including rheumatoid arthritis, psoriatic arthritis, juvenile idiopathic arthritis,…

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